Search for morphological defects
Search strategy
The search at iBeetle-Base allows for very specific searches (e.g. “larva, leg,
size decreased”). However, in order not to miss interesting phenotypes, we
recommend initiating your search broadly for defects of the structure and stage
you are interested in (larva, leg). Further, a penetrance of >50% is recommended
in order to increase the portion of reproducible datasets. Next, the list should
be consolidated by browsing the pictures and detailed annotations displayed in
the search results. Interesting results can be marked by checkboxes. Finally,
the respective details pages should be browsed in order to learn more about
additional phenotypes, the gene structure and sequences and its orthologs.
Reproducibility
Highly penetrant phenotypes with a direct phenotype-genotype relationship
(e.g. lethality, wing blistering) were reproducible at a close to 100% rate
in our hands. Regarding processes where the relation between gene function
and phenotype is complex (e.g. embryonic development), the rate of
reproducibility was between 70% and 80%. Reproducibility of low penetrance
phenotypes (<50%) was significantly lower.

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