Status
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Gene information
General information
TC004152 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007416.3: 1719429..1733579
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC004152
    iBeetle screen iB_10029

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 20.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Fertility
    vitellogenic egg chamber late sometimesdegenerated - Number of animals showing the phenotype: 3

    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: < 50 larval musculature thinner - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    larval musculature anterior not present - Penetrance (percentage of animals/eggs on slide): less than 30%

    Comment: most larvae on slide appear like dying, but always starting anterior. potentially segmentation defect?
    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    head capsule structure irregular - Penetrance (percentage of animals/eggs on slide): less than 30%

    head potentiallysize decreased - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    head appendages orientation irregular - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    labrum size decreased - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    antenna shape irregular - Penetrance (percentage of animals/eggs on slide): 30% - 50%

    head cuticle structure irregular - Penetrance (percentage of animals/eggs on slide): 30% - 50%

    posterior terminus shape irregular - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: % (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: % (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC004152 RA
      MKIDRSRVR KSTSDVPIE CQQLIERLQ ACSRTELLE 
      ELSKINTWT FGKCELLHW ALVLDVFDK ILGEAGRKS 
      FENKWALKC DTHYNSTEK KLLLWILHF TTLLIEHSF 
      SRHLYNSLE HLLVLLESN DMSVVLGVL NLLYMFSKR 
      SNFISRLSP DKKNSLLSR LHHLAENWG GKENGFGLA 
      DCCRADETL PFSATTVHV EFHRESDDP KEAPSKNSK 
      NSPHIIHIE HVDKIHRTP AEIMKSLLG IYYVPPDKQ 
      MWLFTRVRL AYHFADYNN RLLCVQARL QALSVLVYS 
      NAIQDSPHN LLYNGLLEE LVELVEMKD PHLVEIRSA 
      ALRTLTAII HLDRNPHIP KKPGSRLNN IIDVTGASQ 
      YHGFLPLLV RNCIITLTN QSSENQSKK DDTEIIDVD 
      CDEAKVMEN SDVTMSPQQ IADPNAKFP LSLATALFS 
      FLYHLASYE AGGEALVSC GMMESLLQV INWHGVELE 
      HITFVTRAV RVIDLITNI DMQAFQTHG GLQSFINRL 
      DVEVKLCKA EQLYEIKTT VTDQTFLEE GAAGPSTEA 
      PENSSEPTK LVDLEYHSE NVGKTCLPQ RAALLKSML 
      NFLKKALQD STFSDNIRH LMEGTLPNS LKNIIANAE 
      YYGPSLFLL ATDVVTVYV YQEPSLLSA LQDNGLIEV 
      VLHSLLVKE IPATREVLG SLPNVFSAL CLNNRGLQQ 
      FIKMKPFEK TFSVLLSPD YLPAMRRRR SSEPMADTA 
      CNLGNAMDE LMRHQPSLK SDAIKAIID LLEELVNLG 
      TDPKYICWK PHSKSEVSP SSSTRSATN TEGSSDEED 
      EDEEEASTS SQNAQNDAQ VQQENSERT PIALIDYIL 
      NTMKFIDAI LSNNSTDDH CREFVQQGG LRPLLKILG 
      LPNLPVNCP VTNPAQAVA TVCKSILNL AHETNLFKE 
      GLAQLSEVL EVLKPMYTK LDVPSGPKL LLELAGASN 
      VENAFNNAS VTPLLHAMG AAHGYIIML VHVCRTGQS 
      EIRNLSLQN WGSEEGLRV IKGLADLYT SLVWESTLL 
      LAYCSEEFI PSDFTREDI EKLNAFFDK CESSNTGSD 
      STVNVASAM EALTTNPPS IEMDVDQEG ITLNLSTSL 
      KYIKPLLGA SSRLGRALA ELFGLLVKL CVGSPIRQR 
      RGQNIIAAP PLPTPYARS VATALNVLL ADGLDYERL 
      PACPLIKSR ITFLICSVG FTSPMLFDE KRYPYHLML 
      KKFVALGGQ ATFFNTFRW ALSAGGTIP IEKAFEDGP 
      LPEGTAGFL DAWLMLLEK MVNPKAILE SPHIISNRS 
      SQSSTYRGY NFDPLKYLI QIHKLAFEA VILLWNKAP 
      LTTYGTRLS ENILTVLRH ILRGEKIIK EKLKSEENM 
      STDLSRPKS SSGNSSREP EVNPDSLRQ LMDMGFSRE 
      HVTDALLNT LTVEQATDY LLTNPPSLY RISQSFMNS 
      DEDDQMMQA IAISLGVSN NLPSVSKKR QIQDDGKPL 
      AESLIDEFT NHALEACLR LLDNTPECV HKICELLVT 
      IMKRNGRTF RDNLLDTLV KEIYENAKN VCYALKQPE 
      CELPSVAKL PCATRLANY LHLYILFFE VSSYFEMKI 
      PCALAVHKI DLINLLIKL ICMAEKVMS RSEKVTEPK 
      WLASSFLLI DAASKVATC AHRKRNMHL STTRVWRWF 
      HLETGKWTP YSNSNNKLI NDAYWNGEQ SVRVICGRR 
      RYTVTFSNM LQLNDESGN NRPICMTLI NSGLSSCSD 
      VFIVNLEES LRAELTEKE DKRCQYVRN LDKAQETKI 
      IRACVKLMH LTIEKDLLH SILQICIRL TRDFELAKI 
      FVQEGGVKC LIAMKQVRE FPSFGILAT ILIRHTLEE 
      PNTLSYAIE KIIRARTLS TIPPYYKEL LYLTRQIGG 
      AVTRSPETF FEVAKNILR VDTDVNRED VDSRIPVKT 
      EPPTRTRAP PLEEVVSNE VICDLLNAL LNPLEVVDD 
      TQPQTSPQN APPETSSTK PSESVTGDN NDSGSETPA 
      QAEANADDQ SEPIQSMKK MMLPKSVIL KILGDAVVS 
      YGPVARIIT EYTYKAGSN ECIKEDCTA LAFILDYIL 
      PEADDLSDS DCATMCRML IAAIASSNH SPEAQFTLV 
      SEVRAALLR ALVMPESTE KHSQVQLIA GIISIMIDN 
      CPSSQARVK SQPPTPQMN NIVRLMIRK SLFNDLARV 
      PHFLDLSSP NTPFTVNAC LKSLEALSR IVNQPVPAN 
      VQKSRKNQQ ATDESAGTQ SGTSTEGTN AQREVVIDD 
      SVVIEDSEN TEHDIAVVT STIEVEANE NENVLVHMI 
      DQLLEQGND NNQSFSDVA SSRNHTMDI DEDGNLTFE 
      HERDATEEL MSTDSGESD SNPSDQVED EENDDNEGD 
      DENIDDADD TNYDDDDGS DRRRASYMD RNDDVLMIQ 
      YTNPGAENE VVTRMVAYP MGDHAAFPM PLFDEINNS 
      SDHTGPIVH PLLLSRTAN ESNSNTATR TQRVTRARR 
      YQYLFNPRN PNPPVILQR LLGPHEPQV TLASANSIL 
      GGPPEMRES ARLVVMDNF GLLPSHEEQ IDFVDQSSG 
      YLLGPSLAA TLNHISPVL HWWNIESKC LDYESVYDV 
      TTEVCNKLI PILIKQRNV EIVEKRKSH DTLRRFKFF 
      EDDYIKPAE DSTEPNATD GTDEDIDGV PLETSSNDD 
      RSEANNRMD SSPFIGFDN GTEQVRRNS RPSIRSDTV 
      RHNEENNEG GDRNGRSVN PFEIPTLSP YTPPSRLPV 
      IFFPPNVLH SPDAVEQAY QENNEENNE SGDRNGRSV 
      NPFGISTIG TLSPYTPPS RLTDMFSPS VLHPPEMVE 
      HADQENNEA PLTRENEDE NYCCNRNRP TCDSVGDIF 
      EDSLNQQIN SLANSERDP IPTEEAPTT NSIQESGEI 
      TAMPQQQTT SEPGPSSDQ TEEIPDGVD PSFLEALPP 
      DMRQEVLEQ HRILRLQQR IAARTENPE AAAGTTTEV 
      SPEFLAALP PSLQEEVLS QQRLEQQRQ AAAQANPNE 
      PVDAGAFFE TLQPSLRTM ILSDMEDSQ MSALPPDLA 
      AEAQTLRRD WEARNRQLV QERILQSNL TSIIRHSAR 
      ARQQPLHHS SGHFHRAQW THWNREFMN NSATPTPPL 
      KIRGRQLLD HEGLSCLLV LLFTDDPHL GKLRLHRVI 
      RNLCYHAPT REWIVNALL SIIDKSVHV KPDESLNKP 
      ARKMPKPGP LSSKLMTDS KLLQNNGNW LNIRMEAAL 
      GCSANVFII NRSSTGKRS DRSAASSIS IHPQAAPIV 
      CRNALDLFT SLAKAFPSC LLPLKCIRD DREDKNNLS 
      PVRVKSESF GDFWEILLR LDSASTKKG KSIPKSSSS 
      NTAVEPDNK VITFEQSVF GQLLNMLAS PVVNRNTQL 
      TDNLLRLLS VITSGMPEL AKPPTVPIK ATKNKLKEN 
      TTPTNALHL AVNVITYKN CSEEGLEFI TNLLLNLAS 
      STLEMSYMI LNLLLSGAV RIGEIVREQ INNMLIELK 
      EYNAQKRKV TNNDELGPS TSKGTIADR FTKETVIIT 
      ASTKVKASC ELQLPSMVP LTSKSSSQL FFLRVLRVI 
      VQIRNSFKQ NVKRADASW CYDIPALSE QLSSIDSLW 
      ETLSQCLSE LEHTPDHHA VLVLQPAVE AFFLVHSPQ 
      QGPSKKQQD TEPSSSQAP ESRTTTSAE SGDLPPAPS 
      TENKFVNPE TELHTAEST SKTVPPEQQ KFLSFAEKH 
      RRVLNQILR QSTSHLADG PFAVLVDHT RILDFDIKR 
      RYFRSELER MDQGIRREE TAVHVRRSN IFEDSFREL 
      YRRTPEEWK NRFYIVFED EEGQDAGGL LREWYVIIS 
      RDIFNPMYA LFTVSPGDR VTYMINSAS HYNPNHLCY 
      YKFVGRVIA KAIYDNKLL ECYFTRSFY KHILGIPVK 
      YTDMESEDY SFYRGLVYL MENNINNLG LDLTFSTEI 
      NEFGVTETR DLIVNGRHV PVTEETKME YIRLSCQMK 
      MTGAIKQQL NAFLDGFYD IIPMRLISI FNEQELELL 
      ISGLPNVDI DDLKANTEY HKYQANSLQ IQWFWRALR 
      SFDQADRAK FLQFVTGTS KVPLQGFAA LEGMNGVQK 
      FQIHRDDRS TDRLPSAHT CFNQLDLPV YETYDKLRS 
      YLLKAIHEC SEGFGFA
    CDS sequence
    • >TC004152 RA
      atgaaaata gacaggtca cgggtgcgg aaaagcact 
      tctgatgtt cctatcgag tgccaacag cttatcgag 
      aggctccag gcatgttcc cggacagaa cttctggaa 
      gaactgtcc aaaatcaac acctggacg ttcgggaaa 
      tgcgagctg ctgcactgg gccttagtt cttgacgtt 
      ttcgataaa atattggga gaggcggga cggaaatcc 
      tttgaaaac aagtgggct ctgaaatgt gatactcat 
      tacaatagc acagaaaag aaattgtta ctatggatc 
      ttacacttt accacgctt ttgatagaa cattcgttt 
      tcccgacat ttgtacaat tcattggaa cacctcttg 
      gttctcctg gaatccaac gacatgtct gtggttctg 
      ggcgttcta aacctattg tacatgttc tccaaacgt 
      agcaatttt atttcacgg ttgtcaccc gataagaaa 
      aattccttg ctctcgcgg ctccatcat ttggcagag 
      aattggggc ggcaaggag aacgggttc ggtcttgct 
      gactgttgc agagctgat gagaccttg cctttttcc 
      gcgacgact gtgcatgta gagtttcat agggaaagt 
      gatgatcct aaagaagcc ccatcgaaa aatagcaaa 
      aattctcca catattatt cacattgaa catgtagac 
      aaaattcat agaactcct gccgaaatt atgaagtcg 
      ttactggga atttactat gtgcctcct gataaacaa 
      atgtggttg ttcacgcgt gttcgcttg gcttaccac 
      ttcgccgat tacaataac cgtctcctg tgtgtgcaa 
      gctcgactg caggccctt tctgtgctt gtatactct 
      aatgcaatt caagactct cctcataat ctgctctac 
      aatggcctt ctcgaagaa ttggtagag ctggttgaa 
      atgaaggac cctcatttg gttgaaatt cgctctgcg 
      gcgcttagg acgctaaca gctatcata cacttagat 
      agaaatccc catattcca aaaaaaccc ggttctaga 
      cttaataat ataattgac gtcacaggt gctagtcag 
      taccatgga tttttgcct ctcttagtt aggaattgt 
      attataact cttacaaat caaagcagt gagaatcaa 
      agtaaaaaa gacgacacc gaaatcatt gatgttgat 
      tgcgatgaa gcaaaagtg atggaaaac agtgatgtt 
      acaatgagt ccacagcaa attgccgat cctaacgct 
      aaattcccg ctgtcttta gcaactgct ctgttttca 
      tttctgtat catttagcg agttacgaa gcaggaggc 
      gaagctttg gtttcttgc ggaatgatg gaatcgctt 
      ctacaagtc atcaactgg catggagtt gagttggaa 
      cacattact tttgttact cgagccgtt agggtcatt 
      gacctcatt accaacatc gacatgcaa gctttccaa 
      actcatgga gggctgcag agcttcatt aatagactt 
      gatgttgaa gtaaagttg tgcaaagcc gaacaactc 
      tacgaaata aaaactaca gtgactgat caaactttt 
      ctcgaggaa ggcgcagct ggcccctcg actgaagct 
      ccggaaaat tcgagcgag cctactaag ctagtcgat 
      cttgagtac cactctgaa aacgtcgga aaaacctgt 
      ctaccccaa agagcagct ctgttaaaa tcaatgctt 
      aactttttg aagaaagca ttacaagat tcgaccttc 
      tcggataat atccgacat ttaatggaa ggaactttg 
      ccaaattcc ctgaaaaat attatcgca aatgcggaa 
      tattacggc ccgtctttg tttcttcta gccaccgat 
      gttgtcact gtttatgtt taccaagaa ccgtcgctg 
      ttgtccgcc cttcaggat aacggctta attgaagtc 
      gttttgcat tcgttgttg gtgaaggaa attccggcg 
      actcgtgaa gtccttgga tcgctaccc aacgtcttc 
      agtgctttg tgtttgaat aaccgcgga ttgcaacag 
      tttattaaa atgaaacca ttcgaaaaa accttcagc 
      gttttactc tcaccggat tatttacca gcaatgaga 
      cggaggcga agctcggaa ccgatggcc gacaccgct 
      tgtaactta ggaaatgca atggacgag ttaatgcga 
      caccagcca agcctcaaa agcgacgca attaaagca 
      attattgat ctgctcgag gagttggtc aacttggga 
      acagacccg aagtacatt tgttggaaa ccacacagc 
      aagtccgaa gtctcgccc tctagcagt acacggtct 
      gccaccaac actgaaggg tcgtctgat gaagaagac 
      gaagatgaa gaggaggct tcaacttcg tcccagaac 
      gcccaaaac gacgctcaa gtccagcag gaaaacagc 
      gaacgaact ccaatagcc ctcattgac tatattcta 
      aacacaatg aaatttatt gacgctatt cttagcaac 
      aattccact gacgatcac tgtcgcgaa ttcgtccaa 
      caaggcggt ctccgcccg cttttaaaa atccttggt 
      ttaccaaac ctaccagta aattgcccc gtcactaat 
      ccagctcaa gctgttgca accgtctgc aagagcatc 
      ctaaatctc gcacatgaa acgaattta ttcaaagag 
      ggtttagct caactaagc gaagtcctt gaagtattg 
      aagccaatg tatacgaag ttggatgtc ccaagcgga 
      cccaaactc ttactcgag ctagccggc gcgtcaaat 
      gtcgaaaac gcgtttaat aacgctagc gtgacccct 
      ttgttgcac gcaatgggc gccgcacac ggctacatc 
      atcatgctg gtgcacgtt tgtcggact ggtcagagc 
      gaaatccga aatttgtca ctccagaat tggggttcg 
      gaggaaggg cttagggtt attaaagga ctagccgac 
      ttgtacacg tctttggtg tgggaaagc acccttctg 
      ttggcgtat tgtagcgaa gagttcatc ccgtctgac 
      tttacaaga gaggatatc gaaaaactg aacgctttc 
      tttgacaag tgtgaaagt agcaacacg ggaagtgac 
      agcaccgtg aacgtggct tcagccatg gaagccttg 
      accactaac ccaccttca atagaaatg gacgtggac 
      caggaagga ataacactg aatttaagc acaagcttg 
      aaatacatc aaacctttg cttggcgca tcctcacga 
      cttggccga gctttggcc gaactgttc ggacttctt 
      gtaaaattg tgcgtcggt tcgccgatt cgccaaaga 
      cggggtcag aacataatc gcggcgccc ccgttaccc 
      acaccgtac gcacgcagc gtcgccaca gctctgaat 
      gtcttattg gccgatggc ttagactac gagaggctc 
      ccagcgtgt cccttaatt aaatcaagg atcacgttc 
      ttgatttgc agtgttggg ttcacgagc ccaatgctg 
      tttgacgag aagaggtat ccgtatcac ctgatgttg 
      aagaagttt gtggctttg ggaggccag gcgacgttc 
      ttcaacacg tttcgatgg gccctcagc gctggcggg 
      accattccc attgaaaag gcgttcgaa gacgggccg 
      ctgcctgaa ggaaccgcc ggttttctg gacgcgtgg 
      ttgatgcta cttgaaaaa atggtgaac ccgaaagct 
      attcttgag tctcctcat ataatatca aaccggtca 
      tcgcaaagc tccacctat cggggctat aacttcgat 
      ccgcttaaa tacctaatc cagattcat aaattggcg 
      ttcgaggct gtgatattg ctgtggaac aaagcgcct 
      ctcaccact tacggtact cgcttgtcc gagaacatt 
      ttaacagtt ttgcgccac attttgcga ggtgaaaaa 
      ataatcaaa gagaaactg aaatctgag gagaacatg 
      tccactgat ttaagtcga cctaaatcg tcgtccggg 
      aattcgagt cgtgaaccc gaagtgaat cccgatagt 
      ttgaggcag ttgatggat atggggttc tctcgcgag 
      cacgtgact gacgcctta ctcaatacg ttaacagtt 
      gaacaagca actgattat ttactgaca aatccacct 
      tccctatac cgtatttcc cagtcgttc atgaattcc 
      gacgaggac gaccagatg atgcaagcc atagctatt 
      tcactcgga gtttcgaac aatctaccg agtgtgtcg 
      aaaaagcga caaatacaa gatgatgga aaaccacta 
      gctgaaagt ctgattgac gaatttacc aatcacgct 
      ctggaggcc tgtctcaga ctgctagac aacactccg 
      gaatgcgtt cacaaaatt tgcgagtta cttgtaact 
      attatgaaa cgtaacggg cgcacgttc cgtgataat 
      cttctcgat actttagtt aaggagatt tatgagaat 
      gctaaaaat gtttgctac gccctaaaa caacccgaa 
      tgcgagttg ccaagcgtt gcaaaattg ccatgtgcg 
      acacgtttg gcgaattac ttacacttg tatatccta 
      ttcttcgag gtttcgtcc tactttgaa atgaaaatc 
      ccatgtgct ttggcggta cataaaatt gatttgatt 
      aatcttctc attaagttg atttgtatg gccgagaaa 
      gtgatgagt cgttccgag aaagttaca gaaccgaaa 
      tggttagca tcgtcattt cttctgatc gatgctgct 
      tcgaaagtt gcgacttgc gctcatcgc aaacgaaat 
      atgcactta agcacaaca cgggtgtgg cgttggttc 
      cacttagaa acgggtaaa tggacgcct tattcaaat 
      agcaataat aaattaatt aacgatgcc tattggaac 
      ggcgagcaa agcgttaga gtgatttgt ggccgcaga 
      cgctacact gtaaccttc tcgaatatg ctacagttg 
      aacgacgag agcggcaat aaccgcccc atttgtatg 
      actctgatc aattccggc ttgtcgagt tgttctgac 
      gttttcatc gtcaacttg gaagagtcc ttacgagcg 
      gaactcacc gaaaaggaa gacaagaga tgtcaatat 
      gtgcgaaat ctagacaag gcacaagaa actaaaatc 
      atacgagct tgcgtcaaa ctcatgcac ttgacgatc 
      gagaaagac ctcttgcac tcgatccta caaatttgt 
      atccgattg acccgcgat tttgaactg gcgaaaatt 
      ttcgtacag gaaggaggc gtcaagtgt ttaattgca 
      atgaaacaa gtgagagaa ttccccagt tttggtatt 
      ctagcaacg attttaatc cgacatact ttggaggaa 
      cccaacaca ctatcctat gctatagaa aaaattatc 
      agagctcga accctatcg actatacct ccctattac 
      aaagaacta ctctatctt actagacag ataggcggc 
      gctgtgact cgttcccca gaaacgttt ttcgaagtt 
      gccaaaaac attctgcgg gtcgacacc gacgtcaat 
      cgggaagac gtggattcg cggattccg gttaaaacc 
      gagccgccg acgcgaacc cgagcgcca ccgttggaa 
      gaagtcgtt tcgaatgaa gtcatttgc gacttgttg 
      aacgcattg ttgaacccg ctcgaggtt gtcgatgac 
      acgcagcca caaacctcg cctcaaaac gcccctcct 
      gagactagc agcactaaa ccgagcgag agtgtgacc 
      ggcgataac aacgactca ggctcggaa acaccggcc 
      caggctgag gctaacgcc gacgatcaa agcgaaccc 
      atacaaagt atgaagaaa atgatgtta ccaaagtca 
      gtgattttg aagattttg ggtgacgca gtcgtgtcc 
      tacggccct gttgctcga atcattacg gagtatacg 
      tacaaggcc gggtcgaac gagtgcatt aaggaggat 
      tgcacagct ttggcgttc atcctagac tacatattg 
      ccggaagct gatgatttg tccgattcg gattgcgcg 
      acaatgtgt cgcatgttg atcgcggcg atcgcaagc 
      tcgaaccac tcgcctgaa gcgcagttc actctcgtg 
      agtgaggtc cgagctgcg ctgctccgc gccttggtg 
      atgcccgaa tccaccgaa aaacacagt caagtgcaa 
      ttaatcgcg gggattatc tccataatg atcgacaat 
      tgtccgtcg tcgcaagcc agagtcaag tcgcaaccg 
      ccgactccc caaatgaac aacatagtc cgcttgatg 
      attcgcaaa tcgctgttc aacgacttg gcccgagtg 
      ccgcatttc ctcgacttg tcctcaccg aacactccg 
      ttcaccgtc aatgcttgc ttgaaatca cttgaagcc 
      ttatcgaga attgtcaat cagccggtg ccggctaac 
      gtgcagaaa agccgaaag aatcagcag gccaccgat 
      gagagtgct ggcactcag agtgggacc tcgaccgaa 
      gggacaaac gcccaaaga gaggtcgta attgacgat 
      tctgtcgtt attgaggac tcggaaaac accgaacat 
      gatatagct gttgttacg tcgactatt gaagtcgaa 
      gccaacgag aacgagaac gtgctagtg cacatgatt 
      gaccagctg cttgagcaa gggaatgac aacaaccaa 
      agttttagc gacgttgca tcgtctaga aaccataca 
      atggacata gatgaggat ggcaacttg actttcgaa 
      cacgaacga gatgcgact gaggagctg atgagtacc 
      gattcgggt gagtcggat tcgaacccg tctgatcaa 
      gtcgaagac gaagaaaac gatgataat gaaggagac 
      gatgaaaat atcgacgac gctgacgat acgaattac 
      gacgacgat gacggtagt gacagaagg cgagcttcg 
      tacatggac cgcaacgat gacgtatta atgatccaa 
      tacaccaat ccgggggcc gaaaatgag gtggtgacc 
      cggatggtg gcctatcca atgggagac catgctgcc 
      ttccccatg cctttattt gatgaaatt aacaatagc 
      agtgaccac acaggtccc atagtccac ccattgtta 
      ctatctcgt accgcaaat gaaagtaac tcaaataca 
      gcgacacgc acccagcgt gttactagg gcccgccgt 
      taccaatat ttgttcaat ccgcgaaac cccaaccct 
      ccggtcatt ttgcaaaga ttattagga ccacacgaa 
      ccacaggtc actctagct tcagctaat agtatcttg 
      ggtggtcct cctgaaatg cgcgaatcc gcaagactg 
      gtagtaatg gataatttc ggtttgttg ccttcgcac 
      gaggaacaa atcgatttt gttgaccaa tcatcgggt 
      tatcttctc ggcccgagt ttagctgca actttaaat 
      catatttcg ccggtgttg cattggtgg aacatcgag 
      tcgaaatgt ttagactac gagtcggtg tatgatgtt 
      acgacggaa gtatgcaac aaattgata ccgattttg 
      ataaaacaa cgaaatgtt gaaatcgtc gagaaaaga 
      aaatcgcat gatactttg agacggttt aaattcttt 
      gaggatgac tacattaaa ccggcggag gactcgact 
      gagccaaat gcaactgat ggtaccgat gaagacatt 
      gatggcgtt ccgttggaa acctcgtcg aacgatgac 
      cgttcggag gccaacaac cggatggac tcatcacca 
      tttatcgga tttgacaat gggacggaa caagtccgg 
      cggaattca cgtccgagt atcagatct gacactgtt 
      agacataac gaagaaaat aatgaaggt ggcgatcgc 
      aacggcaga tccgtcaat ccgtttgaa attcccaca 
      ctgtcaccc tacacacca ccttcccgt ttgccggta 
      atattcttc ccaccaaat gtgctgcac tccccagac 
      gcagtcgag caagcttat caggaaaac aacgaggaa 
      aataacgag agtggtgac cggaacggc cgatctgtt 
      aacccgttt ggaatttca acaattggg acgctatca 
      ccctacacg ccaccttct cgtctgacg gacatgttc 
      tcaccaagc gtgctacac cctcccgag atggtcgaa 
      cacgcagac caggagaat aacgaggca cctttaaca 
      cgcgaaaac gaagacgag aactactgc tgtaaccga 
      aaccggccg acttgcgac tccgtcggc gatatcttc 
      gaagacagc ctgaaccaa caaatcaac tcactcgcg 
      aattccgaa cgcgacccg atcccaacc gaggaagcc 
      ccaaccacg aattcaatt caagaatcc ggtgagata 
      accgcaatg cctcagcag caaaccacg agcgaacct 
      ggccccagt tcggaccag accgaggaa attcccgac 
      ggtgttgat ccctcgttc ttggaggct ctccctccg 
      gatatgcgc caggaggtg ttggagcaa caccgcatt 
      ttgcgactt cagcagcgt atcgccgca cgaaccgaa 
      aacccggaa gctgcagct gggactacg accgaagtg 
      agtcccgaa tttttggca gctttgccg ccttcactc 
      caagaggag gtgctatcg caacagaga ctcgaacag 
      cagagacag gccgcagca caggccaat ccgaacgaa 
      ccggtcgac gctggcgcg ttcttcgag accttgcag 
      ccgtcattg cgaacgatg attttgtcc gacatggag 
      gactcgcaa atgagtgct ctgccgccg gacttggcg 
      gccgaagcg cagactttg cgccgcgat tgggaggcg 
      aggaatcgc cagttggta caggagagg attttgcag 
      agtaatttg acgagtatt atacgacac tcggccagg 
      gctagacaa cagccgttg catcactcg tcgggacat 
      ttccatcga gcgcagtgg acgcactgg aatagggag 
      ttcatgaat aattcggca acgccgaca ccgcctttg 
      aaaattcga ggaaggcag ttgttagac cacgaggga 
      ctttcgtgt cttctggtg ctattgttc acggatgat 
      ccacacttg ggcaaattg agactgcac cgagttatc 
      aggaatttg tgttaccac gcaccgaca cgtgaatgg 
      attgttaac gcacttttg tcgattatt gataagagc 
      gtccatgtg aagcccgat gagagtttg aataaaccg 
      gctcggaaa atgccaaaa cctggacct ttgtctagc 
      aaattgatg accgactcg aaattgctg caaaacaat 
      gggaactgg ttaaacatc cggatggaa gcagcactt 
      ggatgctcc gcaaatgtt ttcatcatt aataggtcc 
      agcactggg aagagaagc gacagatcg gcggcgtca 
      agcatcagt atccatcct caggctgct ccaattgtg 
      tgtagaaac gccctcgat ttgttcact tcgttggct 
      aaagctttc ccttcgtgc ttgcttccc ctcaagtgc 
      attcgagat gaccgagaa gataaaaac aacttgtcg 
      ccagttcga gtcaagtcg gagtcgttt ggcgatttc 
      tgggagatt ttgctcaga ttggattcc gctagtaca 
      aagaaagga aaaagtatt cctaagagt agtagcagt 
      aatactgcg gttgaaccc gataataaa gttattact 
      ttcgaacag tcggtattt ggtcagttg ctgaatatg 
      ttggcttcg ccggttgtg aatagaaat acgcaactc 
      acagataat ttattgagg ttactatct gtgataact 
      tcaggtatg cccgaatta gccaaacct cctaccgtt 
      ccaattaag gctactaag aacaaactc aaagaaaac 
      acaacaccc accaatgca ctgcacctt gctgttaac 
      gtaatcacg tacaaaaac tgttccgag gaagggctt 
      gaatttatc acaaacttg ctcctgaac ctagcgagt 
      tccacactt gaaatgagc tacatgatc ttgaatctg 
      ttgttgagt ggcgctgtg cgcatcggc gagatagta 
      cgcgaacaa ataaacaac atgttaatt gagttgaaa 
      gaatacaac gcgcagaag cgcaaagta acgaataac 
      gacgagctg ggtccttcc acttcaaaa gggacaatt 
      gcagacagg tttaccaaa gaaactgtg atcatcacc 
      gcatctacc aaagtaaag gcttcatgc gagctccaa 
      ttaccttcc atggtgcct ttaacttcg aaatcttca 
      agtcaacta tttttcttg agggtatta cgcgtcatc 
      gtgcaaata cgcaactcc ttcaaacag aacgtaaaa 
      cgagccgac gcttcatgg tgttacgat attcccgca 
      ctaagcgaa caactaagc agcattgat agtctttgg 
      gaaacatta agccagtgc ctttccgaa ttggagcat 
      actccagat caccatgcc gtccttgta ttgcagccc 
      gctgtggag gctttcttc ctcgttcat tccccccag 
      cagggccct tcaaagaaa cagcaagac accgagccg 
      agttcttcc caagccccc gaaagtcgt acgacaacg 
      tcagccgag tccggcgat ctgccaccg gcaccctcg 
      accgaaaac aagttcgtc aacccggaa actgaactg 
      catacggcc gaaagtacc tcaaaaact gtacccccc 
      gaacaacag aagttcctg agttttgct gagaagcac 
      cgacgcgtc ttgaaccag atcctgagg cagagcacg 
      tcgcatttg gccgatggg ccgttcgct gtgctggtg 
      gaccacacg cgaattctt gattttgat atcaagcgc 
      aggtatttc cggtccgaa ttggagcgg atggatcag 
      ggcatacga cgagaagag acggcggtt catgtgcgc 
      agaagcaac attttcgaa gactcgttc agggagttg 
      tacagacgc actcccgaa gagtggaaa aatcggttc 
      tatatcgtt tttgaagac gaagaggga caagatgcc 
      ggcggtttg ttacgagag tggtacgtg atcatatca 
      cgggacatt tttaatcca atgtatgcc ttgttcact 
      gtctcaccc ggtgataga gtcacttat atgatcaat 
      tcggctagc cattacaat cccaatcat ctctgctac 
      tataagttc gttgggaga gttatcgct aaagccatt 
      tatgacaat aaactactt gagtgttat tttacacga 
      tcattttac aagcacatt ttgggaatt ccggtgaaa 
      tacacagac atggaaagc gaagattac agtttttat 
      aggggctta gtctattta atggaaaat aatattaat 
      aacttagga cttgactta acatttagc actgaaatc 
      aacgagttc ggagttact gaaaccagg gacttgatt 
      gttaacggg cgacatgtc ccagttacc gaagagacg 
      aaaatggaa tacatacga ctctcgtgt cagatgaag 
      atgacgggg gccatcaag caacaactg aacgcattc 
      ctggacgga ttctatgac attattcct atgcgccta 
      atttccata tttaatgaa caagaactt gaattgctt 
      atttccgga ttaccaaat gtagatata gacgacttg 
      aaagccaac actgagtac cataagtac caagcaaat 
      tctcttcag attcaatgg ttttggcgc gcgttgcgg 
      tcgtttgac caggcagat cgggcgaag ttcctccag 
      ttcgtgacc gggacgtca aaggttcca ttacaagga 
      tttgcagca cttgaggga atgaacggt gtacaaaag 
      ttccaaatt catagggac gatcgttca actgatagg 
      ttaccatcg gcacatact tgcttcaat caactggat 
      cttcccgtg tacgaaact tacgacaag ttgcgctcg 
      tacctgttg aaggctatt catgagtgt tctgaaggc 
      ttcggcttt gcttga
    mRNA sequence
    • >TC004152 RA
      tttattttg tcgattgga ctgtatttt gttgaaaat 
      cttgttaaa atcaagcgg tttgaaatt gaattttag 
      tatgttttt gtggaaaag tggtgacca agttggtta 
      aaatcgttt tgagttgag tgaaaatcg gttggaagt 
      tcgttgttg gacggttcg gtggacagt agtgaagga 
      aatcaccac cgaggttgt ggtgcggtc atccagcaa 
      aagcaatat aaacaaagg gttgataag gctctttat 
      taatgattt tccgtgcac aggcccgaa tttaagctt 
      cctgaaagc tcaacttgg tgtaatgct cctgtctta 
      acatatggc acaatgaaa atagacagg tcacgggtg 
      cggaaaagc acttctgat gttcctatc gagtgccaa 
      cagcttatc gagaggctc caggcatgt tcccggaca 
      gaacttctg gaagaactg tccaaaatc aacacctgg 
      acgttcggg aaatgcgag ctgctgcac tgggcctta 
      gttcttgac gttttcgat aaaatattg ggagaggcg 
      ggacggaaa tcctttgaa aacaagtgg gctctgaaa 
      tgtgatact cattacaat agcacagaa aagaaattg 
      ttactatgg atcttacac tttaccacg cttttgata 
      gaacattcg ttttcccga catttgtac aattcattg 
      gaacacctc ttggttctc ctggaatcc aacgacatg 
      tctgtggtt ctgggcgtt ctaaaccta ttgtacatg 
      ttctccaaa cgtagcaat tttatttca cggttgtca 
      cccgataag aaaaattcc ttgctctcg cggctccat 
      catttggca gagaattgg ggcggcaag gagaacggg 
      ttcggtctt gctgactgt tgcagagct gatgagacc 
      ttgcctttt tccgcgacg actgtgcat gtagagttt 
      catagggaa agtgatgat cctaaagaa gccccatcg 
      aaaaatagc aaaaattct ccacatatt attcacatt 
      gaacatgta gacaaaatt catagaact cctgccgaa 
      attatgaag tcgttactg ggaatttac tatgtgcct 
      cctgataaa caaatgtgg ttgttcacg cgtgttcgc 
      ttggcttac cacttcgcc gattacaat aaccgtctc 
      ctgtgtgtg caagctcga ctgcaggcc ctttctgtg 
      cttgtatac tctaatgca attcaagac tctcctcat 
      aatctgctc tacaatggc cttctcgaa gaattggta 
      gagctggtt gaaatgaag gaccctcat ttggttgaa 
      attcgctct gcggcgctt aggacgcta acagctatc 
      atacactta gatagaaat ccccatatt ccaaaaaaa 
      cccggttct agacttaat aatataatt gacgtcaca 
      ggtgctagt cagtaccat ggatttttg cctctctta 
      gttaggaat tgtattata actcttaca aatcaaagc 
      agtgagaat caaagtaaa aaagacgac accgaaatc 
      attgatgtt gattgcgat gaagcaaaa gtgatggaa 
      aacagtgat gttacaatg agtccacag caaattgcc 
      gatcctaac gctaaattc ccgctgtct ttagcaact 
      gctctgttt tcatttctg tatcattta gcgagttac 
      gaagcagga ggcgaagct ttggtttct tgcggaatg 
      atggaatcg cttctacaa gtcatcaac tggcatgga 
      gttgagttg gaacacatt acttttgtt actcgagcc 
      gttagggtc attgacctc attaccaac atcgacatg 
      caagctttc caaactcat ggagggctg cagagcttc 
      attaataga cttgatgtt gaagtaaag ttgtgcaaa 
      gccgaacaa ctctacgaa ataaaaact acagtgact 
      gatcaaact tttctcgag gaaggcgca gctggcccc 
      tcgactgaa gctccggaa aattcgagc gagcctact 
      aagctagtc gatcttgag taccactct gaaaacgtc 
      ggaaaaacc tgtctaccc caaagagca gctctgtta 
      aaatcaatg cttaacttt ttgaagaaa gcattacaa 
      gattcgacc ttctcggat aatatccga catttaatg 
      gaaggaact ttgccaaat tccctgaaa aatattatc 
      gcaaatgcg gaatattac ggcccgtct ttgtttctt 
      ctagccacc gatgttgtc actgtttat gtttaccaa 
      gaaccgtcg ctgttgtcc gcccttcag gataacggc 
      ttaattgaa gtcgttttg cattcgttg ttggtgaag 
      gaaattccg gcgactcgt gaagtcctt ggatcgcta 
      cccaacgtc ttcagtgct ttgtgtttg aataaccgc 
      ggattgcaa cagtttatt aaaatgaaa ccattcgaa 
      aaaaccttc agcgtttta ctctcaccg gattattta 
      ccagcaatg agacggagg cgaagctcg gaaccgatg 
      gccgacacc gcttgtaac ttaggaaat gcaatggac 
      gagttaatg cgacaccag ccaagcctc aaaagcgac 
      gcaattaaa gcaattatt gatctgctc gaggagttg 
      gtcaacttg ggaacagac ccgaagtac atttgttgg 
      aaaccacac agcaagtcc gaagtctcg ccctctagc 
      agtacacgg tctgccacc aacactgaa gggtcgtct 
      gatgaagaa gacgaagat gaagaggag gcttcaact 
      tcgtcccag aacgcccaa aacgacgct caagtccag 
      caggaaaac agcgaacga actccaata gccctcatt 
      gactatatt ctaaacaca atgaaattt attgacgct 
      attcttagc aacaattcc actgacgat cactgtcgc 
      gaattcgtc caacaaggc ggtctccgc ccgctttta 
      aaaatcctt ggtttacca aacctacca gtaaattgc 
      cccgtcact aatccagct caagctgtt gcaaccgtc 
      tgcaagagc atcctaaat ctcgcacat gaaacgaat 
      ttattcaaa gagggttta gctcaacta agcgaagtc 
      cttgaagta ttgaagcca atgtatacg aagttggat 
      gtcccaagc ggacccaaa ctcttactc gagctagcc 
      ggcgcgtca aatgtcgaa aacgcgttt aataacgct 
      agcgtgacc cctttgttg cacgcaatg ggcgccgca 
      cacggctac atcatcatg ctggtgcac gtttgtcgg 
      actggtcag agcgaaatc cgaaatttg tcactccag 
      aattggggt tcggaggaa gggcttagg gttattaaa 
      ggactagcc gacttgtac acgtctttg gtgtgggaa 
      agcaccctt ctgttggcg tattgtagc gaagagttc 
      atcccgtct gactttaca agagaggat atcgaaaaa 
      ctgaacgct ttctttgac aagtgtgaa agtagcaac 
      acgggaagt gacagcacc gtgaacgtg gcttcagcc 
      atggaagcc ttgaccact aacccacct tcaatagaa 
      atggacgtg gaccaggaa ggaataaca ctgaattta 
      agcacaagc ttgaaatac atcaaacct ttgcttggc 
      gcatcctca cgacttggc cgagctttg gccgaactg 
      ttcggactt cttgtaaaa ttgtgcgtc ggttcgccg 
      attcgccaa agacggggt cagaacata atcgcggcg 
      cccccgtta cccacaccg tacgcacgc agcgtcgcc 
      acagctctg aatgtctta ttggccgat ggcttagac 
      tacgagagg ctcccagcg tgtccctta attaaatca 
      aggatcacg ttcttgatt tgcagtgtt gggttcacg 
      agcccaatg ctgtttgac gagaagagg tatccgtat 
      cacctgatg ttgaagaag tttgtggct ttgggaggc 
      caggcgacg ttcttcaac acgtttcga tgggccctc 
      agcgctggc gggaccatt cccattgaa aaggcgttc 
      gaagacggg ccgctgcct gaaggaacc gccggtttt 
      ctggacgcg tggttgatg ctacttgaa aaaatggtg 
      aacccgaaa gctattctt gagtctcct catataata 
      tcaaaccgg tcatcgcaa agctccacc tatcggggc 
      tataacttc gatccgctt aaataccta atccagatt 
      cataaattg gcgttcgag gctgtgata ttgctgtgg 
      aacaaagcg cctctcacc acttacggt actcgcttg 
      tccgagaac attttaaca gttttgcgc cacattttg 
      cgaggtgaa aaaataatc aaagagaaa ctgaaatct 
      gaggagaac atgtccact gatttaagt cgacctaaa 
      tcgtcgtcc gggaattcg agtcgtgaa cccgaagtg 
      aatcccgat agtttgagg cagttgatg gatatgggg 
      ttctctcgc gagcacgtg actgacgcc ttactcaat 
      acgttaaca gttgaacaa gcaactgat tatttactg 
      acaaatcca ccttcccta taccgtatt tcccagtcg 
      ttcatgaat tccgacgag gacgaccag atgatgcaa 
      gccatagct atttcactc ggagtttcg aacaatcta 
      ccgagtgtg tcgaaaaag cgacaaata caagatgat 
      ggaaaacca ctagctgaa agtctgatt gacgaattt 
      accaatcac gctctggag gcctgtctc agactgcta 
      gacaacact ccggaatgc gttcacaaa atttgcgag 
      ttacttgta actattatg aaacgtaac gggcgcacg 
      ttccgtgat aatcttctc gatacttta gttaaggag 
      atttatgag aatgctaaa aatgtttgc tacgcccta 
      aaacaaccc gaatgcgag ttgccaagc gttgcaaaa 
      ttgccatgt gcgacacgt ttggcgaat tacttacac 
      ttgtatatc ctattcttc gaggtttcg tcctacttt 
      gaaatgaaa atcccatgt gctttggcg gtacataaa 
      attgatttg attaatctt ctcattaag ttgatttgt 
      atggccgag aaagtgatg agtcgttcc gagaaagtt 
      acagaaccg aaatggtta gcatcgtca tttcttctg 
      atcgatgct gcttcgaaa gttgcgact tgcgctcat 
      cgcaaacga aatatgcac ttaagcaca acacgggtg 
      tggcgttgg ttccactta gaaacgggt aaatggacg 
      ccttattca aatagcaat aataaatta attaacgat 
      gcctattgg aacggcgag caaagcgtt agagtgatt 
      tgtggccgc agacgctac actgtaacc ttctcgaat 
      atgctacag ttgaacgac gagagcggc aataaccgc 
      cccatttgt atgactctg atcaattcc ggcttgtcg 
      agttgttct gacgttttc atcgtcaac ttggaagag 
      tccttacga gcggaactc accgaaaag gaagacaag 
      agatgtcaa tatgtgcga aatctagac aaggcacaa 
      gaaactaaa atcatacga gcttgcgtc aaactcatg 
      cacttgacg atcgagaaa gacctcttg cactcgatc 
      ctacaaatt tgtatccga ttgacccgc gattttgaa 
      ctggcgaaa attttcgta caggaagga ggcgtcaag 
      tgtttaatt gcaatgaaa caagtgaga gaattcccc 
      agttttggt attctagca acgatttta atccgacat 
      actttggag gaacccaac acactatcc tatgctata 
      gaaaaaatt atcagagct cgaacccta tcgactata 
      cctccctat tacaaagaa ctactctat cttactaga 
      cagataggc ggcgctgtg actcgttcc ccagaaacg 
      tttttcgaa gttgccaaa aacattctg cgggtcgac 
      accgacgtc aatcgggaa gacgtggat tcgcggatt 
      ccggttaaa accgagccg ccgacgcga acccgagcg 
      ccaccgttg gaagaagtc gtttcgaat gaagtcatt 
      tgcgacttg ttgaacgca ttgttgaac ccgctcgag 
      gttgtcgat gacacgcag ccacaaacc tcgcctcaa 
      aacgcccct cctgagact agcagcact aaaccgagc 
      gagagtgtg accggcgat aacaacgac tcaggctcg 
      gaaacaccg gcccaggct gaggctaac gccgacgat 
      caaagcgaa cccatacaa agtatgaag aaaatgatg 
      ttaccaaag tcagtgatt ttgaagatt ttgggtgac 
      gcagtcgtg tcctacggc cctgttgct cgaatcatt 
      acggagtat acgtacaag gccgggtcg aacgagtgc 
      attaaggag gattgcaca gctttggcg ttcatccta 
      gactacata ttgccggaa gctgatgat ttgtccgat 
      tcggattgc gcgacaatg tgtcgcatg ttgatcgcg 
      gcgatcgca agctcgaac cactcgcct gaagcgcag 
      ttcactctc gtgagtgag gtccgagct gcgctgctc 
      cgcgccttg gtgatgccc gaatccacc gaaaaacac 
      agtcaagtg caattaatc gcggggatt atctccata 
      atgatcgac aattgtccg tcgtcgcaa gccagagtc 
      aagtcgcaa ccgccgact ccccaaatg aacaacata 
      gtccgcttg atgattcgc aaatcgctg ttcaacgac 
      ttggcccga gtgccgcat ttcctcgac ttgtcctca 
      ccgaacact ccgttcacc gtcaatgct tgcttgaaa 
      tcacttgaa gccttatcg agaattgtc aatcagccg 
      gtgccggct aacgtgcag aaaagccga aagaatcag 
      caggccacc gatgagagt gctggcact cagagtggg 
      acctcgacc gaagggaca aacgcccaa agagaggtc 
      gtaattgac gattctgtc gttattgag gactcggaa 
      aacaccgaa catgatata gctgttgtt acgtcgact 
      attgaagtc gaagccaac gagaacgag aacgtgcta 
      gtgcacatg attgaccag ctgcttgag caagggaat 
      gacaacaac caaagtttt agcgacgtt gcatcgtct 
      agaaaccat acaatggac atagatgag gatggcaac 
      ttgactttc gaacacgaa cgagatgcg actgaggag 
      ctgatgagt accgattcg ggtgagtcg gattcgaac 
      ccgtctgat caagtcgaa gacgaagaa aacgatgat 
      aatgaagga gacgatgaa aatatcgac gacgctgac 
      gatacgaat tacgacgac gatgacggt agtgacaga 
      aggcgagct tcgtacatg gaccgcaac gatgacgta 
      ttaatgatc caatacacc aatccgggg gccgaaaat 
      gaggtggtg acccggatg gtggcctat ccaatggga 
      gaccatgct gccttcccc atgccttta tttgatgaa 
      attaacaat agcagtgac cacacaggt cccatagtc 
      cacccattg ttactatct cgtaccgca aatgaaagt 
      aactcaaat acagcgaca cgcacccag cgtgttact 
      agggcccgc cgttaccaa tatttgttc aatccgcga 
      aaccccaac cctccggtc attttgcaa agattatta 
      ggaccacac gaaccacag gtcactcta gcttcagct 
      aatagtatc ttgggtggt cctcctgaa atgcgcgaa 
      tccgcaaga ctggtagta atggataat ttcggtttg 
      ttgccttcg cacgaggaa caaatcgat tttgttgac 
      caatcatcg ggttatctt ctcggcccg agtttagct 
      gcaacttta aatcatatt tcgccggtg ttgcattgg 
      tggaacatc gagtcgaaa tgtttagac tacgagtcg 
      gtgtatgat gttacgacg gaagtatgc aacaaattg 
      ataccgatt ttgataaaa caacgaaat gttgaaatc 
      gtcgagaaa agaaaatcg catgatact ttgagacgg 
      tttaaattc tttgaggat gactacatt aaaccggcg 
      gaggactcg actgagcca aatgcaact gatggtacc 
      gatgaagac attgatggc gttccgttg gaaacctcg 
      tcgaacgat gaccgttcg gaggccaac aaccggatg 
      gactcatca ccatttatc ggatttgac aatgggacg 
      gaacaagtc cggcggaat tcacgtccg agtatcaga 
      tctgacact gttagacat aacgaagaa aataatgaa 
      ggtggcgat cgcaacggc agatccgtc aatccgttt 
      gaaattccc acactgtca ccctacaca ccaccttcc 
      cgtttgccg gtaatattc ttcccacca aatgtgctg 
      cactcccca gacgcagtc gagcaagct tatcaggaa 
      aacaacgag gaaaataac gagagtggt gaccggaac 
      ggccgatct gttaacccg tttggaatt tcaacaatt 
      gggacgcta tcaccctac acgccacct tctcgtctg 
      acggacatg ttctcacca agcgtgcta caccctccc 
      gagatggtc gaacacgca gaccaggag aataacgag 
      gcaccttta acacgcgaa aacgaagac gagaactac 
      tgctgtaac cgaaaccgg ccgacttgc gactccgtc 
      ggcgatatc ttcgaagac agcctgaac caacaaatc 
      aactcactc gcgaattcc gaacgcgac ccgatccca 
      accgaggaa gccccaacc acgaattca attcaagaa 
      tccggtgag ataaccgca atgcctcag cagcaaacc 
      acgagcgaa cctggcccc agttcggac cagaccgag 
      gaaattccc gacggtgtt gatccctcg ttcttggag 
      gctctccct ccggatatg cgccaggag gtgttggag 
      caacaccgc attttgcga cttcagcag cgtatcgcc 
      gcacgaacc gaaaacccg gaagctgca gctgggact 
      acgaccgaa gtgagtccc gaatttttg gcagctttg 
      ccgccttca ctccaagag gaggtgcta tcgcaacag 
      agactcgaa cagcagaga caggccgca gcacaggcc 
      aatccgaac gaaccggtc gacgctggc gcgttcttc 
      gagaccttg cagccgtca ttgcgaacg atgattttg 
      tccgacatg gaggactcg caaatgagt gctctgccg 
      ccggacttg gcggccgaa gcgcagact ttgcgccgc 
      gattgggag gcgaggaat cgccagttg gtacaggag 
      aggattttg cagagtaat ttgacgagt attatacga 
      cactcggcc agggctaga caacagccg ttgcatcac 
      tcgtcggga catttccat cgagcgcag tggacgcac 
      tggaatagg gagttcatg aataattcg gcaacgccg 
      acaccgcct ttgaaaatt cgaggaagg cagttgtta 
      gaccacgag ggactttcg tgtcttctg gtgctattg 
      ttcacggat gatccacac ttgggcaaa ttgagactg 
      caccgagtt atcaggaat ttgtgttac cacgcaccg 
      acacgtgaa tggattgtt aacgcactt ttgtcgatt 
      attgataag agcgtccat gtgaagccc gatgagagt 
      ttgaataaa ccggctcgg aaaatgcca aaacctgga 
      cctttgtct agcaaattg atgaccgac tcgaaattg 
      ctgcaaaac aatgggaac tggttaaac atccggatg 
      gaagcagca cttggatgc tccgcaaat gttttcatc 
      attaatagg tccagcact gggaagaga agcgacaga 
      tcggcggcg tcaagcatc agtatccat cctcaggct 
      gctccaatt gtgtgtaga aacgccctc gatttgttc 
      acttcgttg gctaaagct ttcccttcg tgcttgctt 
      cccctcaag tgcattcga gatgaccga gaagataaa 
      aacaacttg tcgccagtt cgagtcaag tcggagtcg 
      tttggcgat ttctgggag attttgctc agattggat 
      tccgctagt acaaagaaa ggaaaaagt attcctaag 
      agtagtagc agtaatact gcggttgaa cccgataat 
      aaagttatt actttcgaa cagtcggta tttggtcag 
      ttgctgaat atgttggct tcgccggtt gtgaataga 
      aatacgcaa ctcacagat aatttattg aggttacta 
      tctgtgata acttcaggt atgcccgaa ttagccaaa 
      cctcctacc gttccaatt aaggctact aagaacaaa 
      ctcaaagaa aacacaaca cccaccaat gcactgcac 
      cttgctgtt aacgtaatc acgtacaaa aactgttcc 
      gaggaaggg cttgaattt atcacaaac ttgctcctg 
      aacctagcg agttccaca cttgaaatg agctacatg 
      atcttgaat ctgttgttg agtggcgct gtgcgcatc 
      ggcgagata gtacgcgaa caaataaac aacatgtta 
      attgagttg aaagaatac aacgcgcag aagcgcaaa 
      gtaacgaat aacgacgag ctgggtcct tccacttca 
      aaagggaca attgcagac aggtttacc aaagaaact 
      gtgatcatc accgcatct accaaagta aaggcttca 
      tgcgagctc caattacct tccatggtg cctttaact 
      tcgaaatct tcaagtcaa ctatttttc ttgagggta 
      ttacgcgtc atcgtgcaa atacgcaac tccttcaaa 
      cagaacgta aaacgagcc gacgcttca tggtgttac 
      gatattccc gcactaagc gaacaacta agcagcatt 
      gatagtctt tgggaaaca ttaagccag tgcctttcc 
      gaattggag catactcca gatcaccat gccgtcctt 
      gtattgcag cccgctgtg gaggctttc ttcctcgtt 
      cattccccc cagcagggc ccttcaaag aaacagcaa 
      gacaccgag ccgagttct tcccaagcc cccgaaagt 
      cgtacgaca acgtcagcc gagtccggc gatctgcca 
      ccggcaccc tcgaccgaa aacaagttc gtcaacccg 
      gaaactgaa ctgcatacg gccgaaagt acctcaaaa 
      actgtaccc cccgaacaa cagaagttc ctgagtttt 
      gctgagaag caccgacgc gtcttgaac cagatcctg 
      aggcagagc acgtcgcat ttggccgat gggccgttc 
      gctgtgctg gtggaccac acgcgaatt cttgatttt 
      gatatcaag cgcaggtat ttccggtcc gaattggag 
      cggatggat cagggcata cgacgagaa gagacggcg 
      gttcatgtg cgcagaagc aacattttc gaagactcg 
      ttcagggag ttgtacaga cgcactccc gaagagtgg 
      aaaaatcgg ttctatatc gtttttgaa gacgaagag 
      ggacaagat gccggcggt ttgttacga gagtggtac 
      gtgatcata tcacgggac atttttaat ccaatgtat 
      gccttgttc actgtctca cccggtgat agagtcact 
      tatatgatc aattcggct agccattac aatcccaat 
      catctctgc tactataag ttcgttggg agagttatc 
      gctaaagcc atttatgac aataaacta cttgagtgt 
      tattttaca cgatcattt tacaagcac attttggga 
      attccggtg aaatacaca gacatggaa agcgaagat 
      tacagtttt tataggggc ttagtctat ttaatggaa 
      aataatatt aataactta ggacttgac ttaacattt 
      agcactgaa atcaacgag ttcggagtt actgaaacc 
      agggacttg attgttaac gggcgacat gtcccagtt 
      accgaagag acgaaaatg gaatacata cgactctcg 
      tgtcagatg aagatgacg ggggccatc aagcaacaa 
      ctgaacgca ttcctggac ggattctat gacattatt 
      cctatgcgc ctaatttcc atatttaat gaacaagaa 
      cttgaattg cttatttcc ggattacca aatgtagat 
      atagacgac ttgaaagcc aacactgag taccataag 
      taccaagca aattctctt cagattcaa tggttttgg 
      cgcgcgttg cggtcgttt gaccaggca gatcgggcg 
      aagttcctc cagttcgtg accgggacg tcaaaggtt 
      ccattacaa ggatttgca gcacttgag ggaatgaac 
      ggtgtacaa aagttccaa attcatagg gacgatcgt 
      tcaactgat aggttacca tcggcacat acttgcttc 
      aatcaactg gatcttccc gtgtacgaa acttacgac 
      aagttgcgc tcgtacctg ttgaaggct attcatgag 
      tgttctgaa ggcttcggc tttgcttga ataattatt 
      tatatttaa gactgataa aagtgttaa tttttgtta 
      atatcaaag taggtagtc actatgtaa ataagatat 
      atctactac tgtacaaaa ggactcatt gtaatataa 
      aaaaaagat tgttttcat tttgatatg aacagaagt 
      tgagttata agtatgtgt acttcaatt gcattaaac 
      atgtataaa tttaattcg aagtgacat tgtattttt 
      gtaaagggc ctctgcggc aattgagcg tgatagaat 
      gaatttgat tcgcatgtc agattcact ccttcttat 
      tgattaata ttattttaa gtattcaat tgttaataa 
      tttcttagg atttaatat cgtttattt tgtacaagt 
      ttcgtttct ggtttactt tttttacat tttaaatgt 
      tgtagtaat ccagttttc tcatattta ataaatttt 
      tcttaacat c
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