Status
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Gene information
General information
TC007308 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007419.2: 6259522..6279698
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC007308
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
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    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_07193

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 30.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 2 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 larval musculature pattern irregular - Penetrance (percentage of animals/eggs on slide): more than 80%

    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    remarks: muscle pattern potentially obscured by segmentation defect,
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    embryo/egg without visible larval cuticle in cuticle preparation - Penetrance (percentage of animals/eggs on slide): less than 30%
    cuticle remnants strongly fragmented (cuticle crumbs) - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    cuticle remnants with some identifiable segments - Penetrance (percentage of animals/eggs on slide): less than 30%

    cuticle remnants without visible segmentation but ap-polarity - Penetrance (percentage of animals/eggs on slide): less than 30%

    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: % (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: % (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC007308 RA
      MIEEQQMGS QTLEILRQG VWASLTGGW FFDPHQDVF 
      CNTFHLYIW LFLLCLPFT IYVYFPPTK YMWYFYCLS 
      VTIVLAVIK LVNYGLHHM YDTSECIHE EIDENWQEV 
      KREEEGIEL QVLSNKTET NSRPAVSGS FISYAEAGA 
      LPSTDADSL ESTEFQQAE AAKDTKPSS TIDLKAEVH 
      RKNSSESSD GAAAPVLEI VTYQPDVPE RKPKKSDRR 
      PKHQRSKTD GFVCVRITD DTKPNRSSF RKLYQQADS 
      ADGNLLIQR PSLQSVDCE QGPSSGRRH SNFTNSSLN 
      FLPSTDIKP TGSLELGYL DKNPSEGFY FKTNGRGGV 
      RRIRSTALE TCCPPPALI VHPNSLEVI GCKGARNPL 
      PPPSSSLVR NQHLNLCSY YGSEIVYPI AEQSDEHQT 
      SHGPDTDID SSAHISDSD FEENQGSNS PLFYITVKT 
      MTKNVPYEK THPKIEEKC SEERTSATS KDALLDNDN 
      SNSSATPEM HDARTDCYG TDNECSDKK LMNEPHIFR 
      KRNVKRNRR RKSGEGAKT VEKDNCTSL VELDLDWLF 
      DDENQHNQH KKEPLKRDT EWSSTTTVS LEHDVNKVL 
      QEQVPSTRS LGAIPKKTR SNSSHNDQS SGRKTPKSE 
      SEKCSMCRC KSDENEPRN RSLKENKLT QTLRQNDCP 
      SSVEGLECI VLQKPQRVD IPKRYVRTS RDRNEEGSS 
      GGSNNELST LLPPAPLLS AFLASRRDY PLSVCYLPP 
      SETIKFSHV SPQRNRLKR SRVSRRRSC QRNKRDSAI 
      ASSLSAGHG THCAKNFND TTDGSVHCF MDEHGNWIT 
      YTFDEKGLG TANNRLHEK SSTGDKPHR RRPSDAAST 
      SRGTRNNSQ DFCDSNSTD SICNSSVSI ILDAPASKT 
      PSTSMIPLQ NSDLSSAQM KVRDTIRRR LFANQGFID 
      PLDSLISIV QGENEGDVE TNLARNQFK FIQNSDQVN 
      NNYPRTKSF YKFKVFPWT YVKVTLDRL KLLALLDRN 
      LTFFETLLS IGFGILVSV SGAILLYYD FYEDLLAFI 
      FCFVMASCQ YSLLKSVQP DAASPTHGF NRIIAYSRP 
      IYFCICAGI ILILDSYID KSAESQVYS LSSGGLTHM 
      QVLLLVRDF LIKFILFFP VLFSLGLFP QINTFIMYL 
      LEQVDMHIF GGNAMSSLL ASFYCIFRS LLAVIVMNG 
      FAYGGLSEP KSSQHILFS IFCACLVAC SYHLSRSAS 
      DPSHLWNIV KRHVWPSDI YREHSKDRV DKVESKEEK 
      PLTEKQPKK SVKFPSETS EKVNDHVDP LPHKLQKTV 
      NARLKNDII LCGLIAVLV FSVHASTVF TALQPELSP 
      VLWTISAVL GFVLHYVTP QLRKQLPWL CIASPVLRS 
      RELLQYQIR GPAKIMWFE RVYIYLCFV ERNILYPLL 
      FLSVLTEDS PKVVKKFGP LLGSFVVVI CGLKCLRSS 
      YSNQSCQYL VLTFTALAF RYDYSFMEQ TFLVQYFFV 
      SIVFHKFYE LLLKVQFVV TYIAPWQIT WGSAFHAFA 
      QPFSVPHSA MLFLQAFIS AILSTPLNP FLGSAIFLT 
      SYVRPIKFW ERDYNTRRV DHSNTPLSS HLDRNLGAD 
      DNNLNSIFY EHLTRSLQH SLCGDLILG RWGLVSQGD 
      CFVLASDYL NCLVHIIEL GNGLVTFQM RGLEFKGTY 
      CQQREVEAI TEGIEENHA CCCIETDHF TGILSISSA 
      FSQRWLAWE VIAAKYILE GYSISDNSA VSMLQVFEF 
      RKVLISYYV KSIIFYTVR SPKLEEWLS SQTILSALQ 
      PMEHKNFVD LDPVFNYNI DEDFDIANS GMTRHMFCQ 
      IHGEWISFC VEKAEKNVD SGNNSTLVL LCFALSLLG 
      RRALGAVSH NTVSSVEFF LFGLHALFK GDFRITCAR 
      DEWVFTDMD LLKTVVAPG IRMSLKLHQ DHFMSPDEY 
      EELPALYDA ICKHEEELV ISHEGDPAW RNAVLSGTP 
      SLLALRHVL DDGSDEYKI IMLNKRYLS FRVIKINKE 
      CVRGLWAGQ QQELVYLRN RNPERGSIQ NAKQALRNI 
      INSSCDQPI GYPIYVSPL TTSYAETNE QYCSLVGGS 
      VSLTKIKNY IFNVFRRIR KRCGEGCSS GASARDEIG 
      MGHEGVYAM TTVTPLNHQ TAGSQSTDG SHLSGSMGR 
      GSSLSRTSL GGNRGSLVS VGKPTSATL ASLAGLFKE 
      RDERAVSQT PDGQPRNDE FDETAEKEY SVQRVRIVD 
      PNLVYDAIN LGRRIDVTW PTEYMRVRG GRSFWKDWV 
      PETGMEGPV VHRWTPCHK DPGRRSHVD RTILLVQID 
      DKFVPIAES GVQDLGQEV
    CDS sequence
    • >TC007308 RA
      atgatagaa gaacagcaa atgggctcg caaacattg 
      gagatttta agacaaggt gtttgggct tctttgacc 
      gggggttgg ttcttcgac ccccatcaa gatgtgttt 
      tgcaacacg ttccacctc tacatctgg ctattcttg 
      ctatgtttg cccttcacg atatacgtg tacttccca 
      ccgacgaag tacatgtgg tacttctat tgtctctcg 
      gtgacgata gttctagct gtgatcaag ctggttaat 
      tacggcttg catcacatg tatgacaca tccgaatgc 
      attcatgag gaaattgat gagaactgg caggaagtc 
      aaaagggag gaggaaggg attgagctg caagttttg 
      tccaacaag acggaaaca aactcgaga cctgccgtc 
      agcggctcg tttatttct tacgcggaa gcgggggct 
      cttccgagc accgatgct gacagtctg gagtcgacg 
      gagtttcag caagctgaa gccgccaaa gacaccaaa 
      ccgagcagc accatagac ttgaaggcc gaggtgcac 
      cgcaaaaac tcttcggag agcagcgac ggcgccgcc 
      gcccccgtc ctagaaata gtaacctat caaccggac 
      gtgcctgag cgcaaaccc aaaaaatcc gaccgtcgt 
      ccgaaacat caacgttca aaaaccgac ggtttcgtt 
      tgcgtccga atcaccgat gacaccaaa ccgaatcgt 
      tcgagtttt cgtaaacta tatcagcag gccgattcg 
      gccgacggc aatctctta atccagcgg ccgtcttta 
      caaagcgtc gattgcgaa caggggcct tcaagcggc 
      cgaagacac tccaatttt accaatagt agtttgaat 
      tttttacca tcgactgat attaagccg actggttct 
      ttggagctg ggctatttg gataaaaac ccgtctgag 
      gggttttac tttaagacg aatggccgc gggggcgtg 
      cggaggata cgctcgacg gccttggag acgtgctgt 
      ccgcccccg gcgctcatc gtccacccc aacagcttg 
      gaggtgatt gggtgcaag ggggcgcgg aatccgctg 
      ccgccccca agctcgagt ctggtgcgg aaccagcac 
      ttgaatctg tgttcgtac tatgggtcc gagattgtg 
      tacccgatc gcggaacag tcggacgaa catcaaact 
      tcgcatggg cctgacact gatatcgat tcttcggcc 
      cacatttcc gactcggat ttcgaggag aatcaaggg 
      agcaactcg cccctgttt tacatcact gtgaagaca 
      atgacgaaa aacgtgcct tacgaaaaa acccatccg 
      aaaatcgag gaaaagtgc agtgaggaa aggacgagt 
      gcgacgtcg aaagacgca ctcttagat aacgataat 
      tcgaattcg agtgcgacg ccggaaatg cacgacgct 
      aggactgac tgttacggg acggataac gaatgcagt 
      gataaaaaa ttaatgaat gagccacac atcttccgg 
      aaaaggaac gtcaaaagg aacaggcgg aggaagtcg 
      ggagaggga gccaagacg gtcgaaaag gacaattgc 
      accagtttg gtggaactg gacttggat tggctgttc 
      gacgacgag aaccagcac aaccaacac aaaaaagaa 
      ccgttaaaa agagacacg gagtggtcg agcaccacc 
      acagtatcg ctcgagcac gacgttaac aaagtcctt 
      caagagcaa gttccttcg acccgcagc ctcggcgca 
      attcccaaa aaaacccgt tcaaattct agtcacaac 
      gatcaatca tcaggccgt aaaacccca aaaagcgaa 
      tcggaaaag tgcagcatg tgtcgttgc aaatcggac 
      gaaaacgag ccacgaaac cgttcattg aaagaaaac 
      aaactcacg caaacactg cgtcaaaac gactgtcca 
      agttccgtc gaaggactc gaatgtatc gtcttgcaa 
      aaaccccaa agagttgat atcccgaaa cgctatgtg 
      cggacgtcg agggatcga aacgaggaa ggctcttca 
      ggtggttcc aacaatgaa ttgagcacg ttgttacca 
      ccagcccct cttctatcc gcctttttg gcctcgagg 
      agggactat ccactgtcg gtgtgctat ctaccacca 
      agtgagacg atcaaattc agtcatgtg tcaccgcag 
      aggaatagg ttgaaacgg agtagagtt agtaggagg 
      aggtcgtgc caaagaaac aagagggat agtgcaata 
      gctagttct ttatcggcg ggacatggg acacattgt 
      gccaaaaat ttcaacgat accaccgat gggtccgtt 
      cactgcttc atggacgag cacgggaac tggatcact 
      tacacattc gatgaaaaa ggattaggt accgcaaac 
      aaccgcctc cacgaaaaa tcctccact ggcgacaag 
      ccccaccgg cggcgtccc agcgacgcc gcctccacg 
      tcccgaggg actcgcaac aactcgcag gatttctgc 
      gacagcaac agcaccgac tccatctgc aacagctca 
      gtatccata atcctggac gctcccgcg tcgaaaacg 
      ccctcaacc agcatgatt ccgctccaa aattctgac 
      ctcagctcg gctcaaatg aaagtgcgt gatacaatc 
      cgtcgccgc ttgttcgcc aatcagggt ttcatcgat 
      ccgttggac tccttgatc agtatagtg caaggcgag 
      aacgagggc gacgttgag acgaatctg gcccgcaat 
      cagttcaaa ttcatccaa aattccgat caagtgaac 
      aataactat ccgaggacc aagtcgttt tataagttt 
      aaagtgttc ccgtggact tatgtgaaa gtgacgctc 
      gatcggctg aagctgctc gcgttgctc gacaggaac 
      ttgacgttt ttcgagacg cttctgtcg attgggttc 
      gggattcta gtctctgtt tctggtgct attttgttg 
      tattatgac ttttatgaa gacttgttg gcgttcatc 
      ttttgtttt gttatggcg agttgtcag tactcgctg 
      ctgaagagt gtgcaaccg gacgctgcc tcgcctacg 
      catgggttt aaccggatc atagcctac tcgcgcccg 
      atttatttc tgtatctgt gcagggatt attctaatt 
      ctggactcc tacattgat aaatcggcg gaaagtcaa 
      gtttatagt ctgagtagc ggcggtttg acacatatg 
      caggtgctc ctcctggtc cgggatttc ctaatcaag 
      tttatactc ttcttcccc gtgttattc tcgctaggg 
      ttgttcccc caaatcaac accttcatt atgtatttg 
      ttggaacag gtggatatg catattttc ggcgggaac 
      gcaatgtcg agtctcctc gcttcgttc tattgcatc 
      ttccgctcg cttctggct gtgattgtg atgaacggg 
      ttcgcctac ggcggcttg agcgagccg aagagttcg 
      cagcacatt ttattctcg attttttgt gcctgtctg 
      gtggcttgt tcgtaccat ttgagccga agcgccagc 
      gacccgtca cacttatgg aacatagtg aaacgtcac 
      gtctggccc tcggacata taccgcgaa cacagcaaa 
      gaccgagtc gataaggtc gaaagcaag gaagaaaaa 
      cccctcact gagaaacaa cccaaaaaa tcggtcaaa 
      ttcccgagt gagaccagc gaaaaagtc aacgaccac 
      gtcgacccg ctgccccac aagttgcag aaaactgta 
      aatgcgcgc ctgaagaac gacataatc ctgtgcggg 
      ttgatcgcg gttttggtg tttagcgtg cacgcgagt 
      accgtgttc acggcgctc cagccagag ctgagtccc 
      gttctgtgg acgatctcg gccgttttg gggtttgtc 
      ctccactat gtcacccca cagctgcgc aaacagttg 
      ccctggctg tgcattgct agtcctgtt ttgaggtcg 
      cgcgaattg ttgcagtat cagatcagg gggccggcc 
      aaaatcatg tggttcgaa cgggtgtac atttatttg 
      tgtttcgtt gaacggaat attttgtac ccgcttttg 
      ttcctctcg gttctgacg gaggattcg cccaaagtc 
      gttaagaag ttcggaccg ctgctcggg tcttttgtt 
      gttgttatt tgcgggttg aagtgttta cgtagttcc 
      tattcgaat cagagttgt cagtatctc gttttgact 
      ttcacggcg ttggcgttt cgttatgat tatagtttc 
      atggaacag acgtttcta gtgcagtat ttcttcgtg 
      agcatcgtt ttccacaag ttctacgag ttgctactc 
      aaggtccaa ttcgtggtg acctacatc gccccatgg 
      cagatcacg tggggctcg gccttccac gcctttgcc 
      cagcctttt tcagtacct cactcggcc atgttgttc 
      ctgcaagcc ttcatttcg gccatttta tcaacccct 
      ttgaacccg ttcttaggt agcgcgatt tttctaact 
      tcgtacgtt cgaccaatc aaattttgg gaacgtgac 
      tacaacact cgtcgagtt gatcactca aatacgccg 
      ctttcgtca catcttgat cgaaatttg ggcgccgat 
      gataataat ttgaattcg attttttac gaacacctt 
      acaagatca ttgcaacat tcgttgtgt ggcgatttg 
      attttggga cgctggggg ttggtcagt caaggcgat 
      tgcttcgtt ttggcatcg gattattta aactgcctg 
      gtgcatatc atcgagttg gggaacggg ttggtgacg 
      tttcaaatg cgagggttg gagttcaaa gggacgtat 
      tgtcagcag agagaagtc gaggcgatt accgaaggg 
      attgaggag aatcacgca tgttgttgt atcgaaaca 
      gaccatttc accgggatt ttgagcatc agttctgcg 
      ttcagccaa cgctggctg gcttgggaa gtcatcgcg 
      gctaaatac atactcgag ggttacagc atatccgac 
      aacagcgcc gtctcaatg ttgcaagtg ttcgaattc 
      cgaaaagtc ctcatctct tattacgtc aaaagtatc 
      attttttac accgtacgt tctcccaaa ctggaggaa 
      tggctctcc tcgcaaaca attctatca gctttacaa 
      ccaatggaa cacaagaac ttcgtcgat ctggacccg 
      gtgttcaac tacaacatc gacgaagac ttcgacata 
      gccaacagc gggatgacg cgccacatg ttctgccaa 
      atccacggc gaatggatc agtttttgc gtggagaag 
      gcggagaaa aacgtcgat tcggggaat aactcgact 
      ttggtgctg ctttgtttc gcgctgagt ttgctggga 
      cgtcgcgct ttgggcgcc gtgtcgcac aacactgtc 
      tcaagcgtt gagtttttt ctcttcggg ttgcatgca 
      ctgttcaag ggggatttc cgcatcact tgcgcccgc 
      gacgagtgg gttttcacc gacatggac ctcctgaaa 
      accgtagtg gcgccaggg attcgcatg tcgctgaaa 
      ctgcaccaa gaccatttt atgtcaccg gacgaatac 
      gaggaactg ccagccctc tacgacgcc atctgcaag 
      cacgaagaa gagttggtg atttcgcac gagggtgac 
      ccagcctgg aggaacgcc gttttgagt ggaacaccc 
      agtctttta gccttgagg catgtgttg gacgatggc 
      agcgacgag tacaagatt atcatgctg aataagcgg 
      tatttgagt ttccgtgtg atcaaaata aacaaggag 
      tgtgttcgg gggctttgg gccggccag caacaagaa 
      ctggtctac ttgcgtaat aggaacccg gagcggggg 
      agtatccaa aacgccaag caagccttg aggaacatt 
      atcaactcg tcgtgtgac caaccgatc ggctatcca 
      atttacgtc tcacctcta accacaagt tacgccgaa 
      acgaacgag caatactgc agtctagtc gggggttcg 
      gtcagtttg accaaaatc aagaactac attttcaat 
      gtattcaga cgtatccgt aagcgatgt ggcgagggt 
      tgttcgagc ggggcttcg gctcgtgac gagatcggg 
      atggggcac gagggggtg tatgccatg acgacggtc 
      acacccctt aaccaccaa acagccggc agccaatcg 
      acggatggg tcgcacttg agtggcagc atgggacgt 
      gggtctagt ctgagccgc acttcgttg ggcggcaat 
      agggggagt ttggtgtcg gtggggaaa cccacaagt 
      gccactttg gccagtttg gcggggctg ttcaaagag 
      cgggatgaa cgggcggtg tcgcaaacg cccgatggg 
      cagccgagg aacgacgag tttgacgaa accgccgag 
      aaggaatat tccgttcag agagttcgg atcgttgat 
      ccaaatttg gtatacgac gctatcaat ttggggcga 
      aggattgac gttacgtgg ccgactgag tacatgagg 
      gtgagaggc ggccgttcg ttttggaag gattgggtg 
      cctgagacg gggatggaa ggaccggtg gtgcatcga 
      tggacgccc tgtcacaaa gacccaggg cggaggtct 
      cacgtcgac cggacgata ctcctggtt caaattgac 
      gataagttt gtgcccatt gcagagagc ggtgtgcag 
      gatctaggg caggaggta tag
    mRNA sequence
    • >TC007308 RA
      cccaacagg atttcgcac tgacgggac gagaaattg 
      aggttaact ttgacgtaa cggcgaact gacagactg 
      gattttttg accaaatct cgaactttt gataagcaa 
      aaagacggc aaacttccg gcatgagtg ataatcggg 
      gcgttgcga gcgttattt tgtgaaatc cgcggcttg 
      tgagtgaaa tttacaaaa tcagctgga acggcaaga 
      tgtcgtgct ccaagtctg tcatcgatt cagcccgac 
      tgtaaacat gtaagccac ccgaaatgt tttaatttt 
      actatgata gaagaacag caaatgggc tcgcaaaca 
      ttggagatt ttaagacaa ggtgtttgg gcttctttg 
      accgggggt tggttcttc gacccccat caagatgtg 
      ttttgcaac acgttccac ctctacatc tggctattc 
      ttgctatgt ttgcccttc acgatatac gtgtacttc 
      ccaccgacg aagtacatg tggtacttc tattgtctc 
      tcggtgacg atagttcta gctgtgatc aagctggtt 
      aattacggc ttgcatcac atgtatgac acatccgaa 
      tgcattcat gaggaaatt gatgagaac tggcaggaa 
      gtcaaaagg gaggaggaa gggattgag ctgcaagtt 
      ttgtccaac aagacggaa acaaactcg agacctgcc 
      gtcagcggc tcgtttatt tcttacgcg gaagcgggg 
      gctcttccg agcaccgat gctgacagt ctggagtcg 
      acggagttt cagcaagct gaagccgcc aaagacacc 
      aaaccgagc agcaccata gacttgaag gccgaggtg 
      caccgcaaa aactcttcg gagagcagc gacggcgcc 
      gccgccccc gtcctagaa atagtaacc tatcaaccg 
      gacgtgcct gagcgcaaa cccaaaaaa tccgaccgt 
      cgtccgaaa catcaacgt tcaaaaacc gacggtttc 
      gtttgcgtc cgaatcacc gatgacacc aaaccgaat 
      cgttcgagt tttcgtaaa ctatatcag caggccgat 
      tcggccgac ggcaatctc ttaatccag cggccgtct 
      ttacaaagc gtcgattgc gaacagggg ccttcaagc 
      ggccgaaga cactccaat tttaccaat agtagtttg 
      aatttttta ccatcgact gatattaag ccgactggt 
      tctttggag ctgggctat ttggataaa aacccgtct 
      gaggggttt tactttaag acgaatggc cgcgggggc 
      gtgcggagg atacgctcg acggccttg gagacgtgc 
      tgtccgccc ccggcgctc atcgtccac cccaacagc 
      ttggaggtg attgggtgc aagggggcg cggaatccg 
      ctgccgccc ccaagctcg agtctggtg cggaaccag 
      cacttgaat ctgtgttcg tactatggg tccgagatt 
      gtgtacccg atcgcggaa cagtcggac gaacatcaa 
      acttcgcat gggcctgac actgatatc gattcttcg 
      gcccacatt tccgactcg gatttcgag gagaatcaa 
      gggagcaac tcgcccctg ttttacatc actgtgaag 
      acaatgacg aaaaacgtg ccttacgaa aaaacccat 
      ccgaaaatc gaggaaaag tgcagtgag gaaaggacg 
      agtgcgacg tcgaaagac gcactctta gataacgat 
      aattcgaat tcgagtgcg acgccggaa atgcacgac 
      gctaggact gactgttac gggacggat aacgaatgc 
      agtgataaa aaattaatg aatgagcca cacatcttc 
      cggaaaagg aacgtcaaa aggaacagg cggaggaag 
      tcgggagag ggagccaag acggtcgaa aaggacaat 
      tgcaccagt ttggtggaa ctggacttg gattggctg 
      ttcgacgac gagaaccag cacaaccaa cacaaaaaa 
      gaaccgtta aaaagagac acggagtgg tcgagcacc 
      accacagta tcgctcgag cacgacgtt aacaaagtc 
      cttcaagag caagttcct tcgacccgc agcctcggc 
      gcaattccc aaaaaaacc cgttcaaat tctagtcac 
      aacgatcaa tcatcaggc cgtaaaacc ccaaaaagc 
      gaatcggaa aagtgcagc atgtgtcgt tgcaaatcg 
      gacgaaaac gagccacga aaccgttca ttgaaagaa 
      aacaaactc acgcaaaca ctgcgtcaa aacgactgt 
      ccaagttcc gtcgaagga ctcgaatgt atcgtcttg 
      caaaaaccc caaagagtt gatatcccg aaacgctat 
      gtgcggacg tcgagggat cgaaacgag gaaggctct 
      tcaggtggt tccaacaat gaattgagc acgttgtta 
      ccaccagcc cctcttcta tccgccttt ttggcctcg 
      aggagggac tatccactg tcggtgtgc tatctacca 
      ccaagtgag acgatcaaa ttcagtcat gtgtcaccg 
      cagaggaat aggttgaaa cggagtaga gttagtagg 
      aggaggtcg tgccaaaga aacaagagg gatagtgca 
      atagctagt tctttatcg gcgggacat gggacacat 
      tgtgccaaa aatttcaac gataccacc gatgggtcc 
      gttcactgc ttcatggac gagcacggg aactggatc 
      acttacaca ttcgatgaa aaaggatta ggtaccgca 
      aacaaccgc ctccacgaa aaatcctcc actggcgac 
      aagccccac cggcggcgt cccagcgac gccgcctcc 
      acgtcccga gggactcgc aacaactcg caggatttc 
      tgcgacagc aacagcacc gactccatc tgcaacagc 
      tcagtatcc ataatcctg gacgctccc gcgtcgaaa 
      acgccctca accagcatg attccgctc caaaattct 
      gacctcagc tcggctcaa atgaaagtg cgtgataca 
      atccgtcgc cgcttgttc gccaatcag ggtttcatc 
      gatccgttg gactccttg atcagtata gtgcaaggc 
      gagaacgag ggcgacgtt gagacgaat ctggcccgc 
      aatcagttc aaattcatc caaaattcc gatcaagtg 
      aacaataac tatccgagg accaagtcg ttttataag 
      tttaaagtg ttcccgtgg acttatgtg aaagtgacg 
      ctcgatcgg ctgaagctg ctcgcgttg ctcgacagg 
      aacttgacg tttttcgag acgcttctg tcgattggg 
      ttcgggatt ctagtctct gtttctggt gctattttg 
      ttgtattat gacttttat gaagacttg ttggcgttc 
      atcttttgt tttgttatg gcgagttgt cagtactcg 
      ctgctgaag agtgtgcaa ccggacgct gcctcgcct 
      acgcatggg tttaaccgg atcatagcc tactcgcgc 
      ccgatttat ttctgtatc tgtgcaggg attattcta 
      attctggac tcctacatt gataaatcg gcggaaagt 
      caagtttat agtctgagt agcggcggt ttgacacat 
      atgcaggtg ctcctcctg gtccgggat ttcctaatc 
      aagtttata ctcttcttc cccgtgtta ttctcgcta 
      gggttgttc ccccaaatc aacaccttc attatgtat 
      ttgttggaa caggtggat atgcatatt ttcggcggg 
      aacgcaatg tcgagtctc ctcgcttcg ttctattgc 
      atcttccgc tcgcttctg gctgtgatt gtgatgaac 
      gggttcgcc tacggcggc ttgagcgag ccgaagagt 
      tcgcagcac attttattc tcgattttt tgtgcctgt 
      ctggtggct tgttcgtac catttgagc cgaagcgcc 
      agcgacccg tcacactta tggaacata gtgaaacgt 
      cacgtctgg ccctcggac atataccgc gaacacagc 
      aaagaccga gtcgataag gtcgaaagc aaggaagaa 
      aaacccctc actgagaaa caacccaaa aaatcggtc 
      aaattcccg agtgagacc agcgaaaaa gtcaacgac 
      cacgtcgac ccgctgccc cacaagttg cagaaaact 
      gtaaatgcg cgcctgaag aacgacata atcctgtgc 
      gggttgatc gcggttttg gtgtttagc gtgcacgcg 
      agtaccgtg ttcacggcg ctccagcca gagctgagt 
      cccgttctg tggacgatc tcggccgtt ttggggttt 
      gtcctccac tatgtcacc ccacagctg cgcaaacag 
      ttgccctgg ctgtgcatt gctagtcct gttttgagg 
      tcgcgcgaa ttgttgcag tatcagatc agggggccg 
      gccaaaatc atgtggttc gaacgggtg tacatttat 
      ttgtgtttc gttgaacgg aatattttg tacccgctt 
      ttgttcctc tcggttctg acggaggat tcgcccaaa 
      gtcgttaag aagttcgga ccgctgctc gggtctttt 
      gttgttgtt atttgcggg ttgaagtgt ttacgtagt 
      tcctattcg aatcagagt tgtcagtat ctcgttttg 
      actttcacg gcgttggcg tttcgttat gattatagt 
      ttcatggaa cagacgttt ctagtgcag tatttcttc 
      gtgagcatc gttttccac aagttctac gagttgcta 
      ctcaaggtc caattcgtg gtgacctac atcgcccca 
      tggcagatc acgtggggc tcggccttc cacgccttt 
      gcccagcct ttttcagta cctcactcg gccatgttg 
      ttcctgcaa gccttcatt tcggccatt ttatcaacc 
      cctttgaac ccgttctta ggtagcgcg atttttcta 
      acttcgtac gttcgacca atcaaattt tgggaacgt 
      gactacaac actcgtcga gttgatcac tcaaatacg 
      ccgctttcg tcacatctt gatcgaaat ttgggcgcc 
      gatgataat aatttgaat tcgattttt tacgaacac 
      cttacaaga tcattgcaa cattcgttg tgtggcgat 
      ttgattttg ggacgctgg gggttggtc agtcaaggc 
      gattgcttc gttttggca tcggattat ttaaactgc 
      ctggtgcat atcatcgag ttggggaac gggttggtg 
      acgtttcaa atgcgaggg ttggagttc aaagggacg 
      tattgtcag cagagagaa gtcgaggcg attaccgaa 
      gggattgag gagaatcac gcatgttgt tgtatcgaa 
      acagaccat ttcaccggg attttgagc atcagttct 
      gcgttcagc caacgctgg ctggcttgg gaagtcatc 
      gcggctaaa tacatactc gagggttac agcatatcc 
      gacaacagc gccgtctca atgttgcaa gtgttcgaa 
      ttccgaaaa gtcctcatc tcttattac gtcaaaagt 
      atcattttt tacaccgta cgttctccc aaactggag 
      gaatggctc tcctcgcaa acaattcta tcagcttta 
      caaccaatg gaacacaag aacttcgtc gatctggac 
      ccggtgttc aactacaac atcgacgaa gacttcgac 
      atagccaac agcgggatg acgcgccac atgttctgc 
      caaatccac ggcgaatgg atcagtttt tgcgtggag 
      aaggcggag aaaaacgtc gattcgggg aataactcg 
      actttggtg ctgctttgt ttcgcgctg agtttgctg 
      ggacgtcgc gctttgggc gccgtgtcg cacaacact 
      gtctcaagc gttgagttt tttctcttc gggttgcat 
      gcactgttc aagggggat ttccgcatc acttgcgcc 
      cgcgacgag tgggttttc accgacatg gacctcctg 
      aaaaccgta gtggcgcca gggattcgc atgtcgctg 
      aaactgcac caagaccat tttatgtca ccggacgaa 
      tacgaggaa ctgccagcc ctctacgac gccatctgc 
      aagcacgaa gaagagttg gtgatttcg cacgagggt 
      gacccagcc tggaggaac gccgttttg agtggaaca 
      cccagtctt ttagccttg aggcatgtg ttggacgat 
      ggcagcgac gagtacaag attatcatg ctgaataag 
      cggtatttg agtttccgt gtgatcaaa ataaacaag 
      gagtgtgtt cgggggctt tgggccggc cagcaacaa 
      gaactggtc tacttgcgt aataggaac ccggagcgg 
      gggagtatc caaaacgcc aagcaagcc ttgaggaac 
      attatcaac tcgtcgtgt gaccaaccg atcggctat 
      ccaatttac gtctcacct ctaaccaca agttacgcc 
      gaaacgaac gagcaatac tgcagtcta gtcgggggt 
      tcggtcagt ttgaccaaa atcaagaac tacattttc 
      aatgtattc agacgtatc cgtaagcga tgtggcgag 
      ggttgttcg agcggggct tcggctcgt gacgagatc 
      gggatgggg cacgagggg gtgtatgcc atgacgacg 
      gtcacaccc cttaaccac caaacagcc ggcagccaa 
      tcgacggat gggtcgcac ttgagtggc agcatggga 
      cgtgggtct agtctgagc cgcacttcg ttgggcggc 
      aataggggg agtttggtg tcggtgggg aaacccaca 
      agtgccact ttggccagt ttggcgggg ctgttcaaa 
      gagcgggat gaacgggcg gtgtcgcaa acgcccgat 
      gggcagccg aggaacgac gagtttgac gaaaccgcc 
      gagaaggaa tattccgtt cagagagtt cggatcgtt 
      gatccaaat ttggtatac gacgctatc aatttgggg 
      cgaaggatt gacgttacg tggccgact gagtacatg 
      agggtgaga ggcggccgt tcgttttgg aaggattgg 
      gtgcctgag acggggatg gaaggaccg gtggtgcat 
      cgatggacg ccctgtcac aaagaccca gggcggagg 
      tctcacgtc gaccggacg atactcctg gttcaaatt 
      gacgataag tttgtgccc attgcagag agcggtgtg 
      caggatcta gggcaggag gtatagcat ttgtttttg 
      cgtttgtcc gtctctaac atcagagaa gggattaaa 
      tctgatttt agacttcca ttaggagta taattatag 
      aaagactta attttatat gaattgtta ctatcgtta 
      agaaagtga atttacata taaaacaaa atgtacagt 
      aggtaatct ttatattgt ttttaactg gaagttgtt 
      tccttattt cgtttttac acatacaca gactaattg 
      tttaactgc cattctttt acgatgatt gtgatgtag 
      aatcttttt ttatgacat acgtccaaa gattttgta 
      cttgaggga gaagtgtca aaatgattt gtattataa 
      attaggctt cttaatatt tatgaattg ttgttacgc 
      agttgcctt attaaaata gactgattt ttatgtgta 
      tttagttaa gaaaagtgt acaattttt ccaataatt 
      tatatttaa ttaaaaaag gaggaaata agttgtcca 
      tgtttataa acgggtttt tatttaact tactaggtt 
      ttcgcataa tcccaaata atcacattg ttgctgcag 
      atatctata gattttata atgttatgt aatgtatta 
      actctactt ttttataag gacatcatt tttggccta 
      tgattgtaa aaacgatta taaaaaaga aaataaaca 
      cactcattg tct
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