Status
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Gene information
General information
TC000871 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007417.3: 7540641..7565324
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC000871
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
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    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
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    Email
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_06402

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 30.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 2 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 larval musculature pattern irregular - Penetrance (percentage of animals/eggs on slide): more than 80%

    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    remarks: muscle pattern potentially obscured by segmentation defect,
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    legs partially fused - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    Comment: The leg pairs are partially fused together, mostly affected is the metathoracic leg pair.
    legs shape irregular - Penetrance (percentage of animals/eggs on slide): more than 80%
    abdomen circumference irregular - Penetrance (percentage of animals/eggs on slide): more than 80%
    abdomen dv-orientation irregular - Penetrance (percentage of animals/eggs on slide): more than 80%

    abdomen everted (inside-out) - Penetrance (percentage of animals/eggs on slide): more than 80%
    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 10.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 80.0% (includes death as larva, prepupa, pupa, adult)

    adult lethality immediately after eclosion - Number of animals showing the phenotype: 2 (16 dpi)
    Days post injection


    eclosion delayed (still pupa) - Number of animals showing the phenotype: 7 (16 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 5 (22 dpi)
    Days post injection


    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC000871 RA
      MLIRIPATI TVALLAIFR ISLAQNSSS NLFSCPNGW 
      ELRGLHCYK FFNIRHSWE KAAELCRRY GSDLMSVES 
      YGENNLTAT IATASVPIE RRGVNHYWL GLASLDDLR 
      TNTLESAAG TLVSQYSGF WSQHQPDPK AGECVDVAV 
      TEENESWEL TTCESLLPF MCRSKACPS GSYHCSNGN 
      CINEKFRCD KEDDCEDGS DEIDCAANC NFYLASSGD 
      VVESPYYPH KYAPLTNCK WTLEGPQGH NILLQFQEF 
      ETEKTFDTV QILVGGRTE DTSVNLATL SGKQDLTNR 
      SFVSASNFM IIKFSTDAS VERKGFRAS WKTEPQTCG 
      GTLRATPQA QVLTSPGYP EQYPGGLEC LYIIQAQNG 
      RIITLEIDD LDLDNIRDY ILVRDGDSP KSQAIARLT 
      GDLENNQRV VISTNSKLY LYFKTSLGD SNRGFRIRY 
      TQGCRATIV ARNGTLMSP AYGLSQYPS NQDCLYKIR 
      NPGGGPLSL NFENFNVDK SDFVQVYDG ATTSGLRLH 
      SGNGFTADS KPKITLTAS SGEMLVRFT TDALHSSEG 
      WLATFSADC PQLQPGAGA MASSRDTAF GTIITFNCP 
      TGQEFATGR NRLTTQCLP GGNWSVSYI PKCQEVYCG 
      PVPQIDNGF SIGSTNVTY RGQAMYQCY AGFAFPTGQ 
      PIEKISCLS DGRWEKKPN CLASQCAAL PEVPHANVT 
      ILNGQGRSY GTIVRYECE PGYIRTGPP VILCMSNGT 
      WSGEVPTCS RAKCPEFPE IKNGFFTDT SRSYFFNDE 
      ARVQCYKGY KLVGNNILR CGENQIFNN PPKCEDINE 
      CISSQCDSA STECINSPG SFHCKCRKG FSPTLECRP 
      VGDLGLTNG GIPDEAITV SSSESGYDK TMVRLNSGV 
      GWCGNTNEP GSNWVLIDL KAPTIIRGF RTTSVPRPD 
      GSLAFTSAV RIQYTDDLT DVFKDYRNP DGTAVEFRI 
      LEPTLSILN LPVPIEAQY IKFKVQDYV VAPCLKLEV 
      MGCTRLECA DINECAVDN GGCDQKCIN SAGDFSCSC 
      NVGFELYAG NGTAAYYIE KSENGLRDG DTYQVNKSC 
      VPVMCPSLS APENGVILS TKEKYHFGD LVRFQCNFG 
      YVLSGSSAL LCTSTGNWN GTMPECSYA KCVSLPDDK 
      NEGLKILRA DESSVLVPF RENVTLTCG STGRKLRGT 
      YTSGFRQCV YDPKPGFPD YWLSGAPPS CPRADCGIP 
      PPTPGAEYG KYVDTKYQS SFFFGCQNT FKLAGQSSK 
      HDNIVRCQA NSVWDFGDL RCEGPVCED PGRPSDGHQ 
      IARSYEQGS EVSFGCNRP GYILINPRP ITCVRDPEC 
      KVVRPLGLA SGRIPDSAI NATSERPNY EARNIRLNS 
      VTGWCGKQE AFTYVSVDL GKVYRVKAI LVKGVVTND 
      IVGRPTEIR FFYKQAENE NYVVYFPNF NLTMRDPGN 
      YGELAMISL PKYVQARFV ILGIVSYMD NACLKFELM 
      GCDEPDTEP LLGYDYGYS PCVDNETPV FQNCPQQPI 
      VVQKDANGG LLPINFTEP TAVDNSGSI ARLEVKPAN 
      FKTPMYVFQ DTVVKYVAF DYDGNVAIC EINITVPDH 
      TPPKLSCPQ SYVIELVDR QDSYVVNFN ETRRRINTT 
      DDSGEVFVT FIPDKATIA IGTFENVTV VAADKYGNR 
      ATCHFQVSV QATPCVDWE LKPPVNGAL NCLPGDKGL 
      QCIATCNPG YRFTDGDPV KTFSCDAKT PWTPTSVVP 
      DCVSENTQQ ADYHVTATV NYRANGAVA TACLNQYSE 
      LISQYYTNL NNILSERCS AVNVKMAVS FLKAVPSLI 
      KENVVKIDY ILNIIPVVR QPQLYDLCG STLSLMFDL 
      SVPYANAVI EPLLNVSAI GNQCPPLKA LNSTNIRGF 
      TCSVGEVLN MDTNDVPRC LHCPAGTYA GEKQKECTY 
      CPRGYYQNR DRQGSCNRC PQGTYTREE GSKSVHDCI 
      PVCGYGTYS PTGLVPCLE CPRNSFTSE PPTGGFKDC 
      QACPANTFT YQPAAPGKD RCRPKCSPG YYSPTGLAP 
      CSACPRDFY QSLPGQTSC NECPTNMKT EGPAATGRD 
      ECHPVQCTE NACQHGGLC VPLGHNIQC ICPAGFSGR 
      RCEIDIDEC SSQPCYNGG TCVDLPQGY RCQCAPGYA 
      GINCQEERS DCRNDTCPE RAMCKDEPG YNNYTCLCR 
      SGYTGVDCD ITIDPCSAS GNPCNNGAT CIALQQGRF 
      MCECLPGWD GQTCDINID DCAEKPCLL GANCTDLVA 
      DFSCSCPPG FTGKRCQEK IDLCGRNPC KNGICVDKL 
      FYHECVCYP GWAGESCES NINDCAQNP CENGGHCID 
      EINDFTCTC EPGFTGKKC QHTIDFCSS KPCQNGASC 
      TDLVDGFSC KCRPGFVGL QCEAEIDEC LSDPCNPIG 
      TERCVDLDN KFVCMCREG YSGTYCEEN IDDCRSDPC 
      LNGGSCRDD VGSYKCICQ PGWTGTNCE TDIGSCYSK 
      PCQNDAKCI NLFQDYFCV CPSGTDGKQ CETAPERCI 
      GNPCMHGGK CQDFGSGLN CSCSDGFTG IGCQYEYDA 
      CQANACKNG ATCTNDPFG FKCVCAPGF TGKYCEEDI 
      IDCKENSCP PSATCIDLT DRFYCQCPF NLTGEDCRK 
      TISVDYDLY FSDATRSSA SQAVPFYTG SKSSLTIAM 
      WIQFTQKDE NGIFFTLYS VSSKHIPKD RKPLIQAHS 
      NGVQVSLFP DIQDVYLSY RDYTTINDA QWHHIAIVW 
      DGENGGELK LITEGLIAS KVEGYGSGR KLPEYAWVT 
      LGKPQSGNP KAYTESGFQ GHLTKVQIW GRALDVTNE 
      VQKQVRDCR TEPVLYRGL ILTWAGYEE TVGGVERIV 
      PSHCGHRVC PPGYIGAKC QELQVDKIA PKVEYCPGD 
      LWIITKNGS ALVSWDEPH FSDNVGVAK ILEKNGHRP 
      GQTLLWGIY QISYVALDE AGNSATCNF KVSVLSEFC 
      PELPDPIGG VQVCKDWGA GGQFKVCEI ACNQGLRFS 
      QEIPKFYTC GAEGFWRPT TNPNLPMVY PACSATKPA 
      QRVFKISML FPSSVLCNE AGQGVLRQR VRNAVNSLN 
      RDWNFCSFS VEGTRECKE LNIDVKCDH RTSRQVRQA 
      NDEDDGGTY VVEASVPAE KTTRQGRQS SSDTYNIEI 
      SFPAVNDPV IHSNTNERS TVKHLLEKL ILEEDQFDV 
      RDILPNTVP DPSSLVLES DYACPVGQV VMAPDCVQC 
      AIGSYYDKK TKTCIPCPQ GTYQSEAGQ LQCIQCPVI 
      AGRAGVTVG LGARSASDC KERCPAGKY YDHDAGLCR 
      SCGHGFYQP EEGSFSCQI CGLGKTTRT SEAVSQKEC 
      RDECESGMQ LALDGKCEA CPRGTYRTQ GIQAACQGC 
      PLGRTTPKS GAMTIEECS LPVCTPGTY LNGTLNSCI 
      PCKKGYYQS ESQQTTCIR CPENTSTKS TAATSKAEC 
      INPCTMSGS GMHCDANAH CLLNPETGE FRCECNTGF 
      NGTGHECSD VCDGYCDND GVCVKDIRG QPSCRCIGS 
      FTGRHCTEK SEFAYIATG IALAVVIII IIVLLIWMI 
      CARSHRRKE PKKLLTPAT DQNGSQVNF YYGAPTPYA 
      ESIAPSHHS TYAHYYDDE EDGWEMPNF YNETYMKES 
      LHNGVNGKM NSLARSNAS IYGTKDDLY DRLKRHAYP 
      GKKDKSDSD SEGQ
    CDS sequence
    • >TC000871 RA
      atgctgatt cggataccg gcgaccatt acggtcgcc 
      ctcttggcc atttttagg ataagttta gcacagaat 
      tcatctagc aacctattt agttgtccg aacggttgg 
      gaactccga ggactgcat tgttataag ttcttcaat 
      attagacat tcttgggaa aaagcagcg gaactttgc 
      agaaggtat ggcagcgac ttgatgtcg gtagaatcc 
      tacggagaa aataattta acggcaacg atcgcaact 
      gcttcagta cccatagaa cgacgaggg gtcaaccat 
      tactggttg ggtttggca tctttagat gacctccga 
      actaatacg ttagaatca gcagccgga acactagtt 
      tctcagtat tccggtttc tggtcgcaa catcaaccc 
      gatcccaaa gccggggaa tgcgtcgat gttgccgtc 
      acggaagaa aacgaatcg tgggaactg acaacatgc 
      gagagtttg ctccctttc atgtgccga tccaaagca 
      tgtccctcg ggatcctac cactgttcc aacgggaac 
      tgcatcaac gaaaagttc agatgcgac aaagaggac 
      gattgcgaa gacggctct gacgaaatc gactgtgca 
      gctaattgc aatttttac ctcgcaagt agtggtgac 
      gttgttgaa agtccctac tacccacac aaatacgca 
      cccttgact aactgcaaa tggaccctg gaaggaccg 
      caaggacac aatatcctc ctccagttc caagaattt 
      gagactgaa aagaccttc gatactgtg caaattcta 
      gtcggggga cgaactgaa gacacctct gtgaatctc 
      gcaacgtta tctggaaaa caagacttg acgaacaga 
      tcgtttgtc tcggcttcg aatttcatg attattaag 
      tttagcacc gatgcttcg gttgaacga aaaggcttt 
      agagcgtct tggaaaact gaaccgcag acttgtggc 
      ggtacctta cgtgccact cctcaggcc caagttttg 
      acgtctcct ggatatccg gaacaatat cctggagga 
      ctcgagtgt ctctacata attcaggcc cagaacggg 
      cgaattatc acactcgaa atcgacgat ttggatttg 
      gataacatc agggattat atccttgtc cgtgatggt 
      gactctccc aaaagtcaa gctattgca cgactgacc 
      ggcgatttg gaaaacaac caaagagtt gtgatttca 
      acaaacagc aaactctac ttatatttt aagaccagt 
      ctgggtgat tcgaaccgc ggttttagg atcagatac 
      acccaaggt tgcagagca acaatcgtt gcgcgaaat 
      ggcacttta atgtcgccc gcttacggt ctgagtcag 
      tatccaagt aaccaggac tgtttgtac aaaatcagg 
      aatccggga ggcgggcca ttgtcgctg aatttcgaa 
      aactttaat gttgataaa tccgatttt gtgcaagtt 
      tacgatggg gccacgact agtgggctg cggcttcac 
      tcaggaaac ggatttacg gccgattca aaacccaaa 
      atcacgctt acggcatca agtggtgaa atgttggtc 
      agatttacg actgatgct ttacatagt agtgaaggc 
      tggcttgcg actttctct gccgattgt cctcaatta 
      caaccggga gctggtgca atggcgtca agtagagat 
      acggctttc ggaaccatc atcacgttt aattgtccg 
      actggtcaa gaattcgca acaggacgt aatagatta 
      accactcag tgcctgcct ggtggtaac tggtctgtg 
      agttatatc ccgaaatgt caggaagtt tactgcgga 
      ccggttccg caaattgat aatggattt tcaattggt 
      tctaccaat gtaacctac cgggggcag gcaatgtac 
      cagtgctat gccgggttt gcgtttcct accggacag 
      ccaattgag aaaatctca tgtttatca gatggccga 
      tgggagaaa aaacccaac tgtcttgca tctcaatgt 
      gctgcgctt ccggaagta ccgcacgct aatgttacg 
      atattaaac ggccaaggc cgttcgtac ggaaccata 
      gtgcgatac gagtgtgaa cctggatac ataagaaca 
      ggaccacct gtaatccta tgtatgagt aatggcacc 
      tggtctggt gaagtacca acatgttca agagctaaa 
      tgtcccgag ttccccgaa atcaaaaac gggtttttc 
      actgacact tcccgttct tatttcttt aatgacgaa 
      gcccgtgtc cagtgttac aaaggttac aaacttgtg 
      ggcaacaac atcctgaga tgtggtgaa aaccaaatt 
      ttcaacaac cctccgaag tgtgaggat atcaatgaa 
      tgtatcagt agtcagtgt gacagtgcc tcgactgaa 
      tgtatcaac tcgcccggt tcgttccat tgcaaatgt 
      cgcaaaggc ttctcgcct acgttagaa tgccgacca 
      gttggcgat ctcggtctc actaacggc ggaattcca 
      gatgaggca attacagtt tcaagcagc gaatctgga 
      tacgataaa acgatggtg cgtcttaac agtggtgta 
      ggttggtgt ggaaatacc aacgagccg ggttccaac 
      tgggtactc atcgacttg aaagcccca actataatc 
      cgaggattt agaacaaca agcgtacca cgtcctgac 
      ggcagtctc gctttcact tcagccgtt cggatccaa 
      tacaccgat gacctcact gatgtgttc aaagattac 
      agaaatccc gatggtacc gcagttgaa ttcagaatt 
      ttggaacct actttatcg atattaaat ctccctgta 
      ccaattgaa gcacaatac atcaagttc aaggttcaa 
      gattacgtt gttgcgcca tgcttgaaa ctcgaagtt 
      atgggctgt accaggttg gaatgtgct gatattaac 
      gaatgtgcg gttgataac ggcgggtgc gaccaaaag 
      tgtattaac agtgccggg gacttttcg tgtagttgc 
      aatgtcggg ttcgagctt tatgcggga aacggtacc 
      gctgcgtac tatattgaa aaatccgaa aacgggtta 
      agagatggt gatacgtac caagtaaac aaatcgtgt 
      gttccggtg atgtgtccg agtttatca gcgcccgaa 
      aacggagtc atcttatca acgaaagaa aagtaccac 
      tttggtgac ctagtcagg ttccagtgc aacttcggg 
      tatgtttta tccggatcc tctgcactt ttgtgtact 
      tccaccgga aactggaac ggtactatg cccgaatgt 
      tcatatgct aaatgcgtt tcactacct gatgataaa 
      aatgaaggc ctaaaaata ttaagagct gacgaaagt 
      agcgtttta gtaccgttt agagagaac gtcactttg 
      acttgcggt agtaccgga cggaaatta agaggaact 
      tatacgtcc ggtttcagg caatgcgtc tatgaccct 
      aaacccggt ttccccgat tattggttg agcggtgct 
      cccccatcg tgcccccgc gccgactgt ggaatcccc 
      ccacctact cccggggcc gaatatgga aaatacgtc 
      gataccaaa taccaatcg tcttttttc ttcggttgt 
      caaaacact ttcaaacta gctggtcaa agtagcaaa 
      catgataat atcgtccga tgccaagca aattccgta 
      tgggatttc ggtgattta cgctgcgag ggtcccgtt 
      tgtgaagac ccgggacgt ccaagtgat ggtcatcaa 
      atcgcccgc agctacgag caaggctct gaagtcagt 
      ttcggttgc aacaggcct gggtatatt ttaattaat 
      cccagaccg ataacttgc gtgcgagac ccggagtgt 
      aaagtcgtg agacctctt ggacttgcc tcggggaga 
      attccagat tccgctatt aacgcaact agtgaaaga 
      ccgaattac gaagcgagg aatattagg ttgaattcg 
      gtcacggga tggtgcgga aaacaagaa gcttttact 
      tatgttagt gtcgatttg ggaaaagtg tatcgcgtt 
      aaagccatt ctagtaaaa ggcgttgtt actaatgat 
      atcgtcgga cggcccact gagatcaga ttcttctac 
      aaacaagcg gaaaatgag aattacgta gtctatttc 
      cccaatttt aatctcacg atgagagat cccggaaac 
      tacggagaa ctagcaatg atttcactc cctaaatat 
      gtccaagcc agattcgtt attttagga attgtgagc 
      tatatggac aatgcgtgt ctgaaattc gaactgatg 
      ggttgcgat gaacccgac acggaacca ctcttgggt 
      tacgactat gggtactct ccgtgcgtt gataacgag 
      acacctgtt ttccaaaac tgcccacaa caacctatt 
      gttgtacaa aaagatgcc aacggcgga cttctccca 
      atcaatttc acagaacca accgcggtt gataattcc 
      ggaagtatt gcccggctt gaagtcaaa ccggcaaac 
      tttaaaaca ccaatgtat gttttccaa gacaccgta 
      gttaaatac gtcgcgttc gattacgac ggaaatgtg 
      gccatttgt gaaataaac atcacagtt cctgaccat 
      actccaccg aaattgagc tgtcctcaa agctatgtt 
      atcgaatta gtcgacagg caagacagt tacgttgtt 
      aatttcaac gaaactcgc cgtaggatc aacaccact 
      gatgattct ggtgaagtc tttgttact ttcatcccc 
      gataaagct actatagct attggcacc tttgaaaat 
      gtaacagtt gttgcggca gacaaatac gggaataga 
      gctacttgc cacttccaa gtctcggta caagcaact 
      ccttgtgtt gattgggaa cttaagccg ccagttaat 
      ggagcttta aattgttta cccggggat aaagggtta 
      caatgtatt gctacatgt aatcctggc tacagattt 
      actgacggt gatccggta aaaactttc tcgtgtgat 
      gctaaaaca ccatggact ccgacatcg gtagtacca 
      gactgtgtg tcagaaaat actcaacag gcagattat 
      cacgttact gctacagtc aactatcgg gcaaatggg 
      gccgttgcc acagcttgt ctcaatcaa tattccgag 
      ctgatttct cagtactac acaaatctt aacaatatt 
      ttatcagaa agatgttcg gctgttaac gtaaaaatg 
      gctgtctcg ttcttgaaa gctgtacct tcgttaatt 
      aaagaaaac gtggtgaaa attgattac attttgaat 
      attataccg gtcgtacgg caaccccaa ttgtacgac 
      ctttgtggc agtactttg agcttaatg tttgacctg 
      tcggtacca tacgcaaat gctgtcatt gaaccgtta 
      ctaaatgtg tctgcaatt ggtaaccaa tgcccgcca 
      ctcaaagct ttgaattcg acaaacatc agaggattc 
      acttgtagt gtaggtgaa gtacttaac atggacact 
      aatgacgtt ccgagatgc ctacactgt cctgctgga 
      acttacgca ggagagaaa caaaaagag tgcacatac 
      tgcccacgc gggtactac caaaatcgg gaccgtcaa 
      ggttcttgt aaccgttgt cctcaaggt acctacact 
      cgcgaagag ggttcaaag agcgttcac gattgtatc 
      cccgtctgt ggttacggt acttactcc cccacgggc 
      ctagtacca tgtctagag tgcccccgt aacagtttc 
      acaagtgaa cccccaacc ggaggcttc aaagactgc 
      caagcttgt cccgctaat acctttacg taccaacct 
      gcagccccc ggcaaagac cgctgcagg cccaagtgc 
      agcccaggg tactactcc ccaaccggt ctagctccg 
      tgttccgcc tgcccacgc gatttctat caatcctta 
      cccggacaa acgtcatgc aatgaatgt ccaacaaat 
      atgaaaact gaaggacct gcagcgacc ggtcgcgat 
      gaatgccat ccggtgcaa tgcacggaa aacgcctgc 
      caacacggc ggcctttgc gtacctctg ggtcacaac 
      atccagtgt atttgcccg gctggattt tccggaagg 
      cgttgtgaa attgacatt gacgaatgc tcctcacaa 
      ccgtgctat aacggtggt acttgcgtc gatttgccg 
      cagggctac aggtgtcaa tgcgccccc ggctatgct 
      gggattaat tgccaggaa gaaaggtca gactgcagg 
      aatgacact tgcccagaa cgagcaatg tgtaaagac 
      gaaccaggc tataacaac tacacttgt ctttgccgc 
      tctggttac actggagtt gattgtgac attacgatt 
      gacccttgc agtgcctca ggaaacccc tgtaataac 
      ggtgcaact tgcattgct ttgcaacaa ggcagattc 
      atgtgtgaa tgcctgcct ggttgggac ggccaaact 
      tgcgacatc aacatagac gactgtgcc gaaaagcca 
      tgtctacta ggcgccaac tgcactgat ttagttgcc 
      gactttagc tgtagttgt cctccaggg ttcacggga 
      aaacgatgc caagagaaa atcgatctg tgcggccgc 
      aatccttgc aaaaatggc atttgtgtt gataaactg 
      ttctaccat gagtgcgtc tgttaccca ggttgggcc 
      ggcgaatct tgcgaatca aacatcaat gattgtgcc 
      caaaatcct tgcgagaat ggaggacat tgtatcgac 
      gaaatcaat gacttcacc tgcacgtgc gaacccgga 
      tttaccggg aaaaaatgc caacacacc atcgatttt 
      tgctcgtcg aaaccatgc caaaacggt gccagttgc 
      accgattta gtcgacggt ttttcgtgc aaatgtcgt 
      ccgggtttc gtcggtttg cagtgtgag gccgagatt 
      gatgaatgt ttgagcgat ccttgcaat cccatcggt 
      acggaacga tgcgtcgat ttggacaat aaattcgtg 
      tgcatgtgt cgcgagggc tactctggc acgtactgc 
      gaagaaaat attgacgac tgccgatct gatccttgt 
      ctaaatgga ggatcatgt cgggatgat gtagggtcg 
      tataaatgt atctgccag ccagggtgg acgggtacc 
      aattgcgaa acagacatt ggaagttgt tactccaaa 
      ccgtgccaa aacgatgcc aaatgtatc aatctcttc 
      caagactat ttctgcgtg tgtccctcg ggaactgac 
      ggcaaacag tgtgaaaca gcccctgag cgatgtatc 
      ggaaaccct tgcatgcat ggaggcaaa tgccaagat 
      tttggatcg ggacttaac tgttcttgc tccgatgga 
      ttcaccggc atagggtgt cagtacgag tacgatgct 
      tgtcaagca aatgcgtgc aaaaatgga gcaacttgc 
      accaacgat ccgttcgga ttcaaatgt gtttgtgct 
      ccaggattt accgggaaa tactgcgag gaggatatc 
      attgattgt aaagagaat tcgtgtcct ccgagcgcc 
      acttgtatc gatcttaca gaccggttt tactgtcaa 
      tgtccattc aatctaact ggcgaagac tgccgcaaa 
      acaatttcc gtggattat gacttgtac tttagcgac 
      gcgacacga agctcagcc tctcaagcc gttccgttc 
      tacaccggt tctaaatca agtctgaca attgcaatg 
      tggattcag ttcactcaa aaagacgag aatgggatt 
      ttcttcacg ttgtatagt gtgtcatct aaacacatt 
      cctaaagac aggaaaccg ttaatccaa gctcattca 
      aacggtgtt caagtgtca ctcttcccc gacatccaa 
      gacgtttat ctcagttat cgagactac accaccata 
      aatgatgcc caatggcac catatcgcg attgtatgg 
      gatggtgaa aacggtgga gaactcaaa ttaatcacc 
      gagggtttg attgccagc aaagtggag ggttacgga 
      agcggacgc aaattaccc gaatatgct tgggttacg 
      ttaggtaaa ccccaatcc ggtaacccc aaagcttac 
      accgaatcc ggcttccaa ggccatttg accaaagtg 
      caaatctgg ggacgcgct ttagacgtt actaacgaa 
      gtccaaaaa caagtcagg gattgtcgg accgaaccc 
      gtcctctat agaggccta atcctgact tgggctggc 
      tacgaagaa acagtcgga ggtgtcgaa cgaatagta 
      ccctctcac tgtggccat agagtttgt cctccgggt 
      tatatcggt gctaaatgc caggaactc caagtcgat 
      aaaattgcc ccgaaggtt gaatactgc cctggtgat 
      ttatggatc atcacaaag aatggatca gcactggtt 
      tcgtgggac gaacctcac tttagtgac aatgtgggc 
      gttgcaaaa attttagaa aagaatggc cacaggccg 
      ggccaaacc ctgctgtgg ggtatctac caaatttcg 
      tacgtggcg ttggacgaa gccggaaat tcggccact 
      tgcaacttc aaagtgtct gtcttatct gaattttgc 
      ccggaattg cctgatccg atcggggga gtccaagtc 
      tgtaaagac tggggtgcc ggtggtcag ttcaaagta 
      tgcgaaatt gcgtgcaat caaggattg agattctcg 
      caagaaatc cccaagttc tacacttgc ggagctgag 
      ggcttctgg cggccaaca accaacccg aatcttccc 
      atggtatac cctgcttgt tctgcgaca aaaccggcc 
      caacgcgtc ttcaaaatt tcgatgttg ttcccaagc 
      tcggtgctt tgcaacgaa gccgggcaa ggagtactc 
      agacagagg gtccgaaac gccgtcaac agtttgaac 
      cgagactgg aatttctgt tcattctcg gttgaaggc 
      acacgagag tgtaaggag ttgaatatt gatgtgaaa 
      tgtgaccat aggactagt cgtcaagtg cgacaagcg 
      aacgatgaa gatgacggt ggtacctat gttgttgaa 
      gctagcgta ccggccgaa aaaactacc cgccaagga 
      cggcaatca tccagcgac acctacaac atagaaatc 
      tccttccca gcagtaaac gaccctgtc atacattct 
      aacactaac gaacgctca accgtcaaa catttactc 
      gaaaaactg atcttggag gaagaccaa ttcgacgtt 
      cgcgacatt ctaccaaac acagtcccc gacccatca 
      tccctggtg ttggaatcc gactacgct tgtccagtg 
      ggacaagtc gtcatggcc ccagactgc gtccaatgt 
      gccatcggt tcttactac gataagaaa acaaagact 
      tgcattcct tgcccgcaa ggaacgtac caaagcgaa 
      gccggacaa ctgcaatgt atccaatgt ccagtcatt 
      gccggacgt gcaggagtc acagtggga ttaggagca 
      cgaagtgct tccgattgt aaagaacgt tgtcctgct 
      ggaaagtac tacgaccac gatgctggg ctttgccgc 
      agctgcggt catggtttc tatcaaccg gaagaaggt 
      tccttctcg tgccaaatc tgcgggctg ggcaaaacc 
      acccgcact agtgaagcg gtttcgcaa aaggaatgc 
      cgagacgag tgtgaaagt ggcatgcag ttggctttg 
      gatggtaaa tgtgaagcc tgccccaga ggtacttac 
      aggactcaa gggatacaa gcggcttgt caagggtgt 
      cctttggga aggaccaca cccaaatcg ggtgccatg 
      accattgaa gagtgttca ctgccggtt tgtactccc 
      gggacgtac ctgaacggt actttaaac agttgcatc 
      ccgtgcaag aaagggtac taccagtcc gagtcgcaa 
      caaacaact tgtattcgc tgtccggaa aatacaagc 
      acgaagagt accgcagcg accagcaaa gccgaatgc 
      attaaccct tgcaccatg agcgggtcg ggcatgcac 
      tgcgacgcc aatgcccat tgtttgtta aatccagaa 
      acgggagaa ttccgctgc gagtgcaac accgggttc 
      aatggtact ggccacgag tgtagcgac gtttgtgat 
      ggttattgc gacaacgac ggcgtctgt gtcaaggat 
      ataagaggt caaccgtcg tgtcgttgc attggcagc 
      ttcaccggt cgtcactgt accgaaaag tccgaattt 
      gcgtacatt gccaccggc attgctcta gctgtcgtt 
      atcataatt atcatcgtt ttgctaatt tggatgatc 
      tgtgcaagg tctcatcgc aggaaagaa ccaaagaaa 
      ctgctcacc cccgcgact gaccagaac ggatctcaa 
      gtcaatttc tactacgga gctccgacc ccatacgct 
      gaaagcata gccccgagc caccactcg acctacgct 
      cactattac gatgacgaa gaggacggc tgggaaatg 
      cccaacttt tacaacgag acgtacatg aaggaaagc 
      ctccacaat ggagtgaat gggaaaatg aatagttta 
      gctagatcg aacgccagt atttacggt acaaaagac 
      gacttatac gatagactt aaacggcat gcttaccca 
      ggcaagaaa gataaaagt gacagtgac agtgaaggt 
      caatag
    mRNA sequence
    • >TC000871 RA
      tagcgttca agtctccgg tgttgacgc aagtacagt 
      taagacaat ggtcaaaac tggcattgc tgtggactt 
      attaatcag ttttactta ttaaaatag aggtaaaat 
      caacaccgc actttgagg aggtagaca taacttctt 
      tctccccac ttcacttga tcgccaaga aagcacctg 
      agccgtcag ttctgttga ggtgccggg gaacggtaa 
      ggacagacg cgtgtggtg tgctgtgat attttgtta 
      agtaaacga gtgagtttc gaaaatttt tattttgag 
      agataagag tgaactata ttcatgata gtgaacaag 
      ggtttattt gagcgacgg tgaagactt ttagggaat 
      gctgattcg gataccggc gaccattac ggtcgccct 
      cttggccat ttttaggat aagtttagc acagaattc 
      atctagcaa cctatttag ttgtccgaa cggttggga 
      actccgagg actgcattg ttataagtt cttcaatat 
      tagacattc ttgggaaaa agcagcgga actttgcag 
      aaggtatgg cagcgactt gatgtcggt agaatccta 
      cggagaaaa taatttaac ggcaacgat cgcaactgc 
      ttcagtacc catagaacg acgaggggt caaccatta 
      ctggttggg tttggcatc tttagatga cctccgaac 
      taatacgtt agaatcagc agccggaac actagtttc 
      tcagtattc cggtttctg gtcgcaaca tcaacccga 
      tcccaaagc cggggaatg cgtcgatgt tgccgtcac 
      ggaagaaaa cgaatcgtg ggaactgac aacatgcga 
      gagtttgct ccctttcat gtgccgatc caaagcatg 
      tccctcggg atcctacca ctgttccaa cgggaactg 
      catcaacga aaagttcag atgcgacaa agaggacga 
      ttgcgaaga cggctctga cgaaatcga ctgtgcagc 
      taattgcaa tttttacct cgcaagtag tggtgacgt 
      tgttgaaag tccctacta cccacacaa atacgcacc 
      cttgactaa ctgcaaatg gaccctgga aggaccgca 
      aggacacaa tatcctcct ccagttcca agaatttga 
      gactgaaaa gaccttcga tactgtgca aattctagt 
      cgggggacg aactgaaga cacctctgt gaatctcgc 
      aacgttatc tggaaaaca agacttgac gaacagatc 
      gtttgtctc ggcttcgaa tttcatgat tattaagtt 
      tagcaccga tgcttcggt tgaacgaaa aggctttag 
      agcgtcttg gaaaactga accgcagac ttgtggcgg 
      taccttacg tgccactcc tcaggccca agttttgac 
      gtctcctgg atatccgga acaatatcc tggaggact 
      cgagtgtct ctacataat tcaggccca gaacgggcg 
      aattatcac actcgaaat cgacgattt ggatttgga 
      taacatcag ggattatat ccttgtccg tgatggtga 
      ctctcccaa aagtcaagc tattgcacg actgaccgg 
      cgatttgga aaacaacca aagagttgt gatttcaac 
      aaacagcaa actctactt atattttaa gaccagtct 
      gggtgattc gaaccgcgg ttttaggat cagatacac 
      ccaaggttg cagagcaac aatcgttgc gcgaaatgg 
      cactttaat gtcgcccgc ttacggtct gagtcagta 
      tccaagtaa ccaggactg tttgtacaa aatcaggaa 
      tccgggagg cgggccatt gtcgctgaa tttcgaaaa 
      ctttaatgt tgataaatc cgattttgt gcaagttta 
      cgatggggc cacgactag tgggctgcg gcttcactc 
      aggaaacgg atttacggc cgattcaaa acccaaaat 
      cacgcttac ggcatcaag tggtgaaat gttggtcag 
      atttacgac tgatgcttt acatagtag tgaaggctg 
      gcttgcgac tttctctgc cgattgtcc tcaattaca 
      accgggagc tggtgcaat ggcgtcaag tagagatac 
      ggctttcgg aaccatcat cacgtttaa ttgtccgac 
      tggtcaaga attcgcaac aggacgtaa tagattaac 
      cactcagtg cctgcctgg tggtaactg gtctgtgag 
      ttatatccc gaaatgtca ggaagttta ctgcggacc 
      ggttccgca aattgataa tggattttc aattggttc 
      taccaatgt aacctaccg ggggcaggc aatgtacca 
      gtgctatgc cgggtttgc gtttcctac cggacagcc 
      aattgagaa aatctcatg tttatcaga tggccgatg 
      ggagaaaaa acccaactg tcttgcatc tcaatgtgc 
      tgcgcttcc ggaagtacc gcacgctaa tgttacgat 
      attaaacgg ccaaggccg ttcgtacgg aaccatagt 
      gcgatacga gtgtgaacc tggatacat aagaacagg 
      accacctgt aatcctatg tatgagtaa tggcacctg 
      gtctggtga agtaccaac atgttcaag agctaaatg 
      tcccgagtt ccccgaaat caaaaacgg gtttttcac 
      tgacacttc ccgttctta tttctttaa tgacgaagc 
      ccgtgtcca gtgttacaa aggttacaa acttgtggg 
      caacaacat cctgagatg tggtgaaaa ccaaatttt 
      caacaaccc tccgaagtg tgaggatat caatgaatg 
      tatcagtag tcagtgtga cagtgcctc gactgaatg 
      tatcaactc gcccggttc gttccattg caaatgtcg 
      caaaggctt ctcgcctac gttagaatg ccgaccagt 
      tggcgatct cggtctcac taacggcgg aattccaga 
      tgaggcaat tacagtttc aagcagcga atctggata 
      cgataaaac gatggtgcg tcttaacag tggtgtagg 
      ttggtgtgg aaataccaa cgagccggg ttccaactg 
      ggtactcat cgacttgaa agccccaac tataatccg 
      aggatttag aacaacaag cgtaccacg tcctgacgg 
      cagtctcgc tttcacttc agccgttcg gatccaata 
      caccgatga cctcactga tgtgttcaa agattacag 
      aaatcccga tggtaccgc agttgaatt cagaatttt 
      ggaacctac tttatcgat attaaatct ccctgtacc 
      aattgaagc acaatacat caagttcaa ggttcaaga 
      ttacgttgt tgcgccatg cttgaaact cgaagttat 
      gggctgtac caggttgga atgtgctga tattaacga 
      atgtgcggt tgataacgg cgggtgcga ccaaaagtg 
      tattaacag tgccgggga cttttcgtg tagttgcaa 
      tgtcgggtt cgagcttta tgcgggaaa cggtaccgc 
      tgcgtacta tattgaaaa atccgaaaa cgggttaag 
      agatggtga tacgtacca agtaaacaa atcgtgtgt 
      tccggtgat gtgtccgag tttatcagc gcccgaaaa 
      cggagtcat cttatcaac gaaagaaaa gtaccactt 
      tggtgacct agtcaggtt ccagtgcaa cttcgggta 
      tgttttatc cggatcctc tgcactttt gtgtacttc 
      caccggaaa ctggaacgg tactatgcc cgaatgttc 
      atatgctaa atgcgtttc actacctga tgataaaaa 
      tgaaggcct aaaaatatt aagagctga cgaaagtag 
      cgttttagt accgtttag agagaacgt cactttgac 
      ttgcggtag taccggacg gaaattaag aggaactta 
      tacgtccgg tttcaggca atgcgtcta tgaccctaa 
      acccggttt ccccgatta ttggttgag cggtgctcc 
      cccatcgtg cccccgcgc cgactgtgg aatcccccc 
      acctactcc cggggccga atatggaaa atacgtcga 
      taccaaata ccaatcgtc ttttttctt cggttgtca 
      aaacacttt caaactagc tggtcaaag tagcaaaca 
      tgataatat cgtccgatg ccaagcaaa ttccgtatg 
      ggatttcgg tgatttacg ctgcgaggg tcccgtttg 
      tgaagaccc gggacgtcc aagtgatgg tcatcaaat 
      cgcccgcag ctacgagca aggctctga agtcagttt 
      cggttgcaa caggcctgg gtatatttt aattaatcc 
      cagaccgat aacttgcgt gcgagaccc ggagtgtaa 
      agtcgtgag acctcttgg acttgcctc ggggagaat 
      tccagattc cgctattaa cgcaactag tgaaagacc 
      gaattacga agcgaggaa tattaggtt gaattcggt 
      cacgggatg gtgcggaaa acaagaagc ttttactta 
      tgttagtgt cgatttggg aaaagtgta tcgcgttaa 
      agccattct agtaaaagg cgttgttac taatgatat 
      cgtcggacg gcccactga gatcagatt cttctacaa 
      acaagcgga aaatgagaa ttacgtagt ctatttccc 
      caattttaa tctcacgat gagagatcc cggaaacta 
      cggagaact agcaatgat ttcactccc taaatatgt 
      ccaagccag attcgttat tttaggaat tgtgagcta 
      tatggacaa tgcgtgtct gaaattcga actgatggg 
      ttgcgatga acccgacac ggaaccact cttgggtta 
      cgactatgg gtactctcc gtgcgttga taacgagac 
      acctgtttt ccaaaactg cccacaaca acctattgt 
      tgtacaaaa agatgccaa cggcggact tctcccaat 
      caatttcac agaaccaac cgcggttga taattccgg 
      aagtattgc ccggcttga agtcaaacc ggcaaactt 
      taaaacacc aatgtatgt tttccaaga caccgtagt 
      taaatacgt cgcgttcga ttacgacgg aaatgtggc 
      catttgtga aataaacat cacagttcc tgaccatac 
      tccaccgaa attgagctg tcctcaaag ctatgttat 
      cgaattagt cgacaggca agacagtta cgttgttaa 
      tttcaacga aactcgccg taggatcaa caccactga 
      tgattctgg tgaagtctt tgttacttt catccccga 
      taaagctac tatagctat tggcacctt tgaaaatgt 
      aacagttgt tgcggcaga caaatacgg gaatagagc 
      tacttgcca cttccaagt ctcggtaca agcaactcc 
      ttgtgttga ttgggaact taagccgcc agttaatgg 
      agctttaaa ttgtttacc cggggataa agggttaca 
      atgtattgc tacatgtaa tcctggcta cagatttac 
      tgacggtga tccggtaaa aactttctc gtgtgatgc 
      taaaacacc atggactcc gacatcggt agtaccaga 
      ctgtgtgtc agaaaatac tcaacaggc agattatca 
      cgttactgc tacagtcaa ctatcgggc aaatggggc 
      cgttgccac agcttgtct caatcaata ttccgagct 
      gatttctca gtactacac aaatcttaa caatatttt 
      atcagaaag atgttcggc tgttaacgt aaaaatggc 
      tgtctcgtt cttgaaagc tgtaccttc gttaattaa 
      agaaaacgt ggtgaaaat tgattacat tttgaatat 
      tataccggt cgtacggca accccaatt gtacgacct 
      ttgtggcag tactttgag cttaatgtt tgacctgtc 
      ggtaccata cgcaaatgc tgtcattga accgttact 
      aaatgtgtc tgcaattgg taaccaatg cccgccact 
      caaagcttt gaattcgac aaacatcag aggattcac 
      ttgtagtgt aggtgaagt acttaacat ggacactaa 
      tgacgttcc gagatgcct acactgtcc tgctggaac 
      ttacgcagg agagaaaca aaaagagtg cacatactg 
      cccacgcgg gtactacca aaatcggga ccgtcaagg 
      ttcttgtaa ccgttgtcc tcaaggtac ctacactcg 
      cgaagaggg ttcaaagag cgttcacga ttgtatccc 
      cgtctgtgg ttacggtac ttactcccc cacgggcct 
      agtaccatg tctagagtg cccccgtaa cagtttcac 
      aagtgaacc cccaaccgg aggcttcaa agactgcca 
      agcttgtcc cgctaatac ctttacgta ccaacctgc 
      agcccccgg caaagaccg ctgcaggcc caagtgcag 
      cccagggta ctactcccc aaccggtct agctccgtg 
      ttccgcctg cccacgcga tttctatca atccttacc 
      cggacaaac gtcatgcaa tgaatgtcc aacaaatat 
      gaaaactga aggacctgc agcgaccgg tcgcgatga 
      atgccatcc ggtgcaatg cacggaaaa cgcctgcca 
      acacggcgg cctttgcgt acctctggg tcacaacat 
      ccagtgtat ttgcccggc tggattttc cggaaggcg 
      ttgtgaaat tgacattga cgaatgctc ctcacaacc 
      gtgctataa cggtggtac ttgcgtcga tttgccgca 
      gggctacag gtgtcaatg cgcccccgg ctatgctgg 
      gattaattg ccaggaaga aaggtcaga ctgcaggaa 
      tgacacttg cccagaacg agcaatgtg taaagacga 
      accaggcta taacaacta cacttgtct ttgccgctc 
      tggttacac tggagttga ttgtgacat tacgattga 
      cccttgcag tgcctcagg aaacccctg taataacgg 
      tgcaacttg cattgcttt gcaacaagg cagattcat 
      gtgtgaatg cctgcctgg ttgggacgg ccaaacttg 
      cgacatcaa catagacga ctgtgccga aaagccatg 
      tctactagg cgccaactg cactgattt agttgccga 
      ctttagctg tagttgtcc tccagggtt cacgggaaa 
      acgatgcca agagaaaat cgatctgtg cggccgcaa 
      tccttgcaa aaatggcat ttgtgttga taaactgtt 
      ctaccatga gtgcgtctg ttacccagg ttgggccgg 
      cgaatcttg cgaatcaaa catcaatga ttgtgccca 
      aaatccttg cgagaatgg aggacattg tatcgacga 
      aatcaatga cttcacctg cacgtgcga acccggatt 
      taccgggaa aaaatgcca acacaccat cgatttttg 
      ctcgtcgaa accatgcca aaacggtgc cagttgcac 
      cgatttagt cgacggttt ttcgtgcaa atgtcgtcc 
      gggtttcgt cggtttgca gtgtgaggc cgagattga 
      tgaatgttt gagcgatcc ttgcaatcc catcggtac 
      ggaacgatg cgtcgattt ggacaataa attcgtgtg 
      catgtgtcg cgagggcta ctctggcac gtactgcga 
      agaaaatat tgacgactg ccgatctga tccttgtct 
      aaatggagg atcatgtcg ggatgatgt agggtcgta 
      taaatgtat ctgccagcc agggtggac gggtaccaa 
      ttgcgaaac agacattgg aagttgtta ctccaaacc 
      gtgccaaaa cgatgccaa atgtatcaa tctcttcca 
      agactattt ctgcgtgtg tccctcggg aactgacgg 
      caaacagtg tgaaacagc ccctgagcg atgtatcgg 
      aaacccttg catgcatgg aggcaaatg ccaagattt 
      tggatcggg acttaactg ttcttgctc cgatggatt 
      caccggcat agggtgtca gtacgagta cgatgcttg 
      tcaagcaaa tgcgtgcaa aaatggagc aacttgcac 
      caacgatcc gttcggatt caaatgtgt ttgtgctcc 
      aggatttac cgggaaata ctgcgagga ggatatcat 
      tgattgtaa agagaattc gtgtcctcc gagcgccac 
      ttgtatcga tcttacaga ccggtttta ctgtcaatg 
      tccattcaa tctaactgg cgaagactg ccgcaaaac 
      aatttccgt ggattatga cttgtactt tagcgacgc 
      gacacgaag ctcagcctc tcaagccgt tccgttcta 
      caccggttc taaatcaag tctgacaat tgcaatgtg 
      gattcagtt cactcaaaa agacgagaa tgggatttt 
      cttcacgtt gtatagtgt gtcatctaa acacattcc 
      taaagacag gaaaccgtt aatccaagc tcattcaaa 
      cggtgttca agtgtcact cttccccga catccaaga 
      cgtttatct cagttatcg agactacac caccataaa 
      tgatgccca atggcacca tatcgcgat tgtatggga 
      tggtgaaaa cggtggaga actcaaatt aatcaccga 
      gggtttgat tgccagcaa agtggaggg ttacggaag 
      cggacgcaa attacccga atatgcttg ggttacgtt 
      aggtaaacc ccaatccgg taaccccaa agcttacac 
      cgaatccgg cttccaagg ccatttgac caaagtgca 
      aatctgggg acgcgcttt agacgttac taacgaagt 
      ccaaaaaca agtcaggga ttgtcggac cgaacccgt 
      cctctatag aggcctaat cctgacttg ggctggcta 
      cgaagaaac agtcggagg tgtcgaacg aatagtacc 
      ctctcactg tggccatag agtttgtcc tccgggtta 
      tatcggtgc taaatgcca ggaactcca agtcgataa 
      aattgcccc gaaggttga atactgccc tggtgattt 
      atggatcat cacaaagaa tggatcagc actggtttc 
      gtgggacga acctcactt tagtgacaa tgtgggcgt 
      tgcaaaaat tttagaaaa gaatggcca caggccggg 
      ccaaaccct gctgtgggg tatctacca aatttcgta 
      cgtggcgtt ggacgaagc cggaaattc ggccacttg 
      caacttcaa agtgtctgt cttatctga attttgccc 
      ggaattgcc tgatccgat cgggggagt ccaagtctg 
      taaagactg gggtgccgg tggtcagtt caaagtatg 
      cgaaattgc gtgcaatca aggattgag attctcgca 
      agaaatccc caagttcta cacttgcgg agctgaggg 
      cttctggcg gccaacaac caacccgaa tcttcccat 
      ggtataccc tgcttgttc tgcgacaaa accggccca 
      acgcgtctt caaaatttc gatgttgtt cccaagctc 
      ggtgctttg caacgaagc cgggcaagg agtactcag 
      acagagggt ccgaaacgc cgtcaacag tttgaaccg 
      agactggaa tttctgttc attctcggt tgaaggcac 
      acgagagtg taaggagtt gaatattga tgtgaaatg 
      tgaccatag gactagtcg tcaagtgcg acaagcgaa 
      cgatgaaga tgacggtgg tacctatgt tgttgaagc 
      tagcgtacc ggccgaaaa aactacccg ccaaggacg 
      gcaatcatc cagcgacac ctacaacat agaaatctc 
      cttcccagc agtaaacga ccctgtcat acattctaa 
      cactaacga acgctcaac cgtcaaaca tttactcga 
      aaaactgat cttggagga agaccaatt cgacgttcg 
      cgacattct accaaacac agtccccga cccatcatc 
      cctggtgtt ggaatccga ctacgcttg tccagtggg 
      acaagtcgt catggcccc agactgcgt ccaatgtgc 
      catcggttc ttactacga taagaaaac aaagacttg 
      cattccttg cccgcaagg aacgtacca aagcgaagc 
      cggacaact gcaatgtat ccaatgtcc agtcattgc 
      cggacgtgc aggagtcac agtgggatt aggagcacg 
      aagtgcttc cgattgtaa agaacgttg tcctgctgg 
      aaagtacta cgaccacga tgctgggct ttgccgcag 
      ctgcggtca tggtttcta tcaaccgga agaaggttc 
      cttctcgtg ccaaatctg cgggctggg caaaaccac 
      ccgcactag tgaagcggt ttcgcaaaa ggaatgccg 
      agacgagtg tgaaagtgg catgcagtt ggctttgga 
      tggtaaatg tgaagcctg ccccagagg tacttacag 
      gactcaagg gatacaagc ggcttgtca agggtgtcc 
      tttgggaag gaccacacc caaatcggg tgccatgac 
      cattgaaga gtgttcact gccggtttg tactcccgg 
      gacgtacct gaacggtac tttaaacag ttgcatccc 
      gtgcaagaa agggtacta ccagtccga gtcgcaaca 
      aacaacttg tattcgctg tccggaaaa tacaagcac 
      gaagagtac cgcagcgac cagcaaagc cgaatgcat 
      taacccttg caccatgag cgggtcggg catgcactg 
      cgacgccaa tgcccattg tttgttaaa tccagaaac 
      gggagaatt ccgctgcga gtgcaacac cgggttcaa 
      tggtactgg ccacgagtg tagcgacgt ttgtgatgg 
      ttattgcga caacgacgg cgtctgtgt caaggatat 
      aagaggtca accgtcgtg tcgttgcat tggcagctt 
      caccggtcg tcactgtac cgaaaagtc cgaatttgc 
      gtacattgc caccggcat tgctctagc tgtcgttat 
      cataattat catcgtttt gctaatttg gatgatctg 
      tgcaaggtc tcatcgcag gaaagaacc aaagaaact 
      gctcacccc cgcgactga ccagaacgg atctcaagt 
      caatttcta ctacggagc tccgacccc atacgctga 
      aagcatagc cccgagcca ccactcgac ctacgctca 
      ctattacga tgacgaaga ggacggctg ggaaatgcc 
      caactttta caacgagac gtacatgaa ggaaagcct 
      ccacaatgg agtgaatgg gaaaatgaa tagtttagc 
      tagatcgaa cgccagtat ttacggtac aaaagacga 
      cttatacga tagacttaa acggcatgc ttacccagg 
      caagaaaga taaaagtga cagtgacag tgaaggtca 
      atagttaaa tctggtcag caatttatt aaatgctca 
      agtagcaca acaaatttc tagtgaaca attttttct 
      tgttaatat gtttattat aagtactac catagttgt 
      taaattata ttaatgtaa aatattaac aatatgttc 
      agttatgtt gtgtgatgt aattttaca tatttgtaa 
      ttctcgtac cttcatccg cttattatt tatagtcac 
      gaaactgtc tttttactt ttttataca aatcgaaat 
      attaattat tattgtagt tattgtaat taagtagac 
      ttctgctga tgtaattat ttttaatta ttgtgttta 
      agagtgcgt cggaatgaa tgtgaaagt tttgtacac 
      atattatac tttataaga atgactgaa taaaatatt 
      acataaaaa
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