Status
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Gene information
General information
TC016161 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007417.3: 136101..165704
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC016161
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
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    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_05965

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 embryo/egg not developed/not fertilized - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    embryo/egg with muscle fluorescence/pattern, but not hatched (pot. late embryonic lethality) - Penetrance (percentage of animals/eggs on slide): less than 30%

    larval musculature pattern irregular - Penetrance (percentage of animals/eggs on slide): less than 30%

    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    remarks: muscle pattern potentially obscured by segmentation defect,
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    embryo/egg without visible larval cuticle in cuticle preparation - Penetrance (percentage of animals/eggs on slide): more than 80%
    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: % (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: % (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC016161 RA
      MDLSPRDFL KLLYKYLDE EAEDVASKQ CNQLLTNFS 
      DALTHEQIN STYLDQSLH YFFSTSSGL HTFVKKIIN 
      KKPFKTSVV KFFEIIYAL INNFPFKLK KYVSVIFET 
      CFKVIKSLL VSSDEKVKS LEVVIVILE KEIFLDNSE 
      IYLEVYNNL LKSISITKT DSVEEKTFI ALGTFAKHF 
      QYLVPNNES LRIVFLNGL ETQMIKLSL SNKQLSGLF 
      TGLDRFCAS FPFDMNSKE DVFVVNKVY KYIETLAIP 
      SGTVKIANK AALTFLANN ISLFINLMV DKHKYWHDT 
      LLKWLESGT EDQKIGILV LEAFYLGLG TFLLNDGSC 
      HYKHVTEYF KEYFIANMT QSKVFNYDK RLCLQGLSS 
      FSGVYQLQL EQEEIKKLF AQIIQNFEQ TYILNLDPS 
      TDVLEFLPF YLQTVANFL QFKTVTNNE LFCLQKGTI 
      LLMKIFPQL PYYCHPLVT EALVLTFYY LSLNSEHIF 
      NTFLENVIF QGVVWTCSH QHITEAELL ETSSQKVVT 
      IKDYLNMWK SLLKIVPVR RFDKFRIFL QERKYILVK 
      VIDKLMRTL LILINKLNV SVTLNDNSE AVTDIQSAY 
      KLNAVNDFA IFLNLVDLY EKIFEYIDS NLLKKCVYK 
      LIHYLIAKC EKHQLISGF YKLLSFCLK ICKDINYFN 
      SSCEDATMC YLTLRKFLT SLLNKTQQF TGDLLIACL 
      QVLLQYPIV IIKDMLSTC TPSFRTIFH VGRTSTKLT 
      YLTLETLEC WQNEIDPDE FEPFLKQIL PLFDSYLQS 
      KSLESMSSG INDNRRKSS QALKKRKVL LDTEPELLR 
      LKTKMIKFV GQQNSLLCE ALAVSEDNA DLTVWANEQ 
      HLKIDLPYE DVKLQVYLD KLLPRIVNV ALNSSDRKT 
      RITACELLQ ATVMIFLGT TKQMSGSGI SDLDELLKH 
      VSVSLLRLG CDMDQVVEQ LFRPLCFQL IHWYTHPFQ 
      SRSGHEAIV IEAILESMT HPTDTALRD FAGKCISEF 
      VKWTIKQSN EKNLSKDPI NIKILVKKM RFYSMHPDS 
      NKKLGAALI FNSIYRDIR EELSLLSMF WIEILHIFV 
      KSFSSLEND GIDENLVTQ INNALSRLE RGFVEKSDL 
      FNNLDTQRR IPNEFNGGK LADVAVWLL KQTGVKNDH 
      CRTKCMEIF CSISSKCKG YTNMQNFIN SHFDGSWMR 
      DIYETYLIQ HPTLQCPMK NEDFTPIKW MQGLLCALD 
      GFIFIIKNK LSSTLSETC TTSIRYFLE NVSTITLDE 
      AFAIIEPKM WMFTTFEKL HFDKQRSQA VIKILQLFT 
      ICETITAFY TSHLWNLLV NFVFNRQSL GFECFQPQD 
      DDNESVLKG FLNSLPQSQ VLQVGNVLS KYVTDNFND 
      EFDLKDHVK LKQRHIVRG IYILQTLSL KQFTVGRVA 
      PLLNKFLQF AEDKIIFLD DLQDTTLSY CITVLNYSL 
      EDQNEFKVF VDYLYKDYK VQTTNCKQP ISFGTYLFT 
      IFEDTIIRK VVTNFDVFF TYCLEYKDK IDKTVEFIF 
      YILRCIGLN KHFKTQHGI VNIVLTNWD IFEEFFNES 
      LSNIQLGYK LLKLFNPTI KSSRLQCDN LKKWLLWVL 
      TYETNVMWR EEFELKIET IDLLSDILD NLDENTDLR 
      RSLDCFKAK LISETSPIP AEERPFILD KLLSLIPKI 
      RCFELLVFI LEIYAKMST GNSISDVKH YMTENIMNN 
      QQEHKLLLV KLYDLCLLE DLDNFQKYK LIIDTSSVF 
      QYCNVTSFE DFFTETIST VLTVLKEPV TTENLSNKI 
      LHFLLVGVL FLRCPLQSD DSEISRITQ AALPQKPNN 
      KTLLLQLLK FTLNAIKDT IDCVVEYEE LFRLYKCHS 
      YNAMISIVC NSMKDANFY TKLFVRQED NKDILWSSL 
      IDTKKTYVF QADFDNIPK QTKILLNIR DEMRLRKRN 
      ENKQTQSVR YIETQRVFN SSLAEDVTK FDFTSSILR 
      TQSDDDAES NELFVQSEI ELDCTDIST HECMANVCG 
      VIEHMFRAG ISEFPDEEE QYELPAWLQ AIRTLLLDE 
      NTAVNVKIF WVKVIDNTI HIFKHFSKY FTEPLLKFI 
      VDRSAGEVM NYFVADVVA VLATWCTEV TLETQTEIQ 
      LASKLVAFL INNLKNDRQ DIFKYHLQL IRLLVEAWK 
      TSIEVPYDL IYAKLKVEP TCKAVEIGI HVSSIFLAN 
      KLLPWKGDS KDFCKSIFN VILKAKYKT IYRPCAETL 
      GLILRETSH DLPKLCGNV HILLKKINE PDKYAHILE 
      GLVLHYPPI VNEGYLNSL LSRIHGVPK PLKIIYLRI 
      LLSRCDDLH KLSDFKTER WETYIENDH LEVQLLALE 
      IVHKSLNVL RFAPTFPEI VQSVCKNVS NTNVLCRTK 
      VFDVVMAIC ETGILPEVK PVLVQGLCD EDTEIRERV 
      YNFWRNNSS VPHPVADRF LYLLKNFYE ESTENDFLG 
      NCCYFLLER LKFADDYSK LLFEHPLED CNFEDYYLE 
      TNWRARYLS VVPLFAETV RSFSMSLQT FDSKLRQTQ 
      TSLEFAPTQ VVRSKQFSQ YTMSESSLF IKPEEEKSF 
      VDPNSINLS YKYRIPKRR FLKDKAKVH SYFAQQQVK 
      KSSEKIEKR KEFAKEREN KVTIYRSYR KGDLPDVQI 
      TLQAVLEPL QILALRDRE ISKILYEKF LKSILEKRK 
      SDANFIQEI SVGIQTIFN NSSEFSRNL FRALFDALI 
      FSKSSIVFP PELIVSVSQ SSGLRGLGA LLLEEYLIS 
      CDVTEVEAK KSRGNQLSQ DTNLWIKLA ELYKEMEEW 
      DVVKSIFLE KTQCPQEVK NALLAESQK QWKDARDLY 
      QSLIETDDV IERKDFYYD SYFKCFAHL GAWNDLINS 
      VDSIVSQNP TETWNNLWD QGFNQEKLL PWYISGHLK 
      DILFTDSST QHFLSSLNS SLESSHLAH LETHYLEEI 
      TMLWIFKND IQEAEHYLK IYINNFLED WQQLDSFYA 
      NLRYMKLLK LRNMIDIDK FLDVLNNIS IENVVEIDG 
      LVKYWNRAA FENLPSILL KEDRVLYRK QFLRTLVRK 
      IESFDNDDF ANTLTQLND MSLKLDEDI LEAAIGENN 
      FYMTKKYLN LSNNRNAFK TQLILSKLA YIKSLMLNN 
      SEQKLNVIL QGIKTLVPI FEETESFLQ LSAHVTFFK 
      HLDYISSLL SQNEDLLQN RQSDLMTLT EVTQSVSSK 
      DVAFFAANK LKSFLHNYN TSDVCTDAY IQYADAYVQ 
      LAYFAKNQG KKYFKDFML FVLRAMKFN SKEGKQLFP 
      CVLMEQEFS LEEQQLFLT ETEQIPVWM FLKWIPQIL 
      VNIDSSKVT VIKPLVLKI ATTYPQAIM YAYRLSKEN 
      YKCEQREAK ELIETLDEL LLTDEGANK FLKALSFIG 
      IPAAILIYY VRKIVKLIA SSELGQAKI VHDFVLKEM 
      FIKADSRDS DLLQGNMFK SITKYEKDL KNIGRLLTK 
      PSETPNVLK QLQKINTNL GNTLQDRRE NQRNSRLLK 
      EYCPWLANF SASKNNLEL EIPGQYDGE RIPLVQHHV 
      KISGFCPNV SIMSSLRKP IKITILGND TKEYPFLVK 
      FGEDVRQDQ RIQQLFSLM NNIFQHDRN LNGRKFHIL 
      TYQVIPLTT SLGIIQWIG NTKSLHEFS NNENFDKVV 
      ETFTKWIYT SANQSPFDA YGRAAMKYS RDKTIVKFK 
      TLVSKISWD VFRSTFLKL SSNTEGFFA LRNNFIKSY 
      AIMCASHWI VGVGDRHLS NSLVCLNSG KVLGIDFGH 
      AFGTATQIL PVPELVPFR LTPHIVNLM EPLGATGLF 
      REIMVHCLR SLRSNSASL LSTMNVFIE EPSLDWLEH 
      ASRFSTGVD TSNCDWYPA QKIEQARKK LAGANSVNI 
      MIEDLLAGH QKNQAYMKA YIALVEGNS DFNVRARLA 
      GNGLSEEDQ AICLIDHAT DYNLLGRMF EGWAAWV
    CDS sequence
    • >TC016161 RA
      atggattta agtccgcgc gattttcta aaattactg 
      tacaaatac ttggatgaa gaagcagaa gatgtagca 
      agtaaacag tgtaatcaa ttattaacc aactttagt 
      gatgccctt acacatgaa caaataaac tcgacttat 
      cttgatcaa agtctgcat tatttcttc agtacatca 
      tctgggctt cacactttt gtgaagaaa attatcaac 
      aagaaacca ttcaagaca tctgttgta aaatttttt 
      gaaattatt tatgctttg atcaataat tttcccttc 
      aaacttaaa aaatatgtt tctgtaatt tttgaaaca 
      tgcttcaaa gtgattaaa tcattactg gtaagttcc 
      gatgaaaaa gttaaatca ctggaagtc gtcattgtc 
      atacttgaa aaagaaata tttcttgac aattctgaa 
      atttattta gaagtttac aataaccta ttgaaaagt 
      atttctata acaaaaact gattcagtc gaagagaag 
      acatttata gcattggga accttcgct aaacatttc 
      cagtatttg gtgccaaat aatgaaagt ctgagaatt 
      gtctttctt aatggattg gagacacaa atgattaaa 
      ctaagttta tcaaacaaa cagttgtct ggacttttt 
      actggactt gaccgtttc tgtgcaagc tttcctttt 
      gatatgaac tctaaggaa gatgtgttt gttgttaat 
      aaagtatat aagtatatt gaaacacta gcaattcct 
      tctggaact gttaaaatc gcaaataaa gctgcctta 
      actttcctg gctaataat atttcattg tttataaac 
      ttaatggtg gataaacac aagtattgg catgatact 
      ttactcaag tggttagaa tccggtacc gaagaccaa 
      aaaatagga attttggtc cttgaagct ttctactta 
      ggtcttgga actttctta ttaaatgat ggatcttgc 
      cactacaaa catgttacc gagtacttt aaggaatat 
      tttattgca aacatgacc cagagtaaa gtgtttaat 
      tacgataaa aggttatgt ttacaaggt ctttcttca 
      ttttctggg gtgtatcag ttacagcta gagcaagag 
      gaaataaaa aagttgttt gcgcaaata atccaaaat 
      tttgaacag acttacata ctcaacctc gatccttcg 
      actgatgta ttggaattt ctgccgttt tatctacaa 
      actgttgca aattttctc cagtttaaa acagttacc 
      aacaatgaa ctcttttgc cttcagaaa ggaactatt 
      cttcttatg aaaatattt ccacaatta ccatactat 
      tgtcacccg ctggttaca gaagcttta gtattgacg 
      ttttattat ctatcactg aacagcgaa cacatattc 
      aacactttc ctcgaaaat gtaatattc caaggagta 
      gtatggacg tgttctcat caacatatt acggaagct 
      gaattatta gaaacaagc tcacaaaaa gttgttacg 
      ataaaagat tatttgaac atgtggaag tctttactt 
      aaaatcgtc ccagttcgt cgatttgac aagtttagg 
      atttttttg caagaacgc aaatacatt ttagtcaag 
      gtaattgat aagttgatg agaactttg ttgatatta 
      atcaataaa ttaaacgtg tccgtaaca ctgaatgac 
      aatagtgaa gctgttaca gacatacag tctgcgtat 
      aaactgaat gcagttaac gattttgca atttttctc 
      aatctggtc gacctttac gagaagatt ttcgaatat 
      attgactcc aatttatta aagaaatgt gtctacaaa 
      ttgatacat tatctaata gcaaaatgc gaaaagcac 
      caattaatc agtggtttc tacaaacta ctatcattt 
      tgcttgaaa atctgtaaa gatatcaat tatttcaac 
      agttcgtgt gaggacgct acaatgtgt tatttaaca 
      ctgagaaag tttctcacg agtttgttg aacaaaacg 
      caacaattc accggcgat ttgctaatc gcttgtctt 
      caagttctg ttacaatac ccaattgtt ataattaaa 
      gatatgtta tcgacttgt actccgtca tttcgtacc 
      atttttcac gttggtcgt acttccaca aaattaaca 
      tatttgaca ttagaaact ctagagtgt tggcaaaac 
      gagattgat cctgatgag ttcgaaccg tttttaaaa 
      cagattctt ccgctgttt gactcctac ctgcaaagt 
      aaatctttg gaaagcatg agttctggt attaacgac 
      aacagaagg aagagctct caggcgttg aagaagcgc 
      aaagtgttg cttgatact gaaccggaa cttctccgg 
      cttaaaaca aaaatgatc aagtttgtt ggacaacaa 
      aatagtttg ttgtgcgaa gctttggca gtttcagaa 
      gataatgcg gatttgacg gtttgggca aatgaacaa 
      catctaaaa attgattta ccctacgaa gatgttaag 
      ctacaagtt tatttggat aaattacta ccaaggatt 
      gtaaatgtt gccttgaat agttccgat cggaagacc 
      agaataaca gcgtgtgaa ttactgcaa gctactgtt 
      atgattttt cttggcaca actaaacaa atgtcgggt 
      tctggaata tccgatttg gatgaattg ttgaaacat 
      gtctcagtt tccttgctt cgattagga tgtgacatg 
      gatcaagtt gttgaacaa ctctttaga ccactgtgt 
      ttccaatta attcattgg tatacacat cctttccaa 
      tcacgtagt ggacacgaa gccatagtc atcgaagct 
      attttggaa agtatgacg catccaacc gacacggca 
      ttacgtgat tttgccggt aaatgcata agtgaattc 
      gtcaaatgg acgattaaa caatcaaat gaaaaaaat 
      ttgtcgaaa gatccaatc aacataaaa attttagtc 
      aaaaaaatg cgattctac agcatgcat cctgattcc 
      aacaaaaaa ttaggtgcc gctctgatt tttaatagc 
      atatacaga gatattcga gaagaattg tcgcttttg 
      agtatgttt tggatagag attcttcac atttttgtg 
      aaaagtttc tcaagtttg gaaaatgac ggaattgat 
      gagaacttg gtcacacaa attaataat gccttgagt 
      cgacttgaa agaggtttt gtggaaaaa tcagatttg 
      tttaataat cttgatacg caacgaaga attccaaat 
      gagttcaat ggcggaaag ttagccgat gttgccgtg 
      tggttgttg aaacagacg ggtgtaaaa aatgatcat 
      tgtagaaca aagtgtatg gagatcttt tgttcgatt 
      tcatccaaa tgtaaaggt tatacaaat atgcaaaat 
      ttcataaac tcacatttt gatggcagt tggatgcga 
      gatatctac gaaacttat ttaattcag catccaact 
      ttacaatgt ccaatgaag aacgaggat tttactccg 
      attaagtgg atgcaagga ttgttatgt gctttggat 
      ggttttatt tttatcatc aaaaataag ttatcatca 
      actttaagc gaaacttgc actacatct attcgttac 
      tttctcgaa aacgtatca acgattact ttagatgag 
      gcttttgct ataattgag ccaaaaatg tggatgttt 
      acaacattc gaaaaacta cattttgat aaacaacgt 
      tctcaagcc gtcatcaaa attttacaa ctttttacg 
      atatgcgag actataact gcattttat acttctcac 
      ctttggaat ttgttggtt aactttgta tttaatcgt 
      caaagtttg ggttttgag tgttttcaa ccgcaagac 
      gatgataat gaaagtgtt ttgaaagga tttttaaat 
      agtttgcct caaagccaa gttcttcaa gttggaaat 
      gttctatca aagtatgta acggacaat tttaatgat 
      gaatttgat ttgaaagat cacgttaag ttgaaacaa 
      agacacatt gtgagagga atttacatt ttgcaaaca 
      ctttccttg aaacagttt actgttgga agggttgca 
      ccattgttg aataaattt ctccaattt gctgaagat 
      aaaatcatc ttcttagac gacctccaa gacactact 
      ctttcttac tgtattacc gttttaaat tattccctt 
      gaagatcaa aatgagttt aaggttttc gttgattat 
      ttatacaag gattacaaa gttcagact acaaactgc 
      aagcaaccg attagtttt ggtacttac ctatttacc 
      atattcgaa gataccatc atccgtaaa gttgttaca 
      aattttgat gtttttttc acgtactgt ctggaatat 
      aaggacaaa atcgacaaa actgtggaa tttattttc 
      tacatttta agatgcatt ggtcttaat aaacatttt 
      aaaactcaa catggtatt gttaatatc gtattaaca 
      aactgggat atttttgaa gaatttttt aacgaaagc 
      ctttccaac attcagttg gggtataag ttactgaaa 
      ctttttaac ccaaccatc aaatcgagc aggcttcaa 
      tgcgacaat ttgaagaaa tggttactg tgggtatta 
      acctacgaa acaaatgtg atgtggaga gaagaattt 
      gaattgaag attgagacc attgattta ttgagtgac 
      attttggac aaccttgat gaaaataca gatctaaga 
      cgctctctg gattgtttt aaagccaaa ttaatctcc 
      gagacgtca ccaattcct gcagaagag aggccattt 
      atcttggat aaactcctc tctctaatc ccaaaaatt 
      aggtgtttt gagcttctg gttttcatt ctggagatt 
      tatgctaaa atgtccact ggaaacagt atctcggac 
      gtaaagcat tatatgact gaaaatatc atgaataat 
      cagcaagaa cataaatta ttactagtc aaattatat 
      gatttatgt ctacttgaa gaccttgat aatttccaa 
      aagtataaa ttgattatc gatacgagt tcagtcttt 
      cagtactgt aacgttaca tcatttgaa gattttttt 
      acggaaact atttcaaca gtactaacg gttctaaaa 
      gaacccgtc accaccgaa aatttatct aacaagatt 
      ctacatttc ttattggtg ggtgtatta tttttgaga 
      tgtccgcta caaagtgat gatagtgag atcagtcga 
      ataacacaa gcggctcta cctcaaaaa ccaaacaat 
      aagactttg ttgcttcaa ctgttgaag tttacattg 
      aatgctatt aaagacaca attgattgt gtggtagag 
      tacgaggaa ttgtttcgc ttgtataag tgtcattcg 
      tacaatgcg atgatttca atcgtatgc aattcaatg 
      aaagatgcc aatttctac acaaagtta tttgtacgc 
      caggaagac aataaagac atattgtgg agtagctta 
      attgatacg aagaaaact tacgtattt caggccgat 
      tttgataat attcccaaa cagacaaag atcttgcta 
      aatatacga gacgagatg aggcttcgt aaaagaaac 
      gaaaacaag caaactcag tctgtgaga tatatcgag 
      acgcagcga gttttcaac agttcgttg gctgaagac 
      gtgacaaaa ttcgatttc acaagcagt attttgcga 
      acacagtca gatgacgat gcggaaagt aacgaatta 
      tttgtacag agtgaaatc gaactggat tgtaccgat 
      atttcaact cacgaatgt atggccaac gtttgcggt 
      gtgattgaa catatgttt agagctggc attagcgaa 
      tttccagat gaagaggaa caatacgaa ttgccagct 
      tggttacaa gcaattaga acattacta ctcgatgag 
      aacaccgca gttaatgtt aaaatattt tgggtgaaa 
      gttatcgac aataccatt cacattttc aaacacttt 
      tccaaatat ttcacggaa ccacttctc aagtttatc 
      gttgatcga agcgctgga gaggttatg aattatttc 
      gttgccgat gtggtcgca gttttggca acatggtgt 
      accgaagtc actctcgaa acacaaacg gagatccaa 
      cttgcatca aaacttgtc gcatttctg atcaataat 
      cttaaaaac gaccgacaa gatatattc aagtatcac 
      ctccagtta attcggctc ttggttgag gcatggaaa 
      acgtcaatt gaagtccct tacgatcta atttatgcg 
      aaattgaaa gttgaacca acttgcaaa gctgtggaa 
      attggaata catgtctcg tcaatattt ttggcaaac 
      aaacttctg ccatggaaa ggcgacagc aaagacttt 
      tgtaaaagt atctttaac gtaattctt aaagccaag 
      tacaaaact atttatagg ccttgtgct gaaacactt 
      ggacttatc ctacgtgaa accagtcat gatttacca 
      aaactgtgt gggaatgtt cacattttg ttgaaaaaa 
      attaatgag cctgataag tacgcccat atcttagaa 
      gggcttgtt ttacattac ccgccaata gtcaacgag 
      ggttacttg aacagtctc ttaagccga attcatgga 
      gtccctaag ccgttaaag ataatttat ttacgaatt 
      ttactaagt cgttgcgac gatttgcac aaacttagt 
      gatttcaaa acagaaagg tgggagact tatattgaa 
      aatgaccat ctcgaagtg caacttctc gcgcttgaa 
      attgtccat aagagtctg aatgtctta cgttttgct 
      ccaacattt ccagagatt gttcaatca gtttgtaaa 
      aatgtgtca aacacgaac gttttatgc agaactaaa 
      gtgtttgac gttgtgatg gcaatttgc gagacggga 
      attttaccc gaagtaaaa cctgttcta gttcaagga 
      ctttgtgac gaagataca gaaattcga gaaagagta 
      tataatttc tggcggaac aattcgtca gtacctcat 
      ccagtcgct gatcgattt ttatattta ctgaaaaac 
      ttttatgag gaaagcacc gaaaatgat tttcttgga 
      aattgttgt tacttctta ttggagcgt ttgaaattt 
      gcggacgat tatagcaaa ttgcttttt gaacatcct 
      ttggaagac tgtaacttt gaagactat tacttggaa 
      acaaattgg cgtgcccgc tatttatct gttgtaccc 
      ttgtttgcc gaaactgtg agaagtttc agtatgagt 
      ctgcaaact tttgactcg aaactgaga caaacacaa 
      acttcgctt gaatttgca cccacacaa gttgtgagg 
      tctaaacaa ttttcacaa tatacgatg agtgaaagt 
      agtttattt attaaaccc gaagaggag aaaagtttc 
      gttgatcca aactcaatc aatttgtcg tacaaatat 
      cgcatcccc aagcgacgc ttccttaaa gataaagct 
      aaagttcac agttatttc gcccaacag caagtgaag 
      aagtcaagc gagaaaatc gaaaagaga aaagaattt 
      gccaaagaa cgcgaaaat aaagtcact atatataga 
      agttataga aaaggggat ttacccgat gttcaaatt 
      actttacaa gctgtacta gagccgtta caaattctg 
      gctttacgt gatcgtgaa atttcaaaa attttgtat 
      gaaaagttc ttgaagagt atattggaa aaaaggaaa 
      agtgatgcc aactttatt caagaaata tcagttgga 
      atacaaaca atatttaac aattcctcc gaatttagt 
      agaaatctg tttcgagct ctatttgat gctctaatc 
      tttagcaag agttccatt gtatttcca ccagaatta 
      atagtgagc gtttctcag tcaagtggt ttaagaggt 
      ttgggagca ttgcttctg gaggaatat ttaatatct 
      tgcgatgtg acagaagtc gaagcgaag aagtcacgt 
      gggaaccaa ttgagtcaa gacacgaac ctttggata 
      aaattggca gagctgtat aaagaaatg gaagaatgg 
      gacgttgtc aaatcaatt ttcctcgaa aaaacacaa 
      tgccctcaa gaagtaaaa aatgctctt cttgccgaa 
      tcgcaaaaa caatggaaa gatgctcga gatctttat 
      caaagtttg atagaaacc gatgacgtt attgaacga 
      aaagatttt tattatgat tcctatttc aagtgcttt 
      gcacattta ggagcatgg aatgattta ataaactct 
      gtcgattcc atcgtttcg caaaacccc accgaaact 
      tggaataat ttatgggat cagggtttt aatcaagaa 
      aaacttttg ccatggtat ataagtgga cacttgaaa 
      gatattttg tttaccgat agttccacg caacatttt 
      ctctcaagt cttaatagt agtctcgaa tccagtcac 
      ttggcgcat cttgaaaca cattatctc gaagaaatc 
      acaatgttg tggattttt aaaaatgac atacaagaa 
      gccgaacac tatctaaaa atttacatt aacaacttt 
      ttagaagac tggcaacaa ttggattca ttttacgca 
      aatctacgc tacatgaaa ttattaaaa ttgcgaaat 
      atgattgat atcgacaag tttttggac gtgttaaac 
      aacattagc atcgaaaat gtggtagaa attgatggt 
      ttagttaaa tactggaac agagcggcc tttgagaac 
      ttaccttcg attttatta aaggaagac agggtttta 
      taccggaaa caatttctc cgtactttg gtaagaaaa 
      atcgaatcg ttcgataat gatgatttt gcaaacacc 
      ttaacacaa ttaaatgac atgagcctt aaactggac 
      gaagatatt ttggaggca gcgattgga gagaacaat 
      ttttacatg accaaaaaa tacttaaat ctctcgaat 
      aatagaaat gccttcaaa acgcagcta attttaagc 
      aaactggct tatattaaa tcactcatg cttaataac 
      tcggaacaa aaattgaac gtgatattg cagggaatt 
      aagacactt gtccccata tttgaagaa actgaaagt 
      tttcttcaa ctttcagcc cacgttact tttttcaaa 
      cacctcgat tatatctct tcacttctt tcgcaaaac 
      gaagatttg cttcagaat cgtcagtca gatttgatg 
      actttgact gaagtcact caaagtgtt tcttccaaa 
      gatgttgca ttttttgca gctaataag ttaaaatcg 
      tttcttcac aattacaac acttccgat gtttgtact 
      gatgcgtac atacagtac gctgatgcg tacgtacag 
      ttggcttat tttgcaaag aatcaagga aaaaagtat 
      ttcaaagac ttcatgttg tttgtttta agagcaatg 
      aagtttaat tcaaaggag ggcaaacaa cttttccca 
      tgtgttttg atggagcaa gaatttagt cttgaagaa 
      caacaacta tttcttacc gaaactgaa caaatccca 
      gtgtggatg tttttgaaa tggattcct caaatactt 
      gttaatata gattcgtct aaagtcact gttattaaa 
      ccgcttgtg ttgaaaatt gctacaacg tacccacaa 
      gctataatg tacgcttac aggttaagt aaagagaac 
      tataaatgt gaacagcgg gaagctaag gagttgatt 
      gagactctg gacgagctt ttattaacc gacgaggga 
      gcaaataaa tttttgaaa gctttatct ttcattgga 
      ataccagct gccatctta atctactat gttcgaaaa 
      attgtaaaa ctaattgct tccagtgaa ctaggtcaa 
      gctaaaatt gtccacgat tttgtgttg aaagaaatg 
      ttcataaaa gctgactca cgtgatagc gatttacta 
      caaggaaat atgtttaag tcaattaca aaatatgaa 
      aaggatcta aaaaatatt ggaaggttg ttgaccaag 
      ccttcggag acaccaaat gtccttaaa caacttcaa 
      aaaatcaac acaaattta ggaaataca ctgcaggat 
      cgaagggaa aaccagagg aattcacgt cttcttaaa 
      gaatattgt ccttggttg gccaacttt tctgcaagt 
      aaaaataat ttagaactt gaaattcct ggccagtac 
      gatggtgaa aggatacca cttgtccaa caccatgtt 
      aaaatatct ggattttgt ccaaatgtt tccataatg 
      agttctttg cgaaaacct ataaaaata acaattttg 
      ggtaatgat actaaggag tatccattc cttgtaaaa 
      tttggcgaa gacgttcga caggatcaa cgaattcaa 
      cagcttttt tccttgatg aataatatt tttcaacat 
      gatagaaat ttgaacgga cgtaaattt catatactt 
      acataccag gttatacca ttaacaaca agtttaggt 
      ataatacag tggattggc aacacaaag tctcttcat 
      gaattttca aataatgag aattttgac aaagttgtt 
      gaaaccttc acaaaatgg atttatact tccgcgaat 
      caatcacct ttcgatgct tatggaaga gcggccatg 
      aaatattcg cgagataaa accatagtc aagttcaaa 
      acattggtt agcaaaatt agctgggat gttttcaga 
      tctacattt ttgaaatta agcagcaac actgaaggt 
      ttctttgca ctgcgaaat aactttatc aaaagctac 
      gctatcatg tgtgccagc cattggatc gtaggtgta 
      ggcgatcgc catttatca aactcctta gtatgtcta 
      aacagcggc aaggttttg ggtatcgat tttggtcac 
      gcctttggt acggcaacc caaattttg cccgtacca 
      gaactggtt ccgttccgt ctaacacct cacattgtc 
      aacttaatg gagccttta ggagctacg ggattattt 
      agggaaatc atggtgcat tgcttgaga tctctgaga 
      tcgaattct gcttccttg ttgtccaca atgaatgtt 
      ttcattgaa gaaccgtca cttgattgg ctagagcat 
      gcttcgagg tttagcacc ggtgtggat acgtctaat 
      tgtgactgg tatccggca caaaaaatc gaacaagcc 
      agaaagaaa ctagctgga gctaactct gtcaatatt 
      atgattgaa gatttgctt gcgggacat cagaaaaat 
      caagcgtac atgaaggct tatattgcg ttggttgaa 
      ggaaattca gattttaat gttcgagct agattggca 
      ggcaatggt ttgtcagag gaagatcaa gcgatttgt 
      cttatagac catgctact gattataat ttacttggg 
      aggatgttt gaaggttgg gcagcgtgg gtctaa
    mRNA sequence
    • >TC016161 RA
      gtcgaaaaa cgcaacctg cacccgcca atttatgtt 
      ttgacagtt acagttttg tgtattttg aggttatgt 
      tgtttggtg aaactttga ttgttattt tttttgggt 
      attatcctt aaatgttat gaacaccta aatcatgga 
      tttaagtcc gcgcgattt tctaaaatt actgtacaa 
      atacttgga tgaagaagc agaagatgt agcaagtaa 
      acagtgtaa tcaattatt aaccaactt tagtgatgc 
      ccttacaca tgaacaaat aaactcgac ttatcttga 
      tcaaagtct gcattattt cttcagtac atcatctgg 
      gcttcacac ttttgtgaa gaaaattat caacaagaa 
      accattcaa gacatctgt tgtaaaatt ttttgaaat 
      tatttatgc tttgatcaa taattttcc cttcaaact 
      taaaaaata tgtttctgt aatttttga aacatgctt 
      caaagtgat taaatcatt actggtaag ttccgatga 
      aaaagttaa atcactgga agtcgtcat tgtcatact 
      tgaaaaaga aatatttct tgacaattc tgaaattta 
      tttagaagt ttacaataa cctattgaa aagtatttc 
      tataacaaa aactgattc agtcgaaga gaagacatt 
      tatagcatt gggaacctt cgctaaaca tttccagta 
      tttggtgcc aaataatga aagtctgag aattgtctt 
      tcttaatgg attggagac acaaatgat taaactaag 
      tttatcaaa caaacagtt gtctggact ttttactgg 
      acttgaccg tttctgtgc aagctttcc ttttgatat 
      gaactctaa ggaagatgt gtttgttgt taataaagt 
      atataagta tattgaaac actagcaat tccttctgg 
      aactgttaa aatcgcaaa taaagctgc cttaacttt 
      cctggctaa taatatttc attgtttat aaacttaat 
      ggtggataa acacaagta ttggcatga tactttact 
      caagtggtt agaatccgg taccgaaga ccaaaaaat 
      aggaatttt ggtccttga agctttcta cttaggtct 
      tggaacttt cttattaaa tgatggatc ttgccacta 
      caaacatgt taccgagta ctttaagga atattttat 
      tgcaaacat gacccagag taaagtgtt taattacga 
      taaaaggtt atgtttaca aggtctttc ttcattttc 
      tggggtgta tcagttaca gctagagca agaggaaat 
      aaaaaagtt gtttgcgca aataatcca aaattttga 
      acagactta catactcaa cctcgatcc ttcgactga 
      tgtattgga atttctgcc gttttatct acaaactgt 
      tgcaaattt tctccagtt taaaacagt taccaacaa 
      tgaactctt ttgccttca gaaaggaac tattcttct 
      tatgaaaat atttccaca attaccata ctattgtca 
      cccgctggt tacagaagc tttagtatt gacgtttta 
      ttatctatc actgaacag cgaacacat attcaacac 
      tttcctcga aaatgtaat attccaagg agtagtatg 
      gacgtgttc tcatcaaca tattacgga agctgaatt 
      attagaaac aagctcaca aaaagttgt tacgataaa 
      agattattt gaacatgtg gaagtcttt acttaaaat 
      cgtcccagt tcgtcgatt tgacaagtt taggatttt 
      tttgcaaga acgcaaata cattttagt caaggtaat 
      tgataagtt gatgagaac tttgttgat attaatcaa 
      taaattaaa cgtgtccgt aacactgaa tgacaatag 
      tgaagctgt tacagacat acagtctgc gtataaact 
      gaatgcagt taacgattt tgcaatttt tctcaatct 
      ggtcgacct ttacgagaa gattttcga atatattga 
      ctccaattt attaaagaa atgtgtcta caaattgat 
      acattatct aatagcaaa atgcgaaaa gcaccaatt 
      aatcagtgg tttctacaa actactatc attttgctt 
      gaaaatctg taaagatat caattattt caacagttc 
      gtgtgagga cgctacaat gtgttattt aacactgag 
      aaagtttct cacgagttt gttgaacaa aacgcaaca 
      attcaccgg cgatttgct aatcgcttg tcttcaagt 
      tctgttaca atacccaat tgttataat taaagatat 
      gttatcgac ttgtactcc gtcatttcg taccatttt 
      tcacgttgg tcgtacttc cacaaaatt aacatattt 
      gacattaga aactctaga gtgttggca aaacgagat 
      tgatcctga tgagttcga accgttttt aaaacagat 
      tcttccgct gtttgactc ctacctgca aagtaaatc 
      tttggaaag catgagttc tggtattaa cgacaacag 
      aaggaagag ctctcaggc gttgaagaa gcgcaaagt 
      gttgcttga tactgaacc ggaacttct ccggcttaa 
      aacaaaaat gatcaagtt tgttggaca acaaaatag 
      tttgttgtg cgaagcttt ggcagtttc agaagataa 
      tgcggattt gacggtttg ggcaaatga acaacatct 
      aaaaattga tttacccta cgaagatgt taagctaca 
      agtttattt ggataaatt actaccaag gattgtaaa 
      tgttgcctt gaatagttc cgatcggaa gaccagaat 
      aacagcgtg tgaattact gcaagctac tgttatgat 
      ttttcttgg cacaactaa acaaatgtc gggttctgg 
      aatatccga tttggatga attgttgaa acatgtctc 
      agtttcctt gcttcgatt aggatgtga catggatca 
      agttgttga acaactctt tagaccact gtgtttcca 
      attaattca ttggtatac acatccttt ccaatcacg 
      tagtggaca cgaagccat agtcatcga agctatttt 
      ggaaagtat gacgcatcc aaccgacac ggcattacg 
      tgattttgc cggtaaatg cataagtga attcgtcaa 
      atggacgat taaacaatc aaatgaaaa aaatttgtc 
      gaaagatcc aatcaacat aaaaatttt agtcaaaaa 
      aatgcgatt ctacagcat gcatcctga ttccaacaa 
      aaaattagg tgccgctct gatttttaa tagcatata 
      cagagatat tcgagaaga attgtcgct tttgagtat 
      gttttggat agagattct tcacatttt tgtgaaaag 
      tttctcaag tttggaaaa tgacggaat tgatgagaa 
      cttggtcac acaaattaa taatgcctt gagtcgact 
      tgaaagagg ttttgtgga aaaatcaga tttgtttaa 
      taatcttga tacgcaacg aagaattcc aaatgagtt 
      caatggcgg aaagttagc cgatgttgc cgtgtggtt 
      gttgaaaca gacgggtgt aaaaaatga tcattgtag 
      aacaaagtg tatggagat cttttgttc gatttcatc 
      caaatgtaa aggttatac aaatatgca aaatttcat 
      aaactcaca ttttgatgg cagttggat gcgagatat 
      ctacgaaac ttatttaat tcagcatcc aactttaca 
      atgtccaat gaagaacga ggattttac tccgattaa 
      gtggatgca aggattgtt atgtgcttt ggatggttt 
      tatttttat catcaaaaa taagttatc atcaacttt 
      aagcgaaac ttgcactac atctattcg ttactttct 
      cgaaaacgt atcaacgat tactttaga tgaggcttt 
      tgctataat tgagccaaa aatgtggat gtttacaac 
      attcgaaaa actacattt tgataaaca acgttctca 
      agccgtcat caaaatttt acaactttt tacgatatg 
      cgagactat aactgcatt ttatacttc tcacctttg 
      gaatttgtt ggttaactt tgtatttaa tcgtcaaag 
      tttgggttt tgagtgttt tcaaccgca agacgatga 
      taatgaaag tgttttgaa aggattttt aaatagttt 
      gcctcaaag ccaagttct tcaagttgg aaatgttct 
      atcaaagta tgtaacgga caattttaa tgatgaatt 
      tgatttgaa agatcacgt taagttgaa acaaagaca 
      cattgtgag aggaattta cattttgca aacactttc 
      cttgaaaca gtttactgt tggaagggt tgcaccatt 
      gttgaataa atttctcca atttgctga agataaaat 
      catcttctt agacgacct ccaagacac tactctttc 
      ttactgtat taccgtttt aaattattc ccttgaaga 
      tcaaaatga gtttaaggt tttcgttga ttatttata 
      caaggatta caaagttca gactacaaa ctgcaagca 
      accgattag ttttggtac ttacctatt taccatatt 
      cgaagatac catcatccg taaagttgt tacaaattt 
      tgatgtttt tttcacgta ctgtctgga atataagga 
      caaaatcga caaaactgt ggaatttat tttctacat 
      tttaagatg cattggtct taataaaca ttttaaaac 
      tcaacatgg tattgttaa tatcgtatt aacaaactg 
      ggatatttt tgaagaatt ttttaacga aagcctttc 
      caacattca gttggggta taagttact gaaactttt 
      taacccaac catcaaatc gagcaggct tcaatgcga 
      caatttgaa gaaatggtt actgtgggt attaaccta 
      cgaaacaaa tgtgatgtg gagagaaga atttgaatt 
      gaagattga gaccattga tttattgag tgacatttt 
      ggacaacct tgatgaaaa tacagatct aagacgctc 
      tctggattg ttttaaagc caaattaat ctccgagac 
      gtcaccaat tcctgcaga agagaggcc atttatctt 
      ggataaact cctctctct aatcccaaa aattaggtg 
      ttttgagct tctggtttt cattctgga gatttatgc 
      taaaatgtc cactggaaa cagtatctc ggacgtaaa 
      gcattatat gactgaaaa tatcatgaa taatcagca 
      agaacataa attattact agtcaaatt atatgattt 
      atgtctact tgaagacct tgataattt ccaaaagta 
      taaattgat tatcgatac gagttcagt ctttcagta 
      ctgtaacgt tacatcatt tgaagattt ttttacgga 
      aactatttc aacagtact aacggttct aaaagaacc 
      cgtcaccac cgaaaattt atctaacaa gattctaca 
      tttcttatt ggtgggtgt attattttt gagatgtcc 
      gctacaaag tgatgatag tgagatcag tcgaataac 
      acaagcggc tctacctca aaaaccaaa caataagac 
      tttgttgct tcaactgtt gaagtttac attgaatgc 
      tattaaaga cacaattga ttgtgtggt agagtacga 
      ggaattgtt tcgcttgta taagtgtca ttcgtacaa 
      tgcgatgat ttcaatcgt atgcaattc aatgaaaga 
      tgccaattt ctacacaaa gttatttgt acgccagga 
      agacaataa agacatatt gtggagtag cttaattga 
      tacgaagaa aacttacgt atttcaggc cgattttga 
      taatattcc caaacagac aaagatctt gctaaatat 
      acgagacga gatgaggct tcgtaaaag aaacgaaaa 
      caagcaaac tcagtctgt gagatatat cgagacgca 
      gcgagtttt caacagttc gttggctga agacgtgac 
      aaaattcga tttcacaag cagtatttt gcgaacaca 
      gtcagatga cgatgcgga aagtaacga attatttgt 
      acagagtga aatcgaact ggattgtac cgatatttc 
      aactcacga atgtatggc caacgtttg cggtgtgat 
      tgaacatat gtttagagc tggcattag cgaatttcc 
      agatgaaga ggaacaata cgaattgcc agcttggtt 
      acaagcaat tagaacatt actactcga tgagaacac 
      cgcagttaa tgttaaaat attttgggt gaaagttat 
      cgacaatac cattcacat tttcaaaca cttttccaa 
      atatttcac ggaaccact tctcaagtt tatcgttga 
      tcgaagcgc tggagaggt tatgaatta tttcgttgc 
      cgatgtggt cgcagtttt ggcaacatg gtgtaccga 
      agtcactct cgaaacaca aacggagat ccaacttgc 
      atcaaaact tgtcgcatt tctgatcaa taatcttaa 
      aaacgaccg acaagatat attcaagta tcacctcca 
      gttaattcg gctcttggt tgaggcatg gaaaacgtc 
      aattgaagt cccttacga tctaattta tgcgaaatt 
      gaaagttga accaacttg caaagctgt ggaaattgg 
      aatacatgt ctcgtcaat atttttggc aaacaaact 
      tctgccatg gaaaggcga cagcaaaga cttttgtaa 
      aagtatctt taacgtaat tcttaaagc caagtacaa 
      aactattta taggccttg tgctgaaac acttggact 
      tatcctacg tgaaaccag tcatgattt accaaaact 
      gtgtgggaa tgttcacat tttgttgaa aaaaattaa 
      tgagcctga taagtacgc ccatatctt agaagggct 
      tgttttaca ttacccgcc aatagtcaa cgagggtta 
      cttgaacag tctcttaag ccgaattca tggagtccc 
      taagccgtt aaagataat ttatttacg aattttact 
      aagtcgttg cgacgattt gcacaaact tagtgattt 
      caaaacaga aaggtggga gacttatat tgaaaatga 
      ccatctcga agtgcaact tctcgcgct tgaaattgt 
      ccataagag tctgaatgt cttacgttt tgctccaac 
      atttccaga gattgttca atcagtttg taaaaatgt 
      gtcaaacac gaacgtttt atgcagaac taaagtgtt 
      tgacgttgt gatggcaat ttgcgagac gggaatttt 
      acccgaagt aaaacctgt tctagttca aggactttg 
      tgacgaaga tacagaaat tcgagaaag agtatataa 
      tttctggcg gaacaattc gtcagtacc tcatccagt 
      cgctgatcg atttttata tttactgaa aaactttta 
      tgaggaaag caccgaaaa tgattttct tggaaattg 
      ttgttactt cttattgga gcgtttgaa atttgcgga 
      cgattatag caaattgct ttttgaaca tcctttgga 
      agactgtaa ctttgaaga ctattactt ggaaacaaa 
      ttggcgtgc ccgctattt atctgttgt acccttgtt 
      tgccgaaac tgtgagaag tttcagtat gagtctgca 
      aacttttga ctcgaaact gagacaaac acaaacttc 
      gcttgaatt tgcacccac acaagttgt gaggtctaa 
      acaattttc acaatatac gatgagtga aagtagttt 
      atttattaa acccgaaga ggagaaaag tttcgttga 
      tccaaactc aatcaattt gtcgtacaa atatcgcat 
      ccccaagcg acgcttcct taaagataa agctaaagt 
      tcacagtta tttcgccca acagcaagt gaagaagtc 
      aagcgagaa aatcgaaaa gagaaaaga atttgccaa 
      agaacgcga aaataaagt cactatata tagaagtta 
      tagaaaagg ggatttacc cgatgttca aattacttt 
      acaagctgt actagagcc gttacaaat tctggcttt 
      acgtgatcg tgaaatttc aaaaatttt gtatgaaaa 
      gttcttgaa gagtatatt ggaaaaaag gaaaagtga 
      tgccaactt tattcaaga aatatcagt tggaataca 
      aacaatatt taacaattc ctccgaatt tagtagaaa 
      tctgtttcg agctctatt tgatgctct aatctttag 
      caagagttc cattgtatt tccaccaga attaatagt 
      gagcgtttc tcagtcaag tggtttaag aggtttggg 
      agcattgct tctggagga atatttaat atcttgcga 
      tgtgacaga agtcgaagc gaagaagtc acgtgggaa 
      ccaattgag tcaagacac gaacctttg gataaaatt 
      ggcagagct gtataaaga aatggaaga atgggacgt 
      tgtcaaatc aattttcct cgaaaaaac acaatgccc 
      tcaagaagt aaaaaatgc tcttcttgc cgaatcgca 
      aaaacaatg gaaagatgc tcgagatct ttatcaaag 
      tttgataga aaccgatga cgttattga acgaaaaga 
      tttttatta tgattccta tttcaagtg ctttgcaca 
      tttaggagc atggaatga tttaataaa ctctgtcga 
      ttccatcgt ttcgcaaaa ccccaccga aacttggaa 
      taatttatg ggatcaggg ttttaatca agaaaaact 
      tttgccatg gtatataag tggacactt gaaagatat 
      tttgtttac cgatagttc cacgcaaca ttttctctc 
      aagtcttaa tagtagtct cgaatccag tcacttggc 
      gcatcttga aacacatta tctcgaaga aatcacaat 
      gttgtggat ttttaaaaa tgacataca agaagccga 
      acactatct aaaaattta cattaacaa ctttttaga 
      agactggca acaattgga ttcatttta cgcaaatct 
      acgctacat gaaattatt aaaattgcg aaatatgat 
      tgatatcga caagttttt ggacgtgtt aaacaacat 
      tagcatcga aaatgtggt agaaattga tggtttagt 
      taaatactg gaacagagc ggcctttga gaacttacc 
      ttcgatttt attaaagga agacagggt tttataccg 
      gaaacaatt tctccgtac tttggtaag aaaaatcga 
      atcgttcga taatgatga ttttgcaaa caccttaac 
      acaattaaa tgacatgag ccttaaact ggacgaaga 
      tattttgga ggcagcgat tggagagaa caattttta 
      catgaccaa aaaatactt aaatctctc gaataatag 
      aaatgcctt caaaacgca gctaatttt aagcaaact 
      ggcttatat taaatcact catgcttaa taactcgga 
      acaaaaatt gaacgtgat attgcaggg aattaagac 
      acttgtccc catatttga agaaactga aagttttct 
      tcaactttc agcccacgt tactttttt caaacacct 
      cgattatat ctcttcact tctttcgca aaacgaaga 
      tttgcttca gaatcgtca gtcagattt gatgacttt 
      gactgaagt cactcaaag tgtttcttc caaagatgt 
      tgcattttt tgcagctaa taagttaaa atcgtttct 
      tcacaatta caacacttc cgatgtttg tactgatgc 
      gtacataca gtacgctga tgcgtacgt acagttggc 
      ttattttgc aaagaatca aggaaaaaa gtatttcaa 
      agacttcat gttgtttgt tttaagagc aatgaagtt 
      taattcaaa ggagggcaa acaactttt cccatgtgt 
      tttgatgga gcaagaatt tagtcttga agaacaaca 
      actatttct taccgaaac tgaacaaat cccagtgtg 
      gatgttttt gaaatggat tcctcaaat acttgttaa 
      tatagattc gtctaaagt cactgttat taaaccgct 
      tgtgttgaa aattgctac aacgtaccc acaagctat 
      aatgtacgc ttacaggtt aagtaaaga gaactataa 
      atgtgaaca gcgggaagc taaggagtt gattgagac 
      tctggacga gcttttatt aaccgacga gggagcaaa 
      taaattttt gaaagcttt atctttcat tggaatacc 
      agctgccat cttaatcta ctatgttcg aaaaattgt 
      aaaactaat tgcttccag tgaactagg tcaagctaa 
      aattgtcca cgattttgt gttgaaaga aatgttcat 
      aaaagctga ctcacgtga tagcgattt actacaagg 
      aaatatgtt taagtcaat tacaaaata tgaaaagga 
      tctaaaaaa tattggaag gttgttgac caagccttc 
      ggagacacc aaatgtcct taaacaact tcaaaaaat 
      caacacaaa tttaggaaa tacactgca ggatcgaag 
      ggaaaacca gaggaattc acgtcttct taaagaata 
      ttgtccttg gttggccaa cttttctgc aagtaaaaa 
      taatttaga acttgaaat tcctggcca gtacgatgg 
      tgaaaggat accacttgt ccaacacca tgttaaaat 
      atctggatt ttgtccaaa tgtttccat aatgagttc 
      tttgcgaaa acctataaa aataacaat tttgggtaa 
      tgatactaa ggagtatcc attccttgt aaaatttgg 
      cgaagacgt tcgacagga tcaacgaat tcaacagct 
      tttttcctt gatgaataa tatttttca acatgatag 
      aaatttgaa cggacgtaa atttcatat acttacata 
      ccaggttat accattaac aacaagttt aggtataat 
      acagtggat tggcaacac aaagtctct tcatgaatt 
      ttcaaataa tgagaattt tgacaaagt tgttgaaac 
      cttcacaaa atggattta tacttccgc gaatcaatc 
      acctttcga tgcttatgg aagagcggc catgaaata 
      ttcgcgaga taaaaccat agtcaagtt caaaacatt 
      ggttagcaa aattagctg ggatgtttt cagatctac 
      atttttgaa attaagcag caacactga aggtttctt 
      tgcactgcg aaataactt tatcaaaag ctacgctat 
      catgtgtgc cagccattg gatcgtagg tgtaggcga 
      tcgccattt atcaaactc cttagtatg tctaaacag 
      cggcaaggt tttgggtat cgattttgg tcacgcctt 
      tggtacggc aacccaaat tttgcccgt accagaact 
      ggttccgtt ccgtctaac acctcacat tgtcaactt 
      aatggagcc tttaggagc tacgggatt atttaggga 
      aatcatggt gcattgctt gagatctct gagatcgaa 
      ttctgcttc cttgttgtc cacaatgaa tgttttcat 
      tgaagaacc gtcacttga ttggctaga gcatgcttc 
      gaggtttag caccggtgt ggatacgtc taattgtga 
      ctggtatcc ggcacaaaa aatcgaaca agccagaaa 
      gaaactagc tggagctaa ctctgtcaa tattatgat 
      tgaagattt gcttgcggg acatcagaa aaatcaagc 
      gtacatgaa ggcttatat tgcgttggt tgaaggaaa 
      ttcagattt taatgttcg agctagatt ggcaggcaa 
      tggtttgtc agaggaaga tcaagcgat ttgtcttat 
      agaccatgc tactgatta taatttact tgggaggat 
      gtttgaagg ttgggcagc gtgggtcta acttaaggt 
      tatattttt gtactctgt aatgtttta tgttttcta 
      atacagttt acttattaa t
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