Status
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Gene information
General information
TC014438 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007420.3: 10428129..10455273
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC014438
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
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    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
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    Email
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_05632

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 20.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 2 (3 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 embryo/egg with embryonic tissue, no cuticle, no fluorescence - Penetrance (percentage of animals/eggs on slide): more than 80%

    larval musculature pattern irregular - Penetrance (percentage of animals/eggs on slide): less than 30%

    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    remarks: muscle pattern potentially obscured by segmentation defect,
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    embryo/egg without visible larval cuticle in cuticle preparation - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    larva segment number decreased - Penetrance (percentage of animals/eggs on slide): 30% - 50%

    larva everted (inside-out) - Penetrance (percentage of animals/eggs on slide): less than 30%

    affected eggs/embryos/larvae - Penetrance (percentage of animals/eggs on slide): more than 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: % (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: % (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC014438 RB
      MYHRHPKRQ THFRRTMET SIRPPLPPK GEMQSAPVP 
      PPRRHRRAG SIGPSPCPS PTPMRHNQG VPTLARKDT 
      FSFKDKMNS LKRMVGSRP LPPTPISPS SRVSASPPS 
      FDRYNRGFE VPSPSPSLQ QRYRQHQLA MRGTTPNLS 
      SAGSDFDKP PSRDSGYPD WDNEWGRFR SGSISGSET 
      GSRLRKLSN TSCPPPRNL PHSASVFDL NNPMHHHHH 
      HGFIPMQQA QSMAQLNCP GCYQGGWLE CGCDRTGSN 
      LSLNMAPGP YPVNPMWMG TWHGPPPST MYPYPVPMG 
      HMHHHSRPP SPTHSIKSR KSSMSKKSR RKYRESEDT 
      DDDLEDRRS IFSHNDRSE RKSLGSRFP ERQKLPRET 
      ASMPREISR KNSDRIERI SNVRSRRGS SSESDDEQS 
      ESQKESEVL DESEEPEIK PILEVPTSN WECEHCTFV 
      NDPGTKVCL VCCKTATIN VKLVKSDEK TEKPEPKLH 
      TTRSSDDCS KDYSETESL LNKLGKLKT SEPKSPDPK 
      KGKDASEAV SLESVSAVK AVGTSPEND TSVNKVTTG 
      TSPPPQNMS TQTYEDVPP AGEIPKSPR GRPTSRNKR 
      RDLRRSNSL HMGTRRGSE WSLHRSSSR HSLTTDSQS 
      LPGSREQSP APYDYSEES MDRLRKPTM SRSYYSIMD 
      LRKPELYRN EPPFYRNEY PPSHRNRSD SFDLPDSGF 
      NSFKSQGME LVKLLREAE QYKYTADEV QAALCHCKD 
      MNPIDWLRQ NWDATIASV QTLATQMGR EGPMNIVGT 
      VSEEEARAA LRLHKGNLW PAVTECVEQ RQRKYAELA 
      SRGEFSRED ILTVLTAHH GDLEAAFNE LSKTQLKPF 
      LMRIWGPPV GTENEAGNE GAVLEKIGG EVVSDKELT 
      KAVSDSSDK APPTTTDQE LKKTPTEVL ENIESQILQ 
      NLQDMNNLS DTLDDAPPK PNKIYVEKS STVIQVFDH 
      DYEVPEAER DEQKPESDF SDTESSDEG NKVEEFVDA 
      VSDMPEPPR LKRKSVSTL NITLANKEE PGTSTGLPV 
      AQMIQAEDT PTVNEVVLE STANIQLQS VPKNDQVGA 
      SVNKKETEA SIVVPNGET KAQVETKNN LQEGSPTPV 
      ATKEIKDNG ELSPETPSS QKETKTVNE NVQKTTKDD 
      VSMVLVSQT KELQTDDLK NRDSSQNDT KDNQTNTSN 
      QDHTKDSLD KGSINCTET KNDLNETPE GNVENKDPN 
      EFSNKNSSI YEKTIENGN MQTSKNKEE TKTDLKEVA 
      RRNETKGNL NVSKNKDVI TEQIINQSG VTKATNANE 
      TVEHEVNKS QTNHSETKD NATEQITVE NDDANAPEG 
      NEKTKNDQL APLESNNET KNDLNKSEN TVVAQKTIT 
      SVDVKLSNE NEKTKHETN ENVKTSKDN EKTQNGLNS 
      EKPSTSNGP STTEAKNHN EVVESKPPL TKKQKKSMK 
      KSKRRAQKR AARRGSATS TTESSSGEK QSIETDNEV 
      PEPVVKDYE PKIENSSSD NAEKPSTST ETQPKISTT 
      IQIPQNKQS LLPVPPKRP SKIPISRQR SVSKSEPKS 
      PDVQSKIPV KTGSHIPVR CLIEKAKSD TESEKRPVM 
      QKRKSDEIA QEMQQSVQT VKEMNRQLN TVNRGSLSS 
      FRNSSVEST TSSKQLSYT KSLDNDSDS SVSDSNVEE 
      LLDPSTDED SYEDFEEYD GIEESDTED YNEFDKKKA 
      KIANELDIN LAQISARVE ELTTSLGRK NEFDETCES 
      EEEYVSEES EEEDEEEEE DDDDDEDNQ IDLNIEVKQ 
      PSEIELMER QARRFLAEG QVESYQQAE LAVSLMTLK 
      FSAEEALEA AKDCHTLDA AIAYLQQDC ELCAGKYPM 
      NQIISMLKC THRCCQECA KNYFTVQVT DRTIMDCTC 
      PFCKQPELT SSEISEDEV SDYFANLDI LLKGILDAT 
      VHELFQRKL RDRTLMQDP NFKWCVKCS SGFIANPRQ 
      RRLVCPDCK SVTCANCRR PWEKQHEGI SCEKFAEWK 
      DANDPENQA SAVAKHLAE NGIDCPKCK FRYSLARGG 
      CMHFTCTQC KHEFCYGCG KPFMMGAKC GVSQYCGKL 
      GLHAHHPRN CLFYLRDKE PTELQKLLK EHKIPFDTD 
      IPADKEENA AAAAKCFVP LQRETPNGL IDTVCNNEV 
      SPGQAGLCR MHYLEYLCK LIRRHAIDS IDLLNADDL 
      ETVVRRAAK RLPPNAIET RALNSSIAL FLSCLSMST 
      AFLSASSPF RRSKSTAFL TISSISLVR NFLLIPEFV 
      RIPRISFVK TAAVLRPNI FLRLQTYLK DYKPVYNRS 
      LIEKAKSDT ESEKRPVMQ KRKLDEIAQ EMQQSVQTV 
      KEMNRQLNT VNRGSLSSF RNSSVESTT SSKQLSYTK 
      SLDNDSDSS VSDSNVEEL LDPSTDEDS YEDFEEYDG 
      IEESDTEDY NEFDKKKAK IANELDINL AQISARVEE 
      LTTSLGRKN EFDETCESE EEYVSEESE EEDEEEEED 
      DDDDEDNQI DLNIEVKQP SEIELMERQ ARRFLAEGQ 
      VESYQQAEL AVSLMTLKF SAEEALEAA KDCHTLDAA 
      IAYLQQDCE LCAGKYPMN QVSVIFPAN FNQCSSGFI 
      ANPRQRRLV CPDCKSVTC ANCRRPWEK QHEGISCEK 
      FAEWKDAND PENQTSAVA KHLAENGID CPKCKFRYS 
      LARGGCMHF TCTQCKHEF CYGCGKPFM MGAKCGVSQ 
      YCGKLGLHA HHPRNCLFY LRDKEPTEL QKLLKEHKI 
      PFDTDIPAD KEENAAAAA KCFVPLQRE TPNGLIDTV 
      CNNEVSPGQ AGLCRMHYL EYLCKLIRR HAIDSIDLL 
      NADDLETVV RRAAKRLPP NAYGTPREM LHYIEYLVG 
      LIGRHKLDP ITILDLVEV SQELKRRGK DLPERTASC 
      NDQEYRILC VKIVKEQIP LD
    CDS sequence
    • >TC014438 RB
      atgtaccac cgacacccc aaacgccag acccacttc 
      cgacgcacc atggagact tcaatccgg cccccacta 
      cccccaaaa ggagagatg caatccgcc cccgtgccg 
      ccccctcgt cgccaccgc cgcgccggg tccatcgga 
      ccgtcccca tgtcccagc cctaccccc atgagacac 
      aaccagggg gttcccact ttggcgcgg aaagacact 
      ttttcattc aaagacaag atgaatagt ctcaaacgg 
      atggtgggg tcgaggcct ctacctccg acaccgatt 
      tcaccctcg tcgcgtgtc tcagcgagc cccccgagt 
      ttcgatagg tacaatcgc gggttcgaa gtaccaagt 
      cccagcccc tccctgcag cagaggtac cgccaacat 
      cagctggca atgaggggc accacccct aatctatca 
      agtgccgga tctgatttt gataagccc ccgagccgc 
      gatagcggg tacccagac tgggacaat gaatggggt 
      cgcttccgg tcggggagc atttccggc tcggaaacc 
      ggttcccgg ttacggaaa ttgagcaat acttcgtgc 
      cccccgccc aggaatctc cctcacagc gcgtcggtg 
      tttgacttg aataatcca atgcaccac caccaccat 
      catgggttt attcccatg caacaagcc caaagtatg 
      gcccagctg aactgtccg gggtgctac caagggggc 
      tggttggaa tgtgggtgt gacaggacc ggcagtaac 
      ttgagcctg aacatggcg ccagggccg tatccagtc 
      aatcccatg tggatgggc acttggcat gggcctccg 
      ccgagtacc atgtatcca tatcccgtc ccaatgggc 
      cacatgcat caccactca agaccacca tcgcccacc 
      cacagcatc aagtcccgg aagtcatcc atgagtaag 
      aagagtcgg aggaagtac cgcgaaagt gaagacacc 
      gatgatgat ttagaagac cgaagatcg attttcagc 
      cacaatgat cgaagcgag aggaagtcg ctggggtca 
      agattcccc gaaaggcag aaactgcca cgtgaaacc 
      gcctccatg cctcgggaa atttcgaga aaaaattcg 
      gaccgaatt gaacgaatc tcgaacgtg cgaagcaga 
      cgtggttcg tccagtgag agcgacgac gagcaatcg 
      gagagccag aaagagagt gaagtgctt gacgaatca 
      gaagaacca gaaataaag ccaatactg gaagtaccg 
      acctcgaat tgggagtgt gaacactgc accttcgtg 
      aatgaccct ggcactaaa gtttgccta gtctgttgc 
      aaaacggcc acaattaac gtcaaactc gtgaaaagc 
      gacgagaaa accgagaaa cctgagcca aaattgcac 
      acgactcga tcgagtgac gactgtagc aaagactac 
      agcgagacc gaatctctt ttaaataaa ttgggcaaa 
      ctaaaaacc tccgaaccg aaatccccc gacccgaag 
      aaaggaaaa gacgcaagt gaagcggtg tcattggaa 
      agtgttagt gcggttaaa gcggtcggt acttccccc 
      gaaaatgac actagtgtt aataaagtg acaacgggc 
      acatcgcct ccgccccaa aacatgtcg acacaaact 
      tatgaggac gttcctcca gccggggaa atccccaag 
      tcgccacga ggacgaccg acgagtcgc aacaaacga 
      agagacttg cgaaggtcg aactcgctg cacatgggg 
      acgagacgg gggtccgaa tggtcgctg caccgcagc 
      tccagtcgg cactccctc accaccgac tcgcagagt 
      ctccccggg agtcgggaa caaagccca gcgccgtat 
      gactacagt gaggaaagt atggacagg ttgcgcaaa 
      ccgacaatg tctcggtca tattacagc atcatggac 
      ttgcgaaaa ccggaactt taccgaaac gaaccgccg 
      ttttacagg aatgagtac cccccaagt caccgcaac 
      cgctccgac tcgttcgac ctccccgac tcgggcttc 
      aacagcttc aagtcgcag ggaatggag ctggtgaag 
      ctcctccgc gaggctgag cagtacaag tacaccgct 
      gacgaggtc caggcggcc ctgtgccac tgcaaggac 
      atgaatccg atagattgg ctgcgccaa aactgggac 
      gcgactatt gcgagcgtc cagactttg gccacgcag 
      atggggcgc gagggcccc atgaatatc gtcgggacg 
      gtgtctgag gaagaggcc agggccgct ttgagactc 
      cacaagggg aatttgtgg ccagcggtg accgaatgt 
      gtggagcaa aggcagaga aagtatgcc gaacttgcg 
      tcacgtggg gagttcagt cgggaggat attctaaca 
      gtgctaacg gcacatcac ggtgacttg gaggcggcg 
      tttaacgag ctgagtaag actcaactc aagccgttt 
      ctgatgcgg atttgggga ccgccggtt gggacggag 
      aatgaggca ggtaatgag ggggcggtg ttggagaaa 
      attgggggc gaagtagtg agcgataag gaactgaca 
      aaagcggta agtgatagt agtgataaa gcgccccct 
      acaaccacc gaccaggag ttaaaaaaa actccaact 
      gaagttttg gaaaatatc gaatcgcag attttacaa 
      aatttgcaa gacatgaac aatcttagt gacacttta 
      gatgatgcg ccccctaaa cctaacaaa atttacgtg 
      gagaaaagt agtaccgta atacaagtg tttgatcac 
      gattatgaa gtcccggaa gccgagcga gacgaacaa 
      aaaccagag tcggatttt agtgacact gaaagtagc 
      gatgaaggt aacaaagtt gaggaattt gtggatgct 
      gtgagtgat atgccagaa cctcctcgc ctcaaacga 
      aaaagtgtc agtacttta aatatcact ttagccaat 
      aaggaagaa ccgggaaca agtaccgga cttccagtt 
      gcccaaatg attcaagct gaggatact ccgactgtg 
      aatgaagta gtacttgaa agtactgca aatattcag 
      ttacagagt gtcccaaaa aacgatcaa gtgggggcc 
      tcagtgaat aaaaaagaa acagaggcc tccattgtg 
      gttccaaat ggcgaaact aaagctcaa gtagaaaca 
      aaaaataat ttacaagaa ggttccccg actccagtg 
      gcaacaaaa gaaattaaa gataatggg gagctctct 
      ccagaaaca ccctctagt caaaaagaa acaaaaacg 
      gtgaatgaa aacgtacaa aaaacaaca aaagacgat 
      gtaagtatg gttcttgta agtcaaaca aaagagctt 
      caaactgat gatttaaaa aatcgtgat tcaagtcaa 
      aatgatacc aaagacaat caaactaac acttcaaat 
      caggatcac acaaaagat agtttagat aagggttca 
      ataaattgt accgaaaca aaaaacgat ttaaatgag 
      actccggaa ggcaatgta gaaaataaa gatccgaat 
      gagttttcc aataagaat agttcaata tatgaaaaa 
      acaattgaa aatggtaat atgcaaact tctaaaaat 
      aaagaagag acgaaaact gatttaaaa gaggttgca 
      agaagaaac gaaacaaaa ggaaatcta aatgtttct 
      aaaaacaag gatgtaata acagaacag ataataaat 
      cagagcggg gtaacaaaa gccacaaat gctaatgaa 
      acagtagaa cacgaagta aataagagt caaacaaat 
      catagtgaa acaaaagat aacgcgacg gaacagata 
      accgtggaa aacgatgac gcaaacgct cctgaaggt 
      aatgagaaa acaaaaaac gatcaattg gcgcccctt 
      gaaagcaat aatgaaaca aaaaacgat ctgaataaa 
      agcgaaaac actgtagta gcgcaaaaa acaattacg 
      agtgttgat gtaaaacta tctaatgag aatgaaaaa 
      acaaaacac gaaacaaat gaaaatgtt aaaacttcc 
      aaagacaat gagaaaaca caaaacggc ctaaattca 
      gaaaaacct tccacgagc aatggacca agtactacc 
      gaagccaaa aatcataat gaggtcgta gaaagtaaa 
      ccgccgttg acaaaaaag cagaaaaag tccatgaaa 
      aaatcgaaa cgtcgcgcc cagaaacga gcagctcgg 
      agaggctcg gcaacgagt actacggag tcaagcagt 
      ggcgaaaaa cagtcaata gagacagac aacgaggtg 
      cccgaaccc gtcgtcaaa gattatgaa ccaaaaatt 
      gaaaattct tcctctgat aacgctgaa aaaccctcg 
      acctcgacc gaaacccag ccaaaaatt tcaaccaca 
      attcaaata ccccaaaat aaacaatct ctgcttccc 
      gttcccccg aaaagacca tcaaaaatc ccgatttcg 
      cgtcagaga tcagtttcc aaaagcgaa ccgaaatca 
      cccgacgtg caaagtaaa atcccggtt aaaaccggg 
      agtcatatt ccggttagg tgtttgatt gagaaagcg 
      aaaagtgat acggaatcg gagaaacgt ccagttatg 
      caaaaacgg aagtcggac gaaatcgca caagagatg 
      caacaaagt gttcaaact gtcaaagag atgaaccga 
      caattaaat actgtgaac agggggagt ctgagttcg 
      tttcggaac agttccgtt gagtctacg acaagttcg 
      aagcagctg tcttacaca aaatcacta gataatgat 
      agcgattct tctgtttct gacagtaac gttgaagaa 
      ttgctcgac ccgagcact gacgaagac agttacgag 
      gattttgaa gagtatgat gggattgaa gagtccgac 
      actgaggac tataacgag tttgataaa aagaaagcg 
      aagattgcc aatgagctt gatattaat ttggcacaa 
      attagtgca agggttgag gaattgacc acgagtttg 
      ggtcgcaaa aatgagttt gatgagacg tgtgagtcc 
      gaggaggag tatgtttct gaagaaagt gaggaggaa 
      gatgaagaa gaggaagag gatgatgat gacgatgag 
      gataatcaa attgatctt aatattgaa gtaaagcaa 
      ccgagtgaa atcgagctg atggagagg caggcgagg 
      cgcttcctg gccgagggc caagtcgag agctaccaa 
      caagccgag cttgccgtt agcttaatg actcttaaa 
      ttttccgct gaggaagct ctcgaagct gctaaagac 
      tgccacacc ctagacgcc gctatcgca tatttgcaa 
      caagactgc gaactgtgc gctggaaaa tatcccatg 
      aatcagatc atatctatg ctaaaatgt acgcaccgc 
      tgctgtcaa gaatgcgct aaaaattat tttaccgtg 
      caagtgact gacaggacg ataatggac tgcacgtgc 
      cctttctgc aaacaaccg gagttgaca agcagcgaa 
      atatccgaa gacgaagtc tcggattat tttgccaat 
      ttggatatt ctccttaaa ggcattcta gacgcaacc 
      gtccatgag cttttccag aggaaattg cgcgaccgg 
      actttaatg caagaccct aatttcaag tggtgcgtt 
      aagtgttcg agcggattt atcgccaat cctcgccag 
      agacgcctc gtttgtccc gactgcaaa agcgtcacg 
      tgtgcaaac tgtcgccgg ccgtgggag aaacaacac 
      gagggcatc tcttgcgag aaattcgca gaatggaaa 
      gacgccaac gacccggag aaccaggcc tccgcggtt 
      gcgaaacac ttagccgaa aacggcata gactgcccc 
      aaatgtaaa tttcgatat tcactggcc cgagggggc 
      tgcatgcat tttacttgc actcagtgc aaacacgag 
      ttttgctac ggctgtggc aagcctttt atgatgggg 
      gccaagtgt ggggtgagc cagtactgc gggaaattg 
      gggctccat gcgcaccac ccccgcaac tgtctgttc 
      tatttgcgc gataaggaa ccaacagag ctgcaaaag 
      ttgctcaaa gagcacaaa atccccttc gataccgac 
      atcccggcc gataaagag gaaaacgcc gcagccgca 
      gctaagtgt ttcgtgccg ctgcagcgg gaaaccccc 
      aacgggctc atcgacacg gtgtgcaac aacgaggtt 
      tcccccggc caggccggt ctttgcagg atgcattat 
      ttagagtac ttgtgtaag ttaataaga cgtcacgca 
      atcgactca atcgacttg ttaaacgct gatgatctc 
      gagactgtg gtcaggcgg gccgccaaa cgactgccg 
      ccgaatgcg attgagacc cgtgcgctt aattcgtca 
      attgctttg tttctttct tgtctttct atgtcaact 
      gcttttttg agtgcttcg tcgcctttc cgtcgttct 
      aaatcaact gctttttta actatttct tctatttcc 
      ctcgtacgt aattttttg cttattcca gaattcgtt 
      cgaatcccc cgaatctcg tttgttaaa actgcggct 
      gtccttaga cccaacatc tttctgcgg ctacagacc 
      tatttaaaa gattataaa ccagtttac aataggagt 
      ttgattgag aaagcgaaa agtgatacg gaatcggag 
      aaacgtcca gttatgcaa aaacggaag ttggacgaa 
      atcgcacaa gagatgcaa caaagtgtt caaactgtc 
      aaagagatg aaccgacaa ttaaatact gtgaacagg 
      gggagtctg agttcgttt cggaacagt tccgttgag 
      tctacgaca agttcgaag cagctgtct tacacaaaa 
      tcactagat aatgatagc gattcttct gtttctgac 
      agtaacgtt gaagaattg ctcgacccg agcactgac 
      gaagacagt tacgaggat tttgaagag tatgatggg 
      attgaagag tccgacact gaggactat aacgagttt 
      gataaaaag aaagcgaag attgccaat gagcttgat 
      attaatttg gcacagatt agtgcaagg gttgaggaa 
      ttgaccacg agtttgggt cgcaaaaat gagtttgat 
      gagacgtgt gagtccgag gaggagtat gtttctgaa 
      gaaagtgag gaggaagat gaagaagag gaagaggat 
      gatgatgac gatgaggat aatcaaatt gatcttaat 
      attgaagta aagcaaccg agtgaaatc gagctgatg 
      gagaggcag gcgaggcgc ttcctggcc gagggccaa 
      gtcgagagc taccaacaa gccgagctt gccgttagc 
      ttaatgact cttaaattt tccgctgag gaagctctc 
      gaagctgct aaagactgc cacacccta gacgccgct 
      atcgcatat ttgcaacaa gactgcgaa ctgtgcgct 
      ggaaaatat cccatgaat caggtttct gtaattttc 
      ccggctaac tttaatcag tgttcgagc ggatttatc 
      gccaatcct cgccagaga cgcctcgtt tgtcccgac 
      tgcaaaagc gtcacgtgt gcaaactgt cgccggccg 
      tgggagaaa caacacgag ggcatctct tgcgagaaa 
      ttcgcagaa tggaaagac gccaacgac ccggagaac 
      cagacctcc gcggttgcg aaacactta gccgaaaac 
      ggcatagac tgccccaaa tgtaaattt cgatattca 
      ctggcccga gggggctgc atgcatttt acttgcact 
      cagtgcaaa cacgagttt tgctacggc tgtggcaag 
      ccttttatg atgggggcc aagtgtggg gtgagccag 
      tactgcggg aaattgggg ctccatgcg caccacccc 
      cgcaactgt ctgttctat ttgcgcgat aaggaacca 
      acagagctg caaaagttg ctcaaagag cacaaaatc 
      cccttcgat accgacatc ccggccgat aaagaggaa 
      aacgccgca gccgcagct aagtgtttc gtgccgctg 
      cagcgggaa acccccaac gggctcatc gacacggtg 
      tgcaacaac gaggtttcc cccggccag gccggtctt 
      tgcaggatg cattattta gagtacttg tgtaagtta 
      ataagacgt cacgcaatc gactcaatc gacttgtta 
      aacgctgat gatctcgag actgtggtc aggcgggcc 
      gccaaacga ctgccgccg aatgcgtac ggtacgccc 
      cgagaaatg ctgcattac atcgagtat ttagttggg 
      ctcattggc agacacaaa ctggaccca atcacgatc 
      ctggacctg gtggaagtc agtcaggag ttgaagaga 
      cgcggcaaa gacttgccg gaaagaacg gctagttgt 
      aacgaccag gagtacaga attttgtgt gtcaagatt 
      gtgaaggag cagattcca ctggat
    mRNA sequence
    • >TC014438 RB
      gtcaggggc gccaccccc gccaattcc aatcgagga 
      gaagcccca ctcgtcgtt ttcaaaaac ccaagaacc 
      cgattatga agttatcga atttggcca acagtactc 
      aaatgcgcc cccaatacc catcaaaac agagcccaa 
      aagggccga tggaaggca ctgccagct ctgtggtac 
      ctccaaccc ttccatcaa atgcgacca ctgcaacca 
      gatcttctg tatttcctg cgatgatat gtaccaccg 
      acaccccaa acgccagac ccacttccg acgcaccat 
      ggagacttc aatccggcc cccactacc cccaaaagg 
      agagatgca atccgcccc cgtgccgcc ccctcgtcg 
      ccaccgccg cgccgggtc catcggacc gtccccatg 
      tcccagccc tacccccat gagacacaa ccagggggt 
      tcccacttt ggcgcggaa agacacttt ttcattcaa 
      agacaagat gaatagtct caaacggat ggtggggtc 
      gaggcctct acctccgac accgatttc accctcgtc 
      gcgtgtctc agcgagccc cccgagttt cgataggta 
      caatcgcgg gttcgaagt accaagtcc cagcccctc 
      cctgcagca gaggtaccg ccaacatca gctggcaat 
      gaggggcac cacccctaa tctatcaag tgccggatc 
      tgattttga taagccccc gagccgcga tagcgggta 
      cccagactg ggacaatga atggggtcg cttccggtc 
      ggggagcat ttccggctc ggaaaccgg ttcccggtt 
      acggaaatt gagcaatac ttcgtgccc cccgcccag 
      gaatctccc tcacagcgc gtcggtgtt tgacttgaa 
      taatccaat gcaccacca ccaccatca tgggtttat 
      tcccatgca acaagccca aagtatggc ccagctgaa 
      ctgtccggg gtgctacca agggggctg gttggaatg 
      tgggtgtga caggaccgg cagtaactt gagcctgaa 
      catggcgcc agggccgta tccagtcaa tcccatgtg 
      gatgggcac ttggcatgg gcctccgcc gagtaccat 
      gtatccata tcccgtccc aatgggcca catgcatca 
      ccactcaag accaccatc gcccaccca cagcatcaa 
      gtcccggaa gtcatccat gagtaagaa gagtcggag 
      gaagtaccg cgaaagtga agacaccga tgatgattt 
      agaagaccg aagatcgat tttcagcca caatgatcg 
      aagcgagag gaagtcgct ggggtcaag attccccga 
      aaggcagaa actgccacg tgaaaccgc ctccatgcc 
      tcgggaaat ttcgagaaa aaattcgga ccgaattga 
      acgaatctc gaacgtgcg aagcagacg tggttcgtc 
      cagtgagag cgacgacga gcaatcgga gagccagaa 
      agagagtga agtgcttga cgaatcaga agaaccaga 
      aataaagcc aatactgga agtaccgac ctcgaattg 
      ggagtgtga acactgcac cttcgtgaa tgaccctgg 
      cactaaagt ttgcctagt ctgttgcaa aacggccac 
      aattaacgt caaactcgt gaaaagcga cgagaaaac 
      cgagaaacc tgagccaaa attgcacac gactcgatc 
      gagtgacga ctgtagcaa agactacag cgagaccga 
      atctctttt aaataaatt gggcaaact aaaaacctc 
      cgaaccgaa atcccccga cccgaagaa aggaaaaga 
      cgcaagtga agcggtgtc attggaaag tgttagtgc 
      ggttaaagc ggtcggtac ttcccccga aaatgacac 
      tagtgttaa taaagtgac aacgggcac atcgcctcc 
      gccccaaaa catgtcgac acaaactta tgaggacgt 
      tcctccagc cggggaaat ccccaagtc gccacgagg 
      acgaccgac gagtcgcaa caaacgaag agacttgcg 
      aaggtcgaa ctcgctgca catggggac gagacgggg 
      gtccgaatg gtcgctgca ccgcagctc cagtcggca 
      ctccctcac caccgactc gcagagtct ccccgggag 
      tcgggaaca aagcccagc gccgtatga ctacagtga 
      ggaaagtat ggacaggtt gcgcaaacc gacaatgtc 
      tcggtcata ttacagcat catggactt gcgaaaacc 
      ggaacttta ccgaaacga accgccgtt ttacaggaa 
      tgagtaccc cccaagtca ccgcaaccg ctccgactc 
      gttcgacct ccccgactc gggcttcaa cagcttcaa 
      gtcgcaggg aatggagct ggtgaagct cctccgcga 
      ggctgagca gtacaagta caccgctga cgaggtcca 
      ggcggccct gtgccactg caaggacat gaatccgat 
      agattggct gcgccaaaa ctgggacgc gactattgc 
      gagcgtcca gactttggc cacgcagat ggggcgcga 
      gggccccat gaatatcgt cgggacggt gtctgagga 
      agaggccag ggccgcttt gagactcca caaggggaa 
      tttgtggcc agcggtgac cgaatgtgt ggagcaaag 
      gcagagaaa gtatgccga acttgcgtc acgtgggga 
      gttcagtcg ggaggatat tctaacagt gctaacggc 
      acatcacgg tgacttgga ggcggcgtt taacgagct 
      gagtaagac tcaactcaa gccgtttct gatgcggat 
      ttggggacc gccggttgg gacggagaa tgaggcagg 
      taatgaggg ggcggtgtt ggagaaaat tgggggcga 
      agtagtgag cgataagga actgacaaa agcggtaag 
      tgatagtag tgataaagc gccccctac aaccaccga 
      ccaggagtt aaaaaaaac tccaactga agttttgga 
      aaatatcga atcgcagat tttacaaaa tttgcaaga 
      catgaacaa tcttagtga cactttaga tgatgcgcc 
      ccctaaacc taacaaaat ttacgtgga gaaaagtag 
      taccgtaat acaagtgtt tgatcacga ttatgaagt 
      cccggaagc cgagcgaga cgaacaaaa accagagtc 
      ggattttag tgacactga aagtagcga tgaaggtaa 
      caaagttga ggaatttgt ggatgctgt gagtgatat 
      gccagaacc tcctcgcct caaacgaaa aagtgtcag 
      tactttaaa tatcacttt agccaataa ggaagaacc 
      gggaacaag taccggact tccagttgc ccaaatgat 
      tcaagctga ggatactcc gactgtgaa tgaagtagt 
      acttgaaag tactgcaaa tattcagtt acagagtgt 
      cccaaaaaa cgatcaagt gggggcctc agtgaataa 
      aaaagaaac agaggcctc cattgtggt tccaaatgg 
      cgaaactaa agctcaagt agaaacaaa aaataattt 
      acaagaagg ttccccgac tccagtggc aacaaaaga 
      aattaaaga taatgggga gctctctcc agaaacacc 
      ctctagtca aaaagaaac aaaaacggt gaatgaaaa 
      cgtacaaaa aacaacaaa agacgatgt aagtatggt 
      tcttgtaag tcaaacaaa agagcttca aactgatga 
      tttaaaaaa tcgtgattc aagtcaaaa tgataccaa 
      agacaatca aactaacac ttcaaatca ggatcacac 
      aaaagatag tttagataa gggttcaat aaattgtac 
      cgaaacaaa aaacgattt aaatgagac tccggaagg 
      caatgtaga aaataaaga tccgaatga gttttccaa 
      taagaatag ttcaatata tgaaaaaac aattgaaaa 
      tggtaatat gcaaacttc taaaaataa agaagagac 
      gaaaactga tttaaaaga ggttgcaag aagaaacga 
      aacaaaagg aaatctaaa tgtttctaa aaacaagga 
      tgtaataac agaacagat aataaatca gagcggggt 
      aacaaaagc cacaaatgc taatgaaac agtagaaca 
      cgaagtaaa taagagtca aacaaatca tagtgaaac 
      aaaagataa cgcgacgga acagataac cgtggaaaa 
      cgatgacgc aaacgctcc tgaaggtaa tgagaaaac 
      aaaaaacga tcaattggc gccccttga aagcaataa 
      tgaaacaaa aaacgatct gaataaaag cgaaaacac 
      tgtagtagc gcaaaaaac aattacgag tgttgatgt 
      aaaactatc taatgagaa tgaaaaaac aaaacacga 
      aacaaatga aaatgttaa aacttccaa agacaatga 
      gaaaacaca aaacggcct aaattcaga aaaaccttc 
      cacgagcaa tggaccaag tactaccga agccaaaaa 
      tcataatga ggtcgtaga aagtaaacc gccgttgac 
      aaaaaagca gaaaaagtc catgaaaaa atcgaaacg 
      tcgcgccca gaaacgagc agctcggag aggctcggc 
      aacgagtac tacggagtc aagcagtgg cgaaaaaca 
      gtcaataga gacagacaa cgaggtgcc cgaacccgt 
      cgtcaaaga ttatgaacc aaaaattga aaattcttc 
      ctctgataa cgctgaaaa accctcgac ctcgaccga 
      aacccagcc aaaaatttc aaccacaat tcaaatacc 
      ccaaaataa acaatctct gcttcccgt tcccccgaa 
      aagaccatc aaaaatccc gatttcgcg tcagagatc 
      agtttccaa aagcgaacc gaaatcacc cgacgtgca 
      aagtaaaat cccggttaa aaccgggag tcatattcc 
      ggttaggtg tttgattga gaaagcgaa aagtgatac 
      ggaatcgga gaaacgtcc agttatgca aaaacggaa 
      gtcggacga aatcgcaca agagatgca acaaagtgt 
      tcaaactgt caaagagat gaaccgaca attaaatac 
      tgtgaacag ggggagtct gagttcgtt tcggaacag 
      ttccgttga gtctacgac aagttcgaa gcagctgtc 
      ttacacaaa atcactaga taatgatag cgattcttc 
      tgtttctga cagtaacgt tgaagaatt gctcgaccc 
      gagcactga cgaagacag ttacgagga ttttgaaga 
      gtatgatgg gattgaaga gtccgacac tgaggacta 
      taacgagtt tgataaaaa gaaagcgaa gattgccaa 
      tgagcttga tattaattt ggcacaaat tagtgcaag 
      ggttgagga attgaccac gagtttggg tcgcaaaaa 
      tgagtttga tgagacgtg tgagtccga ggaggagta 
      tgtttctga agaaagtga ggaggaaga tgaagaaga 
      ggaagagga tgatgatga cgatgagga taatcaaat 
      tgatcttaa tattgaagt aaagcaacc gagtgaaat 
      cgagctgat ggagaggca ggcgaggcg cttcctggc 
      cgagggcca agtcgagag ctaccaaca agccgagct 
      tgccgttag cttaatgac tcttaaatt ttccgctga 
      ggaagctct cgaagctgc taaagactg ccacaccct 
      agacgccgc tatcgcata tttgcaaca agactgcga 
      actgtgcgc tggaaaata tcccatgaa tcagatcat 
      atctatgct aaaatgtac gcaccgctg ctgtcaaga 
      atgcgctaa aaattattt taccgtgca agtgactga 
      caggacgat aatggactg cacgtgccc tttctgcaa 
      acaaccgga gttgacaag cagcgaaat atccgaaga 
      cgaagtctc ggattattt tgccaattt ggatattct 
      ccttaaagg cattctaga cgcaaccgt ccatgagct 
      tttccagag gaaattgcg cgaccggac tttaatgca 
      agaccctaa tttcaagtg gtgcgttaa gtgttcgag 
      cggatttat cgccaatcc tcgccagag acgcctcgt 
      ttgtcccga ctgcaaaag cgtcacgtg tgcaaactg 
      tcgccggcc gtgggagaa acaacacga gggcatctc 
      ttgcgagaa attcgcaga atggaaaga cgccaacga 
      cccggagaa ccaggcctc cgcggttgc gaaacactt 
      agccgaaaa cggcataga ctgccccaa atgtaaatt 
      tcgatattc actggcccg agggggctg catgcattt 
      tacttgcac tcagtgcaa acacgagtt ttgctacgg 
      ctgtggcaa gccttttat gatgggggc caagtgtgg 
      ggtgagcca gtactgcgg gaaattggg gctccatgc 
      gcaccaccc ccgcaactg tctgttcta tttgcgcga 
      taaggaacc aacagagct gcaaaagtt gctcaaaga 
      gcacaaaat ccccttcga taccgacat cccggccga 
      taaagagga aaacgccgc agccgcagc taagtgttt 
      cgtgccgct gcagcggga aacccccaa cgggctcat 
      cgacacggt gtgcaacaa cgaggtttc ccccggcca 
      ggccggtct ttgcaggat gcattattt agagtactt 
      gtgtaagtt aataagacg tcacgcaat cgactcaat 
      cgacttgtt aaacgctga tgatctcga gactgtggt 
      caggcgggc cgccaaacg actgccgcc gaatgcgat 
      tgagacccg tgcgcttaa ttcgtcaat tgctttgtt 
      tctttcttg tctttctat gtcaactgc ttttttgag 
      tgcttcgtc gcctttccg tcgttctaa atcaactgc 
      ttttttaac tatttcttc tatttccct cgtacgtaa 
      ttttttgct tattccaga attcgttcg aatcccccg 
      aatctcgtt tgttaaaac tgcggctgt ccttagacc 
      caacatctt tctgcggct acagaccta tttaaaaga 
      ttataaacc agtttacaa taggagttt gattgagaa 
      agcgaaaag tgatacgga atcggagaa acgtccagt 
      tatgcaaaa acggaagtt ggacgaaat cgcacaaga 
      gatgcaaca aagtgttca aactgtcaa agagatgaa 
      ccgacaatt aaatactgt gaacagggg gagtctgag 
      ttcgtttcg gaacagttc cgttgagtc tacgacaag 
      ttcgaagca gctgtctta cacaaaatc actagataa 
      tgatagcga ttcttctgt ttctgacag taacgttga 
      agaattgct cgacccgag cactgacga agacagtta 
      cgaggattt tgaagagta tgatgggat tgaagagtc 
      cgacactga ggactataa cgagtttga taaaaagaa 
      agcgaagat tgccaatga gcttgatat taatttggc 
      acagattag tgcaagggt tgaggaatt gaccacgag 
      tttgggtcg caaaaatga gtttgatga gacgtgtga 
      gtccgagga ggagtatgt ttctgaaga aagtgagga 
      ggaagatga agaagagga agaggatga tgatgacga 
      tgaggataa tcaaattga tcttaatat tgaagtaaa 
      gcaaccgag tgaaatcga gctgatgga gaggcaggc 
      gaggcgctt cctggccga gggccaagt cgagagcta 
      ccaacaagc cgagcttgc cgttagctt aatgactct 
      taaattttc cgctgagga agctctcga agctgctaa 
      agactgcca caccctaga cgccgctat cgcatattt 
      gcaacaaga ctgcgaact gtgcgctgg aaaatatcc 
      catgaatca ggtttctgt aattttccc ggctaactt 
      taatcagtg ttcgagcgg atttatcgc caatcctcg 
      ccagagacg cctcgtttg tcccgactg caaaagcgt 
      cacgtgtgc aaactgtcg ccggccgtg ggagaaaca 
      acacgaggg catctcttg cgagaaatt cgcagaatg 
      gaaagacgc caacgaccc ggagaacca gacctccgc 
      ggttgcgaa acacttagc cgaaaacgg catagactg 
      ccccaaatg taaatttcg atattcact ggcccgagg 
      gggctgcat gcattttac ttgcactca gtgcaaaca 
      cgagttttg ctacggctg tggcaagcc ttttatgat 
      gggggccaa gtgtggggt gagccagta ctgcgggaa 
      attggggct ccatgcgca ccacccccg caactgtct 
      gttctattt gcgcgataa ggaaccaac agagctgca 
      aaagttgct caaagagca caaaatccc cttcgatac 
      cgacatccc ggccgataa agaggaaaa cgccgcagc 
      cgcagctaa gtgtttcgt gccgctgca gcgggaaac 
      ccccaacgg gctcatcga cacggtgtg caacaacga 
      ggtttcccc cggccaggc cggtctttg caggatgca 
      ttatttaga gtacttgtg taagttaat aagacgtca 
      cgcaatcga ctcaatcga cttgttaaa cgctgatga 
      tctcgagac tgtggtcag gcgggccgc caaacgact 
      gccgccgaa tgcgtacgg tacgccccg agaaatgct 
      gcattacat cgagtattt agttgggct cattggcag 
      acacaaact ggacccaat cacgatcct ggacctggt 
      ggaagtcag tcaggagtt gaagagacg cggcaaaga 
      cttgccgga aagaacggc tagttgtaa cgaccagga 
      gtacagaat tttgtgtgt caagattgt gaaggagca 
      gattccact ggattgagc gaaattaac cccacgtaa 
      aaatttcca atgacataa tatgcagtg ttattgttt 
      tca
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