Status
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Gene information
General information
TC006356 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007423.3: 7810967..7850941
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC006356
    Gene ontology

    GO terms for Tribolium

    • {{ goTerm.term }}
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      Status: {{ goTerm.status }}
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      Quotation: {{ goTerm.quotation }}
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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
    {{ blurIdResult }}
    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
    We will use your email address only for possible questions regarding this annotation. We will never show your address or give it away.
    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.
      {{ unavailableText }}

    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_04120

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: < 20 embryo/egg with embryonic tissue, no cuticle, but muscle fluorescence - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    embryo/egg not developed/not fertilized - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): more than 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 100.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 100.0% (includes death as larva, prepupa, pupa, adult)

    pupal molt not fulfilled (died as prepupa) - Number of animals showing the phenotype: 10 (11 dpi)
    Days post injection



    iBeetle screen iB_10956

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    Fertility
    egg chamber mostlynot present - Number of animals showing the phenotype: 4

    mature egg not present - Number of animals showing the phenotype: 4
    previtellogenic egg chamber not present - Number of animals showing the phenotype: 4

    vitellogenic egg chamber potentially degenerated - Number of animals showing the phenotype: 3

    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: % (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: % (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC006356 RA
      MVRETRHLW VGNLPDNIR EDRIREHFK RYGRVQSVK 
      LLSRGAKEE AGEGAMACT VAFMDIKSA SKAHNAEHK 
      IDDRTLTTE YYEPAAIPS AASPQNTPS SYSTSPGSN 
      RFPNGHGST EEHANFGDR FYERPNNRV TEGEFIRRT 
      NYHDNCRGR NRDRNYRNG PYNAIMDRS HRTLNNTWS 
      SYDSTRYNS QNETGYVST PSDTNERRS SEQTSTKKK 
      TKSRSGSRS PSPSGSTSS RSPSRSRSR SSSSSSTSS 
      TSHDTSSSS EKRPVAIRV KNLPPRSSD TSLKDGLFH 
      EYKKHGKVT WVKVVGQGA DRYAIVCFK KPEDVEKAL 
      EVSYDKLFF GCKIEVEPY QGYDVEDND LRPYEAEID 
      EFHPKATRT LFIGNLEKD VTASDLRKH FDLFGEIIE 
      IDIKKQGAV GSYAFCQYS DIVSVVKAI RAMDGEHLG 
      NNRIKLGFG KSMPTNCVW VDGVLDCNE KYLRIQFEQ 
      FGAISKVHV DRDKGQALV FYEQVVGAQ LAVNKMRGF 
      SLKGNKIQV DFASRECQE SFFEHLEKQ AGAPMDRTG 
      FEERRDSVS RTFDATTNR FSRYETPTR PRTASYSSR 
      SSVAPSQPA AIPSPGTPG SVTPRGTGS RSRLRFSDY 
      YDQTGEYGP ERHFRNYDE FSQGSGASH EDGYEHEYP 
      YTSPSNVET LPPIVNDHS GTQFVQPEL RNLQKERVH 
      LLEQLEECP SSGDELISP KKRLKLDLL ENSVPSDVI 
      IEANRDHRK VMEVRRLSD PNLKHHRRP SVDNKHLAH 
      DRYLPHAIC KRRKTAGSD SSRTHHYDH SGSESVGGS 
      RPGTPLVDE RPEHFPSEP RRVPREREG PLTLPLPRF 
      AAQVMNRGS VSVAGIKGQ KDTILSSPP PVTSPRISN 
      PKPPSPVPV PPPASPPPR PPSLSSNSS DSSDITPPS 
      PSLDERIRS LVEKYEKWS GSRALSAAG GEALAKLDA 
      TREKFRSRH KLLDLDLKE VQPSEIVKS VMAKRSVFD 
      EDLKRLENV GEKYEPKDF SAFPRVTTS VQISIPTLP 
      PTVPTATQL PKTPTMLSP RSTGTNVTA AKGLQYPFP 
      SHPPSLTPT TPTSTAAPS PASTTSTIT RGTNHGDTR 
      LKPCASVAS DNRTSSKVN VNRSGVVIK TSEKNSVNI 
      PSDTSAVVT TATTTTTQT SVKTKPSEK PSDKVTNRR 
      DSSSSGSDV KTRRNSDAK KEDSDEKER LEKEKQEKE 
      RLEKEKLER ERLERESEL EKERKEKER REKEEQEKK 
      ELEEKEKRE REEEERLEK ERQEKLEKE KEKERERKK 
      EEEKKHKED NHEKRKDDH RHRENHSES KHRDNNHTK 
      EHESRSSHE KNRHHIERD AERRKESVK ENRDNNIHE 
      KKNFEKVES RHMSIDFDR NKSYENIAK IDPSKRKER 
      NNSLPANIG IKRRLSAHD SVEHLDEVK KMKLSQDHK 
      KLSERRDSK DSTRSDEKA KSKHKNNTK VYDDKVKHN 
      NTKEKDRDE RHKNKQKLE KHKIKSKSR EKECRESPT 
      TPKSPGKEL SDKDFLARL DLRSNEEVE KQKQRKESK 
      DKKKLEEDE TKKSETKKD KHLEKSKSR EDSRSEDKK 
      CQKKDRTRK LTQNSSDNS DSDEPKKHS IFDIVDDEP 
      AYISMYDKV KARSCKNMQ KQEEEKRQE KIKAKFSQL 
      KQSRAKREE KKRSTSWDE DSDSDRERS DKIDHKTKR 
      GNKMLIMSS DEDEPRKSH KKREIYSDS DSERPRQIK 
      SEHNETSED DRVKSKLQR KGSKSRITS DTSDDELKK 
      NPIKSEIFS DNEVDQGFA DSEDKPFAK VKDEFNRII 
      KKARDKHQE TIVDQMNAQ IFGDSSSPL LDIKTERFN 
      NRHSFIENS SADENNDKK ERIEVRKKH KKKQKRQKH 
      SLSSEECNK LETVVDGIL TEEKKHHEK KKQHSKKDK 
      KRDKPKDER DKSKKSKKN KSDLKSDLK RDGKMENIF 
      GSLSEDSES GVKESDDHK PNFLDRFGD TNIQSSVYA 
      SDSDREPEK LEKERESKE EHRKRKERK RREKERRLQ 
      EEAASEQIN ENSMDYADM GKQLEANIK DDSMEEIDK 
      NEIDASHDT TDDSFRFNE NEIHEKKED RKEPREKKK 
      KRKKSKEEK QKHHHHHHH DKNKVKTEV KKEPTTPPE 
      EIKVESEES KSLPNLTDP TPSPPQNKS SSSLDFSIS 
      PVPREALIS PIPKTPTTS KEKKRDKLI PGFGTEIDE 
      KLHENAVKS ISEFEPPKE VAKQVEETK PEPAPESSE 
      EKPRVVISQ EETEDAVAA LLGESFGSG QFDECYNEE 
      EISSTNDQS SNLGEGNIA QDDEEMRQA VQSLSANDI 
      DVKPETPQS EHELQIDTD TEEAEETSN RFDQPPKTP 
      EITEQPKAP ELPSFYRPE TKATPNIGS PPSLTPIKP 
      QVSVQNEIK RPEEPKVSL SLPMLPEQP RSVISQAWN 
      IEKKDDQAN QPKIRTYGS PPIVKITEP AYPPLAALT 
      KQEHPQISS AEPIKIQTY PVLTNQKIQ MPVCAPKTS 
      TPDSPKVTT STNLSLSRL PITPIMVSK PLQATTVLL 
      PQAKIAHSL EPPVLVSTS DPRPQERPR MVFQTTSNI 
      TPHFPNIVQ SPPRMVRSL PPQALLMPA RQLPPTPYS 
      TSSQSSVPK PTIIMSTSQ LPTSKPFMP VIKETPPKL 
      VTIPEIKVT QPAVIQQTK EIKEEKPPE TEIRTSTPS 
      PVIVQTPKE PEKKPEIEE PTPPPPPSP QQQQQLAIE 
      KVTEELNLT LKKETDVKE EVETKKEQV EEKLIEEKV 
      QETLPDLKP KLETLPLST VKDQEEEKA DTESGISDI 
      SKERSSAEI LTNKDDPLD NKEDSDYWS AKEVNIDSV 
      IKILCSADE LSDHSSETG KDDWLDESK TDEKSDDSS 
      KKEEVGDEM DDITENDDK ETAGRGGRR GGRARGRKT 
      RGGMQNRRG KPVKEVVTT TVAKRGGRG GCRQKGERK 
      LSKSESDVT SDVYEFRDD SDENKERPR LILTIKSPA 
      AVNTQAVVK EVSKDVVKE PSPKPETKE EFLSPVANT 
      RKSRRLQER DVLRNTVDD TIEDVVRNT VVTRSNQNA 
      RRSTRQAVV NKPSPETPR KSPRGGRKK DRRASDPSE 
      DSSEEKSKT DSETRSESD LTEIEKPKE VEKEGIKEP 
      PHEGLKVKM LRRVKGEMQ EPTNLIDPV TGLLTPMRE 
      CEEGRYIPM LKTAEAQQQ SVIASPQQP KPKPQSLKA 
      HVLSSQAAK AVVSQQQQQ QQPPPQPIP KKSIIVTSQ 
      PVTIQPPLS KPTTPLSQA LNVNVSMPT YTAAHLSPR 
      HTVAVNVLT KALTKPQLS PNQMAALNQ KQMMNPILT 
      TQSQIINLK QPPIKQPVI NKAKPVHQQ QMLTGSVAS 
      PPLNKGPMP GLGASQNRI VQPPHPKGV MEPPKIDVS 
      LSNVILGPR SNLSPQSQL RHVPMPAYE ASLGEAIAH 
      FPPGAVPLR PPHDLPPGH YIHPHMYQL MRQQPYHLS 
      RSPMVAGTL EKSGDGQEG EEAPVTSPP LELRRPGSV 
      GLALTGRTA AVPHSLHSP HDRTTDSPQ VGQVYNVHT 
      ARMQHYHST GRYYEQTAE PPPAHRPLT SHTSLTALP 
      NDRSMSHMA ALGAPERPL SMQPDRPLS SHSALAAHM 
      GPLGTPERP MSTHLPAMG AGLGAAGNL MGAVARHVG 
      VDAPASQRG LQAATPPHA SQVPPQAES LFMLLKQYP 
      CMWQGLLAL KNDQAAVQM YFVSGNDSV AKCSLPKNT 
      DGSTPPLRI FQRMRLEPP QVEGVARKM QMENEHCML 
      LALPCGHDH MDVLKQSTN LTNGFITYL QQKQAAGIV 
      NVAAPGTTQ PPAYVVHIF PSCDFVNEN LRRIAPSLL 
      ERVADIAHL LIVITTV
    CDS sequence
    • >TC006356 RA
      atggtcaga gagactaga catttgtgg gtaggaaat 
      ttgcccgat aacatacga gaagaccgc atacgagaa 
      catttcaaa cggtatggc cgcgtgcag agtgtcaaa 
      ttgttgtcg aggggcgcc aaggaggag gcgggcgag 
      ggcgcgatg gcgtgtacg gtggcgttc atggacatc 
      aaaagtgcg tccaaagcc cacaacgcc gaacataaa 
      atcgacgat agaactctg accacggag tactacgaa 
      cctgctgcc attccgtcc gctgcttca ccgcagaac 
      acgccctcc tcgtattct acctctccg ggtagcaac 
      agatttccc aacggccat gggtcgaca gaagaacat 
      gcgaatttc ggcgaccgc ttctacgag agacccaat 
      aacagggta accgaaggt gaatttatc cgtcgaacg 
      aactaccat gataattgt aggggacgc aacagggat 
      cgaaattat agaaatggt ccctacaat gcaatcatg 
      gatcgatct cataggaca ctcaataat acatggtca 
      tcgtatgac tcgacaagg tacaatagt caaaatgaa 
      acagggtat gtatcgaca ccttcggat accaacgag 
      aggcggtcg tccgaacaa acaagtaca aagaaaaaa 
      acgaaatca agatcggga agtcggtcg ccgtcacct 
      tcggggagc acatccagc agatcacca tcgaggtct 
      cgttcgcgg agcagcagc agctcgtcg acgtcgtcc 
      acctcgcac gacacctcc tcgagcagc gaaaagcgc 
      ccggtggcc atccgcgtg aagaacttg ccaccgcgc 
      tcttcggac acgtcgctg aaagacggc cttttccac 
      gagtacaaa aaacacggc aaagtgacg tgggtcaaa 
      gtcgtaggc cagggcgcc gatcgctac gcgatcgtc 
      tgcttcaaa aagcccgaa gacgtggaa aaggccctg 
      gaggtcagc tacgataaa ctgttcttc gggtgcaaa 
      atcgaagtg gagccctac caaggctac gatgtcgaa 
      gacaacgac ttgcgaccc tacgaggcc gaaatcgat 
      gagttccac ccaaaggcc acgcggacg ctcttcatc 
      ggtaacttg gaaaaggac gttaccgct tctgatctc 
      aggaaacac ttcgacctc ttcggcgaa atcattgaa 
      atcgatatc aagaaacag ggggctgtg ggttcgtac 
      gcgttctgt caatattcg gacatcgtg agtgtagtg 
      aaggccata agggccatg gatggtgaa catttgggg 
      aataatcgg attaagttg ggattcggg aaatcgatg 
      ccgacgaat tgtgtgtgg gttgatgga gtgctcgat 
      tgcaatgag aagtacctg aggatacag ttcgagcag 
      ttcggcgcg attagtaaa gtgcacgtg gatagggac 
      aagggacag gcgttggtg ttttatgag caagtggtg 
      ggggcgcag ttggcggtt aataaaatg cgggggttt 
      agtttgaaa gggaataaa atacaagtg gattttgcc 
      agtagggaa tgtcaggaa tccttcttc gaacacttg 
      gaaaaacaa gcaggcgcg cccatggac aggacggga 
      ttcgaggag aggcgggat tcggtctcg aggactttc 
      gatgccacc accaacaga ttttcaaga tatgagact 
      cccacccgc ccccgcacc gcctcgtac agcagtcgc 
      tccagtgtg gcccccagc caacctgcc gccatccct 
      tcgcccgga actccggga tctgtaact ccacgcggg 
      accggttcg cgttcccgc ctccggttt tccgactac 
      tacgaccaa accggagaa tacggcccg gaacgccac 
      ttccggaac tacgacgag tttagtcaa ggctccggg 
      gcgtctcat gaagacggc tacgaacac gaatatccc 
      tatactagc ccctcaaat gtggagacc ctaccaccg 
      atcgtcaac gaccattcc ggcactcag ttcgttcaa 
      cccgaacta agaaattta caaaaagaa cgagtccat 
      ctacttgaa caactcgaa gagtgcccc agctctgga 
      gacgagctc ataagtccg aaaaaacgc ctgaaattg 
      gacttactc gaaaactcg gtacctagt gatgtgata 
      atcgaagct aatcgcgat caccggaaa gtgatggaa 
      gtgaggagg ttgtccgat ccgaatttg aaacaccat 
      cgaagacca tcagtggac aacaaacac ctagcacac 
      gaccggtat cttccccat gccatttgc aaaaggagg 
      aagaccgca gggagtgac tcctcaagg actcatcac 
      tacgaccat tccgggtcg gaaagcgtc gggggatct 
      cgaccgggg actccccta gtcgacgaa cggcccgaa 
      cactttccg agtgagccc cgacgcgtc ccgagggaa 
      cgcgaaggc cccctcaca ctccccctg cctcgattc 
      gccgctcaa gtgatgaat cgcggaagc gtttccgtc 
      gcaggaatc aaaggccag aaagacacc attctatct 
      agtccacca cccgttact agcccccgc atctccaac 
      cctaaacca cctagtcca gtccccgtg cccccgccg 
      gcatcgccg cccccacga ccgccaagt ctgagctca 
      aattcgagc gacagtagt gacatcacc ccaccaagt 
      ccgtcacta gacgaacgg atacgatca ctggtcgaa 
      aaatacgaa aaatggtct gggagtcgc gcattaagt 
      gctgcagga ggcgaagcg ttggctaag ttggacgcc 
      acaagggaa aagttcagg tcgaggcat aagctactc 
      gacttggac ttgaaagaa gtccaacca agtgaaatc 
      gtcaagtct gtgatggca aaaaggagt gtcttcgat 
      gaagattta aaacggttg gagaacgtg ggggagaaa 
      tacgaaccg aaggatttt agtgcgttt ccaagggtc 
      acgacaagt gtccaaatt tcaataccc acattacca 
      ccgacagta cctacagca acccagcta cctaaaaca 
      cccacaatg ctatcaccg aggtcaact ggtaccaac 
      gtgacggcg gccaaaggt ctccagtac ccgttcccg 
      agtcaccct ccgagtctc acccccacc actccgacg 
      tcaacagca gcaccctca ccggcgtcg acgacaagt 
      acaataacc aggggcacc aaccacggt gataccaga 
      ctgaaaccg tgcgcgagt gtcgctagt gataatcga 
      acatctagt aaagtgaat gtaaataga agtggtgta 
      gtgataaaa actagtgaa aagaacagc gtcaacatt 
      ccgagtgat acaagtgcg gtggtgacg acggcgacg 
      acgaccacg acccaaact agtgtcaaa acaaaaccg 
      agtgaaaaa cctagtgac aaagtcaca aatcggagg 
      gactcgagc agtagcggt agtgatgtg aaaacgcga 
      cgaaatagt gacgcgaaa aaggaagac agtgacgag 
      aaagagcgc ttggagaaa gagaaacaa gagaaagaa 
      agacttgaa aaggagaaa ctcgaacgg gaacgactg 
      gaacgtgaa agcgagtta gagaaagaa aggaaagag 
      aaagaacgt cgcgaaaaa gaagagcag gaaaagaag 
      gaactcgag gagaaagaa aaacgggaa cgggaagaa 
      gaggaacgt ttggagaaa gagcgacag gagaagctc 
      gaaaaagaa aaagaaaaa gagcgggag cgcaaaaag 
      gaagaagaa aagaaacac aaagaggac aatcacgag 
      aaacggaaa gacgaccac aggcatcgg gagaatcac 
      agtgagagc aaacataga gataacaat cacaccaaa 
      gagcacgaa tcaagaagt agccacgag aaaaaccga 
      caccacatt gaaagagat gccgaaagg agaaaggaa 
      agcgtcaag gaaaatcgc gataacaac atccacgaa 
      aagaaaaac tttgaaaag gtcgaaagc agacacatg 
      agtatcgac ttcgaccgc aacaaatcc tacgagaat 
      atcgctaaa atagatccc agcaaacga aaagaacgt 
      aacaatagt ttaccggca aacatcggg attaaaagg 
      cgcctcagt gctcatgac tcagtcgaa catttggat 
      gaagtgaag aagatgaaa ctgagtcaa gaccataag 
      aaattatcc gaaaggcga gactccaaa gacagcaca 
      cgatccgac gaaaaagcc aagagtaaa cataaaaac 
      aacacaaaa gtctacgac gacaaagtc aagcataac 
      aacacaaaa gaaaaagat cgggacgag agacacaaa 
      aataaacaa aaattggag aaacacaaa attaagagt 
      aaaagtcgg gagaaggaa tgtcgcgaa tctcctaca 
      acaccgaaa agccctggc aaagaattg tcagataag 
      gatttccta gctcgactc gacttacgt tcgaatgaa 
      gaagtcgag aagcagaaa caacgcaaa gagagtaaa 
      gacaagaag aaactcgaa gaagacgag acgaaaaaa 
      tccgaaact aagaaagac aaacacttg gaaaagagc 
      aaatcgcgt gaagactcg cgcagtgaa gataaaaaa 
      tgtcaaaag aaagaccgg acgagaaaa ctgacacag 
      aatagttcc gacaattcc gattccgac gaaccaaag 
      aaacattca atttttgat attgtggac gacgaaccg 
      gcgtacatt tccatgtat gataaagtc aaagcccgc 
      agttgcaaa aatatgcaa aaacaagag gaggaaaaa 
      cgccaggag aagattaag gccaagttt agtcagttg 
      aagcaaagt cgagccaaa cgtgaggag aagaaacgt 
      tctacttcg tgggacgaa gactcggat tcggatcgc 
      gaaagaagc gataaaatc gatcacaaa acgaaacga 
      gggaacaaa atgctgatc atgagttcg gatgaggat 
      gagccgagg aagagtcat aagaaacgc gaaatttac 
      agcgattct gactcagaa aggccgagg caaatcaag 
      tctgagcac aacgaaacc agcgaggat gaccgcgtt 
      aagagtaaa ttgcagcga aagggctcc aagtctcga 
      atcacgagc gatacgtct gacgatgag ttgaagaag 
      aatccgatc aaatcggag atcttctcg gataatgag 
      gtcgatcaa gggtttgcc gattcggag gataagccc 
      tttgcgaaa gtcaaagac gagttcaat cggattatc 
      aaaaaggcg agggataaa caccaagaa acgatcgtt 
      gatcagatg aatgctcag atctttggc gattcgagt 
      tcgccgttg cttgacata aaaactgaa cgattcaat 
      aatagacat tcattcatt gagaattct tcggctgat 
      gaaaacaat gataagaag gaacgaatt gaagtgagg 
      aaaaagcat aagaagaag cagaaacgc caaaaacac 
      tcactgagc agcgaagaa tgtaataaa cttgagaca 
      gtcgttgat gggattctc acagaagag aagaagcac 
      cacgagaaa aagaaacag cacagtaag aaggataag 
      aaaagggat aaacccaag gatgagcgg gacaagtcg 
      aaaaaatcg aagaagaat aagtctgat ctcaaatct 
      gatcttaaa cgtgatggg aaaatggag aatatattc 
      ggatcgttg tctgaagat tcggaaagt ggggttaag 
      gaatcagat gaccacaaa cccaacttt ctggaccga 
      tttggggac actaatatc caaagctcg gtctatgct 
      agtgactct gatcgcgaa cctgaaaaa ctggaaaaa 
      gagcgcgaa tcgaaagaa gaacatcgc aaacgcaaa 
      gagaggaaa cgtcgcgaa aaagaacga aggcttcaa 
      gaagaagct gcttccgag caaatcaat gaaaacagt 
      atggattat gctgatatg ggcaaacaa ctagaggcg 
      aatatcaag gacgacagt atggaagaa attgataaa 
      aatgaaatc gatgctagt cacgacaca actgatgat 
      tccttccgt tttaacgaa aacgaaatt catgagaag 
      aaggaggat cggaaagaa ccacgcgaa aagaagaag 
      aaacgcaag aagagcaag gaggagaaa cagaaacac 
      caccatcac catcaccac gataagaac aaggtgaag 
      accgaagta aagaaagaa ccgacgact cctcctgag 
      gaaatcaaa gtcgagagt gaagaaagc aagagtctt 
      ccgaattta acagacccg acaccgagt cctcctcaa 
      aataaatca tcatccagt ctcgatttc tccatatct 
      ccggtacca agagaagct ttaataagt ccaattccg 
      aaaacccct actacgtcc aaagagaag aaaagggat 
      aagcttatt cctggcttt ggcaccgaa atcgatgag 
      aaactgcac gagaacgct gtaaaatca atttccgag 
      tttgaacca ccgaaagaa gtggcaaaa caggttgag 
      gaaaccaaa cccgaaccc gcacctgaa tcaagtgaa 
      gaaaaacct cgtgttgtt atctcgcaa gaagaaacc 
      gaagatgcc gtggcagcc cttctcggt gaaagcttt 
      gggagcgga caattcgat gaatgttac aatgaggaa 
      gagatcagt tctactaat gaccaatcc tcgaatctt 
      ggtgaaggc aatatagct caagatgat gaagaaatg 
      cgacaagcg gtccaaagt ttgagcgcg aatgatatt 
      gacgtcaaa cctgaaacg ccgcaaagc gaacacgaa 
      ttgcaaatt gacacagac actgaagaa gcggaagaa 
      acttcgaat cgatttgac caacctccg aaaacaccg 
      gaaattacc gaacagccg aaagcccca gaactaccg 
      tctttctat cggccagaa acaaaagca acacctaat 
      atcggaagt ccgccatct ttaaccccg attaagcca 
      caagtttcg gtccaaaac gaaataaaa cgacccgag 
      gaacccaaa gtgtctcta agtttaccg atgttgcct 
      gaacagccg cgatcagta atttcgcaa gcttggaat 
      attgaaaag aaggatgat caggccaac caaccgaaa 
      atacgtact tatggtagt cccccaatt gttaaaatc 
      actgaaccg gcatatccg ccgttggca gcactgacg 
      aaacaggaa catccacaa ataagttcg gctgagccg 
      attaaaatt caaacctat ccagtgttg acaaaccaa 
      aagatacaa atgcccgtc tgcgcgccc aaaactagc 
      acacctgat tcaccaaaa gtcacaaca agcaccaat 
      ctctctcta agtcggctt cctataaca cctatcatg 
      gtttcgaaa ccgttacaa gcaaccacg gttttgtta 
      ccgcaggct aaaatcgcc cacagttta gagccccca 
      gttttagtt tcgacttct gatcctcga ccccaagaa 
      aggccacga atggttttc caaacaacg tcaaatatt 
      actccccac tttccaaat atcgttcaa agtccacca 
      agaatggtt cgatcgcta ccacctcaa gcactcctc 
      atgcctgcg aggcagcta ccaccaaca ccatatagt 
      accagcagc caaagtagc gttccgaaa ccaaccata 
      ataatgtca accagtcaa ctacccact tcgaaacca 
      tttatgccg gttattaaa gaaacacca ccaaaatta 
      gtaacgata ccagaaata aaggttaca cagcctgct 
      gttattcaa caaactaaa gaaattaag gaagaaaaa 
      ccaccagaa acggagatc aggacatca acaccgagt 
      ccggtgatt gtccaaaca cccaaagag cccgaaaag 
      aaacctgaa attgaggaa cctacacca ccaccacca 
      ccatcgcca caacaacaa caacaacta gccatagaa 
      aaagttact gaagagttg aatttgacc ctcaagaag 
      gaaaccgac gttaaggag gaagttgaa acgaaaaag 
      gaacaagtt gaagagaag ttaattgag gaaaaagtc 
      caagaaact ctacctgat ctcaaacca aaactggaa 
      acgcttcca ctctctact gttaaagac caagaggag 
      gaaaaagcc gacactgag agtggcata agcgacata 
      agtaaagaa aggtcaagt gccgaaatt ttgaccaat 
      aaggatgat cctctcgac aacaaagaa gatagtgat 
      tattggtcg gccaaagaa gttaatatc gactcagtc 
      atcaagatt ttatgttcc gctgacgaa ctttccgac 
      catagcagc gaaaccggc aaagacgat tggttagac 
      gaatccaaa accgatgaa aaatcagac gattcgtcc 
      aaaaaagag gaagtcggt gacgaaatg gacgatatt 
      acggaaaat gacgacaaa gaaacagct ggacgtggc 
      ggccgccga ggaggtcgg gccagaggc cgaaaaact 
      cgtggtggt atgcaaaac cgtcgcggt aaacccgtc 
      aaagaagtg gttactacc actgttgct aaacgtggt 
      ggacgcggc ggttgtcgg caaaagggc gaacgaaaa 
      ttatcaaaa tctgagtct gatgttact tctgatgtt 
      tacgaattt agagatgac tctgacgaa aataaggaa 
      cggccaaga ctgattttg actatcaaa tcgccggct 
      gcagtcaac actcaagct gtagtcaag gaagttagt 
      aaagatgtt gttaaggag ccgtcacct aagcctgaa 
      accaaagaa gagttcctg tcgccggtt gcaaacact 
      agaaagtct aggagattg caagaacgt gacgttttg 
      aggaatacg gttgatgat acaatcgaa gatgttgtg 
      aggaatacg gtggtcact aggtcgaat caaaacgca 
      cgaaggtca acacgccag gctgtggtt aataaacct 
      agccccgaa actccaaga aaatcgcca agaggtggt 
      cggaaaaag gataggaga gcctctgat ccgtctgag 
      gactcctct gaggagaaa tctaaaacc gattcggag 
      accaggtct gagagtgat ttgaccgaa attgagaaa 
      cctaaagaa gtggagaaa gagggaatt aaagaacct 
      ccgcatgaa ggcctcaaa gttaaaatg ttaagacgc 
      gtcaaaggc gaaatgcaa gaaccgacg aatttgatc 
      gatccagtg accggtctt ttgactcca atgagagaa 
      tgtgaagaa ggccgttac ataccaatg ctcaaaaca 
      gccgaagct caacaacaa tcagtcatc gcatcgcca 
      caacaacca aaacctaaa ccacagagc ctgaaagct 
      cacgtccta tcatcacag gctgccaaa gctgtagtc 
      tcccaacag caacaacaa caacaaccc ccacctcaa 
      cccattccc aaaaagagt atcattgtg acaagccaa 
      cctgtcaca atccaaccc cccttatcc aaacccacc 
      acaccccta agccaggct ttgaacgtg aacgtatca 
      atgccgact tacactgca gcccaccta tccccccgt 
      cacaccgtc gcagtaaac gtactcacc aaagcccta 
      accaaaccc caactatca cccaatcag atggcagcc 
      ttgaatcag aaacaaatg atgaacccg atcctcacc 
      acacagtca caaatcatc aacttgaaa cagccacca 
      atcaaacaa cccgtcatc aacaaagcc aaaccagtt 
      caccaacaa caaatgttg actggatcg gtggcaagt 
      cctccacta aacaaaggc ccaatgcca ggcttgggg 
      gctagtcag aacagaatc gtacaacca ccacacccc 
      aagggggtg atggagccc ccgaagatc gatgtgtcg 
      ctatcgaac gtgatcctc ggcccgaga tccaatctc 
      tcgccccaa agccagctg agacacgta ccgatgccc 
      gcgtacgag gcgagtttg ggtgaagcc attgcgcat 
      ttcccgccg ggtgcggtg cccctgcgg cccccacac 
      gaccttcca cccggccat tacatccac ccccatatg 
      taccaactg atgcggcag caaccctac catttatct 
      cgctcgcct atggtagcc ggcactttg gaaaaatca 
      ggcgacggc caagagggt gaagaagcc cctgtgaca 
      tcaccaccc cttgaactg cgccgccct ggctcagtc 
      ggcctggcc ttgacgggt cgaactgcg gccgtaccc 
      catagcctc cactcaccc catgacaga acaacagat 
      tcgcctcaa gtcggccaa gtctacaac gtgcacact 
      gcgcgaatg caacactac cattccacc ggtcgttac 
      tacgaacaa acggccgag cccccacct gcccaccgc 
      ccccttacg agccacacc tcgctcaca gccctcccc 
      aacgaccgg tccatgtcc cacatggcg gcgttgggg 
      gcccccgaa cgccccctc agcatgcaa ccggaccgg 
      cccctcagc tcgcactcg gctctggcg gctcacatg 
      ggccccttg ggcaccccc gagaggccc atgtcgacc 
      cacttaccc gcgatgggg gccggactc ggagccgcc 
      gggaatctc atgggggct gtggccaga catgtgggg 
      gtggatgca cccgccagt caacgcggc ctgcaagct 
      gcgacgccg ccacacgcc agtcaagtg ccaccgcaa 
      gccgaaagt cttttcatg ctcttaaaa caatatcca 
      tgcatgtgg caagggttg ctagctttg aagaatgat 
      caagcggct gttcaaatg tatttcgtt tcgggtaat 
      gattcggtg gccaagtgc agtttgccc aagaataca 
      gacgggtcg actccaccc ttgaggatt ttccaaagg 
      atgaggctg gagccgcct caggttgag ggagtcgcc 
      agaaaaatg cagatggag aacgagcac tgcatgctt 
      ttggcgctt ccttgcggc cacgaccac atggacgta 
      cttaaacaa tcaacgaat ttgaccaac ggtttcatc 
      acttacttg caacagaag caggccgcc gggatcgtg 
      aacgtggcc gccccggga accacccaa cctccggct 
      tacgtggtg cacattttc ccgtcgtgc gacttcgtg 
      aacgagaac ctgcgccgg atagccccc agcctgctc 
      gagcgcgtg gccgacatc gcccaccta ctcatcgta 
      ataactaca gtgtga
    mRNA sequence
    • >TC006356 RA
      tgtgtagag cgaaaatat gaggtgaag tcgctcgca 
      cagtgttta gtgaatttt cccttaaaa aaattcagt 
      ggtgcaaga tgtgattgt gtgggtacg agacggcgg 
      cagtgtttt gtttttgca gtgcgacca accatgaag 
      ttaaaacgg ctgtgttgt ttttttgtg aaatagtgt 
      ccgtgcgcc aaaaaacaa caattcctc aatgtggtg 
      tttagggca aaatggtca gagagacta gacatttgt 
      gggtaggaa atttgcccg ataacatac gagaagacc 
      gcatacgag aacatttca aacggtatg gccgcgtgc 
      agagtgtca aattgttgt cgaggggcg ccaaggagg 
      aggcgggcg agggcgcga tggcgtgta cggtggcgt 
      tcatggaca tcaaaagtg cgtccaaag cccacaacg 
      ccgaacata aaatcgacg atagaactc tgaccacgg 
      agtactacg aacctgctg ccattccgt ccgctgctt 
      caccgcaga acacgccct cctcgtatt ctacctctc 
      cgggtagca acagatttc ccaacggcc atgggtcga 
      cagaagaac atgcgaatt tcggcgacc gcttctacg 
      agagaccca ataacaggg taaccgaag gtgaattta 
      tccgtcgaa cgaactacc atgataatt gtaggggac 
      gcaacaggg atcgaaatt atagaaatg gtccctaca 
      atgcaatca tggatcgat ctcatagga cactcaata 
      atacatggt catcgtatg actcgacaa ggtacaata 
      gtcaaaatg aaacagggt atgtatcga caccttcgg 
      ataccaacg agaggcggt cgtccgaac aaacaagta 
      caaagaaaa aaacgaaat caagatcgg gaagtcggt 
      cgccgtcac cttcgggga gcacatcca gcagatcac 
      catcgaggt ctcgttcgc ggagcagca gcagctcgt 
      cgacgtcgt ccacctcgc acgacacct cctcgagca 
      gcgaaaagc gcccggtgg ccatccgcg tgaagaact 
      tgccaccgc gctcttcgg acacgtcgc tgaaagacg 
      gccttttcc acgagtaca aaaaacacg gcaaagtga 
      cgtgggtca aagtcgtag gccagggcg ccgatcgct 
      acgcgatcg tctgcttca aaaagcccg aagacgtgg 
      aaaaggccc tggaggtca gctacgata aactgttct 
      tcgggtgca aaatcgaag tggagccct accaaggct 
      acgatgtcg aagacaacg acttgcgac cctacgagg 
      ccgaaatcg atgagttcc acccaaagg ccacgcgga 
      cgctcttca tcggtaact tggaaaagg acgttaccg 
      cttctgatc tcaggaaac acttcgacc tcttcggcg 
      aaatcattg aaatcgata tcaagaaac agggggctg 
      tgggttcgt acgcgttct gtcaatatt cggacatcg 
      tgagtgtag tgaaggcca taagggcca tggatggtg 
      aacatttgg ggaataatc ggattaagt tgggattcg 
      ggaaatcga tgccgacga attgtgtgt gggttgatg 
      gagtgctcg attgcaatg agaagtacc tgaggatac 
      agttcgagc agttcggcg cgattagta aagtgcacg 
      tggataggg acaagggac aggcgttgg tgttttatg 
      agcaagtgg tgggggcgc agttggcgg ttaataaaa 
      tgcgggggt ttagtttga aagggaata aaatacaag 
      tggattttg ccagtaggg aatgtcagg aatccttct 
      tcgaacact tggaaaaac aagcaggcg cgcccatgg 
      acaggacgg gattcgagg agaggcggg attcggtct 
      cgaggactt tcgatgcca ccaccaaca gattttcaa 
      gatatgaga ctcccaccc gcccccgca ccgcctcgt 
      acagcagtc gctccagtg tggccccca gccaacctg 
      ccgccatcc cttcgcccg gaactccgg gatctgtaa 
      ctccacgcg ggaccggtt cgcgttccc gcctccggt 
      tttccgact actacgacc aaaccggag aatacggcc 
      cggaacgcc acttccgga actacgacg agtttagtc 
      aaggctccg gggcgtctc atgaagacg gctacgaac 
      acgaatatc cctatacta gcccctcaa atgtggaga 
      ccctaccac cgatcgtca acgaccatt ccggcactc 
      agttcgttc aacccgaac taagaaatt tacaaaaag 
      aacgagtcc atctacttg aacaactcg aagagtgcc 
      ccagctctg gagacgagc tcataagtc cgaaaaaac 
      gcctgaaat tggacttac tcgaaaact cggtaccta 
      gtgatgtga taatcgaag ctaatcgcg atcaccgga 
      aagtgatgg aagtgagga ggttgtccg atccgaatt 
      tgaaacacc atcgaagac catcagtgg acaacaaac 
      acctagcac acgaccggt atcttcccc atgccattt 
      gcaaaagga ggaagaccg cagggagtg actcctcaa 
      ggactcatc actacgacc attccgggt cggaaagcg 
      tcgggggat ctcgaccgg ggactcccc tagtcgacg 
      aacggcccg aacactttc cgagtgagc cccgacgcg 
      tcccgaggg aacgcgaag gccccctca cactccccc 
      tgcctcgat tcgccgctc aagtgatga atcgcggaa 
      gcgtttccg tcgcaggaa tcaaaggcc agaaagaca 
      ccattctat ctagtccac cacccgtta ctagccccc 
      gcatctcca accctaaac cacctagtc cagtccccg 
      tgcccccgc cggcatcgc cgcccccac gaccgccaa 
      gtctgagct caaattcga gcgacagta gtgacatca 
      ccccaccaa gtccgtcac tagacgaac ggatacgat 
      cactggtcg aaaaatacg aaaaatggt ctgggagtc 
      gcgcattaa gtgctgcag gaggcgaag cgttggcta 
      agttggacg ccacaaggg aaaagttca ggtcgaggc 
      ataagctac tcgacttgg acttgaaag aagtccaac 
      caagtgaaa tcgtcaagt ctgtgatgg caaaaagga 
      gtgtcttcg atgaagatt taaaacggt tggagaacg 
      tgggggaga aatacgaac cgaaggatt ttagtgcgt 
      ttccaaggg tcacgacaa gtgtccaaa tttcaatac 
      ccacattac caccgacag tacctacag caacccagc 
      tacctaaaa cacccacaa tgctatcac cgaggtcaa 
      ctggtacca acgtgacgg cggccaaag gtctccagt 
      acccgttcc cgagtcacc ctccgagtc tcaccccca 
      ccactccga cgtcaacag cagcaccct caccggcgt 
      cgacgacaa gtacaataa ccaggggca ccaaccacg 
      gtgatacca gactgaaac cgtgcgcga gtgtcgcta 
      gtgataatc gaacatcta gtaaagtga atgtaaata 
      gaagtggtg tagtgataa aaactagtg aaaagaaca 
      gcgtcaaca ttccgagtg atacaagtg cggtggtga 
      cgacggcga cgacgacca cgacccaaa ctagtgtca 
      aaacaaaac cgagtgaaa aacctagtg acaaagtca 
      caaatcgga gggactcga gcagtagcg gtagtgatg 
      tgaaaacgc gacgaaata gtgacgcga aaaaggaag 
      acagtgacg agaaagagc gcttggaga aagagaaac 
      aagagaaag aaagacttg aaaaggaga aactcgaac 
      gggaacgac tggaacgtg aaagcgagt tagagaaag 
      aaaggaaag agaaagaac gtcgcgaaa aagaagagc 
      aggaaaaga aggaactcg aggagaaag aaaaacggg 
      aacgggaag aagaggaac gtttggaga aagagcgac 
      aggagaagc tcgaaaaag aaaaagaaa aagagcggg 
      agcgcaaaa aggaagaag aaaagaaac acaaagagg 
      acaatcacg agaaacgga aagacgacc acaggcatc 
      gggagaatc acagtgaga gcaaacata gagataaca 
      atcacacca aagagcacg aatcaagaa gtagccacg 
      agaaaaacc gacaccaca ttgaaagag atgccgaaa 
      ggagaaagg aaagcgtca aggaaaatc gcgataaca 
      acatccacg aaaagaaaa actttgaaa aggtcgaaa 
      gcagacaca tgagtatcg acttcgacc gcaacaaat 
      cctacgaga atatcgcta aaatagatc ccagcaaac 
      gaaaagaac gtaacaata gtttaccgg caaacatcg 
      ggattaaaa ggcgcctca gtgctcatg actcagtcg 
      aacatttgg atgaagtga agaagatga aactgagtc 
      aagaccata agaaattat ccgaaaggc gagactcca 
      aagacagca cacgatccg acgaaaaag ccaagagta 
      aacataaaa acaacacaa aagtctacg acgacaaag 
      tcaagcata acaacacaa aagaaaaag atcgggacg 
      agagacaca aaaataaac aaaaattgg agaaacaca 
      aaattaaga gtaaaagtc gggagaagg aatgtcgcg 
      aatctccta caacaccga aaagccctg gcaaagaat 
      tgtcagata aggatttcc tagctcgac tcgacttac 
      gttcgaatg aagaagtcg agaagcaga aacaacgca 
      aagagagta aagacaaga agaaactcg aagaagacg 
      agacgaaaa aatccgaaa ctaagaaag acaaacact 
      tggaaaaga gcaaatcgc gtgaagact cgcgcagtg 
      aagataaaa aatgtcaaa agaaagacc ggacgagaa 
      aactgacac agaatagtt ccgacaatt ccgattccg 
      acgaaccaa agaaacatt caatttttg atattgtgg 
      acgacgaac cggcgtaca tttccatgt atgataaag 
      tcaaagccc gcagttgca aaaatatgc aaaaacaag 
      aggaggaaa aacgccagg agaagatta aggccaagt 
      ttagtcagt tgaagcaaa gtcgagcca aacgtgagg 
      agaagaaac gttctactt cgtgggacg aagactcgg 
      attcggatc gcgaaagaa gcgataaaa tcgatcaca 
      aaacgaaac gagggaaca aaatgctga tcatgagtt 
      cggatgagg atgagccga ggaagagtc ataagaaac 
      gcgaaattt acagcgatt ctgactcag aaaggccga 
      ggcaaatca agtctgagc acaacgaaa ccagcgagg 
      atgaccgcg ttaagagta aattgcagc gaaagggct 
      ccaagtctc gaatcacga gcgatacgt ctgacgatg 
      agttgaaga agaatccga tcaaatcgg agatcttct 
      cggataatg aggtcgatc aagggtttg ccgattcgg 
      aggataagc cctttgcga aagtcaaag acgagttca 
      atcggatta tcaaaaagg cgagggata aacaccaag 
      aaacgatcg ttgatcaga tgaatgctc agatctttg 
      gcgattcga gttcgccgt tgcttgaca taaaaactg 
      aacgattca ataatagac attcattca ttgagaatt 
      cttcggctg atgaaaaca atgataaga aggaacgaa 
      ttgaagtga ggaaaaagc ataagaaga agcagaaac 
      gccaaaaac actcactga gcagcgaag aatgtaata 
      aacttgaga cagtcgttg atgggattc tcacagaag 
      agaagaagc accacgaga aaaagaaac agcacagta 
      agaaggata agaaaaggg ataaaccca aggatgagc 
      gggacaagt cgaaaaaat cgaagaaga ataagtctg 
      atctcaaat ctgatctta aacgtgatg ggaaaatgg 
      agaatatat tcggatcgt tgtctgaag attcggaaa 
      gtggggtta aggaatcag atgaccaca aacccaact 
      ttctggacc gatttgggg acactaata tccaaagct 
      cggtctatg ctagtgact ctgatcgcg aacctgaaa 
      aactggaaa aagagcgcg aatcgaaag aagaacatc 
      gcaaacgca aagagagga aacgtcgcg aaaaagaac 
      gaaggcttc aagaagaag ctgcttccg agcaaatca 
      atgaaaaca gtatggatt atgctgata tgggcaaac 
      aactagagg cgaatatca aggacgaca gtatggaag 
      aaattgata aaaatgaaa tcgatgcta gtcacgaca 
      caactgatg attccttcc gttttaacg aaaacgaaa 
      ttcatgaga agaaggagg atcggaaag aaccacgcg 
      aaaagaaga agaaacgca agaagagca aggaggaga 
      aacagaaac accaccatc accatcacc acgataaga 
      acaaggtga agaccgaag taaagaaag aaccgacga 
      ctcctcctg aggaaatca aagtcgaga gtgaagaaa 
      gcaagagtc ttccgaatt taacagacc cgacaccga 
      gtcctcctc aaaataaat catcatcca gtctcgatt 
      tctccatat ctccggtac caagagaag ctttaataa 
      gtccaattc cgaaaaccc ctactacgt ccaaagaga 
      agaaaaggg ataagctta ttcctggct ttggcaccg 
      aaatcgatg agaaactgc acgagaacg ctgtaaaat 
      caatttccg agtttgaac caccgaaag aagtggcaa 
      aacaggttg aggaaacca aacccgaac ccgcacctg 
      aatcaagtg aagaaaaac ctcgtgttg ttatctcgc 
      aagaagaaa ccgaagatg ccgtggcag cccttctcg 
      gtgaaagct ttgggagcg gacaattcg atgaatgtt 
      acaatgagg aagagatca gttctacta atgaccaat 
      cctcgaatc ttggtgaag gcaatatag ctcaagatg 
      atgaagaaa tgcgacaag cggtccaaa gtttgagcg 
      cgaatgata ttgacgtca aacctgaaa cgccgcaaa 
      gcgaacacg aattgcaaa ttgacacag acactgaag 
      aagcggaag aaacttcga atcgatttg accaacctc 
      cgaaaacac cggaaatta ccgaacagc cgaaagccc 
      cagaactac cgtctttct atcggccag aaacaaaag 
      caacaccta atatcggaa gtccgccat ctttaaccc 
      cgattaagc cacaagttt cggtccaaa acgaaataa 
      aacgacccg aggaaccca aagtgtctc taagtttac 
      cgatgttgc ctgaacagc cgcgatcag taatttcgc 
      aagcttgga atattgaaa agaaggatg atcaggcca 
      accaaccga aaatacgta cttatggta gtcccccaa 
      ttgttaaaa tcactgaac cggcatatc cgccgttgg 
      cagcactga cgaaacagg aacatccac aaataagtt 
      cggctgagc cgattaaaa ttcaaacct atccagtgt 
      tgacaaacc aaaagatac aaatgcccg tctgcgcgc 
      ccaaaacta gcacacctg attcaccaa aagtcacaa 
      caagcacca atctctctc taagtcggc ttcctataa 
      cacctatca tggtttcga aaccgttac aagcaacca 
      cggttttgt taccgcagg ctaaaatcg cccacagtt 
      tagagcccc cagttttag tttcgactt ctgatcctc 
      gaccccaag aaaggccac gaatggttt tccaaacaa 
      cgtcaaata ttactcccc actttccaa atatcgttc 
      aaagtccac caagaatgg ttcgatcgc taccacctc 
      aagcactcc tcatgcctg cgaggcagc taccaccaa 
      caccatata gtaccagca gccaaagta gcgttccga 
      aaccaacca taataatgt caaccagtc aactaccca 
      cttcgaaac catttatgc cggttatta aagaaacac 
      caccaaaat tagtaacga taccagaaa taaaggtta 
      cacagcctg ctgttattc aacaaacta aagaaatta 
      aggaagaaa aaccaccag aaacggaga tcaggacat 
      caacaccga gtccggtga ttgtccaaa cacccaaag 
      agcccgaaa agaaacctg aaattgagg aacctacac 
      caccaccac caccatcgc cacaacaac aacaacaac 
      tagccatag aaaaagtta ctgaagagt tgaatttga 
      ccctcaaga aggaaaccg acgttaagg aggaagttg 
      aaacgaaaa aggaacaag ttgaagaga agttaattg 
      aggaaaaag tccaagaaa ctctacctg atctcaaac 
      caaaactgg aaacgcttc cactctcta ctgttaaag 
      accaagagg aggaaaaag ccgacactg agagtggca 
      taagcgaca taagtaaag aaaggtcaa gtgccgaaa 
      ttttgacca ataaggatg atcctctcg acaacaaag 
      aagatagtg attattggt cggccaaag aagttaata 
      tcgactcag tcatcaaga ttttatgtt ccgctgacg 
      aactttccg accatagca gcgaaaccg gcaaagacg 
      attggttag acgaatcca aaaccgatg aaaaatcag 
      acgattcgt ccaaaaaag aggaagtcg gtgacgaaa 
      tggacgata ttacggaaa atgacgaca aagaaacag 
      ctggacgtg gcggccgcc gaggaggtc gggccagag 
      gccgaaaaa ctcgtggtg gtatgcaaa accgtcgcg 
      gtaaacccg tcaaagaag tggttacta ccactgttg 
      ctaaacgtg gtggacgcg gcggttgtc ggcaaaagg 
      gcgaacgaa aattatcaa aatctgagt ctgatgtta 
      cttctgatg tttacgaat ttagagatg actctgacg 
      aaaataagg aacggccaa gactgattt tgactatca 
      aatcgccgg ctgcagtca acactcaag ctgtagtca 
      aggaagtta gtaaagatg ttgttaagg agccgtcac 
      ctaagcctg aaaccaaag aagagttcc tgtcgccgg 
      ttgcaaaca ctagaaagt ctaggagat tgcaagaac 
      gtgacgttt tgaggaata cggttgatg atacaatcg 
      aagatgttg tgaggaata cggtggtca ctaggtcga 
      atcaaaacg cacgaaggt caacacgcc aggctgtgg 
      ttaataaac ctagccccg aaactccaa gaaaatcgc 
      caagaggtg gtcggaaaa aggatagga gagcctctg 
      atccgtctg aggactcct ctgaggaga aatctaaaa 
      ccgattcgg agaccaggt ctgagagtg atttgaccg 
      aaattgaga aacctaaag aagtggaga aagagggaa 
      ttaaagaac ctccgcatg aaggcctca aagttaaaa 
      tgttaagac gcgtcaaag gcgaaatgc aagaaccga 
      cgaatttga tcgatccag tgaccggtc ttttgactc 
      caatgagag aatgtgaag aaggccgtt acataccaa 
      tgctcaaaa cagccgaag ctcaacaac aatcagtca 
      tcgcatcgc cacaacaac caaaaccta aaccacaga 
      gcctgaaag ctcacgtcc tatcatcac aggctgcca 
      aagctgtag tctcccaac agcaacaac aacaacaac 
      ccccacctc aacccattc ccaaaaaga gtatcattg 
      tgacaagcc aacctgtca caatccaac cccccttat 
      ccaaaccca ccacacccc taagccagg ctttgaacg 
      tgaacgtat caatgccga cttacactg cagcccacc 
      tatcccccc gtcacaccg tcgcagtaa acgtactca 
      ccaaagccc taaccaaac cccaactat cacccaatc 
      agatggcag ccttgaatc agaaacaaa tgatgaacc 
      cgatcctca ccacacagt cacaaatca tcaacttga 
      aacagccac caatcaaac aacccgtca tcaacaaag 
      ccaaaccag ttcaccaac aacaaatgt tgactggat 
      cggtggcaa gtcctccac taaacaaag gcccaatgc 
      caggcttgg gggctagtc agaacagaa tcgtacaac 
      caccacacc ccaaggggg tgatggagc ccccgaaga 
      tcgatgtgt cgctatcga acgtgatcc tcggcccga 
      gatccaatc tctcgcccc aaagccagc tgagacacg 
      taccgatgc ccgcgtacg aggcgagtt tgggtgaag 
      ccattgcgc atttcccgc cgggtgcgg tgcccctgc 
      ggcccccac acgaccttc cacccggcc attacatcc 
      acccccata tgtaccaac tgatgcggc agcaaccct 
      accatttat ctcgctcgc ctatggtag ccggcactt 
      tggaaaaat caggcgacg gccaagagg gtgaagaag 
      cccctgtga catcaccac cccttgaac tgcgccgcc 
      ctggctcag tcggcctgg ccttgacgg gtcgaactg 
      cggccgtac cccatagcc tccactcac cccatgaca 
      gaacaacag attcgcctc aagtcggcc aagtctaca 
      acgtgcaca ctgcgcgaa tgcaacact accattcca 
      ccggtcgtt actacgaac aaacggccg agcccccac 
      ctgcccacc gccccctta cgagccaca cctcgctca 
      cagccctcc ccaacgacc ggtccatgt cccacatgg 
      cggcgttgg gggcccccg aacgccccc tcagcatgc 
      aaccggacc ggcccctca gctcgcact cggctctgg 
      cggctcaca tgggcccct tgggcaccc ccgagaggc 
      ccatgtcga cccacttac ccgcgatgg gggccggac 
      tcggagccg ccgggaatc tcatggggg ctgtggcca 
      gacatgtgg gggtggatg cacccgcca gtcaacgcg 
      gcctgcaag ctgcgacgc cgccacacg ccagtcaag 
      tgccaccgc aagccgaaa gtcttttca tgctcttaa 
      aacaatatc catgcatgt ggcaagggt tgctagctt 
      tgaagaatg atcaagcgg ctgttcaaa tgtatttcg 
      tttcgggta atgattcgg tggccaagt gcagtttgc 
      ccaagaata cagacgggt cgactccac ccttgagga 
      ttttccaaa ggatgaggc tggagccgc ctcaggttg 
      agggagtcg ccagaaaaa tgcagatgg agaacgagc 
      actgcatgc ttttggcgc ttccttgcg gccacgacc 
      acatggacg tacttaaac aatcaacga atttgacca 
      acggtttca tcacttact tgcaacaga agcaggccg 
      ccgggatcg tgaacgtgg ccgccccgg gaaccaccc 
      aacctccgg cttacgtgg tgcacattt tcccgtcgt 
      gcgacttcg tgaacgaga acctgcgcc ggatagccc 
      ccagcctgc tcgagcgcg tggccgaca tcgcccacc 
      tactcatcg taataacta cagtgtgat agcatgatt 
      gtttcagta tttcgttca ctctgacac tggaaatga 
      ctactttaa ccacaatgt gtgtcttac tctcaccga 
      tttttttcg caaaatctc gaaatgtgg acgttatcc 
      aaaactgga attacttaa aatatattt aaaagtttc 
      actgtgatt tcttgacaa acgttattt actattatt 
      aaaaaaatg ataaaacta ttaaaaaaa cgctaaaat 
      taacttact acctattta agaagatct catattgaa 
      tttagttat acaattttt tcttgtttg aaagatctt 
      tattttcgt acgtgtaca cgttcgggg catacttgc 
      aatatttgc aagtatgcc gcgaaagtt attttaagt 
      ttgactttg ggattttgg tgctctagg tttattttt 
      ttatcattt tattatcac acgagcgcg ctcgccagc 
      gagcgcgtt cgtgtgact cttatttta atactttct 
      actagagcg tttatatag tttttgtta ttatttttt 
      gggtttatt ttgtagaaa gtatggaaa tgagttgtg 
      caacgcaat ctcaaagtt ttgttgcgg cttcagcaa 
      ggctgtaca tttcaaatt aaacgttac ccgtttgta 
      gtttgaaaa tatggctaa tataaataa acaaaaaaa 
      gtatataga cataatata taaatatgt agcatatat 
      gattatatg aagaaatca atcattttt taaattaca 
      atgtaatat atatgtgaa tatagttta atttgttac 
      tttaagctt tttttgagt tatcgttaa gatgttctg 
      tacagtgta ctctaggct gtaagtatg agttagcca 
      gcgttacaa aaataatat agggaacat tgtgatgtc 
      tatatatta ctgtaaatt ttgtacata aactgtgta 
      ttgtgagta tacattatt ataactatt acaacaaaa 
      cgtctctca tttcaattc aaattcccc gcctacaaa 
      agattaggc cggcatggg gcccctgtt gacttctcg 
      gggggcacg taaccgatc ctcgcgtaa acttcctcc 
      ttcggcttg gggccgctc tgccaactt gggcccccc 
      tcaaagacc ttcgccttc tcctgctcc ttggctatc 
      tgctgccgc atgaactca tactcgcga atatcgtcc 
      actttcagt tctatagtc gtggggggc ctccgtaac 
      atgattcgt ctgaaaaac tcaaacata accttttga 
      agcaaaaaa actcactct atacaaatt tgtcgcaac 
      tgataaaag cctgaagtg gtatttatg tttatatca 
      tagaatact gaacggttt ttttattgt ttgcctggt 
      ttatctaat taacaccaa cataacctc aaatcttag 
      tacagtcta cttcgcacg taacgtcaa attgtac
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