Status
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Gene information
General information
TC004749 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007416.3: 6357346..6370599
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC004749
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
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    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
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    Email
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    Publish name
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_03833

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 20.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 embryo/egg with muscle fluorescence/pattern, but not hatched (pot. late embryonic lethality) - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    larval musculature irregular - Penetrance (percentage of animals/eggs on slide): less than 30%
    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    remarks: muscle pattern potentially obscured by segmentation defect,
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    larva random partiallyconstricted - Penetrance (percentage of animals/eggs on slide): less than 30%
    abdomen partially circumference constricted - Penetrance (percentage of animals/eggs on slide): less than 30%
    abdomen partially constricted - Penetrance (percentage of animals/eggs on slide): less than 30%

    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): less than 30%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 10.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 10.0% (includes death as larva, prepupa, pupa, adult)

    larva lethality - Number of animals showing the phenotype: 1 (11 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 2 (41 dpi)
    Days post injection


    Fertility
    egg production: number no/almost no eggs -
    mature egg deposition >5 number 2nd lateral oviduct: number 1st lateral oviduct: blocked - Number of animals showing the phenotype: 4
    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC004749 RA
      MSVASDYSS EEELSLFRP FTRESLAVI ETRIAEEYA 
      KQKELEKKR AEGEIRYED EDEDEGPQP DPTLEQGLP 
      LPVRLHSTF PPELASTPL EDIDPFYSN QRTFVVVSK 
      GKDIFRFSA TNALWVLDP FNPIRRVAI YILVHPLFS 
      LFIITTILV NCILMIMPT TPTVESTEV IFTGIYTFE 
      SAVKVMARG FILQPFTYL RDAWNWLDF VVIALAYVT 
      MGIDLGNLA ALRTFRVLR ALKTVAIVP GLKTIVGAV 
      IESVKNLRD VIILTMFSL SVFALIGLQ IYMGVLTQK 
      CIKEFPLDG SWGNLTHEN WERFVSNES NWYWDDEKG 
      ERPLCGNSS GSGMCKEGY VCLQGYGDN PNYGYTSFD 
      TFGWALLSA FRLMTQDYW ENLYQLVLR SAGPWHMLF 
      FIVIIFLGS FYLVNLILA IVAMSYDEL QKKAQDEEE 
      AEANAIREA EQKAKDKQD RADARAAAA VEAAEAAAA 
      AAAAAAAGC DNDQYIIKS SSDYSCHSY ESFVGQPNG 
      QDDNNKEKI SIRSEGLDS VSEQRRVPT NLSKMRKVS 
      AASLSLPGS PFNLRRGSR GSHQFTLRN NRRMVAPPG 
      DRKPLVLST YLDAQEHLP YADDSNAVT PMSEENGVM 
      VLPMYYTNL GSRHSSYTS HASRMSYTS HGDLLGGLG 
      SNGKMMTKE SQLRNRSLR NGPAAAPLN HKSTRGVYD 
      GPTGHICES KVKQIDNPF IDSNQRQTV VDMKDVMVL 
      NDIIEQAAV SGGSDRGAN NDDEEEEPT FRERFLAYA 
      IKIIDMFCV WDCCKCWVV IQKFVALLV FDPFVELFI 
      TLCIVVNTL FMALDHHDM DKDLEKALK SGNYFFTAT 
      FMIEATLKL IAMSPKYYF QEGWNIFDF IIVALSLLE 
      LGLEGVQGL SVLRSFRLL RVFKLAKSW PTLNLLISI 
      MGRTMGALG NLTFVLCII IFIFAVMGM QLFGKNYTD 
      NVDRFPDHE LPRWNFTDF MHSFMIVFR VLCGEWIES 
      MWDCMLVGD VSCIPFFLA TVVIGNLVV LNLFLALLL 
      SNFGSSSLS APTADNDTN KIAEAFDRI GRFIRWIKG 
      NVLHIAKLV RFKLTNQIS DQPSDVRCD GGLDISGDE 
      ILADGIIKK SPKDRLEVT IGTGMDLTV HGDPKRGKN 
      NINKSKTIG NSILEHGMY IGHLDEDEI SNKSYGSHK 
      NRFKEESHK GSVDMLDDH EEKRDASKE ELGIGEEET 
      EDDRFDLEK PLTDIVIVG NADDIIIDD YAADCFPDS 
      CYKKFPFLA GDEDSPFWQ GWGNLRSKT YRLIENKYF 
      ETAVITMIL LSSMALALE DVHLQSRPI LQDILYYMD 
      RIFTVIFFF EMLIKWLAL GFQKYFTNA WCWLDFVIV 
      MVSLINFIA SLCGAGGIQ AFKTMRTLR ALRPLRAMS 
      RMQGMRVVV NALVQAIPS IFNVLLVCL IFWLIFAIM 
      GVQLFAGKY FKCVDANKT TLSYEIIPD VNACKAENY 
      TWENSPMNF DHVGKAYLC LFQVATFKG WIQIMNDAI 
      DSRDINKQP IRETNIYMY LYFVFFIIF GSFFTLNLF 
      IGVIIDNFN EQKKKGGDS LALMMTDAQ KKYYNAMKK 
      MGSKKPMKA IPRPRWRPQ AIVFEIVTN KKFDMIIML 
      FIGLNMLTM TMDHYQQKE TFTKVLDSL NMIFIVIFS 
      TECLMKIFA LRYHYFTEP WNLFDLVVV ILSILGLVL 
      SDIIEKYFV SPTLLRVVR VAKVGRVLR LVKGAKGIR 
      TLLFALAMS LPALFNICL LLFLVMFIF AIFGMSFFM 
      HVKDKSGLD DVYNFKTFG QSMILLFQM STSAGWDGV 
      LDGIINEED CKPPNSEIG ETGNCGNST IGIAFLLSY 
      LVISFLIVI NMYIAVILE NYSQATEDV QEGLTDDDY 
      DMYYEIWQQ FDPDGTQYI RYDQLSDLF DVLEPPLQI 
      HKPNKFKIY SMDIPICKG DMMFCVDIL DALTKDFFA 
      RKGNEIEET AELSEVQPR QNEPGYEQV SSTLYRQRE 
      EYCARLIQN AWRKYRQRT GGAPEQVNV DGAAGEGDG 
      EVEVHQTAV LVESDGFVT KNGHKVVLH SRTPSISSK 
      SADV
    CDS sequence
    • >TC004749 RA
      atgtccgtt gcctctgac tattcgtcc gaggaggag 
      ctcagccta ttccgtcca ttcactcgc gagtctctt 
      gcggtcatc gagacgaga attgcggaa gaatatgct 
      aagcagaag gagctcgaa aagaaaaga gctgaagga 
      gagattcgg tatgaggac gaggacgaa gatgaaggt 
      ccccagcct gatccaact ctggagcag gggctgccc 
      ttgccagta cgtcttcac agtaccttt cctccggaa 
      ctggccagt acaccactt gaagacatc gaccctttt 
      tacagtaac caaaggact tttgtagtg gttagtaaa 
      ggcaaggac attttccgg tttagcgcc acaaacgcc 
      ctgtgggta ctcgatccc ttcaatccg atccgtcga 
      gtggccatt tacattcta gtgcatcct ttgttttct 
      ctttttatc attaccaca atcctcgtt aactgtatc 
      cttatgatc atgcccaca acacccacc gtagagtca 
      accgaagtg atattcaca ggcatctac acgtttgaa 
      tcagctgtg aaggtgatg gcgagaggt tttatccta 
      caaccgttc acctacctt agagatgca tggaactgg 
      ctcgacttc gtagtcata gctttagct tatgtcacc 
      atgggtata gaccttggg aatcttgct gccttgaga 
      acatttagg gtactacga gctctaaaa actgttgcc 
      attgtgcca ggtttgaag actatcgtg ggagctgta 
      atagaatct gtaaaaaat ctccgagat gtgataatt 
      ttaacaatg ttttccctg tcagtgttc gcattgata 
      ggtttacaa atttatatg ggtgtttta acacaaaaa 
      tgtatcaaa gaatttcct ctggatggc tcttggggg 
      aacctcacc cacgaaaac tgggagaga tttgttagc 
      aacgaatcc aactggtat tgggatgac gaaaaaggc 
      gaaaggcct ctgtgtgga aactcctca ggatcggga 
      atgtgcaaa gagggttac gtttgtttg caaggttac 
      ggtgataac ccaaactat ggttacacc agctttgat 
      acttttggt tgggcatta ctttccgcc ttcagatta 
      atgactcag gattattgg gagaattta taccaactg 
      gttttaaga tcagccggt ccttggcat atgctattt 
      tttatcgtg attatattt ttgggttcg ttttattta 
      gttaacttg atcttggct atcgtcgct atgtcgtac 
      gacgagttg cagaagaaa gcccaagat gaggaagaa 
      gctgaagct aacgctata agggaagcc gagcaaaag 
      gcaaaggac aagcaagat cgggcggat gcgagggca 
      gcggcggcc gtggaggcg gccgaggca gcggccgct 
      gccgcggcg gcggcggca gcagggtgt gacaacgac 
      cagtacatc ataaaatcg tcttcggac tactcgtgt 
      cacagctat gagtcgttc gtggggcaa cccaacggt 
      caagacgac aacaacaag gagaagatt agcatacgc 
      tcggaagga ttagattcc gtgagtgaa cagagaaga 
      gttcctact aatctgagc aagatgcgg aaagtcagc 
      gctgccagt ctcagcctc cccggctct cccttcaac 
      cttcggcga gggtcccga ggtagccac cagttcacc 
      ttgcggaac aataggcgc atggtggct ccgccgggc 
      gatcgaaag cccttggtg ctgtcgacc taccttgac 
      gcccaagag cacctcccc tacgccgac gactctaac 
      gccgtcacc cccatgagc gaggagaac ggcgtcatg 
      gtcctgccc atgtactac accaacctg ggatcacgt 
      cattcatcg tacacttca catgcctca cggatgtca 
      tacacttct catggagat ttgttaggc ggtttggga 
      agcaatggc aaaatgatg acgaaggag agccagctc 
      aggaaccga tcgctgaga aacggacca gcggccgct 
      cccctaaac cacaagtca acgcgaggc gtctacgat 
      ggtcccacg gggcacatt tgcgaatca aaagttaag 
      caaattgac aatcctttt atcgatagc aatcagcga 
      cagacagtc gtggacatg aaagatgtt atggtgctg 
      aacgacatc atcgagcaa gctgccgtg agcggaggc 
      agtgaccgc ggagccaat aatgacgac gaagaggaa 
      gagccgacg ttcagggaa cgcttcctg gcttatgcc 
      atcaaaatc attgacatg ttttgcgta tgggattgt 
      tgtaaatgt tgggtcgtt attcagaag tttgtcgcc 
      cttcttgtc ttcgaccca ttcgtcgag ctttttatc 
      acgctgtgc attgttgtt aacaccttg tttatggca 
      ttggatcac cacgacatg gacaaggat ttggaaaag 
      gctttgaag agcggaaac tactttttt actgcgact 
      tttatgatt gaagctact ttaaaattg attgcaatg 
      agtccgaaa tactacttt caagaaggc tggaacatt 
      tttgatttt attatagtg gcgttatcg ttgctggag 
      ctaggactg gaaggcgtt caaggctta tcggtcttg 
      cgttcattt cgactgtta cgagtgttc aaactggcc 
      aagtcgtgg ccaacttta aatttactc atttccata 
      atgggtaga acgatgggt gctttagga aacttgact 
      tttgtgctc tgtattata atatttatt tttgccgtt 
      atgggcatg caactgttt gggaaaaat tacacagat 
      aacgtggat cggtttccc gaccacgag ctcccccgc 
      tggaacttc accgacttc atgcattcg tttatgata 
      gtttttcgc gttttgtgt ggcgaatgg atcgagtcc 
      atgtgggac tgtatgctg gtgggcgac gtctcttgc 
      attccgttc tttctcgca actgtcgtg attggcaat 
      cttgtggtc cttaatctt ttcttagcc ctgcttttg 
      agtaacttt ggatcttcg agtctgtcg gcgccgact 
      gccgacaat gacacgaat aaaatagca gaggctttt 
      gacagaatc ggccgcttt atcagatgg atcaaaggc 
      aatgtttta catatcgca aaactggtc cgattcaag 
      ctcaccaac caaatttcc gaccagccg tcagatgtg 
      agatgtgat ggtggttta gatatctcc ggagacgaa 
      attttagcc gacggtata attaaaaaa agtcctaaa 
      gaccgactg gaagtaaca attggcacc ggaatggat 
      cttaccgtg catggtgat cccaaaaga ggcaaaaac 
      aatattaac aaaagcaaa acaatcgga aattcaatt 
      ctggaacat ggaatgtac atcggtcac ctggacgaa 
      gacgaaatt agtaacaaa tcgtacggt agtcacaaa 
      aatcgattt aaagaggaa agtcataaa gggagtgtt 
      gatatgtta gacgaccat gaggagaaa cgagatgct 
      agtaaagaa gaattagga attggtgaa gaagaaaca 
      gaagacgac agatttgac ttggaaaaa ccactgact 
      gacattgtg attgtggga aacgctgac gatataatt 
      atcgacgat tacgcagcc gactgcttt cccgattca 
      tgttacaag aagtttccg tttcttgca ggcgacgag 
      gattcgccg ttttggcag ggttggggg aatttaagg 
      tcgaagact tatagacta atagagaac aaatatttt 
      gaaacggcc gtaatcacg atgattttg ttgagtagc 
      atggcgttg gcgttagaa gacgtacat ttgcaaagt 
      cggccgatt ttgcaagac atactgtat tacatggat 
      cgaatattc accgtgata ttctttttc gagatgttg 
      ataaagtgg ttagcgtta gggttccaa aaatacttt 
      acgaacgct tggtgctgg ctagatttt gtgattgta 
      atggtgtct ctcattaat tttattgcc tctctttgt 
      ggcgctggc gggattcaa gcatttaaa actatgcga 
      acgctgcgg gctttgaga ccacttcgc gccatgtcc 
      cgcatgcaa gggatgagg gttgtcgtt aatgcattg 
      gtgcaagcg ataccgtct atcttcaat gtactgcta 
      gtgtgctta atattttgg ttaattttt gctataatg 
      ggtgtgcag ttattcgct ggtaaatac tttaagtgc 
      gtggatgca aacaaaacc acactaagc tatgagatt 
      atccctgat gttaacgcg tgtaaagct gagaattac 
      acgtgggaa aactcccca atgaatttt gatcatgtg 
      ggcaaagca tatttgtgc ttatttcaa gtggcgaca 
      ttcaagggg tggattcaa attatgaac gatgctata 
      gattctaga gacatcaac aaacaacca ataagagaa 
      acaaacatt tatatgtat ttatacttc gtatttttt 
      ataatattt ggatcgttt tttacactt aacttattc 
      attggtgta atcatcgat aattttaac gaacaaaag 
      aaaaagggt ggcgattca ttggcactg atgatgaca 
      gacgcccag aagaaatat tacaatgcg atgaaaaaa 
      atgggctct aagaaacca atgaaggcg ataccgagg 
      ccgaggtgg agacctcaa gctatagtt ttcgaaata 
      gtaacaaat aagaaattt gatatgata atcatgttg 
      tttattgga ctgaacatg cttacgatg acaatggat 
      cactaccaa cagaaagaa actttcacg aaagtcctc 
      gattccctc aacatgatt ttcattgtt atctttagt 
      accgagtgc ctcatgaaa atttttgcg ttacgttac 
      cactacttt acggaacct tggaacctg ttcgattta 
      gtggtagta atattatca attttgggt ttggttttg 
      agtgacatc atagagaaa tatttcgtg tcaccgacg 
      ttgttaagg gtggttcgt gtggccaaa gtagggcga 
      gttctgcgt ttggtgaaa ggtgcaaag ggcattcgg 
      acactgctg ttcgcacta gccatgtca ctgccggca 
      ctgttcaac atctgtttg ttgctgttc ctggtcatg 
      ttcattttt gccatcttc gggatgtcg ttcttcatg 
      cacgtgaag gacaagagc ggacttgac gatgtctac 
      aactttaaa acgtttggc cagtcgatg attctcctc 
      ttccagatg tccacttcg gcgggctgg gatggagtc 
      ctggatggt attatcaat gaagaagat tgtaaaccg 
      ccaaacagt gagatcggc gagaccgga aattgcggg 
      aattcgaca attggtatc gcattcctg ctcagctat 
      ctcgtgatt tccttcctc atcgtcatc aacatgtac 
      atcgctgtg attttggag aactactcc caggcgacg 
      gaggatgtg caagagggt ctgaccgat gatgactac 
      gacatgtac tacgagatc tggcagcag ttcgaccct 
      gacggcacc cagtacatc cgctacgac caactgtcg 
      gacttgttc gatgtgttg gagcctccg ctacagatc 
      cacaagccc aacaagttc aaaatctac tccatggac 
      attccgatc tgcaagggt gacatgatg ttttgtgtg 
      gacattttg gacgcgcta acaaaagac ttcttcgct 
      cgcaagggc aacgaaatc gaggaaact gctgaactt 
      agtgaagtg caaccgaga cagaacgaa ccgggttac 
      gaacaagtc agttcgacg ctttacaga cagcgcgaa 
      gaatattgt gcgagactg atccagaat gcctggcgc 
      aagtataga cagcgcact ggcggtgct ccagagcaa 
      gtgaatgtc gatggggct gccggcgag ggcgatggg 
      gaggtggag gtccaccaa acggccgtt ctggtcgag 
      agcgacggc tttgtgacc aagaacggg cacaaggtt 
      gtgctgcac agtcgcaca cccagcatc agctccaag 
      tctgcggac gtctga
    mRNA sequence
    • >TC004749 RA
      caagttctc tttttattt tcaggttag ttatgtttt 
      tggccccca aaattgccc aatctgaat acgaggtat 
      cgtgggggc ctaggcgcg aggagacat gtccgttgc 
      ctctgacta ttcgtccga ggaggagct cagcctatt 
      ccgtccatt cactcgcga gtctcttgc ggtcatcga 
      gacgagaat tgcggaaga atatgctaa gcagaagga 
      gctcgaaaa gaaaagagc tgaaggaga gattcggta 
      tgaggacga ggacgaaga tgaaggtcc ccagcctga 
      tccaactct ggagcaggg gctgccctt gccagtacg 
      tcttcacag tacctttcc tccggaact ggccagtac 
      accacttga agacatcga cccttttta cagtaacca 
      aaggacttt tgtagtggt tagtaaagg caaggacat 
      tttccggtt tagcgccac aaacgccct gtgggtact 
      cgatccctt caatccgat ccgtcgagt ggccattta 
      cattctagt gcatccttt gttttctct ttttatcat 
      taccacaat cctcgttaa ctgtatcct tatgatcat 
      gcccacaac acccaccgt agagtcaac cgaagtgat 
      attcacagg catctacac gtttgaatc agctgtgaa 
      ggtgatggc gagaggttt tatcctaca accgttcac 
      ctaccttag agatgcatg gaactggct cgacttcgt 
      agtcatagc tttagctta tgtcaccat gggtataga 
      ccttgggaa tcttgctgc cttgagaac atttagggt 
      actacgagc tctaaaaac tgttgccat tgtgccagg 
      tttgaagac tatcgtggg agctgtaat agaatctgt 
      aaaaaatct ccgagatgt gataatttt aacaatgtt 
      ttccctgtc agtgttcgc attgatagg tttacaaat 
      ttatatggg tgttttaac acaaaaatg tatcaaaga 
      atttcctct ggatggctc ttgggggaa cctcaccca 
      cgaaaactg ggagagatt tgttagcaa cgaatccaa 
      ctggtattg ggatgacga aaaaggcga aaggcctct 
      gtgtggaaa ctcctcagg atcgggaat gtgcaaaga 
      gggttacgt ttgtttgca aggttacgg tgataaccc 
      aaactatgg ttacaccag ctttgatac ttttggttg 
      ggcattact ttccgcctt cagattaat gactcagga 
      ttattggga gaatttata ccaactggt tttaagatc 
      agccggtcc ttggcatat gctattttt tatcgtgat 
      tatattttt gggttcgtt ttatttagt taacttgat 
      cttggctat cgtcgctat gtcgtacga cgagttgca 
      gaagaaagc ccaagatga ggaagaagc tgaagctaa 
      cgctataag ggaagccga gcaaaaggc aaaggacaa 
      gcaagatcg ggcggatgc gagggcagc ggcggccgt 
      ggaggcggc cgaggcagc ggccgctgc cgcggcggc 
      ggcggcagc agggtgtga caacgacca gtacatcat 
      aaaatcgtc ttcggacta ctcgtgtca cagctatga 
      gtcgttcgt ggggcaacc caacggtca agacgacaa 
      caacaagga gaagattag catacgctc ggaaggatt 
      agattccgt gagtgaaca gagaagagt tcctactaa 
      tctgagcaa gatgcggaa agtcagcgc tgccagtct 
      cagcctccc cggctctcc cttcaacct tcggcgagg 
      gtcccgagg tagccacca gttcacctt gcggaacaa 
      taggcgcat ggtggctcc gccgggcga tcgaaagcc 
      cttggtgct gtcgaccta ccttgacgc ccaagagca 
      cctccccta cgccgacga ctctaacgc cgtcacccc 
      catgagcga ggagaacgg cgtcatggt cctgcccat 
      gtactacac caacctggg atcacgtca ttcatcgta 
      cacttcaca tgcctcacg gatgtcata cacttctca 
      tggagattt gttaggcgg tttgggaag caatggcaa 
      aatgatgac gaaggagag ccagctcag gaaccgatc 
      gctgagaaa cggaccagc ggccgctcc cctaaacca 
      caagtcaac gcgaggcgt ctacgatgg tcccacggg 
      gcacatttg cgaatcaaa agttaagca aattgacaa 
      tccttttat cgatagcaa tcagcgaca gacagtcgt 
      ggacatgaa agatgttat ggtgctgaa cgacatcat 
      cgagcaagc tgccgtgag cggaggcag tgaccgcgg 
      agccaataa tgacgacga agaggaaga gccgacgtt 
      cagggaacg cttcctggc ttatgccat caaaatcat 
      tgacatgtt ttgcgtatg ggattgttg taaatgttg 
      ggtcgttat tcagaagtt tgtcgccct tcttgtctt 
      cgacccatt cgtcgagct ttttatcac gctgtgcat 
      tgttgttaa caccttgtt tatggcatt ggatcacca 
      cgacatgga caaggattt ggaaaaggc tttgaagag 
      cggaaacta cttttttac tgcgacttt tatgattga 
      agctacttt aaaattgat tgcaatgag tccgaaata 
      ctactttca agaaggctg gaacatttt tgattttat 
      tatagtggc gttatcgtt gctggagct aggactgga 
      aggcgttca aggcttatc ggtcttgcg ttcatttcg 
      actgttacg agtgttcaa actggccaa gtcgtggcc 
      aactttaaa tttactcat ttccataat gggtagaac 
      gatgggtgc tttaggaaa cttgacttt tgtgctctg 
      tattataat atttatttt tgccgttat gggcatgca 
      actgtttgg gaaaaatta cacagataa cgtggatcg 
      gtttcccga ccacgagct cccccgctg gaacttcac 
      cgacttcat gcattcgtt tatgatagt ttttcgcgt 
      tttgtgtgg cgaatggat cgagtccat gtgggactg 
      tatgctggt gggcgacgt ctcttgcat tccgttctt 
      tctcgcaac tgtcgtgat tggcaatct tgtggtcct 
      taatctttt cttagccct gcttttgag taactttgg 
      atcttcgag tctgtcggc gccgactgc cgacaatga 
      cacgaataa aatagcaga ggcttttga cagaatcgg 
      ccgctttat cagatggat caaaggcaa tgttttaca 
      tatcgcaaa actggtccg attcaagct caccaacca 
      aatttccga ccagccgtc agatgtgag atgtgatgg 
      tggtttaga tatctccgg agacgaaat tttagccga 
      cggtataat taaaaaaag tcctaaaga ccgactgga 
      agtaacaat tggcaccgg aatggatct taccgtgca 
      tggtgatcc caaaagagg caaaaacaa tattaacaa 
      aagcaaaac aatcggaaa ttcaattct ggaacatgg 
      aatgtacat cggtcacct ggacgaaga cgaaattag 
      taacaaatc gtacggtag tcacaaaaa tcgatttaa 
      agaggaaag tcataaagg gagtgttga tatgttaga 
      cgaccatga ggagaaacg agatgctag taaagaaga 
      attaggaat tggtgaaga agaaacaga agacgacag 
      atttgactt ggaaaaacc actgactga cattgtgat 
      tgtgggaaa cgctgacga tataattat cgacgatta 
      cgcagccga ctgctttcc cgattcatg ttacaagaa 
      gtttccgtt tcttgcagg cgacgagga ttcgccgtt 
      ttggcaggg ttgggggaa tttaaggtc gaagactta 
      tagactaat agagaacaa atattttga aacggccgt 
      aatcacgat gattttgtt gagtagcat ggcgttggc 
      gttagaaga cgtacattt gcaaagtcg gccgatttt 
      gcaagacat actgtatta catggatcg aatattcac 
      cgtgatatt ctttttcga gatgttgat aaagtggtt 
      agcgttagg gttccaaaa atactttac gaacgcttg 
      gtgctggct agattttgt gattgtaat ggtgtctct 
      cattaattt tattgcctc tctttgtgg cgctggcgg 
      gattcaagc atttaaaac tatgcgaac gctgcgggc 
      tttgagacc acttcgcgc catgtcccg catgcaagg 
      gatgagggt tgtcgttaa tgcattggt gcaagcgat 
      accgtctat cttcaatgt actgctagt gtgcttaat 
      attttggtt aatttttgc tataatggg tgtgcagtt 
      attcgctgg taaatactt taagtgcgt ggatgcaaa 
      caaaaccac actaagcta tgagattat ccctgatgt 
      taacgcgtg taaagctga gaattacac gtgggaaaa 
      ctccccaat gaattttga tcatgtggg caaagcata 
      tttgtgctt atttcaagt ggcgacatt caaggggtg 
      gattcaaat tatgaacga tgctataga ttctagaga 
      catcaacaa acaaccaat aagagaaac aaacattta 
      tatgtattt atacttcgt attttttat aatatttgg 
      atcgttttt tacacttaa cttattcat tggtgtaat 
      catcgataa ttttaacga acaaaagaa aaagggtgg 
      cgattcatt ggcactgat gatgacaga cgcccagaa 
      gaaatatta caatgcgat gaaaaaaat gggctctaa 
      gaaaccaat gaaggcgat accgaggcc gaggtggag 
      acctcaagc tatagtttt cgaaatagt aacaaataa 
      gaaatttga tatgataat catgttgtt tattggact 
      gaacatgct tacgatgac aatggatca ctaccaaca 
      gaaagaaac tttcacgaa agtcctcga ttccctcaa 
      catgatttt cattgttat ctttagtac cgagtgcct 
      catgaaaat ttttgcgtt acgttacca ctactttac 
      ggaaccttg gaacctgtt cgatttagt ggtagtaat 
      attatcaat tttgggttt ggttttgag tgacatcat 
      agagaaata tttcgtgtc accgacgtt gttaagggt 
      ggttcgtgt ggccaaagt agggcgagt tctgcgttt 
      ggtgaaagg tgcaaaggg cattcggac actgctgtt 
      cgcactagc catgtcact gccggcact gttcaacat 
      ctgtttgtt gctgttcct ggtcatgtt catttttgc 
      catcttcgg gatgtcgtt cttcatgca cgtgaagga 
      caagagcgg acttgacga tgtctacaa ctttaaaac 
      gtttggcca gtcgatgat tctcctctt ccagatgtc 
      cacttcggc gggctggga tggagtcct ggatggtat 
      tatcaatga agaagattg taaaccgcc aaacagtga 
      gatcggcga gaccggaaa ttgcgggaa ttcgacaat 
      tggtatcgc attcctgct cagctatct cgtgatttc 
      cttcctcat cgtcatcaa catgtacat cgctgtgat 
      tttggagaa ctactccca ggcgacgga ggatgtgca 
      agagggtct gaccgatga tgactacga catgtacta 
      cgagatctg gcagcagtt cgaccctga cggcaccca 
      gtacatccg ctacgacca actgtcgga cttgttcga 
      tgtgttgga gcctccgct acagatcca caagcccaa 
      caagttcaa aatctactc catggacat tccgatctg 
      caagggtga catgatgtt ttgtgtgga cattttgga 
      cgcgctaac aaaagactt cttcgctcg caagggcaa 
      cgaaatcga ggaaactgc tgaacttag tgaagtgca 
      accgagaca gaacgaacc gggttacga acaagtcag 
      ttcgacgct ttacagaca gcgcgaaga atattgtgc 
      gagactgat ccagaatgc ctggcgcaa gtatagaca 
      gcgcactgg cggtgctcc agagcaagt gaatgtcga 
      tggggctgc cggcgaggg cgatgggga ggtggaggt 
      ccaccaaac ggccgttct ggtcgagag cgacggctt 
      tgtgaccaa gaacgggca caaggttgt gctgcacag 
      tcgcacacc cagcatcag ctccaagtc tgcggacgt 
      ctgagagcg gccccgccc ctcccctac ctcgccgta 
      gcctgagcg gctcaggag gcacgtctt tttcgtctc 
      ggctgtacg ccagactac cctcactgt tacatcgaa 
      ttccataag aattgcgtt cattgcgtt aagaccgag 
      actaaaatc acgtcgact caagtctgt gctgtgtag 
      tttggtgga gaaggtatc gtataacta ggtgtcaac 
      tgcttttgc tgctcatat cgctatcgt actatttaa 
      ctaatggtt acttaactg aaatccaca ccctcaacc 
      agacatagt gtatgaaca gtgaattta accactaac 
      tagtcctct attttcaca cagatcgtt cgattagaa 
      tgactgtcg taattctag tcgaatgca atgtggcaa 
      aatgtccca gcatttggt gccacatgt gaaaatacc 
      gacactagt ccgagacag ttgatgtag tcactgaat 
      cctgttaat tcgaaatgt agagttttg gtttctgtt 
      acccctctg tgacacact ttgacttaa tgggacgac 
      agttattat aattttgca gtaaatcct gtaaatagt 
      cttgttgaa accggaaca ggtagaaca aagcttggc 
      gcgagccga gcatatcat cctgagtct attagcctt 
      aaaatgccg ccaaagcaa tcatttaga ctaaaaatt 
      tagcaaatt gttatttgg gagcaaccg ttcccaagt 
      ggctcccaa aactcccca cgattttaa ggataaaga 
      ttcagggac ttccaagtc aaattcgcg aaaagtgta 
      tgattttga tccgattcg ggcacaaat ttattgaat 
      cgaggaata cacgtttcg aggattggc cgcaaatgt 
      tatattcta aatgggccc gaatcatca gttatttgt 
      gaaattatg gtgctttct tcaattgct aatcttcaa 
      gctatcttc acatgctac atggaccgc attcaaggg 
      aggggcaaa tgggttaaa atttgcaaa aatacacaa 
      atttttgta cgcctcatg taaattcgt atgtgtgac 
      atttttgtg gagcaacag gcacacggc agttttgta 
      attagttag ctgaaatag tggttgata tttcattta 
      ataaacacc aaagcattt taagacgtg atggcacgg 
      ttgtacaaa ttatacttc acaaaattg tacattatg 
      tagggctgt ttatacgtc atcctaaat tttgtatca 
      tggctggac cattaacta agtaataac gtgtccatc 
      attttaaaa tgtgtggaa aaatgtcac gcataccct 
      tgcaacaac tttattgat aatgtaact agggcaggg 
      gtgcagcct cttgctcga agttacgcc acgctgtta 
      cattttgtt aattattaa taatattaa ttgattgaa 
      taattatta ttgttgtta aagttttat atgaatatt 
      acggaattg gttagtgtt tgtttgacg tggtttatt 
      gcgtatgtt attatcatt gtcatcatt atattcccg 
      taatctttc ttggtccca caagccatt ataatatat 
      gatactcaa cctg
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