Status
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Gene information
General information
TC001109 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007417.3: 11077462..11090981
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC001109
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
    {{ blurIdResult }}
    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
    We will use your email address only for possible questions regarding this annotation. We will never show your address or give it away.
    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.
      {{ unavailableText }}

    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_03138

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: < 50
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: % (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: % (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC001109 RA
      MTQRDEVQK FEQGRIRVL QEERLYIQK KTFTKWMNS 
      FLQKVRMEV DDLFVDLAD GKKLLKLLE IISGEKLAK 
      PNNGKMRVH KIENVNKSL AFLHTKVRL ESIGAEDIV 
      DGNPRLILG LIWTIILRF QIQEIEIDV DEENESSEK 
      KSAKDALLL WAQRKTQGY KGVDIRDFS TSWRTGLGF 
      NALIHAHRP DLFTYDDLV HNRNIDNLN HAFDVANNE 
      LGIPRLLDA EDIDNSRPD EKSIMTYVA SYYHTFARM 
      KNEEKSGRR IAKIIKQMV DADKMKVNY DELTTDLLN 
      WIKIKIVEL EDRNFPNSL EGIQTLFLA FARYRTKEK 
      PPKYIERSE IEALFFNIN TQLKELRQP AFIPPDGKL 
      VQDIERAWE TLERAEHNR EVALRNELL RQERLEQLY 
      CKFERKSVL REGYVKEMI QVLSDPRYG SNRDQVDAT 
      VKKHEAISA DILARQERV NDLTQMCNE LVREKYRNS 
      DRVVKREAE ILNQWKQLL DLLEKHKLK LNRMVNIKS 
      LEMEIDTTL NSMQQLKAD LSTTDTGIH LMAVEELLH 
      KHALQELQV SSLGETERR LNRLAESTL AQNPQEEKL 
      KKKIQELSA TYKDLQDAS DKRKGLLEE ARNFYQFLQ 
      DQEDEEAWL IEKQRICQA GITAKDLRG VLSLQQKHK 
      VLMDEIKAR RNKFDQLGA TGRQLIAEK HPRSNEIQQ 
      HMDRNKQAW SDLEKLVND RTKQLQDAA ETYQFYADA 
      NEADSWLNE KTSILNSSD YGSDEPSAQ ALLQRHKDL 
      EGELNAYKG DILSLNTQA DRLIASGIS NLDLTAEVE 
      VAEPVEEIV YENRMIPTE VWVEEPVEK VEYKMVVEE 
      KKVPQVKAL YPFNDHGLN MVKGEVMYL LNKSNPDWW 
      CVRKADGTD GFAPAKYVT EIEPRLLQM QYRKPETVK 
      VMQKVKKTK MVNQKVPVK VFRQRKPVK RKVDDNDSV 
      PKRQKKIND TYQHLLDVA AKRHALLED AVKLFRFYK 
      ECDDFEKWI KDKEKLLAV DDPNDSIEQ AKRKYEKFV 
      TDLSANNKR MDELNDDVK EFEKQKHSQ IDKIKSRHR 
      QVQGAWQRL NLLKARKEK SLEGASSVE LFQKTCDEA 
      RDWMLEKMT QLDTHVSAH DLKTVQALQ RRHDNLERE 
      LAPVEEKVT KVMHLANSV KSAYPNERQ NVARRQDEI 
      EGLWRQVKD KASERRARL ENAVGEQIF TNSCKDLLR 
      WVADVKDQL NADNMVRDV QTAEALLKN HKDLGEEIK 
      AKNDEFYEL TDLGKKLLK SNPELPEVA ERIERLTAE 
      QAAIGRGWK EKQRWLDQC HQLQLFNRE ADNIDAATS 
      AHQAFLEFS DLGNSLDEV EALQKQHKA FANTLFAQD 
      DRVNLFSKK ADALIADDH YESKGIDDK RNEVLQRRQ 
      AVKDLCQQR TNVLDASKN YQEFCAEVH DLRSWLNEK 
      LKTASDESY RDLTNLERK LQKHEAFER ELRANEGQL 
      RTVNKLGQA LIAQDSYRK DDVAKTLKE LNDEWQQLV 
      GLSLEKGRR LRQAVVQHD YNTSIDDIQ TKLDEINEN 
      LCSTNVGTD LRSCRDLLK RQDVLETEL GQCAARVDE 
      LVNKSNDMM HDGHFDADA IRQKALDGQ KRLKQLEEP 
      ARKRRDVLE EALKFYNFH FELDAELQW IKEHLPLAS 
      SATLGQNLH QAQNLFKKH KKLEAEIVG HQPAIDKTL 
      QAGQTLVDL KHPESAKIK DLCGVLQDA WDELNEKAS 
      ERAQKLELS LKAQQFFFE ANEVESWLN EKADILAST 
      DYGRDRDSA TKLLTKHKA LELELDTYN NIIVEMGRG 
      AQNLIQNKH PDSKLIAER QSSLEHLVR SLQRKAVLR 
      QHHLMESLF RHEYFLESE ELDRWIAEN LQQASSEDY 
      GQDYEHLLI LQAKFDDLK HRIEAGAER FRQCEDLAQ 
      KLIANESSY ISDIQKKQL QLETLTQSD AVEEVRQRH 
      DVVRQSWQK LHDQMQNRE QRLLAAGEI HRFHRDVAD 
      AMQRIQEKS AALGTDLGR DLNSALTLL RKHEAFENE 
      LVALEAQLQ VLVEDGSKL QKIYPSNQS SIQLQQEVV 
      IDAWDYLKE RAELRHDQL QASVDLQKF LTQVRNLTN 
      WATALRLDM QAEENVRSI ARAQFLRNE HEGLKNEIE 
      AREADFKDV AENLTAMEQ TGHYAANEA GERYKNLLQ 
      ERERLHADW QIKKIHLDQ LCDLHMLLR EAKLIEDAT 
      NAQEATLSN LDFGETVDE VANQVKKHE EFEKLIVHQ 
      DEKFDTLVK TGQKLIGQQ HFDSKNIAK RLQEVGARR 
      QQVHQLSDR KKQLLADAL LYAEFNRDV GEAQIWIAE 
      KQKKLEKQV KTGEVTNLD DKIKELQKH QAFQAEIAA 
      NEGKIKEVK SKGETLLAK KHKASKDIE VQLRNLDDA 
      WRQLLREVD SRGKGLEEA QDILEFNNQ LDKIESWIR 
      DKEVMIQAG DVGKDYEHC QALQRKLDD VDSDMRIDD 
      TRIKTINSL ANKLAKQGH PGVQQRRDN FIKKWQDLQ 
      GALAKYRNK LAAASEVHL FDRDVADTA ERINEKLLA 
      METDDVGRS LPAVELLSR KQEALESEM TAVENKLQD 
      HGKDAVLLS DKYPHAVQH LQGKMEELQ NEWEKLIAA 
      RERRRNNLK GSHARQKFL SDVKDLEQW VSDTTKRME 
      AHQPPSSVN EAETLLGLH DELKAEING RNEVFAKLI 
      NFGRSFSES DDSDIIDGV NKLKELQSY IQQAWEQHK 
      DALTYEYDL QDFKEQANQ LNNWLADKE AFLNNDDVG 
      DTPRAVEAL IRKHEVFET MLTQPLSRI DELSRKKVG 
      GKTPTDPTY ANSEVATKL NEIMARKNR LLGKAAERK 
      KILHESKAL QKFLKNEYD VEVWLNHKL QIATDENYR 
      EPYNLQNKI QKHVTFEAE VFANHERVT NVIEEGRDL 
      IENKHYASK DIADRIEEL ENRWKELIE QSHLKRDRL 
      NEAYQALLF NRSLDEFEA WLLEVEAQL TSTDVGKDL 
      ATVNNLLKK HTILENDIQ QHTDNCETI NDAADQFVK 
      NNHFMSEEI QQRAQDAIT RFHQLKEPV QQKRDLLEG 
      SMMLQQFTR DVEDELQWL ADREPLAAS RDLGASLTA 
      VQSLHKKHQ ALEAELSSR EPIIGSLVG RANSLARSG 
      HVSAPLISQ KAKELQQKF ASIRDLASI RRLRLQDAL 
      EVQTYYEEA TEAEAWMRD KRPSLVTRE VGKDEDSAE 
      SLKRKLEAT ELEIKAFEV TIKKLKQSA DELIERQHY 
      DAVNIEKRK NQLDEQFNE LRKLVSERE VRLDEALRY 
      FTFVRECLD VQEWMKDQI LKTDSEEYG NDVEHVELL 
      IQAFDTFHA SLMNSEPRI QSCIQNGNI LIEAKSSHS 
      PEVQQKVAD IRDQWDDLL ELANARKDA LAGAKRVHV 
      FDRTAEEII SWIQEKKAD LSYDTFGQD LESIQDLLR 
      KHQALENEM KVIREKVEN VEQEGEKLI NEFPDTKEH 
      IDDKCEDML SAWGSLQTE AARRKDHLQ QAEQLQAYF 
      DQFQDLLAW ITEMVAKIT APDLPNDCN EAELLIERH 
      KEYKVEISA KSNAFKQFY DSGNKFIEE GHLFASEIQ 
      DKIKVLRQR LEFLNNTWE KRNLLYNQN LDVLLFKRE 
      ADILDNWLA VREGTLKEG ITGDSIHHV EDLIRKHGD 
      FEEAVKAQE DKFEALKRK TLIEDAFLL QREQEALAK 
      KAEKERQEQ ERLEHLKRL EIQKINEKR RQERPQPPE 
      IVEELVNGT KHEEEGRPV ATVRKTNSV VQTFERDRG 
      GLRRGSDSA IQRSASMKV GTNVTGSKP KRTPTFTTR 
      RRPSFKSKP TEAPPADAQ SFLDRKQLT TANGKRATN 
      RTWKNSYTV LCGQLLCFF KNRDDFAAS KASGPPVNV 
      HNAMCSIAD DYQKKKHTF RLELTDGSE FLFACSSDS 
      EMDNWIQKI SFRARLPPS QQLLHLEIP KDQNDYEMS 
      SQSSRTSSP DVADQVVLR HDPQSTNGS LSSLASSRH 
      TMDGSGMSS KQDWQPNVQ RPQTMQPND APKSRLFER 
      IFKKKRNTS QM
    CDS sequence
    • >TC001109 RA
      atgactcaa agggatgaa gtacagaag ttcgagcag 
      ggccgaata cgcgtcctg caggaagaa cgtctgtac 
      atacagaag aagacgttc accaaatgg atgaactcc 
      tttcttcaa aaggttcgg atggaggtc gacgattta 
      tttgtagat ttagcagac ggcaagaaa ttattaaaa 
      cttttagaa ataatatcc ggtgaaaaa ctagcaaaa 
      ccaaacaat ggcaaaatg cgggtacac aaaattgaa 
      aacgtcaac aaaagtttg gcgtttttg cacacaaaa 
      gttcggtta gaaagcata ggagccgaa gatattgtc 
      gatgggaac ccccgactt atcttaggt ttaatctgg 
      accatcatt ttaagattc caaattcaa gaaatcgaa 
      attgacgtg gacgaggaa aacgaaagt tctgaaaag 
      aaatcagcc aaagatgcc cttcttcta tgggcacag 
      cgtaaaaca caggggtat aagggtgtt gatattcga 
      gatttttca acatcgtgg cgcactggt ctaggcttt 
      aatgcccta atccatgcc cacagaccg gacctgttt 
      acttacgac gatttagta cataaccga aacattgat 
      aacttaaac catgctttt gacgttgct aataacgaa 
      ttgggaatt ccccggctt ttggatgcc gaagatatt 
      gataattct agaccagac gagaaaagt atcatgact 
      tacgtcgcc tcatattat cacactttt gcccgaatg 
      aaaaatgaa gaaaagtcc ggacgacga attgccaaa 
      ataattaaa caaatggtt gacgccgac aaaatgaaa 
      gtcaattat gacgaacta accactgat ttactaaat 
      tggataaaa attaaaatc gtagaactg gaagatcgc 
      aattttccg aattcacta gaaggcatc caaacgctt 
      tttctagcc tttgctcgc tacagaacg aaggaaaaa 
      cctccgaaa tacatcgaa cggagcgaa atcgaagcc 
      ttatttttc aacatcaac acccagctt aaagaactg 
      agacaaccg gcttttatc ccacctgat ggtaaactc 
      gtgcaagac atagaacgg gcttgggaa acccttgaa 
      agggccgaa cacaaccgt gaagtggcc ctccgcaac 
      gaattgctc cgacaagag cgtctcgaa caactttac 
      tgcaaattc gaacgtaaa agtgtgctc cgagaaggt 
      tacgttaaa gaaatgatc caagtctta tccgaccct 
      cgatatggc tctaaccga gaccaagtt gatgctact 
      gtcaagaaa cacgaagcc ataagtgct gatatttta 
      gcgaggcaa gaacgtgtc aatgatttg actcaaatg 
      tgcaatgaa ttggtgaga gaaaaatac agaaattcc 
      gatcgggtt gtaaagaga gaggctgaa attttaaac 
      caatggaaa cagttgtta gacctgttg gaaaaacat 
      aaactgaaa ttgaatcgt atggtcaat atcaaatct 
      ttggagatg gaaattgat acgactttg aacagcatg 
      cagcagttg aaagccgat ttatcaact actgatacg 
      ggaatacat ctgatggct gttgaggaa ttactgcac 
      aaacatgcc ttacaagag ctacaagtg agctctttg 
      ggcgaaact gaacggaga ctcaatcgt ctcgctgag 
      agtacgttg gctcaaaat ccgcaagag gaaaaattg 
      aaaaagaaa attcaagag ttgtctgcg acttacaaa 
      gacttgcag gatgctagt gacaagaga aagggtctg 
      cttgaagaa gcaagaaat ttctatcaa ttcctccaa 
      gaccaagag gacgaagaa gcctggctg attgaaaaa 
      cagcgaatt tgtcaagcc ggtattaca gctaaagac 
      ttacgtggc gtattatct ctacagcaa aaacacaaa 
      gtcctcatg gatgaaatc aaagcacgt agaaataaa 
      ttcgatcaa ttaggagcg actggaaga caactaatc 
      gcagaaaaa catcccagg tctaatgaa attcaacaa 
      cacatggat cgcaacaaa caagcttgg agcgattta 
      gaaaaacta gtcaatgat agaacaaaa cagttacaa 
      gacgctgct gaaacttat cagttttac gccgatgct 
      aacgaggct gattcgtgg ttgaatgaa aaaacgtcg 
      attttgaat tctagtgat tacggaagt gacgaacca 
      agcgcccaa gcacttctc caaagacat aaggacttg 
      gaaggagag ttgaacgct tacaaaggg gatatttta 
      agtttgaat acgcaagct gaccgtttg attgcgtca 
      ggcatttcc aatctcgat ttaactgcc gaagttgaa 
      gtagctgag ccggttgaa gaaatagtg tacgaaaat 
      aggatgatt ccgactgaa gtttgggtt gaagaaccc 
      gtggaaaaa gtcgagtac aaaatggtc gtcgaagag 
      aaaaaggtg cctcaagtc aaagcattg tacccattt 
      aatgaccat ggccttaac atggttaaa ggcgaagtg 
      atgtatttg ttaaataag agcaacccg gattggtgg 
      tgtgtacgt aaagcggac ggtactgac ggtttcgcc 
      cccgctaaa tacgtaacg gagatcgaa cccaggttg 
      ttacaaatg caataccgt aaacctgaa actgttaaa 
      gttatgcag aaagttaaa aagacgaaa atggtgaat 
      cagaaagtc ccagtcaag gttttcagg caacgcaaa 
      cctgtgaaa aggaaagtt gacgacaat gatagtgtc 
      ccgaaaaga cagaagaaa atcaacgat acgtatcaa 
      cacctcctg gatgttgca gcaaaaaga catgctctc 
      ttggaagac gccgtgaag ctgttccga ttttataaa 
      gaatgtgac gattttgag aaatggatt aaagataaa 
      gaaaaattg ctcgctgtt gacgatccc aatgacagt 
      atcgagcaa gcaaaacgc aaatacgag aaatttgtg 
      actgatttg tccgccaac aacaaacgc atggacgaa 
      ctaaacgac gatgttaaa gaattcgag aaacagaaa 
      cattcgcaa attgacaaa atcaaatcg cgccaccgc 
      caagtccaa ggcgcttgg cagcgtctc aacttgctc 
      aaagcccga aaagagaaa agtctcgaa ggagcaagt 
      agtgttgag cttttccag aaaacttgt gacgaagct 
      agggactgg atgttggag aaaatgact cagcttgat 
      acccacgtt tcggctcac gacttaaaa accgttcaa 
      gctttacaa cgtagacat gataatctc gaacgtgag 
      ctcgcccct gttgaggaa aaagtgacc aaagtaatg 
      catttggca aattcggtc aaatcagcg tatcctaat 
      gagcgacaa aacgttgcg cgaagacaa gacgaaatc 
      gaaggtttg tggcgacag gtcaaagac aaagctagt 
      gaacgtaga gccaggctt gagaatgcc gttggtgag 
      caaatattt accaattcg tgtaaagat cttttgcgg 
      tgggtcgcc gatgttaaa gatcagttg aatgctgat 
      aacatggtt agagacgtg cagactgct gaagcatta 
      ctcaaaaat cataaggac ttgggggag gaaattaaa 
      gctaagaat gacgaattc tacgagttg accgatttg 
      ggtaaaaag cttctaaaa tctaatccc gaacttccc 
      gaagttgcg gaacgtatc gaaagactg actgcggaa 
      caagcggcc ataggtcgc ggttggaag gaaaaacag 
      cgttggtta gaccagtgc caccaatta caactattc 
      aacagagaa gccgataat atcgacgct gcaacttcg 
      gcccatcaa gcatttttg gaattttcc gatttaggg 
      aattccctt gatgaagtg gaagccttg caaaagcag 
      cacaaagct ttcgctaac actttattc gcacaagac 
      gaccgcgtc aatctcttc agcaaaaaa gccgacgcg 
      ttaatcgct gatgaccat tatgaaagc aaaggaatc 
      gacgataaa agaaacgaa gtcctgcaa cggcgccaa 
      gctgttaaa gatttgtgc caacagaga acaaacgtt 
      ctggacgcg tcgaaaaat tatcaagag ttttgtgcc 
      gaagtgcac gatttgcgt agctggttg aatgagaaa 
      cttaaaact gcatctgat gaaagttac cgagaccta 
      actaacctg gagcgaaag ttacaaaaa cacgaagct 
      tttgaacga gaattgaga gctaacgaa ggacagctt 
      cgcacagtg aacaaatta ggccaagct ttgattgct 
      caagacagt tacaggaag gacgacgtg gcgaaaact 
      ttgaaagaa ctgaacgat gagtggcaa caactcgtc 
      ggactttcc cttgaaaag gggagaagg ctgagacaa 
      gccgttgtc caacacgac tataacact tcaattgac 
      gatattcag accaaattg gatgaaatc aacgagaat 
      ttgtgtagc actaacgtt ggaaccgat ttgagatct 
      tgtcgcgat ttattaaaa cgccaagac gtgctcgag 
      actgaactt ggacaatgt gcggccaga gtcgacgaa 
      ttagtgaat aaaagtaac gatatgatg catgatggg 
      cactttgat gccgacgca atccgccaa aaagccctc 
      gacggccaa aaacgcctc aaacaacta gaagaaccg 
      gccagaaaa cgacgagat gtcctagaa gaggctttg 
      aaattctac aatttccat tttgaactc gacgctgag 
      ttgcaatgg atcaaagag cacctccct ctcgcatcg 
      tcggccact ctgggccaa aatctacac caagcccag 
      aatctcttc aaaaaacac aaaaaactc gaagctgaa 
      attgttggt catcaaccc gccattgat aaaaccttg 
      caagctgga caaacccta gttgatttg aaacatcca 
      gaaagtgcc aaaatcaaa gacttgtgt ggagtgctc 
      caagacgcg tgggacgaa ttaaatgaa aaagcgagc 
      gaacgtgca caaaaactg gaattgtcg ttgaaagct 
      caacaattc ttctttgaa gcgaacgaa gttgagtcg 
      tggctgaac gaaaaagct gatattttg gccagtact 
      gactatggt agagatagg gattcagct acgaaattg 
      ctgaccaaa cacaaggca ctcgaatta gaattggac 
      acttacaac aacattata gtcgagatg ggacgtggt 
      gcccaaaat ttgatacaa aataagcac ccagattcg 
      aaattaatt gccgaaaga cagtccagt ttggaacat 
      ttagttcgc tctttgcaa aggaaagct gttttaaga 
      caacaccac cttatggag tcactgttt cgtcatgaa 
      tactttctg gagtcggag gaattggat cggtggatt 
      gccgaaaac ttacaacaa gcgtcttcg gaggattat 
      ggacaagat tacgagcac cttctgatc cttcaagcc 
      aaatttgac gatttgaaa caccgaatt gaagcagga 
      gccgagcga ttccgccag tgcgaagac ttggcccag 
      aagttaatc gccaatgaa agctcgtat atttcagat 
      atacagaaa aagcaactt caactcgaa accctaaca 
      caatcagac gcagtcgag gaagttagg cagaggcat 
      gacgttgta cggcaatcg tggcaaaaa ctgcacgac 
      cagatgcag aaccgcgag cagcggctt cttgcagcc 
      ggtgaaatc caccgtttc catcgcgat gtggccgat 
      gccatgcaa cgaatccaa gaaaagagc gctgcttta 
      ggcaccgac ctaggacgc gacctaaac tccgcctta 
      acactactt agaaaacac gaagctttc gaaaacgaa 
      ttggtggca cttgaggct caattacaa gtcctggtt 
      gaagatgga tcaaaatta caaaaaatc tacccaagt 
      aatcaatct agcattcaa cttcaacaa gaagtagtg 
      atcgatgct tgggattac ttgaaagaa cgagcagaa 
      ttgagacac gaccagctc caggctagt gtggatttg 
      caaaaattc ctaacccaa gtcagaaat ttgacaaat 
      tgggcgact gcgttaaga ctagacatg caagctgag 
      gaaaacgtg aggagtatc gcgagagca cagtttcta 
      cgtaacgaa cacgaaggt ttgaagaat gagattgaa 
      gcgagggaa gccgatttt aaagacgtt gccgaaaat 
      ttaacagcg atggaacaa accgggcac tatgcagca 
      aatgaagcc ggcgaaaga tacaaaaac ttgcttcag 
      gagcgagaa agacttcac gccgactgg cagataaag 
      aaaatacac ttggaccaa ttgtgcgac ttgcatatg 
      ctactaaga gaggcaaaa ctgatcgaa gacgccacc 
      aatgcacaa gaagccact ttgagtaac ctagatttt 
      ggcgaaact gtcgacgaa gtcgccaat caagtcaag 
      aaacacgaa gaatttgaa aaactaatc gtccatcag 
      gacgaaaag ttcgacact cttgttaag accggccaa 
      aaattaatc ggccaacag catttcgac agcaaaaac 
      atcgctaaa cgtttgcaa gaagtcgga gccaggcgg 
      caacaagtc caccaattg agcgatcgc aagaaacaa 
      ctcctcgcc gatgctctg ttgtatgcg gaattcaat 
      agagacgtg ggcgaggcc cagatatgg atagccgag 
      aaacaaaag aagttggaa aagcaagta aagaccggc 
      gaagtgacc aatctggac gacaaaatc aaagaacta 
      cagaaacac caagcgttc caagccgaa atcgcagcc 
      aatgagggc aaaatcaag gaagttaag tctaaggga 
      gagactctt ttagcaaag aaacacaaa gcttcgaaa 
      gacattgaa gtgcaattg aggaatttg gacgatgct 
      tggaggcaa cttttgcgc gaggtggac tcgcgtggt 
      aaaggtctg gaagaggcg caggatatt ttagaattc 
      aacaatcaa ctggacaag atcgagtca tggatcagg 
      gacaaagaa gtgatgatt caagccggc gacgtgggg 
      aaagactac gaacattgc caagcgttg cagagaaaa 
      ctcgacgat gtggatagc gatatgcgg atcgacgat 
      acccggatc aaaaccatc aattccctg gctaacaaa 
      ctggcaaag caagggcac cccggagtg caacaaaga 
      cgcgacaat ttcatcaag aaatggcag gatttgcaa 
      ggcgctttg gccaaatat cgcaataaa ttagctgca 
      gcttccgaa gttcacttg tttgatcgc gatgtcgct 
      gatacggct gagagaatt aatgaaaaa ctgctcgcg 
      atggaaact gacgacgtc ggtcgcagt ttacccgcc 
      gttgagctg ctttcgcga aaacaggaa gcactagag 
      agtgaaatg accgccgtt gaaaataaa ttgcaggat 
      catggaaaa gatgctgtt ttattgagt gataaatac 
      ccgcacgct gtccaacac ctccagggt aaaatggaa 
      gagttgcag aacgaatgg gagaagctg atcgcagcg 
      agagaacgt cgcagaaat aatcttaaa ggatcgcat 
      gccaggcaa aaattctta tcagatgtt aaggatttg 
      gaacagtgg gttagtgac acgactaaa cgaatggaa 
      gcacaccaa ccgccaagt agtgtcaac gaggctgag 
      acactttta ggcttacat gatgaactt aaagccgaa 
      atcaatgga cgtaacgag gtttttgcg aaactgatc 
      aatttcggg cgcagtttt tccgaaagc gacgattct 
      gatataatt gacggagtg aacaaattg aaggagctt 
      cagagttac attcagcaa gcttgggag caacacaaa 
      gacgcacta acgtacgaa tacgacctc caagatttc 
      aaagaacaa gccaaccag ttaaacaat tggttagcc 
      gataaggaa gctttcttg aataacgac gacgtgggg 
      gatacacct cgcgcagtt gaagctctc atcagaaaa 
      cacgaagtt tttgaaaca atgttaacg caaccactg 
      tcacgtatc gatgaattg tcgcgtaaa aaagtagga 
      ggtaaaaca ccaactgac ccaacttac gcaaacagc 
      gaagtcgca acaaaatta aacgagata atggctcgc 
      aaaaaccga cttttgggc aaagcagca gagcgcaag 
      aaaatccta cacgaatca aaagcatta caaaaattc 
      ctcaaaaac gaatacgac gttgaggtt tggttgaac 
      cacaagctt caaatcgca accgacgaa aattatcgc 
      gaaccttac aacttgcaa aacaaaatc caaaaacat 
      gtcactttc gaagccgaa gtttttgca aaccatgaa 
      cgcgtcacc aacgtaatt gaagaaggg cgagacttg 
      atcgaaaat aaacactac gctagcaaa gacattgcc 
      gaccgaatt gaggaattg gaaaatcgg tggaaggaa 
      ttaattgaa cagtcacac ctgaaacgt gaccgactg 
      aacgaagct tatcaagcg ttacttttc aaccgatct 
      ctcgatgaa ttcgaagct tggttgctc gaagtcgaa 
      gcccaacta acatccaca gatgtcggc aaagatttg 
      gcaactgtt aacaaccta ctcaagaaa cacacaatt 
      cttgaaaac gacattcag caacacact gataattgt 
      gaaacgatc aacgatgcg gctgatcag ttcgttaaa 
      aataatcat ttcatgagt gaagagatt caacagagg 
      gctcaggac gctattact cgattccat caactcaaa 
      gagcccgtt caacagaag agagatttg ttagagggg 
      tcgatgatg ttgcaacaa ttcactcga gatgttgaa 
      gacgaatta caatggttg gccgatagg gagccactt 
      gccgcctcc agagacttg ggagcaagt ttgacagcc 
      gtacaaagc ttacacaag aaacaccaa gcgcttgaa 
      gctgaatta tcatcaaga gaaccaatt attggatcg 
      cttgtaggt cgtgcaaat tctctcgcg agatcgggg 
      catgtttca gccccgctt atcagtcag aaagcgaag 
      gaattgcaa cagaaattc gcaagtatt agggatcta 
      gccagtatc aggagattg agactacaa gatgctttg 
      gaagttcaa acgtattat gaagaggca acagaagct 
      gaggcatgg atgcgggac aaacgcccg agtttagtg 
      accagagaa gtcgggaaa gatgaagac tcagccgaa 
      tctttaaaa cgtaaattg gaagccacc gaattagaa 
      ataaaagcg ttcgaagtg actattaaa aaattgaaa 
      cagtcggcc gatgagcta atcgagaga caacattac 
      gatgctgtt aacatcgaa aagagaaag aatcaactc 
      gatgagcaa tttaacgaa ctgcgaaaa ctggtttcg 
      gagcgtgaa gttcggctc gacgaagcc cttcgttac 
      tttactttt gtgcgcgaa tgtttggac gtccaggaa 
      tggatgaaa gaccaaata cttaaaacc gattccgaa 
      gaatacgga aatgatgtc gaacacgtc gaactacta 
      atccaagct tttgacaca ttccatgca agtctaatg 
      aacagcgaa cctcgaatt caatcctgt atccagaac 
      ggaaatatc ctaattgaa gctaaaagc agccacagt 
      ccggaagtg caacaaaaa gtggccgat atccgcgac 
      caatgggac gatttgctc gaacttgcc aacgcgcgt 
      aaagacgcc ttagctggg gccaaacga gtgcatgtt 
      ttcgatcgc acagctgag gaaattatt tcgtggatc 
      caggaaaag aaagccgac ttatcgtac gatacattc 
      gggcaagac ttggaaagt atccaagat cttctcaga 
      aaacaccaa gcgttggag aatgagatg aaagtgatt 
      agggaaaaa gtggaaaat gtggaacaa gaaggcgag 
      aaacttata aacgagttt ccggatacc aaagaacat 
      attgacgat aagtgcgag gatatgttg tcagcttgg 
      gggagtctt caaaccgaa gcagcgcgg agaaaagat 
      cacttacag caagccgaa caacttcaa gcttacttc 
      gaccagttc caagattta ttggcgtgg attacggaa 
      atggtggct aaaatcaca gcacctgac cttccaaat 
      gactgcaac gaggccgag cttttgatc gaacggcac 
      aaagagtac aaagttgaa atcagtgca aaatcaaac 
      gcttttaaa caattctac gactccggt aataaattc 
      atcgaagag ggtcacctg ttcgctagc gaaatccaa 
      gacaaaatc aaagtgtta cgccagaga ctggagttt 
      ttgaataac acgtgggag aaacgcaat ttgctctac 
      aaccaaaat ttggacgtc ctcttgttc aaacgcgag 
      gcagatatt ttggataat tggctagct gtgagggaa 
      ggtacccta aaggaggga attactgga gatagcatc 
      caccacgtg gaagatttg atccgaaaa cacggcgat 
      ttcgaagaa gcagtcaaa gcacaagag gacaagttt 
      gaagcactc aaacgcaaa actttaatt gaagatgcg 
      ttccttctc caacgggaa caggaagct ttggccaaa 
      aaagccgag aaagagcgc caggaacag gaacgtttg 
      gagcacttg aaacgactc gaaatccag aaaatcaac 
      gaaaaaaga aggcaagaa agaccccaa ccgccggaa 
      attgtcgag gaactggtc aatgggacc aaacacgag 
      gaagaaggc cgtccggtt gcaacagtt cgtaaaaca 
      aattccgtt gttcagacg tttgagaga gaccgtggt 
      gggttaagg agagggtca gatagtgca attcaacgg 
      tcggcaagc atgaaagtt ggtacaaat gttacggga 
      agtaagccg aaaagaact cctactttt actacgagg 
      cgaaggcca tcgttcaag tctaaacca accgaggca 
      ccacctgcg gacgcccag tcgttcctc gatcgcaaa 
      caattaacc acagcaaat ggaaaacgc gccactaac 
      aggacttgg aagaattca tacacggtt ttgtgcgga 
      cagttattg tgtttcttt aaaaatcgc gatgatttt 
      gcggctagt aaagctagt ggtccaccg gttaatgtt 
      cataatgcg atgtgttca atagcggat gattaccaa 
      aagaaaaaa catacgttt agacttgag cttacagac 
      ggttcggaa tttttgttt gcgtgtagt tcggattcg 
      gagatggat aattggatt cagaaaatt agtttcagg 
      gctaggttg cctccaagt cagcaattg ctgcatttg 
      gaaattcca aaggatcaa aacgattac gagatgagt 
      tcacaaagt agcaggacc tctagtccg gacgttgcc 
      gatcaagtt gtcttgcgg cacgatccg caatcaacc 
      aatggcagt ttatcaagt ttagcatct tcgcgtcat 
      actatggat ggtagcgga atgtcgtca aaacaagat 
      tggcaacct aatgtacaa cgtccacaa acgatgcaa 
      cctaatgat gcaccaaag tcacgtctg tttgaaaga 
      attttcaaa aagaaacgg aacacttcg caaatgtaa
    mRNA sequence
    • >TC001109 RA
      cattttcaa tataagcaa aaatgtttt tgttacagt 
      tggcttcgt gcattatga acctagagg gcaaacctt 
      tgtgcaaca tcgaaccaa catgactca aagggatga 
      agtacagaa gttcgagca gggccgaat acgcgtcct 
      gcaggaaga acgtctgta catacagaa gaagacgtt 
      caccaaatg gatgaactc ctttcttca aaaggttcg 
      gatggaggt cgacgattt atttgtaga tttagcaga 
      cggcaagaa attattaaa acttttaga aataatatc 
      cggtgaaaa actagcaaa accaaacaa tggcaaaat 
      gcgggtaca caaaattga aaacgtcaa caaaagttt 
      ggcgttttt gcacacaaa agttcggtt agaaagcat 
      aggagccga agatattgt cgatgggaa cccccgact 
      tatcttagg tttaatctg gaccatcat tttaagatt 
      ccaaattca agaaatcga aattgacgt ggacgagga 
      aaacgaaag ttctgaaaa gaaatcagc caaagatgc 
      ccttcttct atgggcaca gcgtaaaac acaggggta 
      taagggtgt tgatattcg agatttttc aacatcgtg 
      gcgcactgg tctaggctt taatgccct aatccatgc 
      ccacagacc ggacctgtt tacttacga cgatttagt 
      acataaccg aaacattga taacttaaa ccatgcttt 
      tgacgttgc taataacga attgggaat tccccggct 
      tttggatgc cgaagatat tgataattc tagaccaga 
      cgagaaaag tatcatgac ttacgtcgc ctcatatta 
      tcacacttt tgcccgaat gaaaaatga agaaaagtc 
      cggacgacg aattgccaa aataattaa acaaatggt 
      tgacgccga caaaatgaa agtcaatta tgacgaact 
      aaccactga tttactaaa ttggataaa aattaaaat 
      cgtagaact ggaagatcg caattttcc gaattcact 
      agaaggcat ccaaacgct ttttctagc ctttgctcg 
      ctacagaac gaaggaaaa acctccgaa atacatcga 
      acggagcga aatcgaagc cttattttt caacatcaa 
      cacccagct taaagaact gagacaacc ggcttttat 
      cccacctga tggtaaact cgtgcaaga catagaacg 
      ggcttggga aacccttga aagggccga acacaaccg 
      tgaagtggc cctccgcaa cgaattgct ccgacaaga 
      gcgtctcga acaacttta ctgcaaatt cgaacgtaa 
      aagtgtgct ccgagaagg ttacgttaa agaaatgat 
      ccaagtctt atccgaccc tcgatatgg ctctaaccg 
      agaccaagt tgatgctac tgtcaagaa acacgaagc 
      cataagtgc tgatatttt agcgaggca agaacgtgt 
      caatgattt gactcaaat gtgcaatga attggtgag 
      agaaaaata cagaaattc cgatcgggt tgtaaagag 
      agaggctga aattttaaa ccaatggaa acagttgtt 
      agacctgtt ggaaaaaca taaactgaa attgaatcg 
      tatggtcaa tatcaaatc tttggagat ggaaattga 
      tacgacttt gaacagcat gcagcagtt gaaagccga 
      tttatcaac tactgatac gggaataca tctgatggc 
      tgttgagga attactgca caaacatgc cttacaaga 
      gctacaagt gagctcttt gggcgaaac tgaacggag 
      actcaatcg tctcgctga gagtacgtt ggctcaaaa 
      tccgcaaga ggaaaaatt gaaaaagaa aattcaaga 
      gttgtctgc gacttacaa agacttgca ggatgctag 
      tgacaagag aaagggtct gcttgaaga agcaagaaa 
      tttctatca attcctcca agaccaaga ggacgaaga 
      agcctggct gattgaaaa acagcgaat ttgtcaagc 
      cggtattac agctaaaga cttacgtgg cgtattatc 
      tctacagca aaaacacaa agtcctcat ggatgaaat 
      caaagcacg tagaaataa attcgatca attaggagc 
      gactggaag acaactaat cgcagaaaa acatcccag 
      gtctaatga aattcaaca acacatgga tcgcaacaa 
      acaagcttg gagcgattt agaaaaact agtcaatga 
      tagaacaaa acagttaca agacgctgc tgaaactta 
      tcagtttta cgccgatgc taacgaggc tgattcgtg 
      gttgaatga aaaaacgtc gattttgaa ttctagtga 
      ttacggaag tgacgaacc aagcgccca agcacttct 
      ccaaagaca taaggactt ggaaggaga gttgaacgc 
      ttacaaagg ggatatttt aagtttgaa tacgcaagc 
      tgaccgttt gattgcgtc aggcatttc caatctcga 
      tttaactgc cgaagttga agtagctga gccggttga 
      agaaatagt gtacgaaaa taggatgat tccgactga 
      agtttgggt tgaagaacc cgtggaaaa agtcgagta 
      caaaatggt cgtcgaaga gaaaaaggt gcctcaagt 
      caaagcatt gtacccatt taatgacca tggccttaa 
      catggttaa aggcgaagt gatgtattt gttaaataa 
      gagcaaccc ggattggtg gtgtgtacg taaagcgga 
      cggtactga cggtttcgc ccccgctaa atacgtaac 
      ggagatcga acccaggtt gttacaaat gcaataccg 
      taaacctga aactgttaa agttatgca gaaagttaa 
      aaagacgaa aatggtgaa tcagaaagt cccagtcaa 
      ggttttcag gcaacgcaa acctgtgaa aaggaaagt 
      tgacgacaa tgatagtgt cccgaaaag acagaagaa 
      aatcaacga tacgtatca acacctcct ggatgttgc 
      agcaaaaag acatgctct cttggaaga cgccgtgaa 
      gctgttccg attttataa agaatgtga cgattttga 
      gaaatggat taaagataa agaaaaatt gctcgctgt 
      tgacgatcc caatgacag tatcgagca agcaaaacg 
      caaatacga gaaatttgt gactgattt gtccgccaa 
      caacaaacg catggacga actaaacga cgatgttaa 
      agaattcga gaaacagaa acattcgca aattgacaa 
      aatcaaatc gcgccaccg ccaagtcca aggcgcttg 
      gcagcgtct caacttgct caaagcccg aaaagagaa 
      aagtctcga aggagcaag tagtgttga gcttttcca 
      gaaaacttg tgacgaagc tagggactg gatgttgga 
      gaaaatgac tcagcttga tacccacgt ttcggctca 
      cgacttaaa aaccgttca agctttaca acgtagaca 
      tgataatct cgaacgtga gctcgcccc tgttgagga 
      aaaagtgac caaagtaat gcatttggc aaattcggt 
      caaatcagc gtatcctaa tgagcgaca aaacgttgc 
      gcgaagaca agacgaaat cgaaggttt gtggcgaca 
      ggtcaaaga caaagctag tgaacgtag agccaggct 
      tgagaatgc cgttggtga gcaaatatt taccaattc 
      gtgtaaaga tcttttgcg gtgggtcgc cgatgttaa 
      agatcagtt gaatgctga taacatggt tagagacgt 
      gcagactgc tgaagcatt actcaaaaa tcataagga 
      cttggggga ggaaattaa agctaagaa tgacgaatt 
      ctacgagtt gaccgattt gggtaaaaa gcttctaaa 
      atctaatcc cgaacttcc cgaagttgc ggaacgtat 
      cgaaagact gactgcgga acaagcggc cataggtcg 
      cggttggaa ggaaaaaca gcgttggtt agaccagtg 
      ccaccaatt acaactatt caacagaga agccgataa 
      tatcgacgc tgcaacttc ggcccatca agcattttt 
      ggaattttc cgatttagg gaattccct tgatgaagt 
      ggaagcctt gcaaaagca gcacaaagc tttcgctaa 
      cactttatt cgcacaaga cgaccgcgt caatctctt 
      cagcaaaaa agccgacgc gttaatcgc tgatgacca 
      ttatgaaag caaaggaat cgacgataa aagaaacga 
      agtcctgca acggcgcca agctgttaa agatttgtg 
      ccaacagag aacaaacgt tctggacgc gtcgaaaaa 
      ttatcaaga gttttgtgc cgaagtgca cgatttgcg 
      tagctggtt gaatgagaa acttaaaac tgcatctga 
      tgaaagtta ccgagacct aactaacct ggagcgaaa 
      gttacaaaa acacgaagc ttttgaacg agaattgag 
      agctaacga aggacagct tcgcacagt gaacaaatt 
      aggccaagc tttgattgc tcaagacag ttacaggaa 
      ggacgacgt ggcgaaaac tttgaaaga actgaacga 
      tgagtggca acaactcgt cggactttc ccttgaaaa 
      ggggagaag gctgagaca agccgttgt ccaacacga 
      ctataacac ttcaattga cgatattca gaccaaatt 
      ggatgaaat caacgagaa tttgtgtag cactaacgt 
      tggaaccga tttgagatc ttgtcgcga tttattaaa 
      acgccaaga cgtgctcga gactgaact tggacaatg 
      tgcggccag agtcgacga attagtgaa taaaagtaa 
      cgatatgat gcatgatgg gcactttga tgccgacgc 
      aatccgcca aaaagccct cgacggcca aaaacgcct 
      caaacaact agaagaacc ggccagaaa acgacgaga 
      tgtcctaga agaggcttt gaaattcta caatttcca 
      ttttgaact cgacgctga gttgcaatg gatcaaaga 
      gcacctccc tctcgcatc gtcggccac tctgggcca 
      aaatctaca ccaagccca gaatctctt caaaaaaca 
      caaaaaact cgaagctga aattgttgg tcatcaacc 
      cgccattga taaaacctt gcaagctgg acaaaccct 
      agttgattt gaaacatcc agaaagtgc caaaatcaa 
      agacttgtg tggagtgct ccaagacgc gtgggacga 
      attaaatga aaaagcgag cgaacgtgc acaaaaact 
      ggaattgtc gttgaaagc tcaacaatt cttctttga 
      agcgaacga agttgagtc gtggctgaa cgaaaaagc 
      tgatatttt ggccagtac tgactatgg tagagatag 
      ggattcagc tacgaaatt gctgaccaa acacaaggc 
      actcgaatt agaattgga cacttacaa caacattat 
      agtcgagat gggacgtgg tgcccaaaa tttgataca 
      aaataagca cccagattc gaaattaat tgccgaaag 
      acagtccag tttggaaca tttagttcg ctctttgca 
      aaggaaagc tgttttaag acaacacca ccttatgga 
      gtcactgtt tcgtcatga atactttct ggagtcgga 
      ggaattgga tcggtggat tgccgaaaa cttacaaca 
      agcgtcttc ggaggatta tggacaaga ttacgagca 
      ccttctgat ccttcaagc caaatttga cgatttgaa 
      acaccgaat tgaagcagg agccgagcg attccgcca 
      gtgcgaaga cttggccca gaagttaat cgccaatga 
      aagctcgta tatttcaga tatacagaa aaagcaact 
      tcaactcga aaccctaac acaatcaga cgcagtcga 
      ggaagttag gcagaggca tgacgttgt acggcaatc 
      gtggcaaaa actgcacga ccagatgca gaaccgcga 
      gcagcggct tcttgcagc cggtgaaat ccaccgttt 
      ccatcgcga tgtggccga tgccatgca acgaatcca 
      agaaaagag cgctgcttt aggcaccga cctaggacg 
      cgacctaaa ctccgcctt aacactact tagaaaaca 
      cgaagcttt cgaaaacga attggtggc acttgaggc 
      tcaattaca agtcctggt tgaagatgg atcaaaatt 
      acaaaaaat ctacccaag taatcaatc tagcattca 
      acttcaaca agaagtagt gatcgatgc ttgggatta 
      cttgaaaga acgagcaga attgagaca cgaccagct 
      ccaggctag tgtggattt gcaaaaatt cctaaccca 
      agtcagaaa tttgacaaa ttgggcgac tgcgttaag 
      actagacat gcaagctga ggaaaacgt gaggagtat 
      cgcgagagc acagtttct acgtaacga acacgaagg 
      tttgaagaa tgagattga agcgaggga agccgattt 
      taaagacgt tgccgaaaa tttaacagc gatggaaca 
      aaccgggca ctatgcagc aaatgaagc cggcgaaag 
      atacaaaaa cttgcttca ggagcgaga aagacttca 
      cgccgactg gcagataaa gaaaataca cttggacca 
      attgtgcga cttgcatat gctactaag agaggcaaa 
      actgatcga agacgccac caatgcaca agaagccac 
      tttgagtaa cctagattt tggcgaaac tgtcgacga 
      agtcgccaa tcaagtcaa gaaacacga agaatttga 
      aaaactaat cgtccatca ggacgaaaa gttcgacac 
      tcttgttaa gaccggcca aaaattaat cggccaaca 
      gcatttcga cagcaaaaa catcgctaa acgtttgca 
      agaagtcgg agccaggcg gcaacaagt ccaccaatt 
      gagcgatcg caagaaaca actcctcgc cgatgctct 
      gttgtatgc ggaattcaa tagagacgt gggcgaggc 
      ccagatatg gatagccga gaaacaaaa gaagttgga 
      aaagcaagt aaagaccgg cgaagtgac caatctgga 
      cgacaaaat caaagaact acagaaaca ccaagcgtt 
      ccaagccga aatcgcagc caatgaggg caaaatcaa 
      ggaagttaa gtctaaggg agagactct tttagcaaa 
      gaaacacaa agcttcgaa agacattga agtgcaatt 
      gaggaattt ggacgatgc ttggaggca acttttgcg 
      cgaggtgga ctcgcgtgg taaaggtct ggaagaggc 
      gcaggatat tttagaatt caacaatca actggacaa 
      gatcgagtc atggatcag ggacaaaga agtgatgat 
      tcaagccgg cgacgtggg gaaagacta cgaacattg 
      ccaagcgtt gcagagaaa actcgacga tgtggatag 
      cgatatgcg gatcgacga tacccggat caaaaccat 
      caattccct ggctaacaa actggcaaa gcaagggca 
      ccccggagt gcaacaaag acgcgacaa tttcatcaa 
      gaaatggca ggatttgca aggcgcttt ggccaaata 
      tcgcaataa attagctgc agcttccga agttcactt 
      gtttgatcg cgatgtcgc tgatacggc tgagagaat 
      taatgaaaa actgctcgc gatggaaac tgacgacgt 
      cggtcgcag tttacccgc cgttgagct gctttcgcg 
      aaaacagga agcactaga gagtgaaat gaccgccgt 
      tgaaaataa attgcagga tcatggaaa agatgctgt 
      tttattgag tgataaata cccgcacgc tgtccaaca 
      cctccaggg taaaatgga agagttgca gaacgaatg 
      ggagaagct gatcgcagc gagagaacg tcgcagaaa 
      taatcttaa aggatcgca tgccaggca aaaattctt 
      atcagatgt taaggattt ggaacagtg ggttagtga 
      cacgactaa acgaatgga agcacacca accgccaag 
      tagtgtcaa cgaggctga gacactttt aggcttaca 
      tgatgaact taaagccga aatcaatgg acgtaacga 
      ggtttttgc gaaactgat caatttcgg gcgcagttt 
      ttccgaaag cgacgattc tgatataat tgacggagt 
      gaacaaatt gaaggagct tcagagtta cattcagca 
      agcttggga gcaacacaa agacgcact aacgtacga 
      atacgacct ccaagattt caaagaaca agccaacca 
      gttaaacaa ttggttagc cgataagga agctttctt 
      gaataacga cgacgtggg ggatacacc tcgcgcagt 
      tgaagctct catcagaaa acacgaagt ttttgaaac 
      aatgttaac gcaaccact gtcacgtat cgatgaatt 
      gtcgcgtaa aaaagtagg aggtaaaac accaactga 
      cccaactta cgcaaacag cgaagtcgc aacaaaatt 
      aaacgagat aatggctcg caaaaaccg acttttggg 
      caaagcagc agagcgcaa gaaaatcct acacgaatc 
      aaaagcatt acaaaaatt cctcaaaaa cgaatacga 
      cgttgaggt ttggttgaa ccacaagct tcaaatcgc 
      aaccgacga aaattatcg cgaacctta caacttgca 
      aaacaaaat ccaaaaaca tgtcacttt cgaagccga 
      agtttttgc aaaccatga acgcgtcac caacgtaat 
      tgaagaagg gcgagactt gatcgaaaa taaacacta 
      cgctagcaa agacattgc cgaccgaat tgaggaatt 
      ggaaaatcg gtggaagga attaattga acagtcaca 
      cctgaaacg tgaccgact gaacgaagc ttatcaagc 
      gttactttt caaccgatc tctcgatga attcgaagc 
      ttggttgct cgaagtcga agcccaact aacatccac 
      agatgtcgg caaagattt ggcaactgt taacaacct 
      actcaagaa acacacaat tcttgaaaa cgacattca 
      gcaacacac tgataattg tgaaacgat caacgatgc 
      ggctgatca gttcgttaa aaataatca tttcatgag 
      tgaagagat tcaacagag ggctcagga cgctattac 
      tcgattcca tcaactcaa agagcccgt tcaacagaa 
      gagagattt gttagaggg gtcgatgat gttgcaaca 
      attcactcg agatgttga agacgaatt acaatggtt 
      ggccgatag ggagccact tgccgcctc cagagactt 
      gggagcaag tttgacagc cgtacaaag cttacacaa 
      gaaacacca agcgcttga agctgaatt atcatcaag 
      agaaccaat tattggatc gcttgtagg tcgtgcaaa 
      ttctctcgc gagatcggg gcatgtttc agccccgct 
      tatcagtca gaaagcgaa ggaattgca acagaaatt 
      cgcaagtat tagggatct agccagtat caggagatt 
      gagactaca agatgcttt ggaagttca aacgtatta 
      tgaagaggc aacagaagc tgaggcatg gatgcggga 
      caaacgccc gagtttagt gaccagaga agtcgggaa 
      agatgaaga ctcagccga atctttaaa acgtaaatt 
      ggaagccac cgaattaga aataaaagc gttcgaagt 
      gactattaa aaaattgaa acagtcggc cgatgagct 
      aatcgagag acaacatta cgatgctgt taacatcga 
      aaagagaaa gaatcaact cgatgagca atttaacga 
      actgcgaaa actggtttc ggagcgtga agttcggct 
      cgacgaagc ccttcgtta ctttacttt tgtgcgcga 
      atgtttgga cgtccagga atggatgaa agaccaaat 
      acttaaaac cgattccga agaatacgg aaatgatgt 
      cgaacacgt cgaactact aatccaagc ttttgacac 
      attccatgc aagtctaat gaacagcga acctcgaat 
      tcaatcctg tatccagaa cggaaatat cctaattga 
      agctaaaag cagccacag tccggaagt gcaacaaaa 
      agtggccga tatccgcga ccaatggga cgatttgct 
      cgaacttgc caacgcgcg taaagacgc cttagctgg 
      ggccaaacg agtgcatgt tttcgatcg cacagctga 
      ggaaattat ttcgtggat ccaggaaaa gaaagccga 
      cttatcgta cgatacatt cgggcaaga cttggaaag 
      tatccaaga tcttctcag aaaacacca agcgttgga 
      gaatgagat gaaagtgat tagggaaaa agtggaaaa 
      tgtggaaca agaaggcga gaaacttat aaacgagtt 
      tccggatac caaagaaca tattgacga taagtgcga 
      ggatatgtt gtcagcttg ggggagtct tcaaaccga 
      agcagcgcg gagaaaaga tcacttaca gcaagccga 
      acaacttca agcttactt cgaccagtt ccaagattt 
      attggcgtg gattacgga aatggtggc taaaatcac 
      agcacctga ccttccaaa tgactgcaa cgaggccga 
      gcttttgat cgaacggca caaagagta caaagttga 
      aatcagtgc aaaatcaaa cgcttttaa acaattcta 
      cgactccgg taataaatt catcgaaga gggtcacct 
      gttcgctag cgaaatcca agacaaaat caaagtgtt 
      acgccagag actggagtt tttgaataa cacgtggga 
      gaaacgcaa tttgctcta caaccaaaa tttggacgt 
      cctcttgtt caaacgcga ggcagatat tttggataa 
      ttggctagc tgtgaggga aggtaccct aaaggaggg 
      aattactgg agatagcat ccaccacgt ggaagattt 
      gatccgaaa acacggcga tttcgaaga agcagtcaa 
      agcacaaga ggacaagtt tgaagcact caaacgcaa 
      aactttaat tgaagatgc gttccttct ccaacggga 
      acaggaagc tttggccaa aaaagccga gaaagagcg 
      ccaggaaca ggaacgttt ggagcactt gaaacgact 
      cgaaatcca gaaaatcaa cgaaaaaag aaggcaaga 
      aagacccca accgccgga aattgtcga ggaactggt 
      caatgggac caaacacga ggaagaagg ccgtccggt 
      tgcaacagt tcgtaaaac aaattccgt tgttcagac 
      gtttgagag agaccgtgg tgggttaag gagagggtc 
      agatagtgc aattcaacg gtcggcaag catgaaagt 
      tggtacaaa tgttacggg aagtaagcc gaaaagaac 
      tcctacttt tactacgag gcgaaggcc atcgttcaa 
      gtctaaacc aaccgaggc accacctgc ggacgccca 
      gtcgttcct cgatcgcaa acaattaac cacagcaaa 
      tggaaaacg cgccactaa caggacttg gaagaattc 
      atacacggt tttgtgcgg acagttatt gtgtttctt 
      taaaaatcg cgatgattt tgcggctag taaagctag 
      tggtccacc ggttaatgt tcataatgc gatgtgttc 
      aatagcgga tgattacca aaagaaaaa acatacgtt 
      tagacttga gcttacaga cggttcgga atttttgtt 
      tgcgtgtag ttcggattc ggagatgga taattggat 
      tcagaaaat tagtttcag ggctaggtt gcctccaag 
      tcagcaatt gctgcattt ggaaattcc aaaggatca 
      aaacgatta cgagatgag ttcacaaag tagcaggac 
      ctctagtcc ggacgttgc cgatcaagt tgtcttgcg 
      gcacgatcc gcaatcaac caatggcag tttatcaag 
      tttagcatc ttcgcgtca tactatgga tggtagcgg 
      aatgtcgtc aaaacaaga ttggcaacc taatgtaca 
      acgtccaca aacgatgca acctaatga tgcaccaaa 
      gtcacgtct gtttgaaag aattttcaa aaagaaacg 
      gaacacttc gcaaatgta atccgcatt acatacagt 
      aatagttag gagcctttt agtattatg tcaatatat 
      ttttgttta cattcttgt acatagttt cgtagttaa 
      atatatgaa cattatata aatccttca tagattttt 
      attatgaca aaatacatg tttaaatta tcc
    The data is licensed under a Creative Commons Attribution 3.0 Unported License. (CC-BY) CC-BY