Status
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Gene information
General information
TC012717 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007424.3: 13610221..13623184
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC012717
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
    We will use your email address only for possible questions regarding this annotation. We will never show your address or give it away.
    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_02934

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 30.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 3 (3 dpi)
    Days post injection


    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
     about 50

    larva appendages shape irregular - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    larva appendages shortened - Penetrance (percentage of animals/eggs on slide): 30% - 50%

    legs pretarsus shortened - Penetrance (percentage of animals/eggs on slide): more than 80%

    urogomphi shortened - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): more than 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 0.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 50.0% (includes death as larva, prepupa, pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (16 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 2 (19 dpi)
    Days post injection


    adult nutritional state - Number of animals showing the phenotype: 2 (22 dpi)
    Days post injection


    Pupal morphology
    antenna orientation irregular - Number of animals showing the phenotype: 6

    Adult morphology
    antenna orientation irregular - Number of animals showing the phenotype: 3


    club distal size decreased - Number of animals showing the phenotype: 6


    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC012717 RA
      MTAWTRIFQ GPVLVLLFV LWAPQAARA APYEQDTTE 
      IEYYPIADS TGCYYNFQH YDEGDRIIT NEPCLNCTC 
      HNRMLMCYL RVCPFTKAI GQDCKIEKR ADQCCPVIT 
      CPEVPVQLL TSTTQSSTA VGHLDAYGC SIDGLFYSD 
      GARVPSDPN KPCELCYCI RNKTACVMQ ECTLKVEGC 
      KPVYQEGVC CPVRYDCEH PDYNLLETT TRRLITTTT 
      TTQAPTTTL AGPVDCVYN NEVYADGAL VIKEKPCEH 
      CYCMRGDIV CAVQECNPT PLDKVNCTA LPPKEGQCC 
      ADSYDCDHM TEEELTTGY SYTTPSLGS FDEKATARP 
      EIESVTTQQ PVGKEGETQ EPVTVVPSE ADKEHPEQL 
      PEIPEKEDH EEPVKGVTP LFDEHAHVT EPQEVPTTI 
      KTPQEEETN EIPEEHEIV TAGPHIPSQ DEILHPGET 
      EYPKHPTEE HEAGSGEGQ VTEPEIEPG QATETPEIG 
      VPKGTELPQ QPETASEAE ATELPEHAT EAKVPEIPE 
      KPEHVTEGK ITELPPTVT EVEHEQPQH VPIEDHEPE 
      EEHEPEEEH ATEHETHGG KGTEVPQEQ VPEEPEVGT 
      TEHPHVIQH VTEIAPEIG SGLPHEMAA ATEKTEGKG 
      TEMPQEEHI PEVTEKEQV GVTHLPSGH IPKGEENGQ 
      EPIEEGTEL PREHVTETQ TVKAGEIPQ APVTEGVPQ 
      EHVTELEEK ATEVPVSGG EGTEVPREH IPEGGITEI 
      PPKDLVYPT EVPEGQVTE GHELPKEHA TVLPEQGTE 
      LPKEGTELP GEHATQVPG IVPEEQEKE ILPSVTEGP 
      IAEHAPEQI TTAVPTEIK PAGETEEHA THKPESETE 
      VPQEHVTEG QVKGESTEL PQEHVTEEL PQEHELPKE 
      PSVEEESTK LPEEHITQG PESESPTVL PAEHVTEAK 
      IGEESTEQP KEQAAHVPD VAGPVTEPP IEHITEEQV 
      AKGTEVPEK EHITEHPVY GAETTKQPS EHVTEKHIP 
      EVTTLPQEY ITEGHVEEG KVTEVPQPH VTEQGRGTE 
      APEGQVTEI PQPHADEGQ VTEHPEEHV TEGQVKEKP 
      EIITEGKLE ETTKYAEEP TPVEGEIPA NYPVEPEHA 
      PEVPEQQTE KIIPEVPET GTETATSVP SEEGETEKT 
      HKTTTKPSP VGQTEESVT EHEIQTHIP IKPSEEAEG 
      TTHRFPQMP VEEEQETES AIGKVTTEQ PSEKETETP 
      QQATEAPRI PSGEFDSTN APVEPSGEG TEKPTYPHA 
      GHEDVEEEE KPGIPGEGS CLVDGQTYK NNSNVPPIN 
      HCQVSCKCV SSILQCESV TCTPPPSNL QHCMPVYQG 
      PDSCCPTYS CSVPGVTSM ESDSHKVEI STTETVPGT 
      IGVNILIPS EEGTVKPEG TTASSRDST ELPEYSLPE 
      EHVTHKQPE QVSEASETP ESYVPQATT IKSVPAHTE 
      VPVEMATGT EKIEEGQVT EKQGELQPT EISHEGTTL 
      KPSSESEQQ PEVHVTTEY PEGVGHDEV HPDEEENAI 
      EDHTYHQII DSGRVSTER EEEHVTTSS PAIVTDKHP 
      VSVTERQGE IVTEKTIEG EVPATEIPK SEEVPAVTE 
      GVTEGVPET VTEGVKGGV TEVAHEGTM ISVTEPAHK 
      VSSESSVEE EAKVTTEPT KEGSASATE PAKEYVPEA 
      GKEEAPAAT TEYPKPSVP EAETKLPEG VTEGKKELP 
      EVPSITQQE HVTEGVKEQ EPHYDEGVH PHEEHVTEP 
      ELPATVAPE HAPVTEGKA PEQETEKEI IEAVTEPSA 
      TEKIPESIS HVTEKTQEG QIPTHDEGA TQVPEIPEK 
      TSEEGKPAE EPEVTTMHV PAIGVTEPV VTVLPEHKP 
      IETEQLPEH KPTEAQQPE AGITERVGG EEHTTPHVP 
      DEGLPEHAP GTQQPEGTT LRPEGSTVK AAEQPETVQ 
      PVHEIESST VKAAEEPQV TTIQPGYEP EGSTSKAAE 
      EPEITAKPG YEPEGSTPK TVEGEPAIT DKSSFVPEA 
      TTLRGAGEQ EGTTAQPSH EIEGAEKAD ITTMQPSHE 
      AQQPAITTV QPGHEQEGT TVKAVEQQP EITVKPSYE 
      PEGSTLKGA EQPEITAKP SYEPESTTL MGAAHPEIT 
      VKPGYEAEG TTAKSVEQP EITVKPSYG QEGTTLKGV 
      EQPEITAKP SYEPEGTTL RGIEEPEIT AKPSYEPEG 
      TEQPEITAK PGYEPQGTT LKSAEQPEI TVKPSYEPE 
      GTEQPEVTA KPGYEPQGT TLKSAEQPE ITVKPSYEP 
      EGTEQPEIT VKPGYEHEG TTLKSAEQP EVTTVKTGY 
      VPEGSTEAR IPEKEEPPV QTTPGGEEA GVTEKETKP 
      FEYIPPTSD HEHVPEEGG VTDKEGEAH TTIGYKPEA 
      TIRPEHIPS EGEAPKAPE EETTEPVVT VTPVPALPE 
      GQQPEEGEE EAPARPTVP SLEGEKEKS TEVPTTVRS 
      PISGEETTE SRPAIPGEG QESPETSTK PEVFTSPTL 
      TSTAHPNAS ELYTSGPTV EEATKKGIA GELSTSAPS 
      TTLTSSTTL PPPHSMPES PDYQAPVEE EDYGEEDQS 
      AFGPGTCRY GGKVYVSAQ QIPRDDPCD FCFCFRSDI 
      ICLQQSCPP PIPRCHEEP IRGFCCPRY ECPVSMATS 
      VNITTTTTT TTTTLPPHF FSHAYKGRA QRSGCQIRN 
      KAYQVGEEI KSASGPCLH CICGDNGQM KCDPKACSP 
      EPMLRQMIA AAESRRRR
    CDS sequence
    • >TC012717 RA
      atgacggcg tggactcga attttccaa gggccggtc 
      ctggtcctg ctcttcgtc ctttgggca ccgcaagct 
      gcacgagcc gccccgtac gaacaagac acgacagaa 
      atcgaatat tatccaatc gccgattca accggttgc 
      tattacaac ttccaacat tacgacgaa ggagacagg 
      ataatcacg aacgagcca tgtttgaat tgtacttgc 
      cataatagg atgctcatg tgttatcta agagtatgt 
      ccgtttaca aaggcgatc ggtcaagac tgcaaaatc 
      gagaaaaga gcggatcag tgctgtcct gttataacc 
      tgccctgaa gtaccagtg caacttttg acatctacc 
      acccaatcg tcgacagcg gtcggtcat ttggatgct 
      tacgggtgt tccatcgat gggctgttc tattcagac 
      ggagcgaga gtaccgtct gatcccaac aaaccgtgc 
      gaactttgt tactgcatc aggaacaaa acggcctgt 
      gtcatgcaa gaatgtacg ctcaaagtc gaaggatgc 
      aaaccagtt tatcaagaa ggtgtatgt tgtccagtt 
      cggtacgat tgcgaacat cccgattac aaccttcta 
      gaaacgacc accagaaga ctaattacc acaacaaca 
      acaacacaa gctccaaca acgactctc gctggaccg 
      gtcgactgc gtctacaat aacgaagta tacgctgac 
      ggtgctcta gtcatcaaa gaaaaacca tgcgaacat 
      tgctactgc atgagaggt gatattgtg tgtgctgtt 
      caagaatgc aaccctacg ccactcgac aaagtcaac 
      tgtacggca ttaccaccg aaagaagga caatgctgt 
      gcggactct tacgactgc gatcacatg accgaagaa 
      gaacttacg accggctac tcgtacaca acaccatca 
      cttggtagt ttcgatgaa aaagcaaca gctcgaccc 
      gaaattgaa tctgtgaca acacaacaa ccggtgggc 
      aaagaaggt gaaactcaa gaacctgtt acagttgta 
      ccgagcgaa gctgacaaa gaacatccc gaacaactt 
      cctgaaata cccgaaaag gaagatcac gaagaacca 
      gtcaaaggc gttacgcca ctctttgac gaacacgct 
      cacgtcacg gaaccacaa gaagtacca acaactatc 
      aagacacca caagaagaa gaaacgaat gaaattcca 
      gaagaacac gaaattgta actgctggt cctcatatt 
      ccatcacaa gacgagatc cttcatcct ggagaaact 
      gaatatccg aaacatccg actgaagaa catgaagct 
      ggttccggc gaaggacaa gtaacagaa ccggaaatt 
      gaacctgga caagctacg gaaactcca gaaattgga 
      gtacctaaa ggaacagaa ttgcctcaa caaccggaa 
      accgcaagt gaggctgaa gctactgaa cttccggaa 
      catgcaact gaagctaag gtacccgaa attcccgaa 
      aaaccggaa catgtgact gaaggaaag attaccgaa 
      ttaccgcca actgtcact gaagttgaa catgaacaa 
      ccacaacac gtaccaatc gaagaccat gaaccagaa 
      gaagaacac gaaccagaa gaagaacac gctactgaa 
      cacgaaaca cacggaggt aaaggaaca gaagtacca 
      caagaacaa gtaccggaa gaacctgaa gttggtacc 
      actgaacat ccacatgta atccaacac gttacggag 
      attgcacct gaaattggt tctggtttg ccgcatgaa 
      atggcagct gcgactgag aaaactgaa ggtaaaggt 
      accgaaatg ccacaagaa gaacatatt ccggaagta 
      acagaaaaa gaacaagtt ggtgttacg catttgccg 
      tccggtcat attcctaaa ggagaagaa aatggtcaa 
      gagccaatt gaagaaggc actgagctt ccacgagaa 
      cacgtaacg gaaacgcag actgttaag gccggagaa 
      ataccacaa gcacctgtg acagaaggt gtaccacaa 
      gaacatgtg acagaattg gaagaaaag gccactgaa 
      gtaccggta tctggtggt gaaggtaca gaagtacca 
      cgtgaacat ataccagaa ggtggaatt actgaaata 
      ccgcctaaa gatttggta tatcctact gaagtgcct 
      gaaggccaa gtaacagaa ggtcatgag ttaccgaaa 
      gaacatgct acagtattg ccggaacaa ggtactgaa 
      ttaccgaag gaaggaact gagttgcca ggagaacat 
      gctactcaa gtaccaggc atagtacca gaagaacaa 
      gaaaaagaa atattacct tcagtgact gaaggtccg 
      attgctgaa catgctcca gaacaaata actacagca 
      gtacccaca gagatcaaa cctgccgga gaaactgaa 
      gaacacgca acacataaa cctgaaagt gaaactgaa 
      gttccacaa gaacacgtt actgaagga caagttaaa 
      ggcgaaagt actgaattg cctcaggaa catgttaca 
      gaagaacta cctcaagaa cacgaactg cctaaagaa 
      ccttcagtc gaagaagaa agtactaaa ttaccggaa 
      gaacatatt actcaaggc ccagaaagt gaaagtcca 
      actgtattg ccagcggaa catgttact gaagccaag 
      attggagaa gaatctact gaacagcca aaagaacag 
      gctgcacat gttcctgat gttgctggt ccagttact 
      gaaccacca attgaacat ataacggaa gaacaggtc 
      gctaaaggt actgaagta cctgaaaag gaacatatt 
      actgaacat ccggtatat ggagctgaa actaccaaa 
      caaccatct gaacacgta actgagaaa catatccct 
      gaagtaaca acattacca caagaatat atcactgaa 
      ggacatgtg gaagaaggc aaagtcact gaagtacct 
      cagccccat gtgactgaa caaggaaga ggaacggaa 
      gcacccgaa ggtcaagtc actgaaata ccacaaccg 
      catgctgat gaaggtcaa gtaacggaa catccagaa 
      gaacacgtt acagaagga caagttaaa gaaaaacca 
      gaaattatt actgaagga aaacttgaa gaaacaaca 
      aaatatgct gaagagcca acacccgtc gaaggcgaa 
      attcctgca aattatccc gtggaacct gagcatgcg 
      ccggaagtt cctgaacaa caaacagaa aagataatt 
      cctgaagta ccagaaact ggaaccgaa actgcgact 
      tcggtgcct tctgaagaa ggtgagaca gagaaaaca 
      cacaaaacc acgactaaa ccatctcca gttggacaa 
      actgaagaa agtgtcaca gaacacgaa atccaaacc 
      cacattcca attaaacct agtgaagaa gctgaaggt 
      actactcat agattccct caaatgcca gttgaagaa 
      gaacaagaa accgaatct gcgattggt aaagttaca 
      acggaacaa cccagtgaa aaagaaaca gaaactcca 
      caacaagca actgaagct ccaaggatt ccaagcgga 
      gaattcgac tctacgaac gctccagtg gaaccttct 
      ggtgaaggt acagaaaaa cctacttat cctcatgct 
      ggtcatgaa gatgttgaa gaagaagag aaacctgga 
      atacctggt gaaggcagt tgtttggtt gatggacaa 
      acatacaaa aacaactcc aacgttcca ccaattaat 
      cactgtcaa gtgtcttgc aaatgtgtt agttcgatc 
      ttgcagtgc gagtctgta acttgtaca ccacctccg 
      tccaatttg caacactgt atgcctgtg tatcaagga 
      cctgacagt tgttgtccg acatacagt tgcagtgtt 
      cctggagtt actagcatg gaatcagat agtcacaaa 
      gttgaaata tctaccaca gaaacagtt ccaggcaca 
      atcggtgtt aacatcttg ataccaagc gaagaaggt 
      actgttaaa cccgaaggt acgaccgct tcaagccgc 
      gattcgact gaattgcca gaatattca ctaccagaa 
      gaacatgtt actcataaa caacctgaa caagttagt 
      gaagcaagt gagacgccc gaaagctac gttccacaa 
      gctactacg atcaaatcg gtacctgca catacagaa 
      gtaccagtt gaaatggca actggaacc gaaaagatt 
      gaagaagga caagttact gaaaaacaa ggagaattg 
      caacccaca gaaattagt catgaaggc actacactc 
      aaacctagt tctgaaagt gaacaacaa cctgaagtt 
      catgttact acagaatac ccagaaggt gtaggacat 
      gacgaagtt catccagat gaagaagaa aatgctata 
      gaagatcat acatatcac cagattata gattctggc 
      cgggtttct acggaaagg gaagaagaa catgtaacc 
      acttcatcg ccagcaatt gtaactgac aaacatcca 
      gtttctgtt acggaaaga caaggagaa atcgtgaca 
      gaaaaaaca attgaggga gaagtacct gctactgaa 
      attcctaag tctgaagaa gttccagct gtaactgaa 
      ggtgtaaca gaaggtgtt cctgaaact gttactgaa 
      ggtgtaaag ggtggtgtt actgaagtt gctcatgaa 
      ggaactatg atatcagtt actgaacct gctcataaa 
      gttagttct gaatcttca gttgaagaa gaagctaaa 
      gtaaccact gaacctact aaagaaggt tcagcaagt 
      gctactgaa ccggctaaa gaatacgtt cctgaagct 
      ggaaaagaa gaagctcca gctgcaaca actgaatat 
      cctaaacca agtgtccct gaagctgaa acaaaactt 
      ccggaaggt gtaaccgaa ggaaagaaa gaattgcct 
      gaagtacca agcattaca caacaagaa cacgttact 
      gaaggtgtg aaagaacaa gaacctcat tacgatgaa 
      ggtgttcat ccacatgaa gaacacgtc actgaacct 
      gaactaccg gctactgta gcacctgaa catgctcca 
      gtaactgaa ggaaaagct ccagaacag gaaactgaa 
      aaagaaatt attgaagct gttactgaa ccaagcgca 
      acagaaaag atccctgaa agtataagc catgtaact 
      gaaaagaca caagaaggt caaattccc acacatgat 
      gaaggtgca actcaagtt cctgaaata cctgaaaaa 
      acgagtgaa gagggcaaa cctgccgaa gaacctgaa 
      gtcacgact atgcatgtt cctgctatt ggtgtcact 
      gaacctgtg gttacggta cttcctgaa cacaaacct 
      attgaaact gaacaactt ccagaacac aaaccgact 
      gaagctcaa caaccagaa gctggaatt acggaaaga 
      gttggtggg gaggaacat actactcct catgtgcct 
      gacgaaggt ttaccggag catgctcca ggcactcaa 
      caacctgaa ggaacaaca ctacgacct gaaggtagt 
      acggttaaa gccgccgaa cagccagaa acggtacaa 
      ccagttcat gaaattgaa agcagtact gttaaggct 
      gctgaagaa ccgcaagtt acaaccatt caaccaggt 
      tatgaaccc gaaggaagc acttcgaaa gcagctgaa 
      gaaccagaa attactgct aaacctggc tatgaacct 
      gaaggaagc actcctaaa actgttgaa ggagaacct 
      gctattaca gataaatcc agttttgtg cctgaagct 
      actacactc agaggtgct ggagaacaa gaaggtacc 
      acagcacaa cctagtcac gaaattgaa ggtgctgaa 
      aaagccgat attacaacg atgcaacct agtcatgaa 
      gctcaacaa ccagcaatt acaacagtt caacctggc 
      cacgaacaa gaaggtact actgttaag gctgtcgag 
      caacaacca gaaattaca gtcaaaccc agctacgaa 
      ccagagggt agtacactt aagggtgca gaacaacca 
      gaaatcaca gctaaacct agctatgaa cctgaaagt 
      actactctt atgggtgct gcacatcca gaaatcaca 
      gtcaaacct ggctatgaa gccgaaggt actaccgct 
      aagagtgtt gaacaacca gaaattaca gtcaagcct 
      agctacgga caggaaggt actactctt aagggtgtc 
      gaacaaccc gaaatcaca gctaagcct agctatgaa 
      cccgaaggt accactctt aggggtatt gaagaacca 
      gaaattaca gccaaacct agctatgaa ccagaaggt 
      accgagcaa ccagaaatc acagccaaa cctggatat 
      gaaccccaa ggtaccact ctcaagagc gccgaacag 
      cccgaaatc acagtcaag cccagctat gaacctgaa 
      ggtaccgaa caaccagaa gttacagcc aagcctgga 
      tacgagccc caaggtact actcttaag agtgcagaa 
      caacccgaa atcacagtc aaacctagc tatgaacct 
      gaaggtacc gaacaacca gaaatcaca gtcaaacct 
      ggctatgag catgaaggt acaactctt aagagtgcc 
      gaacaaccc gaggtcaca acagttaag actggttat 
      gttcctgaa ggaagtacc gaagccaga attccagaa 
      aaagaagaa cctcctgtt caaaccact cccggagga 
      gaggaagcg ggagtcaca gaaaaggaa actaaacca 
      tttgagtac attcctcct acttctgat catgagcat 
      gtgccagaa gaaggtgga gttactgat aaggaagga 
      gaagctcat acgactata ggctacaaa cctgaagct 
      actattcgt cctgagcat attccaagc gaaggcgaa 
      gcgcctaaa gctccggaa gaagaaacg acggaaccg 
      gtagttaca gttacacca gtacctgca ctaccggaa 
      ggacaacaa cctgaagaa ggtgaagaa gaagctcca 
      gcgagaccc acagttcca agtctcgaa ggagaaaaa 
      gaaaaatca actgaagtt cctacaacg gtacgatct 
      ccaatcagt ggtgaagaa accactgaa tctcgcccc 
      gcaatccct ggcgaaggc caggaaagc cccgaaacg 
      tcaaccaaa cctgaagtt ttcacttcc ccaacactc 
      acgtcaacc gctcatccc aacgcttcc gaattatat 
      acttcgggt ccaactgtt gaagaagcg accaagaaa 
      ggcatcgct ggtgaatta tccacctcc gctccgtcc 
      accactctc accagttcc acaacactg ccaccaccc 
      cacagcatg cccgaatcg cccgactat caagccccc 
      gtcgaggag gaagactac ggcgaagag gaccaaagt 
      gccttcggc cctggcact tgtcgctac ggcggcaaa 
      gtctacgtt tccgctcag caaatccct cgcgacgat 
      ccttgcgat ttctgcttc tgtttccgc agcgacatc 
      atttgtttg cagcagagc tgtcctccg ccaatcccg 
      cgatgccac gaagagccc attcgtgga ttctgttgc 
      ccgagatac gaatgtccc gtttcgatg gcaacttct 
      gtcaatata acaacgacc accaccaca acgacaacc 
      acactacct ccgcacttt ttctcgcac gcttacaag 
      ggcagggcc caacggagc ggatgccag ataaggaac 
      aaagcgtat caagtcggc gaggagatc aagtcagca 
      tctggaccg tgtctccac tgcatatgt ggcgacaac 
      ggtcagatg aaatgtgat ccgaaggct tgcagtcct 
      gagccgatg ctgaggcag atgatcgcc gcggcggag 
      tcgcgaagg aggagatga
    mRNA sequence
    • >TC012717 RA
      ggtttggtg tcgacctcc tggacataa atcgcgaac 
      cgaagacga aaaaaaatt cttcgacaa aagagacac 
      gacatcgca ttgccggtc ggtgccgag tttatttca 
      ttataatac tcttttctt tcaccgaca atctgcgaa 
      gaggacgcg ccatgacgg cgtggactc gaattttcc 
      aagggccgg tcctggtcc tgctcttcg tcctttggg 
      caccgcaag ctgcacgag ccgccccgt acgaacaag 
      acacgacag aaatcgaat attatccaa tcgccgatt 
      caaccggtt gctattaca acttccaac attacgacg 
      aaggagaca ggataatca cgaacgagc catgtttga 
      attgtactt gccataata ggatgctca tgtgttatc 
      taagagtat gtccgttta caaaggcga tcggtcaag 
      actgcaaaa tcgagaaaa gagcggatc agtgctgtc 
      ctgttataa cctgccctg aagtaccag tgcaacttt 
      tgacatcta ccacccaat cgtcgacag cggtcggtc 
      atttggatg cttacgggt gttccatcg atgggctgt 
      tctattcag acggagcga gagtaccgt ctgatccca 
      acaaaccgt gcgaacttt gttactgca tcaggaaca 
      aaacggcct gtgtcatgc aagaatgta cgctcaaag 
      tcgaaggat gcaaaccag tttatcaag aaggtgtat 
      gttgtccag ttcggtacg attgcgaac atcccgatt 
      acaaccttc tagaaacga ccaccagaa gactaatta 
      ccacaacaa caacaacac aagctccaa caacgactc 
      tcgctggac cggtcgact gcgtctaca ataacgaag 
      tatacgctg acggtgctc tagtcatca aagaaaaac 
      catgcgaac attgctact gcatgagag gtgatattg 
      tgtgtgctg ttcaagaat gcaacccta cgccactcg 
      acaaagtca actgtacgg cattaccac cgaaagaag 
      gacaatgct gtgcggact cttacgact gcgatcaca 
      tgaccgaag aagaactta cgaccggct actcgtaca 
      caacaccat cacttggta gtttcgatg aaaaagcaa 
      cagctcgac ccgaaattg aatctgtga caacacaac 
      aaccggtgg gcaaagaag gtgaaactc aagaacctg 
      ttacagttg taccgagcg aagctgaca aagaacatc 
      ccgaacaac ttcctgaaa tacccgaaa aggaagatc 
      acgaagaac cagtcaaag gcgttacgc cactctttg 
      acgaacacg ctcacgtca cggaaccac aagaagtac 
      caacaacta tcaagacac cacaagaag aagaaacga 
      atgaaattc cagaagaac acgaaattg taactgctg 
      gtcctcata ttccatcac aagacgaga tccttcatc 
      ctggagaaa ctgaatatc cgaaacatc cgactgaag 
      aacatgaag ctggttccg gcgaaggac aagtaacag 
      aaccggaaa ttgaacctg gacaagcta cggaaactc 
      cagaaattg gagtaccta aaggaacag aattgcctc 
      aacaaccgg aaaccgcaa gtgaggctg aagctactg 
      aacttccgg aacatgcaa ctgaagcta aggtacccg 
      aaattcccg aaaaaccgg aacatgtga ctgaaggaa 
      agattaccg aattaccgc caactgtca ctgaagttg 
      aacatgaac aaccacaac acgtaccaa tcgaagacc 
      atgaaccag aagaagaac acgaaccag aagaagaac 
      acgctactg aacacgaaa cacacggag gtaaaggaa 
      cagaagtac cacaagaac aagtaccgg aagaacctg 
      aagttggta ccactgaac atccacatg taatccaac 
      acgttacgg agattgcac ctgaaattg gttctggtt 
      tgccgcatg aaatggcag ctgcgactg agaaaactg 
      aaggtaaag gtaccgaaa tgccacaag aagaacata 
      ttccggaag taacagaaa aagaacaag ttggtgtta 
      cgcatttgc cgtccggtc atattccta aaggagaag 
      aaaatggtc aagagccaa ttgaagaag gcactgagc 
      ttccacgag aacacgtaa cggaaacgc agactgtta 
      aggccggag aaataccac aagcacctg tgacagaag 
      gtgtaccac aagaacatg tgacagaat tggaagaaa 
      aggccactg aagtaccgg tatctggtg gtgaaggta 
      cagaagtac cacgtgaac atataccag aaggtggaa 
      ttactgaaa taccgccta aagatttgg tatatccta 
      ctgaagtgc ctgaaggcc aagtaacag aaggtcatg 
      agttaccga aagaacatg ctacagtat tgccggaac 
      aaggtactg aattaccga aggaaggaa ctgagttgc 
      caggagaac atgctactc aagtaccag gcatagtac 
      cagaagaac aagaaaaag aaatattac cttcagtga 
      ctgaaggtc cgattgctg aacatgctc cagaacaaa 
      taactacag cagtaccca cagagatca aacctgccg 
      gagaaactg aagaacacg caacacata aacctgaaa 
      gtgaaactg aagttccac aagaacacg ttactgaag 
      gacaagtta aaggcgaaa gtactgaat tgcctcagg 
      aacatgtta cagaagaac tacctcaag aacacgaac 
      tgcctaaag aaccttcag tcgaagaag aaagtacta 
      aattaccgg aagaacata ttactcaag gcccagaaa 
      gtgaaagtc caactgtat tgccagcgg aacatgtta 
      ctgaagcca agattggag aagaatcta ctgaacagc 
      caaaagaac aggctgcac atgttcctg atgttgctg 
      gtccagtta ctgaaccac caattgaac atataacgg 
      aagaacagg tcgctaaag gtactgaag tacctgaaa 
      aggaacata ttactgaac atccggtat atggagctg 
      aaactacca aacaaccat ctgaacacg taactgaga 
      aacatatcc ctgaagtaa caacattac cacaagaat 
      atatcactg aaggacatg tggaagaag gcaaagtca 
      ctgaagtac ctcagcccc atgtgactg aacaaggaa 
      gaggaacgg aagcacccg aaggtcaag tcactgaaa 
      taccacaac cgcatgctg atgaaggtc aagtaacgg 
      aacatccag aagaacacg ttacagaag gacaagtta 
      aagaaaaac cagaaatta ttactgaag gaaaacttg 
      aagaaacaa caaaatatg ctgaagagc caacacccg 
      tcgaaggcg aaattcctg caaattatc ccgtggaac 
      ctgagcatg cgccggaag ttcctgaac aacaaacag 
      aaaagataa ttcctgaag taccagaaa ctggaaccg 
      aaactgcga cttcggtgc cttctgaag aaggtgaga 
      cagagaaaa cacacaaaa ccacgacta aaccatctc 
      cagttggac aaactgaag aaagtgtca cagaacacg 
      aaatccaaa cccacattc caattaaac ctagtgaag 
      aagctgaag gtactactc atagattcc ctcaaatgc 
      cagttgaag aagaacaag aaaccgaat ctgcgattg 
      gtaaagtta caacggaac aacccagtg aaaaagaaa 
      cagaaactc cacaacaag caactgaag ctccaagga 
      ttccaagcg gagaattcg actctacga acgctccag 
      tggaacctt ctggtgaag gtacagaaa aacctactt 
      atcctcatg ctggtcatg aagatgttg aagaagaag 
      agaaacctg gaatacctg gtgaaggca gttgtttgg 
      ttgatggac aaacataca aaaacaact ccaacgttc 
      caccaatta atcactgtc aagtgtctt gcaaatgtg 
      ttagttcga tcttgcagt gcgagtctg taacttgta 
      caccacctc cgtccaatt tgcaacact gtatgcctg 
      tgtatcaag gacctgaca gttgttgtc cgacataca 
      gttgcagtg ttcctggag ttactagca tggaatcag 
      atagtcaca aagttgaaa tatctacca cagaaacag 
      ttccaggca caatcggtg ttaacatct tgataccaa 
      gcgaagaag gtactgtta aacccgaag gtacgaccg 
      cttcaagcc gcgattcga ctgaattgc cagaatatt 
      cactaccag aagaacatg ttactcata aacaacctg 
      aacaagtta gtgaagcaa gtgagacgc ccgaaagct 
      acgttccac aagctacta cgatcaaat cggtacctg 
      cacatacag aagtaccag ttgaaatgg caactggaa 
      ccgaaaaga ttgaagaag gacaagtta ctgaaaaac 
      aaggagaat tgcaaccca cagaaatta gtcatgaag 
      gcactacac tcaaaccta gttctgaaa gtgaacaac 
      aacctgaag ttcatgtta ctacagaat acccagaag 
      gtgtaggac atgacgaag ttcatccag atgaagaag 
      aaaatgcta tagaagatc atacatatc accagatta 
      tagattctg gccgggttt ctacggaaa gggaagaag 
      aacatgtaa ccacttcat cgccagcaa ttgtaactg 
      acaaacatc cagtttctg ttacggaaa gacaaggag 
      aaatcgtga cagaaaaaa caattgagg gagaagtac 
      ctgctactg aaattccta agtctgaag aagttccag 
      ctgtaactg aaggtgtaa cagaaggtg ttcctgaaa 
      ctgttactg aaggtgtaa agggtggtg ttactgaag 
      ttgctcatg aaggaacta tgatatcag ttactgaac 
      ctgctcata aagttagtt ctgaatctt cagttgaag 
      aagaagcta aagtaacca ctgaaccta ctaaagaag 
      gttcagcaa gtgctactg aaccggcta aagaatacg 
      ttcctgaag ctggaaaag aagaagctc cagctgcaa 
      caactgaat atcctaaac caagtgtcc ctgaagctg 
      aaacaaaac ttccggaag gtgtaaccg aaggaaaga 
      aagaattgc ctgaagtac caagcatta cacaacaag 
      aacacgtta ctgaaggtg tgaaagaac aagaacctc 
      attacgatg aaggtgttc atccacatg aagaacacg 
      tcactgaac ctgaactac cggctactg tagcacctg 
      aacatgctc cagtaactg aaggaaaag ctccagaac 
      aggaaactg aaaaagaaa ttattgaag ctgttactg 
      aaccaagcg caacagaaa agatccctg aaagtataa 
      gccatgtaa ctgaaaaga cacaagaag gtcaaattc 
      ccacacatg atgaaggtg caactcaag ttcctgaaa 
      tacctgaaa aaacgagtg aagagggca aacctgccg 
      aagaacctg aagtcacga ctatgcatg ttcctgcta 
      ttggtgtca ctgaacctg tggttacgg tacttcctg 
      aacacaaac ctattgaaa ctgaacaac ttccagaac 
      acaaaccga ctgaagctc aacaaccag aagctggaa 
      ttacggaaa gagttggtg gggaggaac atactactc 
      ctcatgtgc ctgacgaag gtttaccgg agcatgctc 
      caggcactc aacaacctg aaggaacaa cactacgac 
      ctgaaggta gtacggtta aagccgccg aacagccag 
      aaacggtac aaccagttc atgaaattg aaagcagta 
      ctgttaagg ctgctgaag aaccgcaag ttacaacca 
      ttcaaccag gttatgaac ccgaaggaa gcacttcga 
      aagcagctg aagaaccag aaattactg ctaaacctg 
      gctatgaac ctgaaggaa gcactccta aaactgttg 
      aaggagaac ctgctatta cagataaat ccagttttg 
      tgcctgaag ctactacac tcagaggtg ctggagaac 
      aagaaggta ccacagcac aacctagtc acgaaattg 
      aaggtgctg aaaaagccg atattacaa cgatgcaac 
      ctagtcatg aagctcaac aaccagcaa ttacaacag 
      ttcaacctg gccacgaac aagaaggta ctactgtta 
      aggctgtcg agcaacaac cagaaatta cagtcaaac 
      ccagctacg aaccagagg gtagtacac ttaagggtg 
      cagaacaac cagaaatca cagctaaac ctagctatg 
      aacctgaaa gtactactc ttatgggtg ctgcacatc 
      cagaaatca cagtcaaac ctggctatg aagccgaag 
      gtactaccg ctaagagtg ttgaacaac cagaaatta 
      cagtcaagc ctagctacg gacaggaag gtactactc 
      ttaagggtg tcgaacaac ccgaaatca cagctaagc 
      ctagctatg aacccgaag gtaccactc ttaggggta 
      ttgaagaac cagaaatta cagccaaac ctagctatg 
      aaccagaag gtaccgagc aaccagaaa tcacagcca 
      aacctggat atgaacccc aaggtacca ctctcaaga 
      gcgccgaac agcccgaaa tcacagtca agcccagct 
      atgaacctg aaggtaccg aacaaccag aagttacag 
      ccaagcctg gatacgagc cccaaggta ctactctta 
      agagtgcag aacaacccg aaatcacag tcaaaccta 
      gctatgaac ctgaaggta ccgaacaac cagaaatca 
      cagtcaaac ctggctatg agcatgaag gtacaactc 
      ttaagagtg ccgaacaac ccgaggtca caacagtta 
      agactggtt atgttcctg aaggaagta ccgaagcca 
      gaattccag aaaaagaag aacctcctg ttcaaacca 
      ctcccggag gagaggaag cgggagtca cagaaaagg 
      aaactaaac catttgagt acattcctc ctacttctg 
      atcatgagc atgtgccag aagaaggtg gagttactg 
      ataaggaag gagaagctc atacgacta taggctaca 
      aacctgaag ctactattc gtcctgagc atattccaa 
      gcgaaggcg aagcgccta aagctccgg aagaagaaa 
      cgacggaac cggtagtta cagttacac cagtacctg 
      cactaccgg aaggacaac aacctgaag aaggtgaag 
      aagaagctc cagcgagac ccacagttc caagtctcg 
      aaggagaaa aagaaaaat caactgaag ttcctacaa 
      cggtacgat ctccaatca gtggtgaag aaaccactg 
      aatctcgcc ccgcaatcc ctggcgaag gccaggaaa 
      gccccgaaa cgtcaacca aacctgaag ttttcactt 
      ccccaacac tcacgtcaa ccgctcatc ccaacgctt 
      ccgaattat atacttcgg gtccaactg ttgaagaag 
      cgaccaaga aaggcatcg ctggtgaat tatccacct 
      ccgctccgt ccaccactc tcaccagtt ccacaacac 
      tgccaccac cccacagca tgcccgaat cgcccgact 
      atcaagccc ccgtcgagg aggaagact acggcgaag 
      aggaccaaa gtgccttcg gccctggca cttgtcgct 
      acggcggca aagtctacg tttccgctc agcaaatcc 
      ctcgcgacg atccttgcg atttctgct tctgtttcc 
      gcagcgaca tcatttgtt tgcagcaga gctgtcctc 
      cgccaatcc cgcgatgcc acgaagagc ccattcgtg 
      gattctgtt gcccgagat acgaatgtc ccgtttcga 
      tggcaactt ctgtcaata taacaacga ccaccacca 
      caacgacaa ccacactac ctccgcact ttttctcgc 
      acgcttaca agggcaggg cccaacgga gcggatgcc 
      agataagga acaaagcgt atcaagtcg gcgaggaga 
      tcaagtcag catctggac cgtgtctcc actgcatat 
      gtggcgaca acggtcaga tgaaatgtg atccgaagg 
      cttgcagtc ctgagccga tgctgaggc agatgatcg 
      ccgcggcgg agtcgcgaa ggaggagat gagccgtcg 
      aaggagaat agtgacaat gcacgagtc aggagtgtt 
      gtgcaagtg ataagacaa ttatataat tgattatag 
      tcgcgaact ttaacataa agcattctc gggtgccaa 
      aatgaactc taatctgtt gtataactt aggttttgt 
      gcctttttg cgaggactt ggtcgagtc cccatgtgc 
      atgtggaaa atcgcacga gaaaacaac aaattttgg 
      tgatgtaca cgtatactt tcgactact tatttatat 
      tatgactga actgaaatt ttttacaat ttttgtaat 
      tagattttt tcaagtgtc gttttttga taagccatt 
      tgatatacc ccatgggct cttataata attagtgtt 
      atttgtgtt gcgtatccc gaacgagtc tgagttgtt 
      tgactagca gaaagagca tattttatg tagcttaaa 
      ccgactatt taaattaca aaaaatatt tctgctact 
      tgaacgctt agacggcta cttgtatat taacggatg 
      ctcaatatt atatataat taagtagat catgtagta 
      tttatctat aattaaaaa taaataaat tatgtaaat 
      gatt
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