Status
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Gene information
General information
TC009848 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007422.5: 9042301..9064520
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC009848
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
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    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
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    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
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    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
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    Name
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    Email
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_02858

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)

    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Fertility
    mature egg deposition blocked number 1st lateral oviduct: 3 number 2nd lateral oviduct: 2 - Number of animals showing the phenotype: 2
    mature egg deposition blocked number 1st lateral oviduct: 2 number 2nd lateral oviduct: - Number of animals showing the phenotype: 1
    mature egg deposition blocked number 1st lateral oviduct: 3 number 2nd lateral oviduct: - Number of animals showing the phenotype: 1
    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 embryo/egg with muscle fluorescence/pattern, but not hatched (pot. late embryonic lethality) - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    larval musculature fluorescence decreased - Penetrance (percentage of animals/eggs on slide): less than 30%

    larval musculature pattern irregular - Penetrance (percentage of animals/eggs on slide): less than 30%

    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    remarks: muscle pattern potentially obscured by segmentation defect,
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    cuticle remnants with some identifiable segments - Penetrance (percentage of animals/eggs on slide): less than 30%

    cuticle remnants with unidentifyable segments - Penetrance (percentage of animals/eggs on slide): less than 30%

    appendages random remaining - Penetrance (percentage of animals/eggs on slide): less than 30%
    larva segment not present - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    larva constricted - Penetrance (percentage of animals/eggs on slide): less than 30%

    head not present - Penetrance (percentage of animals/eggs on slide): less than 30%
    legs shortened - Penetrance (percentage of animals/eggs on slide): less than 30%

    legs podomer potentially fused - Penetrance (percentage of animals/eggs on slide): less than 30%
    thorax not present - Penetrance (percentage of animals/eggs on slide): less than 30%
    abdomen not present - Penetrance (percentage of animals/eggs on slide): less than 30%
    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): 50% - 80%
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 0.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 50.0% (includes death as larva, prepupa, pupa, adult)

    adult lethality - Number of animals showing the phenotype: 2 (19 dpi)
    Days post injection


    Pupal morphology
    wings distalorientation irregular - Number of animals showing the phenotype: 10

    Adult morphology
    wings not closed - Number of animals showing the phenotype: 3

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC009848 RA
      MAEDPWLLN EDGYLNADT DIKEIIYHP TLNVILICT 
      NSGIVRVLD VNSGVVLQS SYLSAINQN EVTCKYIPG 
      QDRVLFCDG QAIGVRSDY NSVLLLDSI LQKPVSDPK 
      KEIKLELPL SEAIILKQS LTSANVSGI EHVINELTD 
      VILNAQKQS KKGIKAQKW NTVCLQLPL EMLQMAAMS 
      SVSELLLKN QHTPELSVA SAVQERLSE LSGEQGSAS 
      DRRSMASEA KRRETFTHW PHMDYKWAL PDQMAQAGF 
      YHQPNASGD DRAMCFTCT VCLVCWERT DEPWSEHER 
      HSPSCPFVM GEYTQNVPL SVTYATNPA IDATYRGVN 
      VKILGTSTL SNLLPSANA EGLISVFDI SGKISRTHS 
      FFVTQFDSH ILEKYTQDF GVPGTWSDL DEEKRITSL 
      AIVSTAETT STRPTIICG LQIRCRAQK YQSPVIGSY 
      DDQNKNLME VVESATSST SFSCLYLVV YDFMYSKEK 
      EDKDHESKP NDVNAISEV TAPKNESTQ NENQKNSDY 
      VHPDAVFVE HLSSFYKTL IPGESDEVF LPPPMLVNK 
      PQHSGPRVL PIDMQITET DASQTEPFI INQEYSFMN 
      GQLSSILSE TFEKSISDH ITEMKNNKT AKKLNYSRA 
      VQCVSIPAP YKSRQDLEI SDIIATQDS RHVLVVLKS 
      SLDGKSVLI LYSLDFSQK MVKLVEEPV LVRELNNNE 
      KPTEVSMLP MVDKLGEFA EQGKNGVVG NIVMVCVDG 
      AVRIVELST MKTICMAQL ESEKFVSAA YCNSLERLC 
      ASTAKGSLH FYALNDTDN ESSEDHEED DLFGMTTDG 
      TSSNPAQTS DSLDGSEMT RCFHDPPEI ISLIDLKRL 
      HALCQFEPL RAGYCAVVP PCWSEIQQA QRQRRYPQS 
      LKTDCDQYT KTWRLQTDT TTWDEHIFE ITLPSPMSL 
      GHVDVHFSL QSSTALPHV EVTLLRQNT SGIGHKKDV 
      KFAVDETIT IDMLQQWAD NPVISQEYL RAHNADILA 
      GPVNIASCL DLSEQCGVV TLTSPKLFK SRNRTLLLH 
      IRAVYSKEE ANNKTASKR KRSESKDKT GQCASHKNE 
      FYMGCDCIH ELSITVYSS KHTEIPHER SQRNFMLES 
      ISCVQSLLL TAMNNSSNE SVSLSLDVL TWIASIRLI 
      RNRSNNGEV PNQQMEFLY VIEYNLAKL LQQCLLLGE 
      RSIAHKCMK LIEVCCNGA KNMSETGRS HFEFSILKA 
      LLSLLNTIT DVRSPGGLQ WIFALLLKV ISKNAQYVA 
      TKCVTLLNK MSEELENRT NPYHLLLRS RYGLYGTPL 
      ELELFDIEP PPYAKSTST YVTYATAVS GDSANQNND 
      FFENYSFNK ESINPKDVL SGTETKLKW RNLAPPKIY 
      RGLIETVPL HFTCVSASE GTRLERADA SNNINNIVI 
      NEIPFSITP FHGQGSLDK MDHSKFKSY LVDFVEEPT 
      VTVKEYKNS NPQATTSSV GTWDDNGCE VLIGELPVD 
      VGNHLLKKL DSMYQDLKS SMENKSSAV KNVWQPESL 
      LSPPTNSSL PWQHLLVTP PQQVIVVER MHSGARRYV 
      VLDFGQPIL LTDILLPSC NDLVSVSID IWLKSEDVD 
      GTRLVVAAD IGSKNLVLN DLQPAPLCR YMKITTVGR 
      YGMTTARCR IPIGYFYGH VVVLPEEVP PDLSQNVSN 
      LACTDLDKQ LTILSKLFE DISCRYSLA CSKLKELLR 
      PFLVADMKN ASHLATYMN IMKDKALNT SNPEHSKIF 
      SAYQESITY QRQLNTIRN VMNRLEGSI SKMSVSPRN 
      PKDIPNAST DKLRAIAEG LLEVLLTLD SAIEIDPVT 
      CRKLFQGLC VSQASRLQL LTAIFLDKS CRTKSYWGN 
      FLADTLTEM FATSNTTKF PQDRVFILL AYLSRKSPE 
      RSAVIDAGL RVVSQTLAP LTGDRSNLL AVSVDLPLL 
      SWLLMYLSL QLDLSKNSL QSATRWDWV FGEIVGKVN 
      AESAKIGSR KKNYKRISK QQIDNLDAA QKLVQSSAQ 
      ALSTLSNHA ACLTSKLDA ALKTQQFLM KKVKYKFMD 
      MKNSPAENP LAPKKLKET AAEPVIEKI TEKKMPQHI 
      DVNHCLTVA KGLLTLVLS MDHSSSADM LLLSFKVMA 
      RLVSMAKIK LGQLMNQEQ LLNLFRFCL ASKIPWAPH 
      ALACLLQDV VENENDTDS GASTSWATN DFLSDVANL 
      CEFTDDETF VHEPVITAP PKTGNNNNQ LPSVYESDD 
      SDLEEIVDG FLDKEAMST PKKIPKPTN YSHTTNSVA 
      LDSRLDLSV DVSAEISLR KLINKNTQG LLQSVNAPV 
      VGDESEDAL APWPTVVLP LQPESLLSN TAMLTQCFD 
      SLFENLPMQ DSANIEHIL QLWLTLNNP YKDDKFDPS 
      AVAQIVLKE SSVKALISA IAWTPGLSL ITWCVALQT 
      LTLVCNSNI TSESSLYWS DSYGMASCI VNHPDFVQV 
      FMRLLSGTG LTFIDKVLA GPSLCKALN DFLDRLLMR 
      CYVESPRSK AGKSLKTLL LKIVHQLVL PTGPIALRQ 
      GPLDVQCKL LKIMLDIDY FNADMTIAM SIFESTCVL 
      VHSYFVNVD KIKCINIGE KHNVVTTTF NEIFACVMG 
      SDPIKMDLQ VSTEVLFLR LLKFLGKLV QTQFRQGID 
      QPEAMDVEP LATSQTDES KAEQIQQDS MRNRGENFA 
      DLVLQYHAN IMRLCQSLA ACKSSSLCM LANVSQKAA 
      FSNLSEPSN VGDAVFHVL ALLAKRTSD KKLVLPPLL 
      QFLAHAPQL SEPLLWFLL QILNNEEAI RNFLTAGGI 
      EILGRSFVT SSNTPNTIS KSGTISIVM QHFSGINPT 
      SDASTAIAS ASASRKLQQ ATIENKLSL VNFAPCCTI 
      SCPSGTAQP AEVLIQGTA ATHRRARTP QWSYHFYPD 
      EAHTELTLQ LPSAILLRE VHLQPHLSA LATCPSAVA 
      LEVSANGPS RLVPVCPPL PTSGMVFIR LHLPVPEVV 
      NCVLIRLYR PRDANNIGL SQIRLLGNL AFGGNTNQN 
      LADPVEDES HCRHSLGWL RLLHHCFTL PTEQDLAKQ 
      VIACASGVP RLLSTCCEL LLVPSHVLP IYLPCLEKV 
      LRELSLHNL ENGNNVIKI LLNSRSSII EPLNFADNA 
      WQDRLLINA TGYQSACEL LYQICEHQD SDTFYRVKM 
      MLEWLQSVA VEAMQTGNT QGCNPAYIS SIASILWSA 
      NQARVSYDL PSMITLDFF DTIYNLKTC VENNIALKY 
      SLDSLLCSL CYIRPELFP VLLQRIGVL VPNLSTDHD 
      ASISDDRKD SESMTDDNK QTFELDSEW YGHLVMGEL 
      SKLSLSNEQ LETVALVSR SPSAIQQLL DSGLPKMLN 
      SAIYEFCTS NEDNSVPMA KLENVTAIL KFFTDVSDE 
      KTMRDWLGS SDGSSFWLE LLNWLCKKP FLKKSNLQS 
      EAHAQLEEV CVKFLSKCC LCHPSNQAR LANVLCKVI 
      DLQSNGISG FMRRLTLQL LLENEKIPV SIKADETLY 
      KSVKLTQAY LPVHPAFKQ TYNRALLYL STNTTLADI 
      LEQHIYFNT TYKMETNNS SKRPFVTKK DLFKGWFPE 
      DSDLSMAAG VTAKDKRAK DAKNQAAST PQSKKKRYT 
      ATESLTSGD VIGGRLIKC EAYSDQPLP LNLNLGQLL 
      RLIESKGTT ADWPCVHLV VCQNKNGDK KSESSEVDS 
      SLYQQQPFS SALQVFSSM GGLALLARH LPTVYPEAV 
      RPPLKEKTT SEQSDSEWI KVEDCDDIY EDVEETVGT 
      SSPSKSSGL ISNVPAHSL TAFGLFLRL PGYAEVLLK 
      DMKKALCLL RLVLGVTDD GEGGDIFQS PIADSLPTL 
      PFEVLRKLY DATPLSTDD GRLLRRISI NTGVVHLLL 
      ACLGIFTHQ TQNNEKEGQ KDAKGKDER SQLYWAKGT 
      GYGTGSTQQ IWNVEQALL KQKSEEEHV TVLLQVLAS 
      YISPNGETA DELMEDVLP SSFHDLLAN SSLLPALSS 
      YLRNDSVLD MARHIPLYR AALQLLRAL ATSSQLVDL 
      LLPQKTRIN EPSISSLLK SMKTCVDTY ASKLRLNTK 
      TNTKFKTKL REQLEELEQ GEGLATLMP DIQDTANLV 
      SKVTSGLVD SDHDSEGEV AVDRVIFAS LEEKYLKIM 
      KSLQFGSYE MITELPEGG VKFAVSHHF ENNAKSTGE 
      QSHPARVKR IAQEAVTLS TSLPLSYSS SVFVRYDTS 
      RLDVMKVLM TGPADTPYA NGCFEFDVF FPPDYPLSP 
      MMINLETTG HHTIRFNPN LYNDGKVCL SVLNTWHGR 
      PEEKWNAQT SNFLQVLVS IQSLILVPE PYFNEPGYE 
      RSRGTPAGT QSSREYNAN VSQATVRWA MLEQILNPC 
      LCFKDVIYT HFYLKRHEI LAQVEGWIK DLENDITEK 
      RISRTANKR SPTANIDSF KKIFQQLKE QLTKLKPPE 
      GVVEEDPAP KMETTSASV NGLEGNEQE MDADIDMEK 
      MVKEMCEFD AT
    CDS sequence
    • >TC009848 RA
      atggctgag gatccttgg ttattaaac gaagacggt 
      tacttaaat gcggacaca gacatcaag gaaatcatt 
      taccacccg acactgaac gttattttg atatgtacc 
      aacagtgga atcgttcgg gtgttggat gtcaactcg 
      ggtgttgtt ctccaatcc agctatctc tcagcaata 
      aaccaaaac gaagtaact tgtaagtac attcctgga 
      caagacagg gtgctgttt tgtgatgga caagctatt 
      ggagtcaga tcagactac aacagtgtg cttttactc 
      gacagtatt ctgcagaag ccagtatcg gatcccaag 
      aaggaaatc aagctcgaa ttaccacta tctgaggca 
      atcatcttg aaacaaagc ttgacttca gccaacgtc 
      agcggtatt gaacatgtg ataaacgaa ttaaccgac 
      gttattttg aacgctcaa aaacagtcc aagaagggt 
      attaaagct caaaaatgg aacactgtc tgtctccaa 
      ctccctttg gagatgctc caaatggct gccatgagc 
      agcgtctca gaactactc ctaaaaaac caacacacc 
      ccagaattg agtgttgca tcagccgtg caagagcgc 
      ctctcggag ctcagtggg gaacaaggg agcgcttca 
      gaccgcagg tctatggcc agcgaggcc aaacgacgc 
      gaaacgttc acccattgg ccccacatg gactacaaa 
      tgggccttg ccggaccaa atggcccag gcgggcttc 
      taccaccag cccaacgcg tctggggac gaccgcgcc 
      atgtgcttc acttgcacc gtgtgcctg gtctgttgg 
      gagcgcacc gacgagccc tggagcgag cacgagcgg 
      cattcgccc agttgtccg tttgtcatg ggcgaatac 
      acccagaat gtcccatta tcggtcact tacgccacc 
      aacccggct attgacgcg acctatcga ggggtcaac 
      gtgaaaatc cttggtacg agcaccttg agcaacctt 
      ctgccatcg gcgaacgcc gaaggcctg atctcggtg 
      ttcgacatc tcggggaag atctcaagg acacactct 
      tttttcgtc acacaattt gattcccac attctggag 
      aagtacaca caggatttc ggggtccca ggcacctgg 
      agcgacctc gacgaagaa aagcgaata acatcattg 
      gcgattgtg agcactgcg gagacgacg tccacgcgc 
      cctactatt atttgcggc ctccaaatc cgatgtcgg 
      gcccagaaa taccagtca ccggtgatt ggaagttac 
      gacgatcag aataaaaac ttgatggag gtggtggag 
      tcggcaacg tcttcgacg agtttcagt tgtttgtat 
      ttggtcgtt tacgatttt atgtacagt aaggagaag 
      gaggataag gatcacgag agtaaaccg aacgatgtg 
      aacgccatc tctgaagtg actgcgccc aagaatgaa 
      tcaacgcaa aacgagaac cagaaaaac agtgattac 
      gtgcatccc gacgccgtc ttcgtcgag catttatcg 
      tcgttttac aaaactttg atacctggt gaaagtgac 
      gaggtgttt ctcccgcct ccgatgctc gttaacaaa 
      ccccaacat tcaggtcct agagtatta cccattgac 
      atgcaaatt accgaaact gatgcttcg caaaccgag 
      ccttttata atcaaccag gaatattcg tttatgaac 
      ggccagttg agcagcatt ctttcggag acgttcgaa 
      aagagcatt tccgaccac attaccgaa atgaaaaac 
      aacaaaacg gccaaaaaa ttgaattat agtcgagcg 
      gtgcagtgt gtgtcgata ccggcgcct tataaatcg 
      cgacaggac ttggagatt tccgatatt atcgcgacg 
      caagacagt cgacatgtt ctagtcgtg ttgaaaagc 
      tcgttggac ggtaaaagc gttttgata ctctattct 
      ttggacttc tcacagaag atggtgaag ttggttgaa 
      gagccggtt ttggtgcgc gaattgaat aataatgaa 
      aagccgaca gaagttagt atgttgccg atggtggat 
      aagttgggg gagtttgcc gaacaaggg aagaatgga 
      gtcgtaggg aacatcgtc atggtgtgc gtcgatggg 
      gctgtgaga atcgtggag ttgtcgacg atgaagacc 
      atatgcatg gcgcagttg gagagcgag aagtttgtt 
      tcagcggca tattgcaac agtttggag cgcttgtgc 
      gcctccact gcgaaaggt tccctgcac ttctatgcc 
      cttaacgac accgacaac gaatcctct gaagaccac 
      gaggaagac gacttgttc gggatgacc accgacggt 
      acatcatca aaccccgcc caaaccagc gattcactc 
      gacggaagt gaaatgacg cgttgtttc cacgaccct 
      cccgaaata atttctttg atagacttg aaacgattg 
      cacgctttg tgtcaattc gaaccgtta cgagcaggg 
      tattgcgct gtagttcct ccctgttgg agcgaaatc 
      cagcaggct caaagacag agaaggtac ccccaaagc 
      ctcaaaacc gactgcgac cagtatacg aaaacgtgg 
      cgactgcaa acggacaca accacctgg gatgagcac 
      atcttcgag atcacattg cccagtccc atgtctctg 
      ggccacgtg gacgtgcac ttcagtctg caatcgtcg 
      acggcgttg ccgcatgtc gaagtgacg cttttgcgg 
      caaaacacg agcgggatt gggcacaaa aaagacgtt 
      aagtttgct gtggacgaa accataact atagatatg 
      ttgcaacag tgggccgat aatcccgtt atcagtcag 
      gagtatcta agggcacac aatgccgat attctggca 
      ggtccggtg aacattgcc tcgtgtttg gacttgtcg 
      gaacaatgc ggtgttgtt actttgacc agtccgaaa 
      ttgttcaag tcgaggaat cggaccttg ctgttgcac 
      atcagggct gtttattcc aaagaagag gctaataac 
      aaaactgct tccaagagg aaacgctcc gagagcaag 
      gacaagacg ggtcagtgt gccagccac aaaaatgag 
      ttttacatg gggtgtgat tgcattcac gagttgagt 
      attacggtg tatagttcc aaacatact gaaattccg 
      catgagagg agtcagagg aatttcatg ttggagtct 
      atttcctgc gtccagtcg ctgctgcta acagcaatg 
      aataattcg tcaaatgag tcggtttct ttgtcgttg 
      gatgtactc acgtggatt gcgtccatt cgtttgatt 
      aggaatagg agtaacaac ggggaggtg cctaatcag 
      cagatggaa tttttatac gtgattgag tacaacttg 
      gcgaagctc ctccaacag tgtcttctc ctcggcgaa 
      cgaagcatt gcacataag tgcatgaag ttaatcgaa 
      gtttgttgc aatggcgct aagaacatg agcgagacg 
      gggcgctcc cacttcgag tttagcatc ctgaaggcc 
      cttctctcg cttttgaac acaatcacc gatgtccgg 
      tcacctggc ggcctccag tggatcttc gcacttctc 
      cttaaagtc atttcgaaa aacgctcaa tacgttgca 
      accaaatgc gtaactttg ttgaataaa atgtccgaa 
      gagttagaa aatcgaacg aatccgtac cacttactt 
      ctcaggagt cgttacggc ctatacggc actcctcta 
      gaactagaa ttatttgat atcgaaccg ccaccctac 
      gctaaaagt accagtaca tacgtcact tacgctaca 
      gcggtgtct ggggacagc gccaatcag aataacgac 
      tttttcgag aactattcg ttcaataaa gagagtatt 
      aaccctaaa gatgtgttg tcaggcact gagacgaag 
      ctgaagtgg cgaaattta gcaccaccg aaaatatac 
      agagggtta atagaaacc gttcctttg catttcact 
      tgcgtttcg gcaagtgaa gggacgaga ctagaaagg 
      gccgatgcc tcaaataac atcaataac atcgttatc 
      aacgagata ccgttttca attacgcca ttccatggc 
      cagggctct ttagacaaa atggaccac agcaagttt 
      aaatcctac ttggttgat tttgtggaa gaaccgacc 
      gtcaccgtt aaagaatac aaaaattcg aatccacaa 
      gcaaccact tcgagtgtg ggcacgtgg gacgataac 
      ggctgtgaa gtgttaatc ggagagtta ccagtggat 
      gtcggcaac cacctctta aagaaatta gattccatg 
      tatcaagat ttgaaatct tcaatggaa aataaaagt 
      agcgcagta aagaatgtg tggcaacca gagagttta 
      ctttcgccg ccgactaat agtagtttg ccgtggcaa 
      cacttacta gtaactccg ccacaacag gttattgta 
      gtggaacgg atgcattcg ggggctcgc agatacgtg 
      gttttggat ttcgggcaa ccgattttg ctcactgat 
      attcttcta ccgtcttgc aatgacctg gtctctgtt 
      agtattgac atttggctg aagagtgaa gatgttgat 
      gggactcga ttggtggtt gctgcagat attgggtcg 
      aagaatttg gtgttgaat gatctgcag ccggcgccg 
      ctgtgccga tacatgaag attaccaca gttggtcgt 
      tacggaatg actacagcg agatgcaga atccctatt 
      ggttacttt tacggccac gtggtagtt ctccctgaa 
      gaagtacca ccggatttg tcccaaaac gtttcgaac 
      ttggcttgc actgactta gataagcaa ctaacaatt 
      ttatcgaaa cttttcgaa gatatcagc tgtcgatac 
      agtttggct tgctccaaa ttaaaagag cttttacga 
      ccgttcttg gtggccgac atgaaaaat gcatctcat 
      ctggcgact tatatgaac atcatgaaa gacaaagcc 
      cttaatacc agcaacccc gaacacagt aaaatcttt 
      agcgcttat caggaatca atcacatac cagcgtcag 
      ttgaacacg attcgaaat gtgatgaat cgacttgaa 
      gggagtatt agtaaaatg tcggtctcg ccgagaaat 
      cctaaagac attccgaac gcctcaacc gataaactt 
      agagccatc gctgaaggt ttgcttgag gtgctacta 
      acgctggat tcagcaatc gaaatcgat cccgtcacc 
      tgtcgcaag ctcttccaa gggctatgc gtgtcgcaa 
      gcttcacgt ctgcagtta ctaaccgcc attttcctg 
      gacaagtcc tgcaggacg aagagttac tggggcaat 
      ttcctcgcc gacactttg accgaaatg ttcgcgaca 
      tccaacaca acaaaattc ccccaagac cgcgttttc 
      atcctcttg gcttacttg agccggaaa agccccgaa 
      cggagcgcc gtcattgac gccggtctt cgagtggtt 
      tcgcaaact ttagctcct ttgactgga gatcgctcc 
      aatttactt gcggtctcg gtggatctc cctctactc 
      tcctggctg ttgatgtat ctctcgctc cagttggac 
      ctaagcaag aacagtctc caatcggcc acgagatgg 
      gactgggtg tttggggaa atcgtcggg aaggtcaat 
      gccgaaagt gcgaaaatc ggaagccgg aagaaaaat 
      tacaaacgc atcagcaag caacaaatc gacaatttg 
      gatgcggca cagaagctg gtccagtct tcggctcag 
      gctttgtcg acgttgtcc aaccatgcg gcgtgtctc 
      acatcgaag ttggatgcg gctctgaag acgcaacag 
      tttctgatg aagaaagtt aagtacaag ttcatggat 
      atgaagaat tcgccggcg gagaatcca ctcgcgccg 
      aagaagctg aaggagacg gcggcggaa ccagtaatc 
      gagaaaatt accgagaag aagatgccg cagcatatt 
      gacgttaat cattgtttg actgtggcc aaagggctg 
      ctgactttg gtgctctcg atggaccat tcgagcagt 
      gccgacatg ctcttgctt tcgtttaaa gtaatggcc 
      cgcctggtc agcatggct aaaatcaaa ttgggccag 
      ctgatgaac caggagcag ctcttgaac ttgttccgc 
      ttttgcctc gcttcgaaa attccatgg gcccctcat 
      gctctcgcc tgtctcttg caagacgtc gttgaaaac 
      gaaaacgac accgactct ggggcttcc acaagctgg 
      gccactaac gatttcctc tctgacgtg gcaaacctg 
      tgcgaattc acggacgac gagacattc gttcacgaa 
      cctgtaata acagcgcca cctaaaact ggaaataac 
      aacaaccag ttgccttcg gtttacgaa tccgacgat 
      tcggattta gaggaaatt gttgacggg tttttggac 
      aaggaagcc atgtcgact ccgaagaag ataccgaaa 
      ccaacgaat tactcacac accactaat tcagtagcg 
      ctggattcg agacttgat ctcagtgtt gacgtatca 
      gcggaaata tcgctacgg aagttgatt aataaaaat 
      actcaaggg ttgttgcaa agtgtcaac gcgcctgtg 
      gttggtgac gaaagtgaa gatgcgtta gcgccatgg 
      cctactgtg gtattgccg ctgcaaccg gagtctctt 
      ctgagtaac actgcgatg ctgactcag tgcttcgat 
      tcgttgttt gagaacttg ccgatgcaa gactcggca 
      aacattgag cacattttg cagttgtgg ctgactttg 
      aataacccg tacaaggac gataagttt gatccttca 
      gccgttgct caaatcgtt ctcaaagaa agctcagtg 
      aaggctttg atttcagcg atagcctgg actccgggc 
      ttgtctcta attacgtgg tgtgtcgcc ttacagact 
      ttgactttg gtctgtaat agtaatata acgtcagag 
      tcttccctc tattggtca gattcgtac ggaatggcc 
      tcttgtata gtcaatcac ccggatttc gtccaggtc 
      ttcatgagg ttgttatcg gggactggg cttaccttc 
      attgataaa gttttggcg ggaccttcg ttatgtaaa 
      gctttgaac gattttctc gaccggctt ttgatgagg 
      tgttacgtg gaaagtccc cgaagcaaa gcaggaaaa 
      tcgttaaag actctcttg ttgaaaatt gtgcaccag 
      ttagtgcta cctacaggg ccaattgcc ctacgacaa 
      gggcctcta gatgtgcag tgtaaattg ttgaaaatt 
      atgttagat atagattat tttaacgcc gatatgact 
      atcgcgatg agtattttc gagagtacg tgtgttctg 
      gttcattcg tattttgtt aatgttgat aaaattaaa 
      tgtattaat atcggggag aagcacaac gtggtcacg 
      acgacgttt aatgagatt tttgcctgt gttatgggc 
      tcggacccc atcaaaatg gatctacag gtctccact 
      gaagtgctc tttttgcgg ctcttgaag tttttgggg 
      aaattggtg caaacacag tttagacaa ggcatcgat 
      caaccggaa gcaatggac gttgagccc ttggcgact 
      tcgcaaacc gacgaaagc aaggccgag caaatccaa 
      caagactcg atgcgcaat cgtggcgaa aatttcgcc 
      gatcttgtc ctccaatac cacgctaat attatgcgt 
      ctgtgccag tctttagca gcttgcaaa tcctcgtca 
      ttgtgtatg ctagcaaat gtctcgcaa aaagcggcc 
      ttttccaac ttgagcgaa ccgagtaac gttggagac 
      gcagtgttc cacgtttta gccctgtta gctaagcga 
      acctctgat aaaaagttg gtgttacca ccgttgctt 
      caattctta gcacatgcg cctcaactg agcgagcct 
      ttgttgtgg ttcctattg caaattttg aacaatgaa 
      gaggctatt cggaatttc ctcaccgca ggtggtatt 
      gaaattttg ggccgaagt ttcgtaacg agtagcaac 
      actccgaat accatttcc aagtcaggg actatttcc 
      atagtcatg caacacttc agtgggatt aatcccact 
      tctgacgct agcacagcc atcgcgtca gcatcggct 
      tcaaggaag ctgcaacaa gcaaccatc gaaaataaa 
      ttgtctttg gttaatttc gccccttgc tgcactata 
      agttgccca tcagggaca gcccaaccg gcggaagtc 
      ctaattcaa ggaacggct gcgacccac cgccgggca 
      cgaactccc caatggagt taccacttt taccccgac 
      gaagcccac actgaactc actttgcaa ctcccgagt 
      gcgatttta ctgcgtgag gtgcatttg cagccacac 
      ttgagtgcc ctggcgact tgtccttca gctgtagcc 
      ttggaagtc tcagccaat ggtccttcg cgtttagtc 
      cctgtgtgt ccgccactt cctaccagt ggtatggtt 
      ttcatcagg ctacacttg ccggttccg gaagtcgtc 
      aattgtgtc ttgattcgt ttgtatcgt ccacgtgat 
      gctaacaat atcgggctt tcgcaaatc cgtcttttg 
      ggtaatttg gcttttggc ggaaatacc aatcagaac 
      ttggccgat ccggtcgaa gatgagtca cactgtcgc 
      cacagttta ggctggtta aggttacta caccactgt 
      tttacgtta ccgacagag caggatttg gcaaaacaa 
      gtgatagcg tgtgcgtct ggagtaccg agattgttg 
      agtacttgt tgcgagttg cttctagta ccatcccac 
      gtgcttccg atctattta ccgtgtttg gagaaggtt 
      ttaagggag ttgagtttg cacaatttg gaaaacgga 
      aacaatgtt atcaaaatt ctgctgaac agtcggtcg 
      agtatcata gaaccgcta aatttcgcc gataatgcc 
      tggcaagac aggttgttg ataaatgca acggggtac 
      caatcagct tgtgaattg ttgtaccag atttgcgaa 
      catcaagat tctgatact ttctaccgc gttaagatg 
      atgctggag tggttgcaa agtgtcgca gtcgaagcg 
      atgcaaacc ggaaatacg caagggtgc aaccctgcg 
      tacatatct agcatagct tcgattctg tggtcggcc 
      aatcaggct cgagtcagc tacgactta ccgtcaatg 
      atcacttta gatttcttc gacacgatc tacaacctt 
      aaaacctgc gtggaaaac aacatcgcg cttaaatac 
      tccctcgac tccctgttg tgcagtttg tgttacata 
      aggcctgaa cttttcccg gtgctttta caacgaatc 
      ggagtgtta gttccgaat ttgtccacc gatcatgac 
      gcttcgatc tccgacgac cgcaaagac tccgaaagt 
      atgaccgac gataacaaa caaaccttc gagctagat 
      tcggaatgg tacggccac ctggtaatg ggcgaactc 
      tcgaaactt agtctttcg aacgaacaa ctggaaacc 
      gtggccttg gtgagtcgc tcaccctcg gccatccaa 
      cagttgcta gactccggt ctcccgaag atgttgaac 
      agtgccata tacgagttt tgtacttca aacgaggat 
      aattcagtc ccaatggct aaactggag aacgtgact 
      gcgatttta aagttcttc actgatgtt agcgacgag 
      aaaacgatg cgtgattgg ctggggtcg tccgatggc 
      tcgtcgttt tggctcgag ttgctcaac tggttgtgc 
      aaaaaaccg ttcctgaaa aagtcgaat ctccagtca 
      gaagcgcac gcccaattg gaggaagtg tgtgtcaag 
      tttttgtcg aagtgttgc ctttgtcac cctagtaat 
      caagcgcga ctggcgaat gttttatgc aaagttata 
      gatttgcaa agtaatgga atctccggt ttcatgcgt 
      cggctgact cttcagcta ctgctggaa aacgagaag 
      atccccgtc agtattaaa gcggacgag actttgtat 
      aaaagcgtc aagttgact caggcgtac ttgccggtg 
      catccggcc ttcaaacag acctacaac cgggctttg 
      ctctacttg agcactaat acgactcta gccgacatc 
      ctagagcag cacatttat tttaacacg acctacaag 
      atggagacg aataactcg agtaagcga ccttttgtc 
      actaagaaa gatctattc aaaggttgg ttccccgaa 
      gattcagac ttgagcatg gctgcgggt gttactgcc 
      aaagataaa cgtgccaaa gacgccaaa aatcaagcc 
      gcctcgacg ccccagtcg aagaagaag aggtacacg 
      gcgacggaa agtctgact agtggggac gttattggg 
      ggacgcctg atcaagtgc gaggcgtac tcggaccag 
      cccttgccc ctcaacttg aatctgggg caactgctg 
      cggttgatt gagtcgaag gggacgact gccgattgg 
      ccgtgtgtc catttagtc gtttgtcaa aacaaaaat 
      ggtgataaa aaaagtgaa agtagtgaa gtagattct 
      agtttgtac cagcaacaa ccattcagt agtgcctta 
      caagtgttc agttcgatg ggtgggttg gcgctactg 
      gctcggcat ttgcctacg gtgtaccca gaggcagtg 
      cggccacca cttaaggag aaaaccacg tccgaacaa 
      tcggactcc gagtggatt aaagttgaa gactgcgac 
      gatatctac gaagatgtc gaagaaaca gtcgggacc 
      agttcgcct tcaaagtca tcagggctt atttcaaac 
      gttccagct cactctctc actgccttt ggtctcttt 
      ctccgactg ccgggctac gctgaagtc cttctcaaa 
      gacatgaag aaggctcta tgtctgttg cgcttagta 
      ttgggtgtg accgacgac ggcgaaggc ggtgatata 
      ttccagtcc ccgattgcc gactcgctc cccacgttg 
      ccttttgaa gtgctccga aagctctac gatgccaca 
      cctttgagc accgacgat ggccggctt ctccgacgc 
      atcagcatt aatacgggc gtggtccac ttgctctta 
      gcttgtttg gggattttc acccatcag actcaaaac 
      aacgagaaa gagggccag aaagacgca aaagggaag 
      gacgaacgc tcccagttg tactgggcc aaaggtaca 
      ggctacggt acgggttcg actcaacaa atctggaac 
      gttgaacaa gccctactt aaacaaaag agcgaagag 
      gagcacgtg acagtcctg ttacaagtt ttggcgagc 
      tatatcagt cccaacggg gaaactgcg gatgagtta 
      atggaagat gttttgccg tcgtcgttt catgacctt 
      ttggccaat agctcgctt ttgccggcg cttagctcg 
      tatctgagg aacgattca gttttagat atggcccgg 
      catataccg ctctacaga gcggccttg caactatta 
      agagccttg gctactagt tcgcaactg gtggatttg 
      ctcttgcct caaaaaacc cgcatcaac gaaccatct 
      attagttca ttattgaaa agcatgaag acttgcgtt 
      gatacttat gcttctaaa ttaagactc aacactaaa 
      acaaataca aaattcaaa accaaactt cgggaacaa 
      ctcgaagaa cttgaacag ggtgaaggt ctggcgact 
      ttaatgccc gacatccag gacaccgcc aatttggtg 
      tctaaggta acaagcggc ctcgtagac tcggaccac 
      gatagcgaa ggggaagtt gccgtggat cgggtcata 
      tttgcgtct ttggaagag aaatatctc aagataatg 
      aagagtctg cagtttggt tcgtacgaa atgatcacg 
      gaattgcct gaaggtggt gtaaagttt gcggtgtcg 
      caccatttt gaaaacaac gcgaaatcg acgggggag 
      cagtcgcac ccggcgcgt gtcaagcgg atagcgcag 
      gaggccgta accctatcc acgagtctg cctttgagt 
      tacagcagt tctgttttc gttcgttac gacacctcc 
      cggttggac gtcatgaag gtgctgatg accggccct 
      gcggacact ccctacgcc aacggctgc ttcgaattc 
      gacgttttt ttcccgccg gattacccc ttgtccccc 
      atgatgatc aacctggaa acgacggga caccacact 
      attaggttt aatccgaat ttatataac gacggcaag 
      gtttgtctg tccgtgctg aacacctgg cacggacgg 
      cctgaggag aagtggaac gcccaaacc tccaacttc 
      ctgcaggtc ctggtgtct atccagagc ctgatcctt 
      gtgccagag ccctacttc aacgagccg ggctatgaa 
      aggtcccgc gggacgccg gccggcacg cagagttct 
      agagaatac aacgcgaac gtgtcccaa gccacggtc 
      aggtgggcc atgttagaa caaattctg aacccttgt 
      ttgtgtttt aaagatgtt atttacacg catttctat 
      ttgaaacgt cacgagatc ttggcgcag gtcgagggt 
      tggatcaaa gacctagag aacgatatc acggagaag 
      aggatatcg cggactgcg aataagagg tcgccgacg 
      gcgaatatc gacagtttc aaaaagata ttccagcag 
      ttgaaggag cagttgacc aagttgaag ccgccggaa 
      ggcgtggtg gaggaagac ccggccccg aagatggag 
      accacgagt gcgtcggtt aacgggctg gagggcaac 
      gagcaggag atggacgcg gatatcgac atggagaag 
      atggttaag gaaatgtgc gagtttgac gcaacatag
    mRNA sequence
    • >TC009848 RA
      taacttcca caaatggtg gttttcaat ggcgcaaga 
      tgtgtttag caaaatggc tgaggatcc ttggttatt 
      aaacgaaga cggttactt aaatgcgga cacagacat 
      caaggaaat catttacca cccgacact gaacgttat 
      tttgatatg taccaacag tggaatcgt tcgggtgtt 
      ggatgtcaa ctcgggtgt tgttctcca atccagcta 
      tctctcagc aataaacca aaacgaagt aacttgtaa 
      gtacattcc tggacaaga cagggtgct gttttgtga 
      tggacaagc tattggagt cagatcaga ctacaacag 
      tgtgctttt actcgacag tattctgca gaagccagt 
      atcggatcc caagaagga aatcaagct cgaattacc 
      actatctga ggcaatcat cttgaaaca aagcttgac 
      ttcagccaa cgtcagcgg tattgaaca tgtgataaa 
      cgaattaac cgacgttat tttgaacgc tcaaaaaca 
      gtccaagaa gggtattaa agctcaaaa atggaacac 
      tgtctgtct ccaactccc tttggagat gctccaaat 
      ggctgccat gagcagcgt ctcagaact actcctaaa 
      aaaccaaca caccccaga attgagtgt tgcatcagc 
      cgtgcaaga gcgcctctc ggagctcag tggggaaca 
      agggagcgc ttcagaccg caggtctat ggccagcga 
      ggccaaacg acgcgaaac gttcaccca ttggcccca 
      catggacta caaatgggc cttgccgga ccaaatggc 
      ccaggcggg cttctacca ccagcccaa cgcgtctgg 
      ggacgaccg cgccatgtg cttcacttg caccgtgtg 
      cctggtctg ttgggagcg caccgacga gccctggag 
      cgagcacga gcggcattc gcccagttg tccgtttgt 
      catgggcga atacaccca gaatgtccc attatcggt 
      cacttacgc caccaaccc ggctattga cgcgaccta 
      tcgaggggt caacgtgaa aatccttgg tacgagcac 
      cttgagcaa ccttctgcc atcggcgaa cgccgaagg 
      cctgatctc ggtgttcga catctcggg gaagatctc 
      aaggacaca ctctttttt cgtcacaca atttgattc 
      ccacattct ggagaagta cacacagga tttcggggt 
      cccaggcac ctggagcga cctcgacga agaaaagcg 
      aataacatc attggcgat tgtgagcac tgcggagac 
      gacgtccac gcgccctac tattatttg cggcctcca 
      aatccgatg tcgggccca gaaatacca gtcaccggt 
      gattggaag ttacgacga tcagaataa aaacttgat 
      ggaggtggt ggagtcggc aacgtcttc gacgagttt 
      cagttgttt gtatttggt cgtttacga ttttatgta 
      cagtaagga gaaggagga taaggatca cgagagtaa 
      accgaacga tgtgaacgc catctctga agtgactgc 
      gcccaagaa tgaatcaac gcaaaacga gaaccagaa 
      aaacagtga ttacgtgca tcccgacgc cgtcttcgt 
      cgagcattt atcgtcgtt ttacaaaac tttgatacc 
      tggtgaaag tgacgaggt gtttctccc gcctccgat 
      gctcgttaa caaacccca acattcagg tcctagagt 
      attacccat tgacatgca aattaccga aactgatgc 
      ttcgcaaac cgagccttt tataatcaa ccaggaata 
      ttcgtttat gaacggcca gttgagcag cattctttc 
      ggagacgtt cgaaaagag catttccga ccacattac 
      cgaaatgaa aaacaacaa aacggccaa aaaattgaa 
      ttatagtcg agcggtgca gtgtgtgtc gataccggc 
      gccttataa atcgcgaca ggacttgga gatttccga 
      tattatcgc gacgcaaga cagtcgaca tgttctagt 
      cgtgttgaa aagctcgtt ggacggtaa aagcgtttt 
      gatactcta ttctttgga cttctcaca gaagatggt 
      gaagttggt tgaagagcc ggttttggt gcgcgaatt 
      gaataataa tgaaaagcc gacagaagt tagtatgtt 
      gccgatggt ggataagtt gggggagtt tgccgaaca 
      agggaagaa tggagtcgt agggaacat cgtcatggt 
      gtgcgtcga tggggctgt gagaatcgt ggagttgtc 
      gacgatgaa gaccatatg catggcgca gttggagag 
      cgagaagtt tgtttcagc ggcatattg caacagttt 
      ggagcgctt gtgcgcctc cactgcgaa aggttccct 
      gcacttcta tgcccttaa cgacaccga caacgaatc 
      ctctgaaga ccacgagga agacgactt gttcgggat 
      gaccaccga cggtacatc atcaaaccc cgcccaaac 
      cagcgattc actcgacgg aagtgaaat gacgcgttg 
      tttccacga ccctcccga aataatttc tttgataga 
      cttgaaacg attgcacgc tttgtgtca attcgaacc 
      gttacgagc agggtattg cgctgtagt tcctccctg 
      ttggagcga aatccagca ggctcaaag acagagaag 
      gtaccccca aagcctcaa aaccgactg cgaccagta 
      tacgaaaac gtggcgact gcaaacgga cacaaccac 
      ctgggatga gcacatctt cgagatcac attgcccag 
      tcccatgtc tctgggcca cgtggacgt gcacttcag 
      tctgcaatc gtcgacggc gttgccgca tgtcgaagt 
      gacgctttt gcggcaaaa cacgagcgg gattgggca 
      caaaaaaga cgttaagtt tgctgtgga cgaaaccat 
      aactataga tatgttgca acagtgggc cgataatcc 
      cgttatcag tcaggagta tctaagggc acacaatgc 
      cgatattct ggcaggtcc ggtgaacat tgcctcgtg 
      tttggactt gtcggaaca atgcggtgt tgttacttt 
      gaccagtcc gaaattgtt caagtcgag gaatcggac 
      cttgctgtt gcacatcag ggctgttta ttccaaaga 
      agaggctaa taacaaaac tgcttccaa gaggaaacg 
      ctccgagag caaggacaa gacgggtca gtgtgccag 
      ccacaaaaa tgagtttta catggggtg tgattgcat 
      tcacgagtt gagtattac ggtgtatag ttccaaaca 
      tactgaaat tccgcatga gaggagtca gaggaattt 
      catgttgga gtctatttc ctgcgtcca gtcgctgct 
      gctaacagc aatgaataa ttcgtcaaa tgagtcggt 
      ttctttgtc gttggatgt actcacgtg gattgcgtc 
      cattcgttt gattaggaa taggagtaa caacgggga 
      ggtgcctaa tcagcagat ggaattttt atacgtgat 
      tgagtacaa cttggcgaa gctcctcca acagtgtct 
      tctcctcgg cgaacgaag cattgcaca taagtgcat 
      gaagttaat cgaagtttg ttgcaatgg cgctaagaa 
      catgagcga gacggggcg ctcccactt cgagtttag 
      catcctgaa ggcccttct ctcgctttt gaacacaat 
      caccgatgt ccggtcacc tggcggcct ccagtggat 
      cttcgcact tctccttaa agtcatttc gaaaaacgc 
      tcaatacgt tgcaaccaa atgcgtaac tttgttgaa 
      taaaatgtc cgaagagtt agaaaatcg aacgaatcc 
      gtaccactt acttctcag gagtcgtta cggcctata 
      cggcactcc tctagaact agaattatt tgatatcga 
      accgccacc ctacgctaa aagtaccag tacatacgt 
      cacttacgc tacagcggt gtctgggga cagcgccaa 
      tcagaataa cgacttttt cgagaacta ttcgttcaa 
      taaagagag tattaaccc taaagatgt gttgtcagg 
      cactgagac gaagctgaa gtggcgaaa tttagcacc 
      accgaaaat atacagagg gttaataga aaccgttcc 
      tttgcattt cacttgcgt ttcggcaag tgaagggac 
      gagactaga aagggccga tgcctcaaa taacatcaa 
      taacatcgt tatcaacga gataccgtt ttcaattac 
      gccattcca tggccaggg ctctttaga caaaatgga 
      ccacagcaa gtttaaatc ctacttggt tgattttgt 
      ggaagaacc gaccgtcac cgttaaaga atacaaaaa 
      ttcgaatcc acaagcaac cacttcgag tgtgggcac 
      gtgggacga taacggctg tgaagtgtt aatcggaga 
      gttaccagt ggatgtcgg caaccacct cttaaagaa 
      attagattc catgtatca agatttgaa atcttcaat 
      ggaaaataa aagtagcgc agtaaagaa tgtgtggca 
      accagagag tttactttc gccgccgac taatagtag 
      tttgccgtg gcaacactt actagtaac tccgccaca 
      acaggttat tgtagtgga acggatgca ttcgggggc 
      tcgcagata cgtggtttt ggatttcgg gcaaccgat 
      tttgctcac tgatattct tctaccgtc ttgcaatga 
      cctggtctc tgttagtat tgacatttg gctgaagag 
      tgaagatgt tgatgggac tcgattggt ggttgctgc 
      agatattgg gtcgaagaa tttggtgtt gaatgatct 
      gcagccggc gccgctgtg ccgatacat gaagattac 
      cacagttgg tcgttacgg aatgactac agcgagatg 
      cagaatccc tattggtta cttttacgg ccacgtggt 
      agttctccc tgaagaagt accaccgga tttgtccca 
      aaacgtttc gaacttggc ttgcactga cttagataa 
      gcaactaac aattttatc gaaactttt cgaagatat 
      cagctgtcg atacagttt ggcttgctc caaattaaa 
      agagctttt acgaccgtt cttggtggc cgacatgaa 
      aaatgcatc tcatctggc gacttatat gaacatcat 
      gaaagacaa agcccttaa taccagcaa ccccgaaca 
      cagtaaaat ctttagcgc ttatcagga atcaatcac 
      ataccagcg tcagttgaa cacgattcg aaatgtgat 
      gaatcgact tgaagggag tattagtaa aatgtcggt 
      ctcgccgag aaatcctaa agacattcc gaacgcctc 
      aaccgataa acttagagc catcgctga aggtttgct 
      tgaggtgct actaacgct ggattcagc aatcgaaat 
      cgatcccgt cacctgtcg caagctctt ccaagggct 
      atgcgtgtc gcaagcttc acgtctgca gttactaac 
      cgccatttt cctggacaa gtcctgcag gacgaagag 
      ttactgggg caatttcct cgccgacac tttgaccga 
      aatgttcgc gacatccaa cacaacaaa attccccca 
      agaccgcgt tttcatcct cttggctta cttgagccg 
      gaaaagccc cgaacggag cgccgtcat tgacgccgg 
      tcttcgagt ggtttcgca aactttagc tcctttgac 
      tggagatcg ctccaattt acttgcggt ctcggtgga 
      tctccctct actctcctg gctgttgat gtatctctc 
      gctccagtt ggacctaag caagaacag tctccaatc 
      ggccacgag atgggactg ggtgtttgg ggaaatcgt 
      cgggaaggt caatgccga aagtgcgaa aatcggaag 
      ccggaagaa aaattacaa acgcatcag caagcaaca 
      aatcgacaa tttggatgc ggcacagaa gctggtcca 
      gtcttcggc tcaggcttt gtcgacgtt gtccaacca 
      tgcggcgtg tctcacatc gaagttgga tgcggctct 
      gaagacgca acagtttct gatgaagaa agttaagta 
      caagttcat ggatatgaa gaattcgcc ggcggagaa 
      tccactcgc gccgaagaa gctgaagga gacggcggc 
      ggaaccagt aatcgagaa aattaccga gaagaagat 
      gccgcagca tattgacgt taatcattg tttgactgt 
      ggccaaagg gctgctgac tttggtgct ctcgatgga 
      ccattcgag cagtgccga catgctctt gctttcgtt 
      taaagtaat ggcccgcct ggtcagcat ggctaaaat 
      caaattggg ccagctgat gaaccagga gcagctctt 
      gaacttgtt ccgcttttg cctcgcttc gaaaattcc 
      atgggcccc tcatgctct cgcctgtct cttgcaaga 
      cgtcgttga aaacgaaaa cgacaccga ctctggggc 
      ttccacaag ctgggccac taacgattt cctctctga 
      cgtggcaaa cctgtgcga attcacgga cgacgagac 
      attcgttca cgaacctgt aataacagc gccacctaa 
      aactggaaa taacaacaa ccagttgcc ttcggttta 
      cgaatccga cgattcgga tttagagga aattgttga 
      cgggttttt ggacaagga agccatgtc gactccgaa 
      gaagatacc gaaaccaac gaattactc acacaccac 
      taattcagt agcgctgga ttcgagact tgatctcag 
      tgttgacgt atcagcgga aatatcgct acggaagtt 
      gattaataa aaatactca agggttgtt gcaaagtgt 
      caacgcgcc tgtggttgg tgacgaaag tgaagatgc 
      gttagcgcc atggcctac tgtggtatt gccgctgca 
      accggagtc tcttctgag taacactgc gatgctgac 
      tcagtgctt cgattcgtt gtttgagaa cttgccgat 
      gcaagactc ggcaaacat tgagcacat tttgcagtt 
      gtggctgac tttgaataa cccgtacaa ggacgataa 
      gtttgatcc ttcagccgt tgctcaaat cgttctcaa 
      agaaagctc agtgaaggc tttgatttc agcgatagc 
      ctggactcc gggcttgtc tctaattac gtggtgtgt 
      cgccttaca gactttgac tttggtctg taatagtaa 
      tataacgtc agagtcttc cctctattg gtcagattc 
      gtacggaat ggcctcttg tatagtcaa tcacccgga 
      tttcgtcca ggtcttcat gaggttgtt atcggggac 
      tgggcttac cttcattga taaagtttt ggcgggacc 
      ttcgttatg taaagcttt gaacgattt tctcgaccg 
      gcttttgat gaggtgtta cgtggaaag tccccgaag 
      caaagcagg aaaatcgtt aaagactct cttgttgaa 
      aattgtgca ccagttagt gctacctac agggccaat 
      tgccctacg acaagggcc tctagatgt gcagtgtaa 
      attgttgaa aattatgtt agatataga ttattttaa 
      cgccgatat gactatcgc gatgagtat tttcgagag 
      tacgtgtgt tctggttca ttcgtattt tgttaatgt 
      tgataaaat taaatgtat taatatcgg ggagaagca 
      caacgtggt cacgacgac gtttaatga gatttttgc 
      ctgtgttat gggctcgga ccccatcaa aatggatct 
      acaggtctc cactgaagt gctcttttt gcggctctt 
      gaagttttt ggggaaatt ggtgcaaac acagtttag 
      acaaggcat cgatcaacc ggaagcaat ggacgttga 
      gcccttggc gacttcgca aaccgacga aagcaaggc 
      cgagcaaat ccaacaaga ctcgatgcg caatcgtgg 
      cgaaaattt cgccgatct tgtcctcca ataccacgc 
      taatattat gcgtctgtg ccagtcttt agcagcttg 
      caaatcctc gtcattgtg tatgctagc aaatgtctc 
      gcaaaaagc ggccttttc caacttgag cgaaccgag 
      taacgttgg agacgcagt gttccacgt tttagccct 
      gttagctaa gcgaacctc tgataaaaa gttggtgtt 
      accaccgtt gcttcaatt cttagcaca tgcgcctca 
      actgagcga gcctttgtt gtggttcct attgcaaat 
      tttgaacaa tgaagaggc tattcggaa tttcctcac 
      cgcaggtgg tattgaaat tttgggccg aagtttcgt 
      aacgagtag caacactcc gaataccat ttccaagtc 
      agggactat ttccatagt catgcaaca cttcagtgg 
      gattaatcc cacttctga cgctagcac agccatcgc 
      gtcagcatc ggcttcaag gaagctgca acaagcaac 
      catcgaaaa taaattgtc tttggttaa tttcgcccc 
      ttgctgcac tataagttg cccatcagg gacagccca 
      accggcgga agtcctaat tcaaggaac ggctgcgac 
      ccaccgccg ggcacgaac tccccaatg gagttacca 
      cttttaccc cgacgaagc ccacactga actcacttt 
      gcaactccc gagtgcgat tttactgcg tgaggtgca 
      tttgcagcc acacttgag tgccctggc gacttgtcc 
      ttcagctgt agccttgga agtctcagc caatggtcc 
      ttcgcgttt agtccctgt gtgtccgcc acttcctac 
      cagtggtat ggttttcat caggctaca cttgccggt 
      tccggaagt cgtcaattg tgtcttgat tcgtttgta 
      tcgtccacg tgatgctaa caatatcgg gctttcgca 
      aatccgtct tttgggtaa tttggcttt tggcggaaa 
      taccaatca gaacttggc cgatccggt cgaagatga 
      gtcacactg tcgccacag tttaggctg gttaaggtt 
      actacacca ctgttttac gttaccgac agagcagga 
      tttggcaaa acaagtgat agcgtgtgc gtctggagt 
      accgagatt gttgagtac ttgttgcga gttgcttct 
      agtaccatc ccacgtgct tccgatcta tttaccgtg 
      tttggagaa ggttttaag ggagttgag tttgcacaa 
      tttggaaaa cggaaacaa tgttatcaa aattctgct 
      gaacagtcg gtcgagtat catagaacc gctaaattt 
      cgccgataa tgcctggca agacaggtt gttgataaa 
      tgcaacggg gtaccaatc agcttgtga attgttgta 
      ccagatttg cgaacatca agattctga tactttcta 
      ccgcgttaa gatgatgct ggagtggtt gcaaagtgt 
      cgcagtcga agcgatgca aaccggaaa tacgcaagg 
      gtgcaaccc tgcgtacat atctagcat agcttcgat 
      tctgtggtc ggccaatca ggctcgagt cagctacga 
      cttaccgtc aatgatcac tttagattt cttcgacac 
      gatctacaa ccttaaaac ctgcgtgga aaacaacat 
      cgcgcttaa atactccct cgactccct gttgtgcag 
      tttgtgtta cataaggcc tgaactttt cccggtgct 
      tttacaacg aatcggagt gttagttcc gaatttgtc 
      caccgatca tgacgcttc gatctccga cgaccgcaa 
      agactccga aagtatgac cgacgataa caaacaaac 
      cttcgagct agattcgga atggtacgg ccacctggt 
      aatgggcga actctcgaa acttagtct ttcgaacga 
      acaactgga aaccgtggc cttggtgag tcgctcacc 
      ctcggccat ccaacagtt gctagactc cggtctccc 
      gaagatgtt gaacagtgc catatacga gttttgtac 
      ttcaaacga ggataattc agtcccaat ggctaaact 
      ggagaacgt gactgcgat tttaaagtt cttcactga 
      tgttagcga cgagaaaac gatgcgtga ttggctggg 
      gtcgtccga tggctcgtc gttttggct cgagttgct 
      caactggtt gtgcaaaaa accgttcct gaaaaagtc 
      gaatctcca gtcagaagc gcacgccca attggagga 
      agtgtgtgt caagttttt gtcgaagtg ttgcctttg 
      tcaccctag taatcaagc gcgactggc gaatgtttt 
      atgcaaagt tatagattt gcaaagtaa tggaatctc 
      cggtttcat gcgtcggct gactcttca gctactgct 
      ggaaaacga gaagatccc cgtcagtat taaagcgga 
      cgagacttt gtataaaag cgtcaagtt gactcaggc 
      gtacttgcc ggtgcatcc ggccttcaa acagaccta 
      caaccgggc tttgctcta cttgagcac taatacgac 
      tctagccga catcctaga gcagcacat ttattttaa 
      cacgaccta caagatgga gacgaataa ctcgagtaa 
      gcgaccttt tgtcactaa gaaagatct attcaaagg 
      ttggttccc cgaagattc agacttgag catggctgc 
      gggtgttac tgccaaaga taaacgtgc caaagacgc 
      caaaaatca agccgcctc gacgcccca gtcgaagaa 
      gaagaggta cacggcgac ggaaagtct gactagtgg 
      ggacgttat tgggggacg cctgatcaa gtgcgaggc 
      gtactcgga ccagccctt gcccctcaa cttgaatct 
      ggggcaact gctgcggtt gattgagtc gaaggggac 
      gactgccga ttggccgtg tgtccattt agtcgtttg 
      tcaaaacaa aaatggtga taaaaaaag tgaaagtag 
      tgaagtaga ttctagttt gtaccagca acaaccatt 
      cagtagtgc cttacaagt gttcagttc gatgggtgg 
      gttggcgct actggctcg gcatttgcc tacggtgta 
      cccagaggc agtgcggcc accacttaa ggagaaaac 
      cacgtccga acaatcgga ctccgagtg gattaaagt 
      tgaagactg cgacgatat ctacgaaga tgtcgaaga 
      aacagtcgg gaccagttc gccttcaaa gtcatcagg 
      gcttatttc aaacgttcc agctcactc tctcactgc 
      ctttggtct ctttctccg actgccggg ctacgctga 
      agtccttct caaagacat gaagaaggc tctatgtct 
      gttgcgctt agtattggg tgtgaccga cgacggcga 
      aggcggtga tatattcca gtccccgat tgccgactc 
      gctccccac gttgccttt tgaagtgct ccgaaagct 
      ctacgatgc cacaccttt gagcaccga cgatggccg 
      gcttctccg acgcatcag cattaatac gggcgtggt 
      ccacttgct cttagcttg tttggggat tttcaccca 
      tcagactca aaacaacga gaaagaggg ccagaaaga 
      cgcaaaagg gaaggacga acgctccca gttgtactg 
      ggccaaagg tacaggcta cggtacggg ttcgactca 
      acaaatctg gaacgttga acaagccct acttaaaca 
      aaagagcga agaggagca cgtgacagt cctgttaca 
      agttttggc gagctatat cagtcccaa cggggaaac 
      tgcggatga gttaatgga agatgtttt gccgtcgtc 
      gtttcatga ccttttggc caatagctc gcttttgcc 
      ggcgcttag ctcgtatct gaggaacga ttcagtttt 
      agatatggc ccggcatat accgctcta cagagcggc 
      cttgcaact attaagagc cttggctac tagttcgca 
      actggtgga tttgctctt gcctcaaaa aacccgcat 
      caacgaacc atctattag ttcattatt gaaaagcat 
      gaagacttg cgttgatac ttatgcttc taaattaag 
      actcaacac taaaacaaa tacaaaatt caaaaccaa 
      acttcggga acaactcga agaacttga acagggtga 
      aggtctggc gactttaat gcccgacat ccaggacac 
      cgccaattt ggtgtctaa ggtaacaag cggcctcgt 
      agactcgga ccacgatag cgaagggga agttgccgt 
      ggatcgggt catatttgc gtctttgga agagaaata 
      tctcaagat aatgaagag tctgcagtt tggttcgta 
      cgaaatgat cacggaatt gcctgaagg tggtgtaaa 
      gtttgcggt gtcgcacca ttttgaaaa caacgcgaa 
      atcgacggg ggagcagtc gcacccggc gcgtgtcaa 
      gcggatagc gcaggaggc cgtaaccct atccacgag 
      tctgccttt gagttacag cagttctgt tttcgttcg 
      ttacgacac ctcccggtt ggacgtcat gaaggtgct 
      gatgaccgg ccctgcgga cactcccta cgccaacgg 
      ctgcttcga attcgacgt ttttttccc gccggatta 
      ccccttgtc ccccatgat gatcaacct ggaaacgac 
      gggacacca cactattag gtttaatcc gaatttata 
      taacgacgg caaggtttg tctgtccgt gctgaacac 
      ctggcacgg acggcctga ggagaagtg gaacgccca 
      aacctccaa cttcctgca ggtcctggt gtctatcca 
      gagcctgat ccttgtgcc agagcccta cttcaacga 
      gccgggcta tgaaaggtc ccgcgggac gccggccgg 
      cacgcagag ttctagaga atacaacgc gaacgtgtc 
      ccaagccac ggtcaggtg ggccatgtt agaacaaat 
      tctgaaccc ttgtttgtg ttttaaaga tgttattta 
      cacgcattt ctatttgaa acgtcacga gatcttggc 
      gcaggtcga gggttggat caaagacct agagaacga 
      tatcacgga gaagaggat atcgcggac tgcgaataa 
      gaggtcgcc gacggcgaa tatcgacag tttcaaaaa 
      gatattcca gcagttgaa ggagcagtt gaccaagtt 
      gaagccgcc ggaaggcgt ggtggagga agacccggc 
      cccgaagat ggagaccac gagtgcgtc ggttaacgg 
      gctggaggg caacgagca ggagatgga cgcggatat 
      cgacatgga gaagatggt taaggaaat gtgcgagtt 
      tgacgcaac atagatcaa ctgtttgca tttattttg 
      tttttacca aaatttaga caatacatt tttacaaat 
      tcccatagc ttttcggta tttctcatc gttgattca 
      tcaatacgt cttggtaat cgtattatg atttttaca 
      ttattatta aaactgcat ggctgatca gagaagtgg 
      ttaccagtt ttacttgtg tcataagtg attttttta 
      cagtgattt gtaattaaa ttttttgta ttatgactg 
      taaagttcg ttcatttga aattactgt taagacaca 
      aatgtgatt taaggaaaa taaaataat tttgtttta
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