Status
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Gene information
General information
TC033331
Former TC numbers

If one gene is splitted or genes are merged, the original TC numbers are listed. One listed former TC number indicates the previous gene has be splitted, serveral former TC number represents a merged gene.

TC015434,TC015435,TC015436
Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007421.3: 851141..884750
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC033331
    iBeetle screen iB_02813

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: -1.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: -1.0% (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC033331 RA
      MQSSSSTMA GIDPHTTQM NQFRSYVTM LGDANCKDV 
      LKLKATQEI SKNFEIILS SSLYQSFLD HSVKIFLKI 
      LQEGDPHFI AEYNIQQVR KLILEMLYR LPTNDLLRP 
      YVKSILSLM LRLLEIDNE ENVLICLKI IIELHKQYR 
      PAFNPEIQH FLQFVKSIY SDLPNHMDK IFEPRAPIK 
      VNNLNELNI EELLKETFT MTTIQTEKK NKDDTLVTY 
      YLIPKAVLS LKVLQELPI IVVLMYQLY KQSVHQDVS 
      DFIPLIMKT ITLQPSPEQ RQAPTFNKE IFVDFMGAQ 
      VKTLSFLAY IIKFYLEHV QSHSAMMVQ GMLGLLMLC 
      PMEVAHLRR ELLIAARHI LATDLRNRF VPHMEKLFD 
      EDVLLGRGW TTHESLRPL AYSTLADLV HHVRQQLPL 
      SDLTRAVHL FSKNVHDDT LATTIQTMS CKLLLNLVD 
      CIRARSEAE NSTEGRELL MRMLEVFVV KFKTIAKIQ 
      LPILTAKCK QQQQKTQVE IKTEDGAAN PAEVLENAL 
      ATTQNRAEQ KEEKSKFGF PQNNNYNVA DYHSLVKTL 
      VCGVKTITW GCSACKSSS SHSLVATKH FQPHETLVF 
      VRLVKWALK ALDIYTLYP GPQVTGPQR INQQNERNK 
      EEKVVLEHF SGVFSMMNP QTFHEIFST TIEYLVERV 
      YKNPTLQTV PNTLLANPA TSPIFATVL VEYLLERME 
      EMGSNLERS NLYLKLFKL VFGSVSLFP QENENMLRP 
      HLHQIVNRS MELAMSAKE PYNYFLLLR ALFRSIGGG 
      SHDLLYQEF LPLLPNLLE GLNRLQSGL HKQHMKDLF 
      VELCLTVPV RLSSLLPYL PMLMDPLVS ALNGSHILI 
      SQGLRTLEL CVDNLQHDF LYEHIQPVR ADLMQALWR 
      TLRNNDQVA QVAFKVLGK FGGGNRKMM IEPQKLDYV 
      SSDYDPPAI IAKFYDQDK TIEFPVQKI IETAFNALK 
      QSNTDSFYR KQAWEVINY YLTASRNLS DDKNTLINL 
      FLHSTFQDP KTIPQVKGS VYKSIYKQA RETHQTALT 
      GMFVAAAIK ELRQPVVAL MVAVVRHYT MVAVAQQSG 
      AFACTPKHN EQVALDPLV LVDALAVIM GHEEKELCK 
      PGHVGLVLI LDTASTLLG SKEMACRLP LIEYLSEKM 
      CALCYERAW YAKLGGCIA ISFMFERCA RKWVYEHMF 
      TFLKALLFV MMDLTGEVS SGALDMAKN NLEKMLNVC 
      VTEPPKGAD QETRDLQKK ALHEVTHEL VRQVTSPHT 
      MVREQSMHS LRLLAEKQN KSVTSVMEP FKEVLADMV 
      PPTKHLLKH QPAIAQMGL MDGNQFCTT LNPRLFTID 
      LSIKEHNLF ILDLLSLCN SEDVKLNTF SCYKNITNF 
      IPLRKSALR VLAACHYLE EVREQIFQV LYKALEKPN 
      AELQQTAFE CMRDFIAGY QVNKDLVYQ TIKPFLLTL 
      GDAKNLTLN GVKMLSYLT QLFPLNFNE SLCEQLLEL 
      LKQLLENLT NSHKVSTGV SKKGDEEQK IVTIIGIFH 
      QTPAASSKF INQLCQLIL QTEQAMLIE ASSPFREVL 
      MKFLLRYPG DTLDMFLDD TYVKDKQFS RYLEFLIKH 
      KEGKSFRDY IQTSMVKRL IQMALANVH VNYTLSEQE 
      RNELQYQSI RIISLLIKS DDQWLSEQQ ELVEALKQI 
      WCDDAYQER HKSVDNLEY PHWKEPKLL VKILLHYFC 
      YHPNNVDLL FQLLRCLCH RFIPEFQFL KDFLANTVA 
      QNYTVEWKR SAFFRFVKL FPTNSMSQE LKSKVLQFI 
      LIPCFAVSF EKGETNKLV GGPPMPYQD SPDNVVSVF 
      INKLIDPDN PFPTADCVR IALLQFSCL LVEQASPHI 
      HDHNKTQSS KLRRLMTFA WPCLLVENC FDPATRYHG 
      HLLLSHIID KFAIHRKII LQVFHSLLK AHALEARNV 
      VRQALEILT PSMPLRMEE GNTMLTHWT KKIIVDEGH 
      SMQQLFHIL QLVVKHYKV YYPVRHHLV QHMVNSIQR 
      LGFSPTATL EHRKLAVEL AEVIIKWEL YGIKEEGDC 
      DGVENVATK RPNDDAIET QRKRLAVSQ PSTSYSPTP 
      VVKQEPGIN KPIDRVHID TVLNFLLRL ACQVNDSAP 
      QNPANPTVS SPGELLSRR CVILLKTAL KPDLWPQPI 
      DLKLAFFDK ILLTIEGPS PNIGNVCTA LELLTYLLT 
      VLKKEQILA SFKPLQRGL GACITSTNN KIIKLVHGL 
      LTKLMALFP TERSSTTVC KYEELEILY STVGKVIFE 
      GLNNYETNA QANSSSLFG TMMILKAAC ANNHSYIDL 
      LITPFMRVL HRLAKEHLQ PTSTEYAAI NSELLILSL 
      DLVKTRVVV MGVDMRKTF IGTILVGLI EKTQDIKVM 
      KAITKMLEE WMKCKNVVT LNQAPSLRE KSILLGKMM 
      QYVEKRFPE DADLNAQFL ELVSYVYTD INLKTTELT 
      SKLEPAFLA GLRCNQPHI RAKFFKIFD ESMRRRLHD 
      RLLYIVCSQ NWEAIGQHY WIKQCIELL LVTAVPDTS 
      IQMAHESSI LPSITSVIN SAEKREEFS SMQVDNPNF 
      YTSTEIKEE VLDLDLSNV ESNPPIEEK PIDRAETIS 
      KMIKKHYEF IEISRNVTT DQFLLAASQ LCHMDTSLA 
      EQVWLQFFP RIWEILEQD QRNVLVQEI LPFITSGTH 
      IIQKDCHPS AINTFVEAL SRCNPPIQI APPLMKYLG 
      KSHNLWHRM ALGLEQMAF DPASAKATN ASCYDFETD 
      QSKNELLDS LGELYSLLC EEDLWAGLW LKHAHYKET 
      SIAIAYEQH GFFEQAQGA YESAMAKHK QDNSMGPVP 
      THTQREVLL WTERWIRCT KELNEWNIL MEYAKNGVY 
      DPYLLLESA WRIPNWDIM KEVLSNVEY NCPKELGWK 
      ITMYGGFLL ICQPEESKP LKFVERYVE SASALCLNE 
      WRRLPHIVS HIHLPYLQA AQQIMELQE AYQIHKGLL 
      QGHQNSLHD MKAIVKTWR NRLPVIADD LTHWNDIFT 
      WRQHHYQVI VNHYESIRD TTNTNSMLG IHASAQSII 
      HFGKIARKH KLVNVCLES LNRIYSIKS VPIVDCYQK 
      IRQQVKCYL QLASMNNKN ELQEGLEVI NNTNVKYFA 
      KELTAEIYA LKGMIYHLS NKSDEANKS FSAAVQMHD 
      TSIKAWALY GDYLEQVFT RDSRQINLG VNAMACFLH 
      ACRHQNESK ARKYLAKVL WLLSYDDEN SSLMDALDK 
      YSVGVPPIL WLPWTPQLL NCLVQYEGH VILNLLCQV 
      GRMFPQAVY FPIRTLYLT LRTATARKT NTVQQQPQD 
      QTDTQNNQQ ESGNTATIT TSETSSIKA TPAMIRCSK 
      IMKMQRDIH TTALSSLEG IANQMEWFR ENWYEEVLR 
      QLRQGLTKC YAIAFENRE SVNEAKITP HILNFVKKL 
      MSTFGIGVE NIGSVVTFN SAASESLAR RAEATYQDP 
      VFKEMKQDF TKDFDFSQT NSMRLHTLI FKLKKWIKI 
      LDNRSKMLL QSFLIEEKC RFLSNFTLK TAEVEIPGE 
      FLLPKHNHY YVRITRFMP RVDVVQKHN AAARRLYIR 
      GHNGKIYPY LVVNDSGLV DARREERVL QLLRMLNHC 
      LGKQKETAR RFLHFTVPR VVAVSQQIR LVEDNPASI 
      SLLDIFKKG CAKLGIEHD DPIHYYYER LGGVQSRGI 
      KASHQLSRD ILKGVQTNM VPRTLLKQW AVQTFPSAT 
      DYWQFRKMF TLQLALACF AEHVLHLTR LNPDMMYLH 
      QDSGLMNVA YFKFDVDDG TGEFGATRS VPLSADAEY 
      SSMIATARC FVYPNFKVT AILKPILRD EMVLSRMKK 
      PEEVAGNNT EKLSDSEQI INMVNKAVT SISSRLNSL 
      AHFDGADSK WTVTSGDVM EKTEGFKRS VTKQVLLGL 
      LTNFSSIAP SMSLGFSAV ALPVLTSAT NRYALNSDQ 
      ASWFASIAS LATPFGCLV AGPIADKFG RRRAMYCVN 
      IFCFIGWLL IAWAYYWPQ HQYVILLIG RLLTGLSTG 
      LSSAPATIY MAEIASVNL RGVFCTWNS IAFSLGVLI 
      VYFLGFVLQ DNWGLISLI TAVFPCVGM VFVTFLVPE 
      SPSWLIRKD RFDEAKTNM CKIFGTKEY IPEVAQEID 
      TLIRNRGVK NNPKPKTIL QQVAKKLKY LTRASCLKP 
      LSLVVGFFF FQQFAGTFV IVFYALNIV KEAGVEIDA 
      YVAIVMIGL VRLFSAILV SYISKIFGR RPLSVVSGS 
      GMAVCMMAL AGYILAVTK SKVPEATQQ SLVFLPVVL 
      LLLYFFTST VGFLPMPFA MAAELFPAK IRGTATGLA 
      SGIGYFFNF VTVKIYPAM ISGIGREGV FFFYGAMSL 
      AGTIYVVAL LPETRGKTL QEIEEYFGK KPSKNNSLL 
      KEPV
    CDS sequence
    • >TC033331 RA
      atgcagtca agttcttcg accatggcg ggcatcgac 
      ccccatacg actcaaatg aaccagttc aggagctac 
      gtcacgatg ttgggggac gccaactgt aaggacgtc 
      ctgaaactg aaagccacg caggaaatt agcaaaaat 
      ttcgagatc attctttcg tcgtctctc tatcagagt 
      tttttggac cactctgtg aaaatcttc ctgaaaata 
      ctacaagag ggcgatccg cattttatc gccgagtat 
      aacatacag caagtgcgt aaattaatt ctggagatg 
      ttgtacaga ctgccaacg aatgatctt ctgagacct 
      tatgttaag tcgattttg tcgctcatg ttgcgcctt 
      ttggagatt gataatgag gagaatgtt ttgatctgt 
      ttgaagatt atcatcgag ttgcataag cagtatcgg 
      ccggcgttt aatccagaa atacaacat tttctccaa 
      tttgttaag tcaatttat tcggatttg cccaatcat 
      atggacaag atttttgaa cctagggcg ccaattaaa 
      gtcaataat ttaaatgag ttgaacatt gaggagtta 
      cttaaggag acgttcaca atgacgacc atacaaact 
      gagaagaag aataaagat gacacttta gtcacgtat 
      tacttaatc cctaaagcc gtcctctcc ctcaaagtc 
      cttcaggaa ctcccaata atcgttgtc ctcatgtac 
      caactgtac aaacaaagc gtccatcag gacgtcagt 
      gactttatc cctctaatc atgaaaaca atcaccctc 
      caacccagt cccgaacaa cgccaagcc ccaactttc 
      aacaaagaa atcttcgtt gattttatg ggcgctcaa 
      gtgaaaact ctatcattc ctcgcctac atcatcaaa 
      ttctacctc gaacacgtc caaagccat tccgccatg 
      atggtccaa ggcatgcta ggactcctc atgctatgt 
      ccaatggaa gtggctcat ctcagacgc gagttactc 
      attgccgct cgccatatc ctagcaacc gatctccga 
      aatcgattc gtcccccac atggagaag ctcttcgat 
      gaggacgtc ctccttggc cgcggttgg acgacgcat 
      gagtcgctc cgcccactc gcctactcc acattggcc 
      gatctggtg catcacgtg cgccaacaa ctgccactc 
      agcgattta acacgcgct gttcatttg ttcagcaaa 
      aacgtacat gatgacacg ttggcaacg actatacaa 
      accatgtcg tgtaaacta ctcttgaat ctcgtcgac 
      tgtattcgg gcacgttcg gaggccgag aatagcacc 
      gaaggtcgc gagttgcta atgcgcatg cttgaagtt 
      tttgtcgtc aaatttaaa acaatagct aaaatacaa 
      cttccgatt ttaacggca aagtgcaaa caacaacaa 
      caaaaaaca caagtcgag attaagact gaagatggc 
      gctgcaaat ccggcggaa gttctggaa aatgcgctc 
      gcgacgacg caaaatcgc gccgaacaa aaggaggaa 
      aagtcgaaa tttggtttt ccgcaaaat aataattac 
      aacgttgct gattatcat agtcttgtt aagacttta 
      gtgtgtggg gttaaaact ataacgtgg ggctgttcg 
      gcgtgtaag tcgagttcg agtcatagt ttggtggca 
      acgaaacat tttcaaccg catgaaacg ctggttttt 
      gtcagattg gttaagtgg gctttgaaa gcgttagat 
      atctatacg ttgtatccg ggacctcaa gtgacaggt 
      ccccaaagg attaaccaa caaaatgaa aggaataag 
      gaggagaag gtggttttg gaacatttc agtggagtg 
      ttttcgatg atgaatccg caaacgttt cacgagatt 
      ttttcaacg actattgag tatttggtc gagagggtt 
      tacaagaat ccgactttg caaacggtt ccgaacact 
      ttgcttgca aacccggcc acaagccca attttcgcg 
      accgttttg gtcgaatat ttactagaa cgaatggaa 
      gagatgggt tcaaatctc gaacgtagc aatctctat 
      ttgaaactc ttcaaatta gtgtttggt agcgtttcg 
      ttatttcca caagaaaac gagaacatg ctgcgtcca 
      catttgcac caaatcgtc aatagatca atggagttg 
      gcaatgagt gccaaagaa ccgtacaat tacttcctc 
      cttttgcgc gcacttttc cgctcaatc ggaggcgga 
      agccacgat ttactctac caggagttc ctcccgctc 
      ttgcccaat cttctcgaa ggtttaaac cggctacag 
      agcggtttg cacaaacaa cacatgaag gatctcttc 
      gttgagttg tgtctaacc gttccggtt cggttaagc 
      tcactctta ccctaccta cctatgctg atggatccg 
      ttagtgtcg gctttgaac ggttcacac attttgata 
      agtcaaggc ttgcgcacg ttggaattg tgcgtcgat 
      aacttacaa catgatttc ttgtacgaa catatccaa 
      ccggtcagg gccgacttg atgcaggcc ttgtggcgg 
      actttgcgt aacaatgac caggtggcg caagtggcc 
      tttaaagtt ttgggtaag tttggaggt gggaatcgg 
      aaaatgatg attgaaccg caaaaactg gactatgtg 
      tcgtccgat tacgaccca ccagcgatc attgccaag 
      ttttatgat caggataag acgattgag tttccggtg 
      caaaagata atcgagact gcgtttaat gcacttaaa 
      cagagcaac actgattcg ttctaccgc aaacaagcg 
      tgggaagtt atcaattat tacctaact gcgtctcgt 
      aatctatct gatgataaa aatacgcta attaatctg 
      tttcttcac tcgacgttc caagaccct aaaactata 
      cctcaagtt aagggttcg gtctataag agcatttat 
      aaacaagca cgtgagaca catcagacc gctctcacc 
      ggaatgttt gttgctgca gctattaaa gaattgcgg 
      caaccagtt gttgctttg atggttgct gtcgtccgt 
      cattacacc atggtggcg gtggcgcaa caatcgggc 
      gcgttcgct tgcacgccg aaacataac gaacaagtg 
      gcacttgac ccacttgtg ttggttgat gctctggca 
      gtgattatg ggacatgag gagaaggag ttgtgtaag 
      ccgggtcac gtaggcctt gttttaatc ctcgatacg 
      gcctctaca ctgctcgga agcaaggaa atggcctgt 
      cgtttaccc ttgattgag tatttatcc gaaaaaatg 
      tgtgccctt tgctacgaa agagcatgg tatgcaaaa 
      ttaggcggc tgtatagct atcagtttt atgttcgaa 
      cggtgtgcc cgtaagtgg gtttatgaa cacatgttt 
      acgttcttg aaagcgtta ctgttcgtt atgatggat 
      ttgacgggt gaggtgtcc agtggcgcc ctcgatatg 
      gccaagaat aatctggag aagatgttg aatgtttgt 
      gtgacggaa ccaccgaaa ggtgccgat caggaaacg 
      cgtgacttg caaaagaag gcgctgcat gaggtcaca 
      catgaattg gtgcgtcaa gtcaccagt ccccatact 
      atggtgagg gaacaatcg atgcactcg ttgcgtctc 
      ttggccgaa aaacaaaac aaatcggtc acttcggtc 
      atggaaccg ttcaaagaa gtgctagca gatatggta 
      ccacctacc aaacatcta ctcaaacac caaccggcc 
      attgcccag atgggctta atggacggc aaccagttc 
      tgtaccacc ttgaacccc cgactgttc acaatcgat 
      ctatcaatc aaagaacac aacttgttc atcctcgac 
      ctcctctca ctgtgtaac agcgaagac gtcaaactg 
      aacacgttc agttgctac aaaaacatc accaatttc 
      ataccgttg aggaaatca gcattgcgc gtcctcgcc 
      gcctgtcat tacctcgaa gaagtgcgc gagcaaatt 
      ttccaagtg ttgtacaaa gccctcgaa aagcccaac 
      gccgagcta caacaaacc gcattcgaa tgtatgcgt 
      gatttcatc gctggatat caagtcaac aaggacttg 
      gtctaccaa accattaaa cccttccta ctcacgcta 
      ggcgatgcc aaaaatctg acccttaac ggcgtcaaa 
      atgctatca tatttgaca caactattc ccgttgaat 
      ttcaacgag agtttgtgt gagcaactg ttggaattg 
      ctcaaacaa ctactcgaa aacttgaca aatagccac 
      aaagtgtcc accggtgtg tcgaagaaa ggcgacgag 
      gagcaaaaa atcgtcaca atcatcggg atatttcac 
      caaacgccg gccgcctcc tcgaagttt ataaatcag 
      ttgtgccaa cttattctc caaacggag caggccatg 
      ctgatcgag gccagctct cccttccgg gaggttcta 
      atgaagttt ttgttgcgt tatcccggt gatacgctc 
      gatatgttc ctcgatgat acctacgtt aaggataaa 
      cagtttagt cggtatctt gagtttttg attaagcat 
      aaggagggg aagagtttt cgtgactat atacaaacc 
      agtatggtt aagagattg attcagatg gcgctggcc 
      aacgtccac gttaattac actctgagt gagcaggaa 
      cgtaacgaa ttgcaatat cagagtatt aggattata 
      tccttgttg ataaaaagt gacgatcag tggttgtcc 
      gaacaacag gagttggtg gaggcgttg aaacagatt 
      tggtgtgat gatgcgtat caggagcgg cataaaagt 
      gtcgataac ttggagtat cctcattgg aaggaaccc 
      aaacttttg gtcaagatt ctcttgcat tatttctgc 
      taccatccg aataacgtt gatttgttg ttccaactg 
      ttgaggtgt ttgtgccac cgcttcata cccgagttt 
      cagtttttg aaagacttc ctcgccaat acagtcgcc 
      caaaactat actgttgaa tggaaacgc tcggcgttt 
      ttccgcttc gttaagctt ttcccgact aactctatg 
      tcccaagaa ctgaaatca aaagtgtta caatttatt 
      ctgatccct tgtttcgcc gtcagtttc gaaaagggc 
      gaaacgaac aaactagtc gggggtccc cccatgccc 
      taccaggac agtcccgat aacgtggtg tccgttttt 
      atcaacaaa ctcatcgat cctgataat cccttcccc 
      acagccgac tgtgtccga atcgcgctg ttacaattc 
      tcgtgtctg ctcgttgaa caagcgagt ccacacatc 
      cacgaccat aataagacg caaagttcg aaactgcgt 
      cgtttgatg acgttcgcg tggccgtgt ttgctggtt 
      gagaattgt ttcgaccca gcgacacgt taccacggc 
      cacctacta ctgtcccac atcattgat aagtttgcc 
      atccaccgg aagataatc cttcaggtg tttcacagt 
      ttgttgaaa gcgcacgcg cttgaagcg cgcaatgtc 
      gtcaggcag gcgttggaa atcctgacg ccttcgatg 
      cccctccgt atggaggag ggtaacacg atgttgacg 
      cactggacc aagaaaata atcgtggat gaaggacat 
      tccatgcaa cagttgttc cacattttg caacttgtt 
      gtcaaacat tacaaggtg tattatccc gtgcgccac 
      catttggtg caacatatg gtcaactcg atccaaaga 
      cttggcttc agtccaact gcaacactg gaacaccgg 
      aaattggca gttgagttg gctgaagtc ataatcaag 
      tgggagctg tacgggatt aaggaggag ggtgattgt 
      gatggcgtt gaaaacgtt gcaactaaa agaccaaat 
      gatgatgcg attgaaact cagcggaaa cgtttagct 
      gtgtcacaa ccctcaacg tcatactca cccacgccg 
      gtggtaaaa caggaacct gggattaat aagccaatt 
      gaccgcgtc catattgac acagttttg aattttttg 
      ctgcgtctc gcgtgtcaa gtcaatgat agcgcgccc 
      caaaacccg gccaatccg actgtgagc agccccggc 
      gagttactc tcacgccgt tgcgttatt ttactcaaa 
      acggccctt aaaccggac ctgtggcca caaccgatt 
      gacctaaag ttggcgttc tttgacaaa atacttctc 
      acgattgag ggcccaagc cctaatatt ggcaacgtg 
      tgtacggcg cttgaactg ttaacttat ctcttgact 
      gtgttgaaa aaagagcaa attctggcg agttttaag 
      ccgctccag cgcggtcta ggtgcgtgt ataacgtcc 
      acaaacaac aaaatcata aagctagtg catgggctt 
      ttgaccaag ttaatggca ctgttcccg accgagcgt 
      tccagcaca accgtgtgc aaatacgag gagttggag 
      attttgtat tcaaccgtg gggaaggtg attttcgaa 
      ggcttgaat aattacgag acgaacgcg caagcgaat 
      tcgtccagt ctgttcgga actatgatg attctgaaa 
      gcggcatgt gccaataac cactcgtat attgacttg 
      ttgattacg ccctttatg cgggttttg caccggctg 
      gctaaggag catttgcag ccgacgtcc accgaatac 
      gccgcaatt aacagtgaa ctgctcatc ttgagtctt 
      gatcttgtt aaaacgcgc gttgttgtg atgggtgtt 
      gatatgcgc aagactttt attggcacg attcttgtc 
      ggtcttatt gaaaaaacg caggatatt aaggtgatg 
      aaagctatc actaaaatg ctagaagag tggatgaag 
      tgtaagaac gttgtaaca cttaaccag gcaccgagt 
      ctaagagaa aagtctatt cttttgggg aaaatgatg 
      caatatgtt gagaaacgg tttccggaa gatgccgat 
      cttaatgca cagtttttg gagcttgtc agctacgtt 
      tacactgac ataaatttg aaaacaacc gagctgact 
      tcaaagcta gaaccggct tttttggcc ggtttacgc 
      tgcaatcag cctcatatc cgtgccaag tttttcaaa 
      atcttcgac gagtcaatg cgacgtcgt ttacacgac 
      cgcttacta tatatagtg tgttcgcaa aattgggaa 
      gcaatcggc caacactat tggatcaaa cagtgcatt 
      gaattgtta ctcgtgact gctgtccct gacacttcc 
      atacaaatg gcacacgaa agcagcatt ctcccgagt 
      atcacttcg gtgataaat tccgccgaa aaacgcgaa 
      gaattcagc agtatgcag gttgataat ccaaatttc 
      tacacttcg accgaaatc aaagaagaa gtgttagac 
      ttggacttg tcaaatgtg gagtcaaat ccaccaatt 
      gaggaaaaa ccaatcgat cgcgccgaa actatttcg 
      aaaatgatc aaaaaacac tatgaattt atcgagatt 
      agtcgaaac gtaacgact gatcaattt ctattggcg 
      gcttcgcag ctgtgtcac atggacacg agtctagcc 
      gaacaagtc tggctccag ttcttcccc cgaatttgg 
      gaaatcctg gaacaggac caacgcaac gtcctggtc 
      caggaaatc ctcccgttc ataacctcc ggcacccac 
      atcatccag aaagactgc catccgagc gccatcaac 
      acgttcgtg gaagcccta agtcggtgc aaccccccg 
      atccaaatc gccccgccc cttatgaaa tacctgggt 
      aaatcccac aatctctgg caccgtatg gcgctcgga 
      ttggagcag atggccttt gaccccgcc tctgccaaa 
      gcgaccaat gccagttgc tacgatttt gaaacggac 
      caatcgaaa aacgagctg cttgattcc ttgggcgag 
      ttgtactcg ttgctatgc gaggaggat ctgtgggcg 
      gggctttgg ctcaagcat gcgcactac aaggagacg 
      agtattgcg attgcgtac gaacagcat gggtttttt 
      gagcaggcg caaggtgcg tatgagtcg gccatggcc 
      aaacataag caggataat tccatgggt ccggtgcct 
      acgcatacg caacgggag gtgctgttg tggactgag 
      aggtggatc aggtgtacc aaggagttg aacgagtgg 
      aatatttta atggagtat gcgaagaat ggggtttat 
      gatccatat ttgttgctg gagagtgcc tggaggatc 
      cccaattgg gatattatg aaggaggtg ctcagtaat 
      gtggagtat aactgtccc aaggagttg ggttggaag 
      atcacaatg tatggcggt tttctccta atctgccaa 
      ccagaagag agcaaacct ttaaaattc gtggaacga 
      tatgttgaa agcgccagc gccctctgt ctgaacgag 
      tggcgccgc ctaccacat atcgtcagc cacatccac 
      ttgccctat ctccaagcc gcccaacaa ataatggag 
      ttacaagaa gcctaccag attcacaaa ggccttctt 
      caaggccac caaaactcc ctccatgac atgaaggcc 
      attgtgaaa acatggcgc aaccgactt ccggtaatc 
      gccgacgac ttgacccac tggaacgat attttcaca 
      tggagacag caccattat caagtgatc gtaaaccac 
      tacgagtca atcagagac accaccaat accaactca 
      atgttgggc atacacgcc tcggctcaa tcgatcatc 
      catttcggg aaaattgcc cgaaaacac aaattagtc 
      aacgtttgt ttggaatca ctcaatcgg atctactcg 
      atcaaaagc gtcccgatc gtcgattgt taccaaaaa 
      atcaggcaa caagtcaag tgctaccta cagttggca 
      tcaatgaac aacaaaaac gagctacaa gaaggcttg 
      gaagtgatc aacaacacc aacgtgaaa tacttcgct 
      aaagaactc accgccgag atttacgcc ctcaagggc 
      atgatttac cacttgagc aacaaatcg gacgaagcc 
      aataagtcg ttcagcgcc gccgtgcaa atgcacgac 
      acttcgatc aaggcttgg gcgctttat ggtgactat 
      ttggagcag gtttttaca cgtgattcg cgtcaaatc 
      aatttgggt gtgaatgca atggcgtgt tttttgcac 
      gcctgtcgg catcaaaac gagtctaaa gcacgcaaa 
      tatttggct aaagttttg tggcttttg agttatgat 
      gatgaaaat tcaagttta atggacgcg ttagataag 
      tattcggtc ggggttccc ccgattttg tggttgccg 
      tggacgcca caactgctc aattgtttg gtccagtat 
      gaggggcac gtgattttg aacttgcta tgtcaggtt 
      ggtagaatg ttccctcag gctgtgtac ttccccatc 
      cgtacgtta tacctaact ttacgtacg gcaacagcg 
      cgtaaaaca aacacagtc caacaacaa ccccaagac 
      caaaccgac actcaaaat aaccaacaa gagagtggc 
      aacactgcc acaatcaca accagcgaa acatcttca 
      atcaaagca acacctgct atgatccgc tgttcaaaa 
      ataatgaaa atgcaacgt gatattcac accacggca 
      ctgtcaagt ctcgaagga attgccaat caaatggag 
      tggtttaga gagaattgg tacgaagag gttttgaga 
      cagttaagg cagggtttg actaaatgt tacgcgatt 
      gcgttcgag aatcgtgaa agtgtaaat gaggctaaa 
      ataacacca catatactt aattttgtg aaaaagtta 
      atgtcgacg tttggcatt ggtgttgag aatattggt 
      tcggtggtt acgtttaat tcggcagct agtgaaagt 
      ctggccagg agagccgaa gctacgtat caggatccg 
      gtgtttaag gagatgaag caggatttt accaaggat 
      tttgatttt tcgcaaacg aattcgatg cgcttgcat 
      acgttgatt tttaagctg aagaagtgg atcaagatt 
      ttggataat cgttccaag atgttgtta cagtcgttc 
      ctaattgag gaaaaatgc cgtttcctc tcaaacttc 
      acccttaaa accgccgaa gtggaaatc cccggcgaa 
      tttctcctc cccaaacac aaccattac tacgttcgc 
      ataactcgt ttcatgcct cgtgttgac gtcgtccaa 
      aaacacaac gccgccgcc aggcgtctc tacatccgt 
      ggtcacaac ggaaaaatc tacccttat ttagttgtc 
      aacgattcg ggtctagtc gacgcacgt cgtgaagaa 
      cgcgtcctt caacttctg cgcatgctc aatcactgt 
      ctcggcaaa cagaaagag accgcacga cgttttctc 
      cactttacc gtaccgcgc gttgttgcc gtctcgcag 
      caaatccga ttggtcgaa gataacccc gcctccatc 
      tccctattg gacattttc aaaaagggg tgtgccaag 
      ctaggcatc gagcacgac gatcccatt cattactac 
      tacgaacgc ttgggtggg gtgcagagt aggggaatc 
      aaagcgagc catcaattg agtagggat attttaaaa 
      ggggtgcaa acaaacatg gtaccaaga acgttgttg 
      aaacaatgg gcggtccaa acgttccca tcagccacc 
      gattattgg cagtttcgg aaaatgttc acattgcag 
      ttggctttg gcctgcttt gccgaacat gtcttgcac 
      ttgacgaga cttaatccc gacatgatg tacttgcat 
      caggattcg ggattaatg aacgtggcc tactttaag 
      tttgatgtg gatgatggg acgggggag tttggggcc 
      accagatcg gtgcccctt tcggctgac gccgaatat 
      tcgtccatg attgcgacg gcgaggtgt ttcgtttat 
      ccgaatttt aaagtaacg gcgattttg aagccgatt 
      ttgagagat gagatggtt ttgtcgagg atgaagaag 
      ccggaggaa gtggcaggg aataatacg gagaagttg 
      agcgatagc gaacagatt attaatatg gtcaataag 
      gcagtgacg tcgatctcc agtcggttg aacagtttg 
      gcgcatttt gacggagct gatagcaag tggactgtg 
      acaagtggt gacgtgatg gagaagacg gaggggttc 
      aagaggtcg gtcaccaaa caggtcctc ctcggccta 
      ctgacaaac ttttcaagc atcgccccc agcatgagt 
      cttggattt tcagcagtt gcgctccct gttttaacc 
      agtgctacc aaccgttat gccctaaac agtgaccaa 
      gcttcatgg tttgcaagt atagcctca ctagcgaca 
      ccgttcggt tgtttagtt gccggtccg attgctgat 
      aaattcggc cgaagacgg gccatgtac tgtgtcaat 
      attttctgt tttattggc tggttgctc atagcctgg 
      gcctattat tggccacaa caccaatac gttattctt 
      ttgattggc cgacttttg acggggctt tcgacagga 
      ttgtcgagt gccccagct actatttat atggcagag 
      attgcaagt gttaatttg agaggagtt ttctgcact 
      tggaacagt attgccttc tctttgggg gtccttatt 
      gtctacttt ttaggtttt gtgctacag gacaactgg 
      ggccttatc agcctcata accgccgtt ttcccatgc 
      gtgggcatg gtcttcgtc acattccta gtccccgaa 
      tcgccatct tggctcatt cggaaggac cgcttcgac 
      gaagcgaaa accaacatg tgcaaaata ttcggtacc 
      aaagaatac atccctgaa gttgcacaa gaaattgat 
      actttaatc cgaaaccgc ggtgtgaaa aataaccca 
      aaaccgaaa acaatcctc caacaagtc gccaaaaaa 
      ttaaagtat ttaacccgt gccagctgt ttgaagcct 
      ttaagtctc gttgttggc tttttcttc ttccaacaa 
      tttgccggt acttttgtt atagttttt tatgctttg 
      aacatcgtc aaggaggcc ggggttgag atagacgcc 
      tacgtggca attgtcatg ataggtcta gtccgcctc 
      ttttccgcc atcttggtt agttatatt agcaaaatt 
      ttcgggcgt cgtccatta tcggtcgtt tccggttct 
      ggaatggcg gtttgtatg atggcgctc gctggttac 
      atcctagca gtgacgaag agtaaagta ccggaagcg 
      acgcaacag tcacttgtt tttcttccg gttgtgctt 
      cttttgttg tattttttc acaagtact gttggtttt 
      ctaccaatg ccgtttgca atggcggct gagttattc 
      cccgcaaaa attagggga acagcaaca gggttggcg 
      tcagggatt gggtacttt ttcaatttt gtaactgtc 
      aaaatctac ccggccatg atttcggga attggccgg 
      gaaggagtg ttctttttc tacggtgcc atgagtctc 
      gctggtacc atttatgtg gtggcacta ctgcccgaa 
      actagggga aaaacctta caagagatt gaggagtat 
      tttggtaaa aaaccctca aaaaataat tccctatta 
      aaggaacca gtctaa
    mRNA sequence
    • >TC033331 RA
      agccacttc ccattcatt catcgtgaa tatgtttaa 
      aacacggaa aaaagtgtt ccagtgtta gaaaaacgt 
      gcaattttc gaaaaagtt ttaagatgt aaaaagtga 
      agtgggccc caaatgcag tcaagttct tcgaccatg 
      gcgggcatc gacccccat acgactcaa atgaaccag 
      ttcaggagc tacgtcacg atgttgggg gacgccaac 
      tgtaaggac gtcctgaaa ctgaaagcc acgcaggaa 
      attagcaaa aatttcgag atcattctt tcgtcgtct 
      ctctatcag agttttttg gaccactct gtgaaaatc 
      ttcctgaaa atactacaa gagggcgat ccgcatttt 
      atcgccgag tataacata cagcaagtg cgtaaatta 
      attctggag atgttgtac agactgcca acgaatgat 
      cttctgaga ccttatgtt aagtcgatt ttgtcgctc 
      atgttgcgc cttttggag attgataat gaggagaat 
      gttttgatc tgtttgaag attatcatc gagttgcat 
      aagcagtat cggccggcg tttaatcca gaaatacaa 
      cattttctc caatttgtt aagtcaatt tattcggat 
      ttgcccaat catatggac aagattttt gaacctagg 
      gcgccaatt aaagtcaat aatttaaat gagttgaac 
      attgaggag ttacttaag gagacgttc acaatgacg 
      accatacaa actgagaag aagaataaa gatgacact 
      ttagtcacg tattactta atccctaaa gccgtcctc 
      tccctcaaa gtccttcag gaactccca ataatcgtt 
      gtcctcatg taccaactg tacaaacaa agcgtccat 
      caggacgtc agtgacttt atccctcta atcatgaaa 
      acaatcacc ctccaaccc agtcccgaa caacgccaa 
      gccccaact ttcaacaaa gaaatcttc gttgatttt 
      atgggcgct caagtgaaa actctatca ttcctcgcc 
      tacatcatc aaattctac ctcgaacac gtccaaagc 
      cattccgcc atgatggtc caaggcatg ctaggactc 
      ctcatgcta tgtccaatg gaagtggct catctcaga 
      cgcgagtta ctcattgcc gctcgccat atcctagca 
      accgatctc cgaaatcga ttcgtcccc cacatggag 
      aagctcttc gatgaggac gtcctcctt ggccgcggt 
      tggacgacg catgagtcg ctccgccca ctcgcctac 
      tccacattg gccgatctg gtgcatcac gtgcgccaa 
      caactgcca ctcagcgat ttaacacgc gctgttcat 
      ttgttcagc aaaaacgta catgatgac acgttggca 
      acgactata caaaccatg tcgtgtaaa ctactcttg 
      aatctcgtc gactgtatt cgggcacgt tcggaggcc 
      gagaatagc accgaaggt cgcgagttg ctaatgcgc 
      atgcttgaa gtttttgtc gtcaaattt aaaacaata 
      gctaaaata caacttccg attttaacg gcaaagtgc 
      aaacaacaa caacaaaaa acacaagtc gagattaag 
      actgaagat ggcgctgca aatccggcg gaagttctg 
      gaaaatgcg ctcgcgacg acgcaaaat cgcgccgaa 
      caaaaggag gaaaagtcg aaatttggt tttccgcaa 
      aataataat tacaacgtt gctgattat catagtctt 
      gttaagact ttagtgtgt ggggttaaa actataacg 
      tggggctgt tcggcgtgt aagtcgagt tcgagtcat 
      agtttggtg gcaacgaaa cattttcaa ccgcatgaa 
      acgctggtt tttgtcaga ttggttaag tgggctttg 
      aaagcgtta gatatctat acgttgtat ccgggacct 
      caagtgaca ggtccccaa aggattaac caacaaaat 
      gaaaggaat aaggaggag aaggtggtt ttggaacat 
      ttcagtgga gtgttttcg atgatgaat ccgcaaacg 
      tttcacgag attttttca acgactatt gagtatttg 
      gtcgagagg gtttacaag aatccgact ttgcaaacg 
      gttccgaac actttgctt gcaaacccg gccacaagc 
      ccaattttc gcgaccgtt ttggtcgaa tatttacta 
      gaacgaatg gaagagatg ggttcaaat ctcgaacgt 
      agcaatctc tatttgaaa ctcttcaaa ttagtgttt 
      ggtagcgtt tcgttattt ccacaagaa aacgagaac 
      atgctgcgt ccacatttg caccaaatc gtcaataga 
      tcaatggag ttggcaatg agtgccaaa gaaccgtac 
      aattacttc ctccttttg cgcgcactt ttccgctca 
      atcggaggc ggaagccac gatttactc taccaggag 
      ttcctcccg ctcttgccc aatcttctc gaaggttta 
      aaccggcta cagagcggt ttgcacaaa caacacatg 
      aaggatctc ttcgttgag ttgtgtcta accgttccg 
      gttcggtta agctcactc ttaccctac ctacctatg 
      ctgatggat ccgttagtg tcggctttg aacggttca 
      cacattttg ataagtcaa ggcttgcgc acgttggaa 
      ttgtgcgtc gataactta caacatgat ttcttgtac 
      gaacatatc caaccggtc agggccgac ttgatgcag 
      gccttgtgg cggactttg cgtaacaat gaccaggtg 
      gcgcaagtg gcctttaaa gttttgggt aagtttgga 
      ggtgggaat cggaaaatg atgattgaa ccgcaaaaa 
      ctggactat gtgtcgtcc gattacgac ccaccagcg 
      atcattgcc aagttttat gatcaggat aagacgatt 
      gagtttccg gtgcaaaag ataatcgag actgcgttt 
      aatgcactt aaacagagc aacactgat tcgttctac 
      cgcaaacaa gcgtgggaa gttatcaat tattaccta 
      actgcgtct cgtaatcta tctgatgat aaaaatacg 
      ctaattaat ctgtttctt cactcgacg ttccaagac 
      cctaaaact atacctcaa gttaagggt tcggtctat 
      aagagcatt tataaacaa gcacgtgag acacatcag 
      accgctctc accggaatg tttgttgct gcagctatt 
      aaagaattg cggcaacca gttgttgct ttgatggtt 
      gctgtcgtc cgtcattac accatggtg gcggtggcg 
      caacaatcg ggcgcgttc gcttgcacg ccgaaacat 
      aacgaacaa gtggcactt gacccactt gtgttggtt 
      gatgctctg gcagtgatt atgggacat gaggagaag 
      gagttgtgt aagccgggt cacgtaggc cttgtttta 
      atcctcgat acggcctct acactgctc ggaagcaag 
      gaaatggcc tgtcgttta cccttgatt gagtattta 
      tccgaaaaa atgtgtgcc ctttgctac gaaagagca 
      tggtatgca aaattaggc ggctgtata gctatcagt 
      tttatgttc gaacggtgt gcccgtaag tgggtttat 
      gaacacatg tttacgttc ttgaaagcg ttactgttc 
      gttatgatg gatttgacg ggtgaggtg tccagtggc 
      gccctcgat atggccaag aataatctg gagaagatg 
      ttgaatgtt tgtgtgacg gaaccaccg aaaggtgcc 
      gatcaggaa acgcgtgac ttgcaaaag aaggcgctg 
      catgaggtc acacatgaa ttggtgcgt caagtcacc 
      agtccccat actatggtg agggaacaa tcgatgcac 
      tcgttgcgt ctcttggcc gaaaaacaa aacaaatcg 
      gtcacttcg gtcatggaa ccgttcaaa gaagtgcta 
      gcagatatg gtaccacct accaaacat ctactcaaa 
      caccaaccg gccattgcc cagatgggc ttaatggac 
      ggcaaccag ttctgtacc accttgaac ccccgactg 
      ttcacaatc gatctatca atcaaagaa cacaacttg 
      ttcatcctc gacctcctc tcactgtgt aacagcgaa 
      gacgtcaaa ctgaacacg ttcagttgc tacaaaaac 
      atcaccaat ttcataccg ttgaggaaa tcagcattg 
      cgcgtcctc gccgcctgt cattacctc gaagaagtg 
      cgcgagcaa attttccaa gtgttgtac aaagccctc 
      gaaaagccc aacgccgag ctacaacaa accgcattc 
      gaatgtatg cgtgatttc atcgctgga tatcaagtc 
      aacaaggac ttggtctac caaaccatt aaacccttc 
      ctactcacg ctaggcgat gccaaaaat ctgaccctt 
      aacggcgtc aaaatgcta tcatatttg acacaacta 
      ttcccgttg aatttcaac gagagtttg tgtgagcaa 
      ctgttggaa ttgctcaaa caactactc gaaaacttg 
      acaaatagc cacaaagtg tccaccggt gtgtcgaag 
      aaaggcgac gaggagcaa aaaatcgtc acaatcatc 
      gggatattt caccaaacg ccggccgcc tcctcgaag 
      tttataaat cagttgtgc caacttatt ctccaaacg 
      gagcaggcc atgctgatc gaggccagc tctcccttc 
      cgggaggtt ctaatgaag tttttgttg cgttatccc 
      ggtgatacg ctcgatatg ttcctcgat gatacctac 
      gttaaggat aaacagttt agtcggtat cttgagttt 
      ttgattaag cataaggag gggaagagt tttcgtgac 
      tatatacaa accagtatg gttaagaga ttgattcag 
      atggcgctg gccaacgtc cacgttaat tacactctg 
      agtgagcag gaacgtaac gaattgcaa tatcagagt 
      attaggatt atatccttg ttgataaaa agtgacgat 
      cagtggttg tccgaacaa caggagttg gtggaggcg 
      ttgaaacag atttggtgt gatgatgcg tatcaggag 
      cggcataaa agtgtcgat aacttggag tatcctcat 
      tggaaggaa cccaaactt ttggtcaag attctcttg 
      cattatttc tgctaccat ccgaataac gttgatttg 
      ttgttccaa ctgttgagg tgtttgtgc caccgcttc 
      atacccgag tttcagttt ttgaaagac ttcctcgcc 
      aatacagtc gcccaaaac tatactgtt gaatggaaa 
      cgctcggcg tttttccgc ttcgttaag cttttcccg 
      actaactct atgtcccaa gaactgaaa tcaaaagtg 
      ttacaattt attctgatc ccttgtttc gccgtcagt 
      ttcgaaaag ggcgaaacg aacaaacta gtcgggggt 
      ccccccatg ccctaccag gacagtccc gataacgtg 
      gtgtccgtt tttatcaac aaactcatc gatcctgat 
      aatcccttc cccacagcc gactgtgtc cgaatcgcg 
      ctgttacaa ttctcgtgt ctgctcgtt gaacaagcg 
      agtccacac atccacgac cataataag acgcaaagt 
      tcgaaactg cgtcgtttg atgacgttc gcgtggccg 
      tgtttgctg gttgagaat tgtttcgac ccagcgaca 
      cgttaccac ggccaccta ctactgtcc cacatcatt 
      gataagttt gccatccac cggaagata atccttcag 
      gtgtttcac agtttgttg aaagcgcac gcgcttgaa 
      gcgcgcaat gtcgtcagg caggcgttg gaaatcctg 
      acgccttcg atgcccctc cgtatggag gagggtaac 
      acgatgttg acgcactgg accaagaaa ataatcgtg 
      gatgaagga cattccatg caacagttg ttccacatt 
      ttgcaactt gttgtcaaa cattacaag gtgtattat 
      cccgtgcgc caccatttg gtgcaacat atggtcaac 
      tcgatccaa agacttggc ttcagtcca actgcaaca 
      ctggaacac cggaaattg gcagttgag ttggctgaa 
      gtcataatc aagtgggag ctgtacggg attaaggag 
      gagggtgat tgtgatggc gttgaaaac gttgcaact 
      aaaagacca aatgatgat gcgattgaa actcagcgg 
      aaacgttta gctgtgtca caaccctca acgtcatac 
      tcacccacg ccggtggta aaacaggaa cctgggatt 
      aataagcca attgaccgc gtccatatt gacacagtt 
      ttgaatttt ttgctgcgt ctcgcgtgt caagtcaat 
      gatagcgcg ccccaaaac ccggccaat ccgactgtg 
      agcagcccc ggcgagtta ctctcacgc cgttgcgtt 
      attttactc aaaacggcc cttaaaccg gacctgtgg 
      ccacaaccg attgaccta aagttggcg ttctttgac 
      aaaatactt ctcacgatt gagggccca agccctaat 
      attggcaac gtgtgtacg gcgcttgaa ctgttaact 
      tatctcttg actgtgttg aaaaaagag caaattctg 
      gcgagtttt aagccgctc cagcgcggt ctaggtgcg 
      tgtataacg tccacaaac aacaaaatc ataaagcta 
      gtgcatggg cttttgacc aagttaatg gcactgttc 
      ccgaccgag cgttccagc acaaccgtg tgcaaatac 
      gaggagttg gagattttg tattcaacc gtggggaag 
      gtgattttc gaaggcttg aataattac gagacgaac 
      gcgcaagcg aattcgtcc agtctgttc ggaactatg 
      atgattctg aaagcggca tgtgccaat aaccactcg 
      tatattgac ttgttgatt acgcccttt atgcgggtt 
      ttgcaccgg ctggctaag gagcatttg cagccgacg 
      tccaccgaa tacgccgca attaacagt gaactgctc 
      atcttgagt cttgatctt gttaaaacg cgcgttgtt 
      gtgatgggt gttgatatg cgcaagact tttattggc 
      acgattctt gtcggtctt attgaaaaa acgcaggat 
      attaaggtg atgaaagct atcactaaa atgctagaa 
      gagtggatg aagtgtaag aacgttgta acacttaac 
      caggcaccg agtctaaga gaaaagtct attcttttg 
      gggaaaatg atgcaatat gttgagaaa cggtttccg 
      gaagatgcc gatcttaat gcacagttt ttggagctt 
      gtcagctac gtttacact gacataaat ttgaaaaca 
      accgagctg acttcaaag ctagaaccg gcttttttg 
      gccggttta cgctgcaat cagcctcat atccgtgcc 
      aagtttttc aaaatcttc gacgagtca atgcgacgt 
      cgtttacac gaccgctta ctatatata gtgtgttcg 
      caaaattgg gaagcaatc ggccaacac tattggatc 
      aaacagtgc attgaattg ttactcgtg actgctgtc 
      cctgacact tccatacaa atggcacac gaaagcagc 
      attctcccg agtatcact tcggtgata aattccgcc 
      gaaaaacgc gaagaattc agcagtatg caggttgat 
      aatccaaat ttctacact tcgaccgaa atcaaagaa 
      gaagtgtta gacttggac ttgtcaaat gtggagtca 
      aatccacca attgaggaa aaaccaatc gatcgcgcc 
      gaaactatt tcgaaaatg atcaaaaaa cactatgaa 
      tttatcgag attagtcga aacgtaacg actgatcaa 
      tttctattg gcggcttcg cagctgtgt cacatggac 
      acgagtcta gccgaacaa gtctggctc cagttcttc 
      ccccgaatt tgggaaatc ctggaacag gaccaacgc 
      aacgtcctg gtccaggaa atcctcccg ttcataacc 
      tccggcacc cacatcatc cagaaagac tgccatccg 
      agcgccatc aacacgttc gtggaagcc ctaagtcgg 
      tgcaacccc ccgatccaa atcgccccg ccccttatg 
      aaatacctg ggtaaatcc cacaatctc tggcaccgt 
      atggcgctc ggattggag cagatggcc tttgacccc 
      gcctctgcc aaagcgacc aatgccagt tgctacgat 
      tttgaaacg gaccaatcg aaaaacgag ctgcttgat 
      tccttgggc gagttgtac tcgttgcta tgcgaggag 
      gatctgtgg gcggggctt tggctcaag catgcgcac 
      tacaaggag acgagtatt gcgattgcg tacgaacag 
      catgggttt tttgagcag gcgcaaggt gcgtatgag 
      tcggccatg gccaaacat aagcaggat aattccatg 
      ggtccggtg cctacgcat acgcaacgg gaggtgctg 
      ttgtggact gagaggtgg atcaggtgt accaaggag 
      ttgaacgag tggaatatt ttaatggag tatgcgaag 
      aatggggtt tatgatcca tatttgttg ctggagagt 
      gcctggagg atccccaat tgggatatt atgaaggag 
      gtgctcagt aatgtggag tataactgt cccaaggag 
      ttgggttgg aagatcaca atgtatggc ggttttctc 
      ctaatctgc caaccagaa gagagcaaa cctttaaaa 
      ttcgtggaa cgatatgtt gaaagcgcc agcgccctc 
      tgtctgaac gagtggcgc cgcctacca catatcgtc 
      agccacatc cacttgccc tatctccaa gccgcccaa 
      caaataatg gagttacaa gaagcctac cagattcac 
      aaaggcctt cttcaaggc caccaaaac tccctccat 
      gacatgaag gccattgtg aaaacatgg cgcaaccga 
      cttccggta atcgccgac gacttgacc cactggaac 
      gatattttc acatggaga cagcaccat tatcaagtg 
      atcgtaaac cactacgag tcaatcaga gacaccacc 
      aataccaac tcaatgttg ggcatacac gcctcggct 
      caatcgatc atccatttc gggaaaatt gcccgaaaa 
      cacaaatta gtcaacgtt tgtttggaa tcactcaat 
      cggatctac tcgatcaaa agcgtcccg atcgtcgat 
      tgttaccaa aaaatcagg caacaagtc aagtgctac 
      ctacagttg gcatcaatg aacaacaaa aacgagcta 
      caagaaggc ttggaagtg atcaacaac accaacgtg 
      aaatacttc gctaaagaa ctcaccgcc gagatttac 
      gccctcaag ggcatgatt taccacttg agcaacaaa 
      tcggacgaa gccaataag tcgttcagc gccgccgtg 
      caaatgcac gacacttcg atcaaggct tgggcgctt 
      tatggtgac tatttggag caggttttt acacgtgat 
      tcgcgtcaa atcaatttg ggtgtgaat gcaatggcg 
      tgttttttg cacgcctgt cggcatcaa aacgagtct 
      aaagcacgc aaatatttg gctaaagtt ttgtggctt 
      ttgagttat gatgatgaa aattcaagt ttaatggac 
      gcgttagat aagtattcg gtcggggtt cccccgatt 
      ttgtggttg ccgtggacg ccacaactg ctcaattgt 
      ttggtccag tatgagggg cacgtgatt ttgaacttg 
      ctatgtcag gttggtaga atgttccct caggctgtg 
      tacttcccc atccgtacg ttataccta actttacgt 
      acggcaaca gcgcgtaaa acaaacaca gtccaacaa 
      caaccccaa gaccaaacc gacactcaa aataaccaa 
      caagagagt ggcaacact gccacaatc acaaccagc 
      gaaacatct tcaatcaaa gcaacacct gctatgatc 
      cgctgttca aaaataatg aaaatgcaa cgtgatatt 
      cacaccacg gcactgtca agtctcgaa ggaattgcc 
      aatcaaatg gagtggttt agagagaat tggtacgaa 
      gaggttttg agacagtta aggcagggt ttgactaaa 
      tgttacgcg attgcgttc gagaatcgt gaaagtgta 
      aatgaggct aaaataaca ccacatata cttaatttt 
      gtgaaaaag ttaatgtcg acgtttggc attggtgtt 
      gagaatatt ggttcggtg gttacgttt aattcggca 
      gctagtgaa agtctggcc aggagagcc gaagctacg 
      tatcaggat ccggtgttt aaggagatg aagcaggat 
      tttaccaag gattttgat ttttcgcaa acgaattcg 
      atgcgcttg catacgttg atttttaag ctgaagaag 
      tggatcaag attttggat aatcgttcc aagatgttg 
      ttacagtcg ttcctaatt gaggaaaaa tgccgtttc 
      ctctcaaac ttcaccctt aaaaccgcc gaagtggaa 
      atccccggc gaatttctc ctccccaaa cacaaccat 
      tactacgtt cgcataact cgtttcatg cctcgtgtt 
      gacgtcgtc caaaaacac aacgccgcc gccaggcgt 
      ctctacatc cgtggtcac aacggaaaa atctaccct 
      tatttagtt gtcaacgat tcgggtcta gtcgacgca 
      cgtcgtgaa gaacgcgtc cttcaactt ctgcgcatg 
      ctcaatcac tgtctcggc aaacagaaa gagaccgca 
      cgacgtttt ctccacttt accgtaccg cgcgttgtt 
      gccgtctcg cagcaaatc cgattggtc gaagataac 
      cccgcctcc atctcccta ttggacatt ttcaaaaag 
      gggtgtgcc aagctaggc atcgagcac gacgatccc 
      attcattac tactacgaa cgcttgggt ggggtgcag 
      agtagggga atcaaagcg agccatcaa ttgagtagg 
      gatatttta aaaggggtg caaacaaac atggtacca 
      agaacgttg ttgaaacaa tgggcggtc caaacgttc 
      ccatcagcc accgattat tggcagttt cggaaaatg 
      ttcacattg cagttggct ttggcctgc tttgccgaa 
      catgtcttg cacttgacg agacttaat cccgacatg 
      atgtacttg catcaggat tcgggatta atgaacgtg 
      gcctacttt aagtttgat gtggatgat gggacgggg 
      gagtttggg gccaccaga tcggtgccc ctttcggct 
      gacgccgaa tattcgtcc atgattgcg acggcgagg 
      tgtttcgtt tatccgaat tttaaagta acggcgatt 
      ttgaagccg attttgaga gatgagatg gttttgtcg 
      aggatgaag aagccggag gaagtggca gggaataat 
      acggagaag ttgagcgat agcgaacag attattaat 
      atggtcaat aaggcagtg acgtcgatc tccagtcgg 
      ttgaacagt ttggcgcat tttgacgga gctgatagc 
      aagtggact gtgacaagt ggtgacgtg atggagaag 
      acggagggg ttcaagagg tcggtcacc aaacaggtc 
      ctcctcggc ctactgaca aacttttca agcatcgcc 
      cccagcatg agtcttgga ttttcagca gttgcgctc 
      cctgtttta accagtgct accaaccgt tatgcccta 
      aacagtgac caagcttca tggtttgca agtatagcc 
      tcactagcg acaccgttc ggttgttta gttgccggt 
      ccgattgct gataaattc ggccgaaga cgggccatg 
      tactgtgtc aatattttc tgttttatt ggctggttg 
      ctcatagcc tgggcctat tattggcca caacaccaa 
      tacgttatt cttttgatt ggccgactt ttgacgggg 
      ctttcgaca ggattgtcg agtgcccca gctactatt 
      tatatggca gagattgca agtgttaat ttgagagga 
      gttttctgc acttggaac agtattgcc ttctctttg 
      ggggtcctt attgtctac tttttaggt tttgtgcta 
      caggacaac tggggcctt atcagcctc ataaccgcc 
      gttttccca tgcgtgggc atggtcttc gtcacattc 
      ctagtcccc gaatcgcca tcttggctc attcggaag 
      gaccgcttc gacgaagcg aaaaccaac atgtgcaaa 
      atattcggt accaaagaa tacatccct gaagttgca 
      caagaaatt gatacttta atccgaaac cgcggtgtg 
      aaaaataac ccaaaaccg aaaacaatc ctccaacaa 
      gtcgccaaa aaattaaag tatttaacc cgtgccagc 
      tgtttgaag cctttaagt ctcgttgtt ggctttttc 
      ttcttccaa caatttgcc ggtactttt gttatagtt 
      ttttatgct ttgaacatc gtcaaggag gccggggtt 
      gagatagac gcctacgtg gcaattgtc atgataggt 
      ctagtccgc ctcttttcc gccatcttg gttagttat 
      attagcaaa attttcggg cgtcgtcca ttatcggtc 
      gtttccggt tctggaatg gcggtttgt atgatggcg 
      ctcgctggt tacatccta gcagtgacg aagagtaaa 
      gtaccggaa gcgacgcaa cagtcactt gtttttctt 
      ccggttgtg cttcttttg ttgtatttt ttcacaagt 
      actgttggt tttctacca atgccgttt gcaatggcg 
      gctgagtta ttccccgca aaaattagg ggaacagca 
      acagggttg gcgtcaggg attgggtac tttttcaat 
      tttgtaact gtcaaaatc tacccggcc atgatttcg 
      ggaattggc cgggaagga gtgttcttt ttctacggt 
      gccatgagt ctcgctggt accatttat gtggtggca 
      ctactgccc gaaactagg ggaaaaacc ttacaagag 
      attgaggag tattttggt aaaaaaccc tcaaaaaat 
      aattcccta ttaaaggaa ccagtctaa gggcactag 
      atctgtttt tgacagcta cgaaatgtc aaaacatgt 
      cactaaatt gtgacgtgc ata
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