Status
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Gene information
General information
TC034619 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007418.3: 20806087..20863496
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC034619
    iBeetle screen iB_02724

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 20.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Analysis of embryonic musculature and early development
    number of eggs/embryos/larvae on slide: > 50 embryo/egg with muscle fluorescence/pattern, but not hatched (pot. late embryonic lethality) - Penetrance (percentage of animals/eggs on slide): 50% - 80%

    larval musculature fluorescence decreased - Penetrance (percentage of animals/eggs on slide): 30% - 50%

    affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): 30% - 50%
    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: > 50
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 0.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 0.0% (includes death as larva, prepupa, pupa, adult)

    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC034619 RA
      MMQERDKDD LEMLMDVAK YIAKSAEAT KKSGSATAF 
      ALAESFKEK LAKAKDRRV ERFQELQLP HRHICDLIA 
      MHLNIDPNE VLEAAADSD EHIELLEKF LCKNGIFGL 
      LVYYQDGYG YEVETGRFN PNAMADLVM KRIYFTDGM 
      DEPVKDRVI GIYKIANVE LSLKNINDA IYFTTFDIQ 
      AEKMNSVAV AYKLLGELI DPSFQLNKD WGDLPKTEV 
      GLKQKSNFQ GDFESFVDF LKQTKLDLE MVVSFPYDR 
      GLYRRDLVN EKKRTEAIL NRQIVQQVE STVRTWCKQ 
      MERAQVQYQ QLRRENEFV GPLVEIEYW RRQLARFTS 
      IVEFITDAP CKIHIQFLE ACKSKLLKI WSKHESAVI 
      EAKNECADN MRYLYALEK FCNPLYRCE ATELLHHIP 
      PLLHAIRMT YTTSRYYNN TANVTALLV KVSNQMINV 
      CRAYLNCNG TKTVWNQKK KVVLEKIKV CLDIYLKYY 
      QCFKHIQEE MKEAGEAPF ECSEMYVFG KFETFKKRV 
      EEIVDVLET TTKYSILQS SKIENIDIF AKKFQTFFD 
      NISKQKYDA LNHRLPYFD KDYNEFKQN VVDTEWELE 
      EFVGTSLEK ETNVHNVLR LLKRFEKLK LECLHLEER 
      YLEAMELFQ KELEDLRDR YNEERQTPL LPRNMPPVS 
      GRIMWVRHL YRRMEESME IFMTKSRVM RHRNVQKCI 
      QLYNAMAIV FVHYEQIYH EAWYKFAGQ VRACLNTPI 
      LTRDPKTRR YKVNFHPYI SEVIRESEY MYKLDLAVP 
      DVGQVLVFC KEKILNSFE VIKGLVERN DIIRSTIPP 
      LFIPLIRMQ LIKMEDAFR PGFSVITWT STKIPEYCE 
      EVNNVLDYF EMFVKEVKD MKEARIDEV LDAIAATSL 
      VYLPNVALM PSEFLEQNK KFMEHGVKE IELKSSTAE 
      RAVIDLIEK FLSVIEQPE LQERKYDWL DPDKAIRPI 
      GSASRLNVS PEAAFKEID RNIPLDLNT IHNDCLELF 
      GFFNMKLSE ALVKCVKLS LEQIKKRTA SLRDDSSAL 
      NAPIMKTYM ELQIPITVI NPTLDEIQN YFTQVINKL 
      LNTMSFVCM WGQRGSKKK PRREKPLKF KEIAKLIAK 
      TPPPDRNYY KIVSENKEI IRIFMSLQG VMFLLKPDV 
      AKLLQQYLS YSYLWAEGR VNEIEAFCE KNPLTVEIA 
      EKFQEFENR GEKIRELPD SHNVDSIQI DMEKFKLAL 
      LVESDAWKH ILGKNLAKR YRAKLLELV DFIKNREKV 
      LGRPIKDLD DCRLAMACL ELIRENFIE IDLDLITME 
      EAYNIFSKY KIDIPKEDM DRVESLRFN FQNMVVHAK 
      SVQENICNV QGPLLEELT EGVSNFRDE VEAFDRDFE 
      LNGPMIPGL SAREASDRV LAFQDRFDE LWRKFEMYS 
      SGEKLFGLE VNDYPILHK RKKEFNLLN KLYGLYLAV 
      NHSIDGYFD ILWTDVDTE TIFAELTEF QNRCRKLPK 
      AMRDWPAYL DLKKKIDDF SETCPLLEL MANKAMKER 
      HWKRIAQTT SYTFDIDSP TFTLRNVME APLLQFKDE 
      VEDICISAV KEKDIEAKL KQVIADWSV VELSFSQFK 
      ARGELLLKG TETGEIIMA LEDSLMIMN SLLSNRYNA 
      PFKKDIQTW VHKLVNTSE ILEKWLIVQ NLWVYLEAV 
      FVGGDIAKQ LPGEAKRFN NIDKSWVKI MTRAHELPN 
      AVECCTGDE TMGQLLPHL LEQLETCQK SLTGYLESK 
      RLCFPRFFF ISDPVLLEI LGQSSDPTS IQSHLPSLF 
      DAVYRVEFD PKKPDYIIA MLSDLGESV NFEKPVQCV 
      GGVEIWLNS LLEMVRETV KSVIASQAQ LLNDPDYDF 
      IQGFIPFCA QAGLVGIQI LWTKEAEIA IRKAKVDRF 
      IMKVTNARF LELLNALID LTSKDLSKR ERTRFETMV 
      TIHVHQRDI FDTICKSKV KNLLDFDWQ QQSRFYYNE 
      ENDDVTVRI TDVIFLYQN EYLGITERL CITPLTDRC 
      YITLAQAIW INMGGAPAG PAGTGKTET TKDMGRTLG 
      KFVVVFNCS DQMDFRGLG RIFKGLAQS GTWGCFDEF 
      NRIELPVLS VAAQQIYIV LIARKERKP TFIFMDGDT 
      VSMNIEFGI FLTMNPGYA GRQELPENL KIMFRSVAM 
      MVPDRQIII RVKLASCGF KDNIILARK FFTLYQLCE 
      EQLSKQVHY DFGLRNILS VLRTLGAQK RSHPNDTEE 
      TIVMRVLRD MNLSKLIDE DEPLFLSLI EDMFPGIKL 
      STHSWKDLQ KAITNQTAE MGVINYPPW NLKVIQLYE 
      TSLVRHGLM VLGPTGAGK TKCMHCLMK SMTETGLPH 
      KEMRMNPKA ITAPQMFGR LDVATNDWT DGIFSTLWR 
      RTLKIKKHD HVWLVLDGP VDAVWIENL NSVLDDNKT 
      LTLANGDRI VMAPNAKLV FEPDNVDNA SPATVSRMG 
      MVFMSSSVL PWSPILEAW LKTRTQQEA DVCRTVFGK 
      IYEELHSFV QVKLKAKMK ITEALYIRQ CYDVLAGIL 
      DVGDDTKVW TDKQLERLI LFSMMWSVG AVLELEDRT 
      KMEQFVVTH PSKLDWPKC GENETIFEY VVNPKTGTW 
      QHWSERVEE FIYPTDSVL EFINILVPN IDNVRTAFL 
      IDTVAKQNK AVLLIGEQG TAKTVMIKG YTQTFDPEY 
      KLSKCFNFS SATTPNMVQ RIIESYVDK RVGTTYGPP 
      AGKTLTIFI DDINMPVIN DWGDQITNE IVRQAMECG 
      GFYSLDKPG DFSSIVDVM FLAAMIHPG GGRNDIPHR 
      LKRQFCVFN CTLPSNKAM DVIFSQIAC GYFCIERFN 
      QEIVDFVPR LIPLTRNIW QHTKIKMLP TPAKFHYVF 
      NLRDLSRIW QGILTVQRL ECQTISSML KLWQHECCR 
      VISDRFTKA KEREWFLHL LKNQVKKEL DDVHEEYPE 
      DVTFWVDFL REPPEATGD EPEDFCFDA PKIYEEIPS 
      WEFLKEKLF SFVDQYNEQ IRGAAMDLV FFHDAMVHL 
      MIISRIIRS ARGNALLVG VGGSGKQSL TRLASFIAN 
      YKTFQIQLT RTYNVGNLM EDMKYLYRV AGFEGKGIS 
      FIFTDNEIK DETFLESLN NILSSGEIA NLFAKDEID 
      EITSDLVLV MKKAQPKRA PTGDNLYDF FISRARSNL 
      HVVLCFSPV GEKFRSRAL KFPGLISGC TIDWFFRWP 
      RDALIEVSE HFLNKFSVV ATPDTKKEL IYVMGEIQD 
      YVALTCNSY FEKFRRRTY VTPKTFISF LETYKTVYV 
      KKLANIGEM DSRMRTGLT KLVEAQQNV DELKKELII 
      KEQEMKVAT DAAEKVLDE VLAASEITN KIKEEATVV 
      KDKAEKLVA IISVDQQEA ESKLLAAKP ALDAAEAAL 
      LTIKAADIA TVRKLGKPP YLITLIMDC VLIYFKRKL 
      EPVKADPEK GFLISSWTE SLKVMADTK FLNKLQEYP 
      KDTINAEIV DLLQPYFAF PLYTYENAK TACGNVAGL 
      ISWTIAMAS FFEVNREVL PLKANLAIQ QAKLDKAQA 
      ELSSAMTLL AEKEEEVRQ CQIQYEEAM RHKQEVFDD 
      AMKVKNKMD SATALIDGL AGERIRWTE QLAQFKAET 
      DRLIGDVVL LVGFLSYSG PFNQEYRTN MQKFLLEAV 
      LKRKIPVTI SLNIIDSLT DTATIGEWN LQGLPTDEL 
      SIQNGIIVT TASRFPLLI DPQSQGKFW IKAKEKENH 
      LLVTSLNHK YFRNHIEDA VSLGYPMIV EDINEELDP 
      VLDNVLEKN HIKVGTTYK VKVGDKEVD VNQDFRMYI 
      TTKLANPSY TPEIFARTS VIDFTVTMK GLEDQLLGR 
      VILTEKKEL EAERTNLMR DATANRRKM QELEANLLY 
      KLTTVQGSL LDDPTVIDV LNITRNTAS DIREKLAIA 
      KETEIKINA AREEFRPVA TRGSVLYFL VVSMAMVNN 
      MYQTSLVQF LERFDLSMH RSEKSNITS KRIVFIIDY 
      LTFEIFKYK SRGLYEIHK YMFVLLMCL KIDLEREHI 
      THEEFQNFI KGGAALDLN TCPPKPAKW ITDMTWLNL 
      VELSKLRHF QYIVQQITA NDKLWKHWF DKNAPEEAV 
      VPDGYNNLD TFRKLLLIR AWCPDRTIT QATKYLASS 
      LGQKFAEPV VLNLETLYY ESRAMTPMI CFLSIGSDP 
      TPYIEQLAK RLETKVRSI SMGQGQEVH ARKLMTQAL 
      SEGFWALLQ NCHLSLDYM NEVLLQFMD LEKGVGTYH 
      QDFRLWITT EVHENFPIS LLQICIKFT NEAPSGVKA 
      GLQRTYTSM NQDMLDYSD AWQYIPLVY AISFLHTVV 
      QERRKYGPL GWNIPYEFN SADWLASCL FVQNHLDDL 
      DPKRGVSWP TVRYMLGEV HYGGRVTDD FDKRLLNTF 
      CKVWFHDEM FHDDFIFYE GYKIVRFKN VSEYVSHIE 
      TYATSDPPQ VYGLHPNAD ITYQTNTIA SMFYTMVSI 
      QPKEAGAGG GETREDAVT RQAKEMLEK LPSNYDPYE 
      VKERLRIMG ILNPLNIFL RQEIDRMQK VITNVRTTL 
      KDLLLAIEG IIIMNESLR DALDNIYDA RVPFVWRRG 
      SWTANTLGF WFTELLERN AQFSTWCFG GRPLTFWMA 
      GFFNPQGFL TAMKQEVAR AHKGWALDQ VKLQNMVTK 
      NIKEEILQP PLEGVYVHG LFLDGAGWD RRNARLNES 
      INKVLYTMI PVVHIFATY GTELKTTNL YVCPIYKKM 
      RRTDLNYIT SLYLQTVKP PEHWVLRGV ALLCDTQ
    CDS sequence
    • >TC034619 RA
      atgatgcaa gaacgcgac aaagatgat cttgagatg 
      ctgatggac gttgcgaaa tacatcgca aagtcagct 
      gaagcaacg aaaaaatcc ggaagtgcg acagctttc 
      gccttagca gaatcattc aaagaaaaa ctggccaaa 
      gcgaaagat agacgagta gagaggttt caagagttg 
      caattacca caccgacac atttgcgac ctgattgcg 
      atgcatttg aacattgat ccaaacgag gtgctggaa 
      gcagcagcc gatagtgat gaacatatt gaactattg 
      gagaaattt ttgtgcaag aatgggatt tttgggttg 
      ttggtttat taccaagat gggtatggc tacgaagtt 
      gagacgggg agatttaat cccaatgcc atggcagat 
      ttggtcatg aaacgaatt tatttcact gacggaatg 
      gacgaacca gtcaaggac agagtcatc ggaatctac 
      aagattgca aacgttgag ctgagctta aaaaacata 
      aacgatgcc atctatttt acaacgttt gacattcaa 
      gctgaaaaa atgaattct gtagctgtg gcatataag 
      cttttaggt gaactgata gatccctca ttccaattg 
      aacaaggac tggggtgat ttgcctaaa accgaagta 
      ggacttaag cagaagagc aattttcaa ggagatttt 
      gaatcgttt gtggatttt ttaaaacaa actaaactg 
      gaccttgaa atggttgtt agttttcct tatgataga 
      ggtctgtat cgcagagat ctagtaaat gagaaaaaa 
      cgtactgaa gctattttg aaccgacaa attgtgcaa 
      caagtggaa tcgacggtt cgaacttgg tgcaagcag 
      atggaaagg gctcaagtt cagtaccaa caactacga 
      cgagaaaac gaattcgtt ggtcctctc gttgaaatt 
      gaatactgg cgaagacaa ctcgctcgt tttacaagt 
      attgtcgaa ttcatcact gatgcacct tgcaaaatc 
      catatccaa tttttggaa gcttgcaaa agcaaactt 
      ttgaagatt tggtccaaa cacgaaagt gcagtcatt 
      gaagcaaaa aacgaatgt gctgacaac atgcgatat 
      ttatacgct ttggaaaaa ttttgcaat cctttgtat 
      agatgcgaa gctacggaa cttctccat catattcca 
      ccactactg cacgccata agaatgact tatacaacc 
      tcacgatat tataacaac actgcaaac gttacagcc 
      cttttagtc aaagtttcc aatcaaatg attaatgta 
      tgcagagcg tatcttaac tgcaacgga accaaaact 
      gtctggaat caaaagaaa aaagtcgtg cttgaaaaa 
      attaaagtt tgtctggac atttactta aaatattat 
      caatgtttc aagcacatt caggaagag atgaaagag 
      gcaggtgag gcacctttt gaatgttcc gaaatgtat 
      gtttttgga aaatttgag acgttcaag aagcgagta 
      gaagagatt gtcgatgtt ctcgaaacg accacaaaa 
      tattcaatc ctgcaaagt agcaaaatc gaaaacatt 
      gatattttc gccaagaaa ttccaaacg ttcttcgac 
      aacatatcg aagcaaaaa tacgacgct ttaaaccac 
      cgattgcca tattttgac aaggactac aacgagttc 
      aaacagaac gtggtcgat acagaatgg gaattggag 
      gagtttgtt ggtacgtct ttggaaaaa gaaacaaac 
      gttcacaat gtattaaga ctattgaaa cggtttgag 
      aaactgaaa ttggagtgt ttgcatttg gaagaacgc 
      tatctcgaa gcaatggaa ttgtttcaa aaagaactt 
      gaagattta cgcgatcgt tacaatgaa gaacgacaa 
      acacctttg ttgcccaga aacatgcca ccagttagt 
      ggacgaata atgtgggtg aggcatttg tatcgtcgc 
      atggaggag tcaatggag atttttatg accaaatcg 
      agagttatg agacaccga aatgtgcaa aagtgtatc 
      caattgtac aatgcaatg gctattgtt tttgttcat 
      tatgaacag atttatcat gaggcttgg tacaaattt 
      gctggacag gttcgagct tgtttgaat acaccgatt 
      ttgacaaga gacccaaaa acaaggcga tacaaagtc 
      aattttcat ccgtacatt tctgaagtt attcgagag 
      tcggaatac atgtacaag cttgatctt gctgtgcct 
      gacgttggc caagtgctt gttttctgt aaagaaaaa 
      atcctcaat tcgtttgaa gtgattaaa ggtttggtc 
      gaacgaaac gacattatt cgaagtact attcctcct 
      cttttcatt cctctaatt cgtatgcaa ttgataaag 
      atggaagat gcattcaga ccaggtttc tctgtgata 
      acttggact tcgaccaaa atccctgaa tattgtgaa 
      gaagtcaac aatgtcctg gactacttc gaaatgttt 
      gtcaaagaa gttaaagat atgaaagaa gccagaata 
      gacgaagtt ttggacgca attgctgcc acttctcta 
      gtctatttg ccaaatgtg gccctcatg cctagtgag 
      tttttggaa cagaataaa aagttcatg gaacatgga 
      gtgaaagaa attgaactg aaatcctca acagctgaa 
      cgcgctgtt atcgactta attgagaaa tttttaagt 
      gttattgaa caaccagaa ttgcaagag agaaaatac 
      gactggttg gaccctgat aaagccata agaccaatc 
      ggatcagct tcacgttta aatgtctca ccggaagca 
      gcttttaag gaaattgac cgaaacatt cctctggac 
      ctgaacacg attcacaac gactgtctg gaattgttt 
      ggtttcttt aacatgaaa ttaagcgag gctttagtc 
      aaatgtgtt aaactgtct ttggaacag attaagaaa 
      cgaactgcc agtttgcga gacgacagt agcgcactg 
      aatgccccg attatgaag acttacatg gaactccaa 
      attcctata accgtgatt aatccaact ttggacgaa 
      attcagaat tacttcact caagtcatt aataaactt 
      ctcaacacc atgtcgttt gtatgcatg tggggacaa 
      cgtggcagc aagaagaaa cctcgaaga gaaaaaccg 
      ttgaagttt aaagagatt gcaaaattg atcgctaaa 
      actccccca cctgatcga aactactac aaaatcgtg 
      tccgaaaac aaggaaata atccgaatt tttatgagt 
      ttgcaaggt gttatgttt ttgttgaag cccgacgtt 
      gcgaaattg ttacaacaa tatttaagt tattcgtat 
      ttgtgggct gagggacgt gttaatgaa attgaggcg 
      ttttgcgag aagaatcct ctcactgtt gaaattgcc 
      gaaaagttt caagagttt gaaaataga ggagagaaa 
      ataagggag ttgcccgat agtcataat gttgattcg 
      atacaaatc gacatggag aaattcaaa ttggctcta 
      cttgtggag tctgatgcg tggaaacac attttaggg 
      aaaaatctg gctaagcga tacagagcc aagctgctc 
      gaacttgtc gattttatt aagaataga gaaaaggtt 
      ttgggtaga ccaattaaa gacctggac gattgcagg 
      ctggcaatg gcttgtctg gagttaatc agagaaaac 
      ttcatcgaa atcgactta gacctcatc actatggaa 
      gaagcctac aacattttc agcaaatac aagatagat 
      attccgaaa gaggacatg gacagggtt gagtccctc 
      agatttaat ttccaaaat atggtggtg cacgcaaaa 
      tctgtgcaa gaaaacatt tgcaacgtg caaggcccc 
      cttttggaa gaactaacc gaaggagtt tcgaatttc 
      agggacgaa gtggaagct tttgatcgc gattttgaa 
      ctaaacggt ccgatgatt cccggatta tcggctcgc 
      gaggcaagt gatcgagtc cttgcgttc caagaccga 
      ttcgatgag ctttggcgc aaattcgaa atgtatagc 
      agtggtgaa aaacttttc ggcttggag gtcaacgat 
      tatcccatt ttacacaaa cgcaaaaaa gagtttaat 
      ttgttgaat aaattgtac ggcttgtat ttggccgta 
      aatcacagc attgatggt tatttcgat attttgtgg 
      actgatgtg gatactgaa accattttt gctgaactc 
      actgagttc cagaacagg tgtcgaaag cttcctaag 
      gctatgaga gactggcca gcttatctc gatttaaag 
      aagaaaatt gacgatttc tcagagact tgtcctttg 
      ttggagctt atggccaac aaggctatg aaagaaaga 
      cattggaaa cgtatagca caaacgacc agctatact 
      tttgatatt gattcacca acttttacg ttgcgaaat 
      gtgatggaa gctccattg ttacagttt aaagacgaa 
      gtcgaagat atttgtatt agtgccgtc aaagagaaa 
      gatattgaa gcaaaactc aagcaagta attgcggat 
      tggtcagtg gtggaattg tcgttctcg cagtttaag 
      gcacgagga gaattgctt ttgaaagga acagaaact 
      ggagagata attatggca cttgaagac agtttaatg 
      ataatgaat tctttactc agcaacaga tacaacgca 
      ccgttcaaa aaagacatc caaacatgg gtgcacaag 
      ctggtcaac acgtcagaa attttggaa aaatggctc 
      attgtgcaa aatttatgg gtatattta gaagctgta 
      tttgttggt ggtgatatc gccaaacaa cttcccgga 
      gaagccaaa agattcaat aacattgat aaatcctgg 
      gtgaaaata atgacaaga gcacacgag cttccaaat 
      gccgtcgaa tgttgcaca ggtgacgaa acaatggga 
      cagttactt ccccatctt ttggaacaa cttgaaacg 
      tgccaaaag agcttgacc ggatatttg gaatcgaaa 
      agattgtgt tttccgcgt ttcttcttc atttcggat 
      ccggtttta ttggaaatt ttgggccaa agctcagat 
      ccgacttcg attcaatca catttgcca agtctcttc 
      gacgctgtg tatagagtc gaattcgat ccgaaaaaa 
      cccgattac atcatagcc atgttatcg gatttgggc 
      gaatcggta aattttgaa aaaccggtt caatgtgtc 
      ggaggtgtc gaaatttgg ctaaacagt cttttggaa 
      atggttagg gaaactgta aagtcggta attgcatca 
      caggcgcaa cttttgaat gatccagat tatgatttc 
      atccaagga tttataccg ttttgtgca caagctggt 
      cttgtcggt attcaaatt ttgtggacc aaagaagcc 
      gaaattgca atcaggaaa gccaaagtt gatcgattt 
      attatgaaa gtgaccaat gccaggttt ctggaactt 
      ttgaacgca cttattgat ctcacatcg aaagattta 
      tcgaaaagg gaacgaacg aggtttgag actatggtt 
      acgattcat gtccatcaa agagatatc tttgatacg 
      atttgcaag tcgaaggtc aaaaatttg ctagatttt 
      gattggcaa caacaaagc aggttttac tacaatgaa 
      gagaacgat gatgtgact gtaaggatt accgatgtg 
      atatttttg taccaaaat gagtatttg gggattact 
      gaacgtctg tgtattaca ccgttgact gacaggtgt 
      tacatcact ctagctcaa gctatttgg attaatatg 
      ggaggggct cccgcagga cctgcagga actggcaaa 
      actgagacc actaaagat atgggtaga actttgggt 
      aaatttgtt gtcgtcttt aactgttcg gatcaaatg 
      gattttcga ggcctgggc cgcattttt aaaggtttg 
      gcacagtct ggaacttgg ggttgtttc gatgaattc 
      aaccgaatt gaattacca gtattgtca gtagccgcc 
      caacaaatc tacattgtt ttaatagca agaaaagag 
      cgaaaaccc acgtttatt ttcatggat ggtgacacc 
      gtttcgatg aacatcgaa tttggaatt ttcctgact 
      atgaatccg ggttatgcc ggacgacaa gaactaccg 
      gaaaattta aaaatcatg tttcgaagt gtcgcaatg 
      atggttccc gatcgccaa attataatt cgagtcaag 
      ctggcttct tgtggtttt aaagacaat attatttta 
      gcacgaaaa tttttcaca ctttatcaa ttgtgtgaa 
      gaacaactc tcgaaacag gtgcattat gattttgga 
      ttacgtaat attttgtcg gttttgaga acgctaggt 
      gctcagaaa aggtcgcat cccaatgat acggaggag 
      acaattgtc atgagagtt ttaagagac atgaatttg 
      agcaaacta atcgacgag gatgaaccg ttgttcctg 
      tcgttgatt gaggatatg tttcccgga attaaatta 
      tcgacacat tcttggaaa gatctacaa aaagctata 
      actaatcaa actgccgaa atgggagtc attaattat 
      cctccttgg aatttgaaa gtaattcaa ctttacgaa 
      acttcgtta gtcagacat ggactcatg gtgttggga 
      ccaacaggt gctggtaaa acaaaatgt atgcattgt 
      ttgatgaaa tcaatgacc gaaactggt ctaccacac 
      aaagaaatg agaatgaat ccaaaggct ataacagcc 
      ccccaaatg tttggacga ttggacgtt gcaactaac 
      gattggact gatggtatt ttctcgact ttgtggagg 
      agaactttg aaaatcaag aaacatgat cacgtttgg 
      ttggtcctg gatggtcca gtggatgca gtctggatc 
      gaaaatctc aattctgtg ttagacgat aataaaact 
      ttgacattg gctaatggt gatcgtatt gttatggcg 
      cctaatgca aaactggtc tttgaacct gataacgtt 
      gataacgcc agtccagct accgtatcc cgaatgggt 
      atggtcttt atgagttca tctgtactt ccttggagc 
      ccaatttta gaagcctgg ttaaaaaca cgaacacaa 
      caagaggct gatgtttgt cgaactgtc tttggtaaa 
      atttacgag gaattgcat tcgtttgta caagtgaaa 
      cttaaggca aaaatgaaa attactgaa gctttatat 
      attagacag tgttatgat gttttggct ggaatatta 
      gatgtagga gacgacaca aaagtttgg accgataag 
      cagttggaa cgtttgatt ttattttca atgatgtgg 
      tcagttggg gccgttttg gaattggaa gaccgaaca 
      aaaatggaa caatttgtt gtaacacat ccttccaaa 
      cttgattgg ccaaaatgt ggcgaaaat gagacgatt 
      tttgagtat gttgtcaac ccgaaaacg ggaacttgg 
      caacattgg tctgaaagg gtcgaagaa tttatttat 
      cccactgac agcgttttg gaatttatt aatattttg 
      gtgccaaat atcgacaat gttcgaact gcgttttta 
      atcgacact gtggcaaaa caaaataaa gccgtctta 
      ctgattgga gagcaaggt actgccaaa actgtcatg 
      ataaaagga tatacgcaa acttttgat cctgaatat 
      aaactgagc aaatgtttt aatttctct tctgcgacc 
      acaccaaac atggttcag cgaattatt gagtcgtat 
      gtggacaaa agagtggga acaacttat ggtccacct 
      gctgggaaa acattgacg atatttatc gacgatata 
      aacatgccc gttattaat gactgggga gaccaaata 
      actaacgaa attgtgcgt caagccatg gaatgtgga 
      ggtttttac agtttggat aaaccgggc gatttttca 
      tcaattgtc gatgttatg tttctggct gctatgata 
      catcctggt ggtggacga aatgatatt ccgcatcgt 
      ctcaaacga caattttgt gtttttaat tgcactcta 
      ccaagtaac aaggccatg gatgttatt ttcagccaa 
      attgcttgc ggttacttt tgtattgaa cgcttcaac 
      caagaaatc gtcgatttt gtccccaga cttatccca 
      ttgactcgt aacatttgg caacatact aaaatcaaa 
      atgttgcca acaccggcc aaattccat tacgtgttt 
      aacttgaga gatctttca agaatatgg caaggaatc 
      ttaacagta caacgtcta gaatgccaa actatttca 
      tcaatgctg aaactgtgg cagcatgaa tgttgccga 
      gttatatcg gatcgtttc acaaaagcc aaagaaaga 
      gaatggttc ctgcacttg ctcaaaaac caagtaaaa 
      aaagagcta gacgatgta catgaggag taccctgaa 
      gacgtaacc ttctgggtt gactttttg cgagaacca 
      ccggaagca acaggtgac gaacctgaa gatttttgc 
      ttcgatgct ccaaagatc tatgaagaa ataccaagt 
      tgggaattt ttgaaggaa aaattgttt tctttcgtg 
      gatcagtac aacgagcaa ataagaggt gctgccatg 
      gacttggta tttttccat gacgccatg gttcatttg 
      atgatcatt tcgagaata attagatca gcacgtgga 
      aacgctcta ttggtgggt gttggaggt tccggaaaa 
      cagagtctt acaagactt gcgtccttt atcgcaaat 
      tacaaaacg ttccagatt caattaaca cgaacatac 
      aatgttggt aatttaatg gaagacatg aaatatctc 
      tatcgagtc gctggattt gaagggaaa ggaatttct 
      ttcatattt accgataat gaaattaaa gatgagaca 
      tttttggag agtcttaac aatatattg agttcaggc 
      gaaattgct aatttgttc gctaaagac gaaatcgac 
      gaaataaca tccgattta gttctagta atgaaaaaa 
      gcgcagcca aaaagagca ccaaccggt gataattta 
      tacgatttt ttcataagc agagctcgg tctaactta 
      cacgtagtc ctttgtttc tcacctgtt ggagaaaaa 
      ttccgtagt cgggctttg aagttccca ggtttaatt 
      tccggttgt acaatcgat tggttcttc agatggcca 
      cgagatgcc ctaatcgaa gtatccgaa cattttctc 
      aacaaattc agtgtggtt gcaacaccc gatactaaa 
      aaagaactg atttatgtc atgggtgaa atccaagat 
      tatgtcgca ctgacttgt aacagctac tttgaaaaa 
      ttccggaga aggacttac gtcacaccg aaaactttt 
      atatcgttc cttgaaacg tacaaaaca gtgtatgtt 
      aaaaaactg gcaaatatt ggtgaaatg gattcaagg 
      atgcgtacc ggtttgaca aaactagtc gaagcccaa 
      caaaatgtg gacgaattg aaaaaggaa ttgattatt 
      aaagaacaa gaaatgaaa gttgcaact gacgcagct 
      gagaaagtc ctggacgaa gttttggca gcttcggaa 
      attacaaat aaaattaaa gaagaggcg acagttgtg 
      aaagacaaa gcagaaaaa cttgtggct attatcagt 
      gttgatcaa caagaagct gaaagtaaa ttattggct 
      gctaagccg gccttggat gcagctgag gctgcgctt 
      ttgacaatt aaagccgct gatattgca acagttaga 
      aaattaggt aaaccgcct tatctcatc acgcttatc 
      atggattgt gtattgatt tacttcaaa cggaagctt 
      gaaccggtt aaggccgat cctgaaaaa gggtttttg 
      atttcgtca tggactgaa tcgcttaag gtgatggct 
      gatacgaag tttttgaat aagttgcag gaatatcca 
      aaggatacg attaatgca gaaattgtt gatttgctt 
      caaccttac tttgctttt cctttgtat acgtatgag 
      aatgccaaa acggcttgt ggtaacgtt gcaggtcta 
      atttcttgg actattgca atggcttca ttctttgaa 
      gtcaatcga gaagtattg cctttgaag gctaacctg 
      gctatccaa caagccaaa ctcgacaaa gcccaagcc 
      gaattatcc agtgccatg acactattg gccgagaaa 
      gaagaagaa gtacgacaa tgtcaaatt caatacgaa 
      gaagcaatg agacacaaa caagaagtt tttgatgat 
      gcaatgaaa gtcaaaaat aaaatggac tcagctacc 
      gcccttata gatggtcta gccggtgaa agaattcga 
      tggaccgaa caattggct caattcaaa gcggaaaca 
      gatcgacta atcggagat gtggtcctt ttggtcggt 
      ttcctcagc tattctgga ccatttaat caagagtat 
      cgaacaaac atgcagaaa tttttgctc gaagctgtg 
      ctaaagcgt aaaattccg gtgacgata agtttgaat 
      atcattgac agtcttacg gacacggca actattgga 
      gagtggaac ttgcaaggt ttgcccact gacgaactc 
      tcgatccaa aacgggatt atagtcaca actgcgtcc 
      agatttccc ctcctcatt gacccccaa agtcaggga 
      aaattctgg atcaaggca aaagaaaag gaaaatcat 
      ttactcgtc acttcgctc aaccacaaa tatttccga 
      aaccatatt gaagacgcc gtttcgctc ggttatccc 
      atgattgtc gaagacatt aacgaagaa ctggatccc 
      gtcctggac aacgtactt gaaaaaaat cacatcaaa 
      gtcggaaca acgtacaaa gtcaaagtt ggcgacaaa 
      gaagtggac gttaatcaa gacttccga atgtacatc 
      accaccaaa cttgctaac ccttcctac actcctgaa 
      attttcgca cgaacttcc gtcatcgat tttaccgtc 
      acaatgaaa ggtttggaa gatcagctc ttgggtcgt 
      gtgatttta acggagaag aaagaactg gaagctgaa 
      cgaacgaat ctgatgcgc gatgcgaca gcgaatcga 
      cgaaaaatg caagaattg gaagccaat ttgttgtac 
      aagttgaca acggtgcaa ggatcgctc cttgatgat 
      cccacggta atcgatgtt ttgaacatt acgcgaaat 
      acggcgagt gatattcga gaaaaacta gcaattgct 
      aaagagacc gaaattaag attaatgcc gccagagaa 
      gagtttcgt ccggttgcc actagaggt agcgttttg 
      tatttcttg gtggtcagt atggcaatg gtcaataat 
      atgtaccaa acgtctctg gtccaattt ttggaacga 
      ttcgatttg tcaatgcac cgatctgag aaaagtaat 
      ataacttcg aaacgaatc gtttttatt atcgactat 
      ctgactttt gaaattttt aaatacaaa tcgcgaggt 
      ttgtacgag atacacaag tacatgttt gtgcttctc 
      atgtgtttg aaaatcgac ctggaacgt gagcatata 
      acacatgaa gagtttcaa aattttata aaagggggc 
      gccgctttg gaccttaat acgtgtccc cctaaaccg 
      gccaaatgg ataacggac atgacgtgg ttgaatctg 
      gtcgaattg tccaaactt cgccacttt caatacatt 
      gtccaacaa atcaccgcg aatgataag ctctggaag 
      cattggttt gataaaaat gcaccagag gaagctgtg 
      gtacctgat gggtacaat aatttggat acttttagg 
      aaattgtta ctgattcgt gcttggtgt ccagatcgc 
      acgataact caagcaact aaataccta gctagttcg 
      ttgggtcaa aaatttgca gaacctgtt gttttgaat 
      ttggaaacg ttgtattac gaatctcga gcgatgaca 
      ccgatgatt tgtttcttg agtattggg tctgatccg 
      actccgtat attgaacag ttggctaaa agacttgaa 
      acgaaggtt agatcgatt tcgatgggg caaggacag 
      gaagtacat gcgaggaaa cttatgaca caagctttg 
      tccgagggt ttctgggct ttattacaa aactgccac 
      ctctcgctg gattatatg aatgaggtg ctgttgcaa 
      tttatggat ttggaaaaa ggggtggga acataccac 
      caggacttt agactatgg attacgacc gaagtgcat 
      gaaaatttc ccaattagt ttgctccaa atctgcata 
      aaattcaca aatgaagct ccatcaggt gtcaaagct 
      ggactacaa cgcacctac acttcaatg aaccaagac 
      atgttggat tattcagac gcttggcaa tacattcct 
      ctagtatat gccatttca tttttgcac acagtcgtg 
      caagaaaga cgaaaatac ggccctcta ggctggaat 
      ataccgtac gagtttaat tcagccgat tggttggct 
      agttgcttg tttgtacaa aatcacttg gacgatttg 
      gatcccaag agaggagtg agttggccc actgtcagg 
      tatatgtta ggggaagtc cactatggg ggacgagta 
      accgacgat tttgataaa cgacttttg aacacgttt 
      tgtaaagtg tggttccac gatgaaatg ttccacgac 
      gatttcata ttttatgaa ggttacaaa attgtgaga 
      tttaaaaat gtgtcagaa tacgtgagt catattgag 
      acttatgca acaagtgat cctccgcaa gtctacgga 
      cttcatcca aatgctgac attacttat caaacaaac 
      acgattgca agcatgttt tatactatg gtctctatt 
      cagcctaag gaggctgga gctggtggt ggtgaaaca 
      agggaagat gcggtaaca agacaggca aaagaaatg 
      ttggaaaag cttccatcg aattacgat ccgtacgaa 
      gtgaaagaa agactgcga attatggga attttaaat 
      cctttgaat atatttttg cgacaagag attgatcgc 
      atgcagaaa gtcattaca aatgtacgg acgacgttg 
      aaagacttg ctacttgcg attgaaggg attataatc 
      atgaatgag tcgttgcga gacgctctc gacaacatc 
      tacgacgct cgtgtacca tttgtgtgg agaagaggt 
      tcatggact gccaacaca cttggtttt tggtttaca 
      gagttgtta gaaagaaat gcccaattt agtacttgg 
      tgttttggt ggcagacct ttaactttt tggatggct 
      ggatttttc aatcctcaa ggatttttg actgcaatg 
      aaacaagaa gttgctcgg gcccacaaa ggctgggct 
      ttggatcaa gtcaagtta caaaatatg gtgacaaag 
      aacataaaa gaggaaatt ttgcaacca cctttggag 
      ggtgtttac gttcatgga ctgtttctt gacggtgcc 
      ggttgggat cgcagaaac gcgaggctt aatgagtcg 
      attaataaa gttttgtat accatgatc ccggttgtg 
      catattttt gcaacatat ggaacggag ttgaaaacg 
      acgaatcta tatgtctgt ccgatttac aaaaagatg 
      cgaaggact gatttaaat tatatcacc agtttgtat 
      ttgcaaact gtgaaaccg ccagaacat tgggtcctt 
      cgtggagtg gctctactg tgtgatacg cagtaa
    mRNA sequence
    • >TC034619 RA
      ctcaaacca caaaaacag tggtattat ttttgtttg 
      aacagttgt tagttgtgt taagacatc accaaaaat 
      gatgcaaga acgcgacaa agatgatct tgagatgct 
      gatggacgt tgcgaaata catcgcaaa gtcagctga 
      agcaacgaa aaaatccgg aagtgcgac agctttcgc 
      cttagcaga atcattcaa agaaaaact ggccaaagc 
      gaaagatag acgagtaga gaggtttca agagttgca 
      attaccaca ccgacacat ttgcgacct gattgcgat 
      gcatttgaa cattgatcc aaacgaggt gctggaagc 
      agcagccga tagtgatga acatattga actattgga 
      gaaattttt gtgcaagaa tgggatttt tgggttgtt 
      ggtttatta ccaagatgg gtatggcta cgaagttga 
      gacggggag atttaatcc caatgccat ggcagattt 
      ggtcatgaa acgaattta tttcactga cggaatgga 
      cgaaccagt caaggacag agtcatcgg aatctacaa 
      gattgcaaa cgttgagct gagcttaaa aaacataaa 
      cgatgccat ctattttac aacgtttga cattcaagc 
      tgaaaaaat gaattctgt agctgtggc atataagct 
      tttaggtga actgataga tccctcatt ccaattgaa 
      caaggactg gggtgattt gcctaaaac cgaagtagg 
      acttaagca gaagagcaa ttttcaagg agattttga 
      atcgtttgt ggatttttt aaaacaaac taaactgga 
      ccttgaaat ggttgttag ttttcctta tgatagagg 
      tctgtatcg cagagatct agtaaatga gaaaaaacg 
      tactgaagc tattttgaa ccgacaaat tgtgcaaca 
      agtggaatc gacggttcg aacttggtg caagcagat 
      ggaaagggc tcaagttca gtaccaaca actacgacg 
      agaaaacga attcgttgg tcctctcgt tgaaattga 
      atactggcg aagacaact cgctcgttt tacaagtat 
      tgtcgaatt catcactga tgcaccttg caaaatcca 
      tatccaatt tttggaagc ttgcaaaag caaactttt 
      gaagatttg gtccaaaca cgaaagtgc agtcattga 
      agcaaaaaa cgaatgtgc tgacaacat gcgatattt 
      atacgcttt ggaaaaatt ttgcaatcc tttgtatag 
      atgcgaagc tacggaact tctccatca tattccacc 
      actactgca cgccataag aatgactta tacaacctc 
      acgatatta taacaacac tgcaaacgt tacagccct 
      tttagtcaa agtttccaa tcaaatgat taatgtatg 
      cagagcgta tcttaactg caacggaac caaaactgt 
      ctggaatca aaagaaaaa agtcgtgct tgaaaaaat 
      taaagtttg tctggacat ttacttaaa atattatca 
      atgtttcaa gcacattca ggaagagat gaaagaggc 
      aggtgaggc accttttga atgttccga aatgtatgt 
      ttttggaaa atttgagac gttcaagaa gcgagtaga 
      agagattgt cgatgttct cgaaacgac cacaaaata 
      ttcaatcct gcaaagtag caaaatcga aaacattga 
      tattttcgc caagaaatt ccaaacgtt cttcgacaa 
      catatcgaa gcaaaaata cgacgcttt aaaccaccg 
      attgccata ttttgacaa ggactacaa cgagttcaa 
      acagaacgt ggtcgatac agaatggga attggagga 
      gtttgttgg tacgtcttt ggaaaaaga aacaaacgt 
      tcacaatgt attaagact attgaaacg gtttgagaa 
      actgaaatt ggagtgttt gcatttgga agaacgcta 
      tctcgaagc aatggaatt gtttcaaaa agaacttga 
      agatttacg cgatcgtta caatgaaga acgacaaac 
      acctttgtt gcccagaaa catgccacc agttagtgg 
      acgaataat gtgggtgag gcatttgta tcgtcgcat 
      ggaggagtc aatggagat ttttatgac caaatcgag 
      agttatgag acaccgaaa tgtgcaaaa gtgtatcca 
      attgtacaa tgcaatggc tattgtttt tgttcatta 
      tgaacagat ttatcatga ggcttggta caaatttgc 
      tggacaggt tcgagcttg tttgaatac accgatttt 
      gacaagaga cccaaaaac aaggcgata caaagtcaa 
      ttttcatcc gtacatttc tgaagttat tcgagagtc 
      ggaatacat gtacaagct tgatcttgc tgtgcctga 
      cgttggcca agtgcttgt tttctgtaa agaaaaaat 
      cctcaattc gtttgaagt gattaaagg tttggtcga 
      acgaaacga cattattcg aagtactat tcctcctct 
      tttcattcc tctaattcg tatgcaatt gataaagat 
      ggaagatgc attcagacc aggtttctc tgtgataac 
      ttggacttc gaccaaaat ccctgaata ttgtgaaga 
      agtcaacaa tgtcctgga ctacttcga aatgtttgt 
      caaagaagt taaagatat gaaagaagc cagaataga 
      cgaagtttt ggacgcaat tgctgccac ttctctagt 
      ctatttgcc aaatgtggc cctcatgcc tagtgagtt 
      tttggaaca gaataaaaa gttcatgga acatggagt 
      gaaagaaat tgaactgaa atcctcaac agctgaacg 
      cgctgttat cgacttaat tgagaaatt tttaagtgt 
      tattgaaca accagaatt gcaagagag aaaatacga 
      ctggttgga ccctgataa agccataag accaatcgg 
      atcagcttc acgtttaaa tgtctcacc ggaagcagc 
      ttttaagga aattgaccg aaacattcc tctggacct 
      gaacacgat tcacaacga ctgtctgga attgtttgg 
      tttctttaa catgaaatt aagcgaggc tttagtcaa 
      atgtgttaa actgtcttt ggaacagat taagaaacg 
      aactgccag tttgcgaga cgacagtag cgcactgaa 
      tgccccgat tatgaagac ttacatgga actccaaat 
      tcctataac cgtgattaa tccaacttt ggacgaaat 
      tcagaatta cttcactca agtcattaa taaacttct 
      caacaccat gtcgtttgt atgcatgtg gggacaacg 
      tggcagcaa gaagaaacc tcgaagaga aaaaccgtt 
      gaagtttaa agagattgc aaaattgat cgctaaaac 
      tcccccacc tgatcgaaa ctactacaa aatcgtgtc 
      cgaaaacaa ggaaataat ccgaatttt tatgagttt 
      gcaaggtgt tatgttttt gttgaagcc cgacgttgc 
      gaaattgtt acaacaata tttaagtta ttcgtattt 
      gtgggctga gggacgtgt taatgaaat tgaggcgtt 
      ttgcgagaa gaatcctct cactgttga aattgccga 
      aaagtttca agagtttga aaatagagg agagaaaat 
      aagggagtt gcccgatag tcataatgt tgattcgat 
      acaaatcga catggagaa attcaaatt ggctctact 
      tgtggagtc tgatgcgtg gaaacacat tttagggaa 
      aaatctggc taagcgata cagagccaa gctgctcga 
      acttgtcga ttttattaa gaatagaga aaaggtttt 
      gggtagacc aattaaaga cctggacga ttgcaggct 
      ggcaatggc ttgtctgga gttaatcag agaaaactt 
      catcgaaat cgacttaga cctcatcac tatggaaga 
      agcctacaa cattttcag caaatacaa gatagatat 
      tccgaaaga ggacatgga cagggttga gtccctcag 
      atttaattt ccaaaatat ggtggtgca cgcaaaatc 
      tgtgcaaga aaacatttg caacgtgca aggccccct 
      tttggaaga actaaccga aggagtttc gaatttcag 
      ggacgaagt ggaagcttt tgatcgcga ttttgaact 
      aaacggtcc gatgattcc cggattatc ggctcgcga 
      ggcaagtga tcgagtcct tgcgttcca agaccgatt 
      cgatgagct ttggcgcaa attcgaaat gtatagcag 
      tggtgaaaa acttttcgg cttggaggt caacgatta 
      tcccatttt acacaaacg caaaaaaga gtttaattt 
      gttgaataa attgtacgg cttgtattt ggccgtaaa 
      tcacagcat tgatggtta tttcgatat tttgtggac 
      tgatgtgga tactgaaac catttttgc tgaactcac 
      tgagttcca gaacaggtg tcgaaagct tcctaaggc 
      tatgagaga ctggccagc ttatctcga tttaaagaa 
      gaaaattga cgatttctc agagacttg tcctttgtt 
      ggagcttat ggccaacaa ggctatgaa agaaagaca 
      ttggaaacg tatagcaca aacgaccag ctatacttt 
      tgatattga ttcaccaac ttttacgtt gcgaaatgt 
      gatggaagc tccattgtt acagtttaa agacgaagt 
      cgaagatat ttgtattag tgccgtcaa agagaaaga 
      tattgaagc aaaactcaa gcaagtaat tgcggattg 
      gtcagtggt ggaattgtc gttctcgca gtttaaggc 
      acgaggaga attgctttt gaaaggaac agaaactgg 
      agagataat tatggcact tgaagacag tttaatgat 
      aatgaattc tttactcag caacagata caacgcacc 
      gttcaaaaa agacatcca aacatgggt gcacaagct 
      ggtcaacac gtcagaaat tttggaaaa atggctcat 
      tgtgcaaaa tttatgggt atatttaga agctgtatt 
      tgttggtgg tgatatcgc caaacaact tcccggaga 
      agccaaaag attcaataa cattgataa atcctgggt 
      gaaaataat gacaagagc acacgagct tccaaatgc 
      cgtcgaatg ttgcacagg tgacgaaac aatgggaca 
      gttacttcc ccatctttt ggaacaact tgaaacgtg 
      ccaaaagag cttgaccgg atatttgga atcgaaaag 
      attgtgttt tccgcgttt cttcttcat ttcggatcc 
      ggttttatt ggaaatttt gggccaaag ctcagatcc 
      gacttcgat tcaatcaca tttgccaag tctcttcga 
      cgctgtgta tagagtcga attcgatcc gaaaaaacc 
      cgattacat catagccat gttatcgga tttgggcga 
      atcggtaaa ttttgaaaa accggttca atgtgtcgg 
      aggtgtcga aatttggct aaacagtct tttggaaat 
      ggttaggga aactgtaaa gtcggtaat tgcatcaca 
      ggcgcaact tttgaatga tccagatta tgatttcat 
      ccaaggatt tataccgtt ttgtgcaca agctggtct 
      tgtcggtat tcaaatttt gtggaccaa agaagccga 
      aattgcaat caggaaagc caaagttga tcgatttat 
      tatgaaagt gaccaatgc caggtttct ggaactttt 
      gaacgcact tattgatct cacatcgaa agatttatc 
      gaaaaggga acgaacgag gtttgagac tatggttac 
      gattcatgt ccatcaaag agatatctt tgatacgat 
      ttgcaagtc gaaggtcaa aaatttgct agattttga 
      ttggcaaca acaaagcag gttttacta caatgaaga 
      gaacgatga tgtgactgt aaggattac cgatgtgat 
      atttttgta ccaaaatga gtatttggg gattactga 
      acgtctgtg tattacacc gttgactga caggtgtta 
      catcactct agctcaagc tatttggat taatatggg 
      aggggctcc cgcaggacc tgcaggaac tggcaaaac 
      tgagaccac taaagatat gggtagaac tttgggtaa 
      atttgttgt cgtctttaa ctgttcgga tcaaatgga 
      ttttcgagg cctgggccg catttttaa aggtttggc 
      acagtctgg aacttgggg ttgtttcga tgaattcaa 
      ccgaattga attaccagt attgtcagt agccgccca 
      acaaatcta cattgtttt aatagcaag aaaagagcg 
      aaaacccac gtttatttt catggatgg tgacaccgt 
      ttcgatgaa catcgaatt tggaatttt cctgactat 
      gaatccggg ttatgccgg acgacaaga actaccgga 
      aaatttaaa aatcatgtt tcgaagtgt cgcaatgat 
      ggttcccga tcgccaaat tataattcg agtcaagct 
      ggcttcttg tggttttaa agacaatat tattttagc 
      acgaaaatt tttcacact ttatcaatt gtgtgaaga 
      acaactctc gaaacaggt gcattatga ttttggatt 
      acgtaatat tttgtcggt tttgagaac gctaggtgc 
      tcagaaaag gtcgcatcc caatgatac ggaggagac 
      aattgtcat gagagtttt aagagacat gaatttgag 
      caaactaat cgacgagga tgaaccgtt gttcctgtc 
      gttgattga ggatatgtt tcccggaat taaattatc 
      gacacattc ttggaaaga tctacaaaa agctataac 
      taatcaaac tgccgaaat gggagtcat taattatcc 
      tccttggaa tttgaaagt aattcaact ttacgaaac 
      ttcgttagt cagacatgg actcatggt gttgggacc 
      aacaggtgc tggtaaaac aaaatgtat gcattgttt 
      gatgaaatc aatgaccga aactggtct accacacaa 
      agaaatgag aatgaatcc aaaggctat aacagcccc 
      ccaaatgtt tggacgatt ggacgttgc aactaacga 
      ttggactga tggtatttt ctcgacttt gtggaggag 
      aactttgaa aatcaagaa acatgatca cgtttggtt 
      ggtcctgga tggtccagt ggatgcagt ctggatcga 
      aaatctcaa ttctgtgtt agacgataa taaaacttt 
      gacattggc taatggtga tcgtattgt tatggcgcc 
      taatgcaaa actggtctt tgaacctga taacgttga 
      taacgccag tccagctac cgtatcccg aatgggtat 
      ggtctttat gagttcatc tgtacttcc ttggagccc 
      aattttaga agcctggtt aaaaacacg aacacaaca 
      agaggctga tgtttgtcg aactgtctt tggtaaaat 
      ttacgagga attgcattc gtttgtaca agtgaaact 
      taaggcaaa aatgaaaat tactgaagc tttatatat 
      tagacagtg ttatgatgt tttggctgg aatattaga 
      tgtaggaga cgacacaaa agtttggac cgataagca 
      gttggaacg tttgatttt attttcaat gatgtggtc 
      agttggggc cgttttgga attggaaga ccgaacaaa 
      aatggaaca atttgttgt aacacatcc ttccaaact 
      tgattggcc aaaatgtgg cgaaaatga gacgatttt 
      tgagtatgt tgtcaaccc gaaaacggg aacttggca 
      acattggtc tgaaagggt cgaagaatt tatttatcc 
      cactgacag cgttttgga atttattaa tattttggt 
      gccaaatat cgacaatgt tcgaactgc gtttttaat 
      cgacactgt ggcaaaaca aaataaagc cgtcttact 
      gattggaga gcaaggtac tgccaaaac tgtcatgat 
      aaaaggata tacgcaaac ttttgatcc tgaatataa 
      actgagcaa atgttttaa tttctcttc tgcgaccac 
      accaaacat ggttcagcg aattattga gtcgtatgt 
      ggacaaaag agtgggaac aacttatgg tccacctgc 
      tgggaaaac attgacgat atttatcga cgatataaa 
      catgcccgt tattaatga ctggggaga ccaaataac 
      taacgaaat tgtgcgtca agccatgga atgtggagg 
      tttttacag tttggataa accgggcga tttttcatc 
      aattgtcga tgttatgtt tctggctgc tatgataca 
      tcctggtgg tggacgaaa tgatattcc gcatcgtct 
      caaacgaca attttgtgt ttttaattg cactctacc 
      aagtaacaa ggccatgga tgttatttt cagccaaat 
      tgcttgcgg ttacttttg tattgaacg cttcaacca 
      agaaatcgt cgattttgt ccccagact tatcccatt 
      gactcgtaa catttggca acatactaa aatcaaaat 
      gttgccaac accggccaa attccatta cgtgtttaa 
      cttgagaga tctttcaag aatatggca aggaatctt 
      aacagtaca acgtctaga atgccaaac tatttcatc 
      aatgctgaa actgtggca gcatgaatg ttgccgagt 
      tatatcgga tcgtttcac aaaagccaa agaaagaga 
      atggttcct gcacttgct caaaaacca agtaaaaaa 
      agagctaga cgatgtaca tgaggagta ccctgaaga 
      cgtaacctt ctgggttga ctttttgcg agaaccacc 
      ggaagcaac aggtgacga acctgaaga tttttgctt 
      cgatgctcc aaagatcta tgaagaaat accaagttg 
      ggaattttt gaaggaaaa attgttttc tttcgtgga 
      tcagtacaa cgagcaaat aagaggtgc tgccatgga 
      cttggtatt tttccatga cgccatggt tcatttgat 
      gatcatttc gagaataat tagatcagc acgtggaaa 
      cgctctatt ggtgggtgt tggaggttc cggaaaaca 
      gagtcttac aagacttgc gtcctttat cgcaaatta 
      caaaacgtt ccagattca attaacacg aacatacaa 
      tgttggtaa tttaatgga agacatgaa atatctcta 
      tcgagtcgc tggatttga agggaaagg aatttcttt 
      catatttac cgataatga aattaaaga tgagacatt 
      tttggagag tcttaacaa tatattgag ttcaggcga 
      aattgctaa tttgttcgc taaagacga aatcgacga 
      aataacatc cgatttagt tctagtaat gaaaaaagc 
      gcagccaaa aagagcacc aaccggtga taatttata 
      cgatttttt cataagcag agctcggtc taacttaca 
      cgtagtcct ttgtttctc acctgttgg agaaaaatt 
      ccgtagtcg ggctttgaa gttcccagg tttaatttc 
      cggttgtac aatcgattg gttcttcag atggccacg 
      agatgccct aatcgaagt atccgaaca ttttctcaa 
      caaattcag tgtggttgc aacacccga tactaaaaa 
      agaactgat ttatgtcat gggtgaaat ccaagatta 
      tgtcgcact gacttgtaa cagctactt tgaaaaatt 
      ccggagaag gacttacgt cacaccgaa aacttttat 
      atcgttcct tgaaacgta caaaacagt gtatgttaa 
      aaaactggc aaatattgg tgaaatgga ttcaaggat 
      gcgtaccgg tttgacaaa actagtcga agcccaaca 
      aaatgtgga cgaattgaa aaaggaatt gattattaa 
      agaacaaga aatgaaagt tgcaactga cgcagctga 
      gaaagtcct ggacgaagt tttggcagc ttcggaaat 
      tacaaataa aattaaaga agaggcgac agttgtgaa 
      agacaaagc agaaaaact tgtggctat tatcagtgt 
      tgatcaaca agaagctga aagtaaatt attggctgc 
      taagccggc cttggatgc agctgaggc tgcgctttt 
      gacaattaa agccgctga tattgcaac agttagaaa 
      attaggtaa accgcctta tctcatcac gcttatcat 
      ggattgtgt attgattta cttcaaacg gaagcttga 
      accggttaa ggccgatcc tgaaaaagg gtttttgat 
      ttcgtcatg gactgaatc gcttaaggt gatggctga 
      tacgaagtt tttgaataa gttgcagga atatccaaa 
      ggatacgat taatgcaga aattgttga tttgcttca 
      accttactt tgcttttcc tttgtatac gtatgagaa 
      tgccaaaac ggcttgtgg taacgttgc aggtctaat 
      ttcttggac tattgcaat ggcttcatt ctttgaagt 
      caatcgaga agtattgcc tttgaaggc taacctggc 
      tatccaaca agccaaact cgacaaagc ccaagccga 
      attatccag tgccatgac actattggc cgagaaaga 
      agaagaagt acgacaatg tcaaattca atacgaaga 
      agcaatgag acacaaaca agaagtttt tgatgatgc 
      aatgaaagt caaaaataa aatggactc agctaccgc 
      ccttataga tggtctagc cggtgaaag aattcgatg 
      gaccgaaca attggctca attcaaagc ggaaacaga 
      tcgactaat cggagatgt ggtcctttt ggtcggttt 
      cctcagcta ttctggacc atttaatca agagtatcg 
      aacaaacat gcagaaatt tttgctcga agctgtgct 
      aaagcgtaa aattccggt gacgataag tttgaatat 
      cattgacag tcttacgga cacggcaac tattggaga 
      gtggaactt gcaaggttt gcccactga cgaactctc 
      gatccaaaa cgggattat agtcacaac tgcgtccag 
      atttcccct cctcattga cccccaaag tcagggaaa 
      attctggat caaggcaaa agaaaagga aaatcattt 
      actcgtcac ttcgctcaa ccacaaata tttccgaaa 
      ccatattga agacgccgt ttcgctcgg ttatcccat 
      gattgtcga agacattaa cgaagaact ggatcccgt 
      cctggacaa cgtacttga aaaaaatca catcaaagt 
      cggaacaac gtacaaagt caaagttgg cgacaaaga 
      agtggacgt taatcaaga cttccgaat gtacatcac 
      caccaaact tgctaaccc ttcctacac tcctgaaat 
      tttcgcacg aacttccgt catcgattt taccgtcac 
      aatgaaagg tttggaaga tcagctctt gggtcgtgt 
      gattttaac ggagaagaa agaactgga agctgaacg 
      aacgaatct gatgcgcga tgcgacagc gaatcgacg 
      aaaaatgca agaattgga agccaattt gttgtacaa 
      gttgacaac ggtgcaagg atcgctcct tgatgatcc 
      cacggtaat cgatgtttt gaacattac gcgaaatac 
      ggcgagtga tattcgaga aaaactagc aattgctaa 
      agagaccga aattaagat taatgccgc cagagaaga 
      gtttcgtcc ggttgccac tagaggtag cgttttgta 
      tttcttggt ggtcagtat ggcaatggt caataatat 
      gtaccaaac gtctctggt ccaattttt ggaacgatt 
      cgatttgtc aatgcaccg atctgagaa aagtaatat 
      aacttcgaa acgaatcgt ttttattat cgactatct 
      gacttttga aatttttaa atacaaatc gcgaggttt 
      gtacgagat acacaagta catgtttgt gcttctcat 
      gtgtttgaa aatcgacct ggaacgtga gcatataac 
      acatgaaga gtttcaaaa ttttataaa agggggcgc 
      cgctttgga ccttaatac gtgtccccc taaaccggc 
      caaatggat aacggacat gacgtggtt gaatctggt 
      cgaattgtc caaacttcg ccactttca atacattgt 
      ccaacaaat caccgcgaa tgataagct ctggaagca 
      ttggtttga taaaaatgc accagagga agctgtggt 
      acctgatgg gtacaataa tttggatac ttttaggaa 
      attgttact gattcgtgc ttggtgtcc agatcgcac 
      gataactca agcaactaa atacctagc tagttcgtt 
      gggtcaaaa atttgcaga acctgttgt tttgaattt 
      ggaaacgtt gtattacga atctcgagc gatgacacc 
      gatgatttg tttcttgag tattgggtc tgatccgac 
      tccgtatat tgaacagtt ggctaaaag acttgaaac 
      gaaggttag atcgatttc gatggggca aggacagga 
      agtacatgc gaggaaact tatgacaca agctttgtc 
      cgagggttt ctgggcttt attacaaaa ctgccacct 
      ctcgctgga ttatatgaa tgaggtgct gttgcaatt 
      tatggattt ggaaaaagg ggtgggaac ataccacca 
      ggactttag actatggat tacgaccga agtgcatga 
      aaatttccc aattagttt gctccaaat ctgcataaa 
      attcacaaa tgaagctcc atcaggtgt caaagctgg 
      actacaacg cacctacac ttcaatgaa ccaagacat 
      gttggatta ttcagacgc ttggcaata cattcctct 
      agtatatgc catttcatt tttgcacac agtcgtgca 
      agaaagacg aaaatacgg ccctctagg ctggaatat 
      accgtacga gtttaattc agccgattg gttggctag 
      ttgcttgtt tgtacaaaa tcacttgga cgatttgga 
      tcccaagag aggagtgag ttggcccac tgtcaggta 
      tatgttagg ggaagtcca ctatggggg acgagtaac 
      cgacgattt tgataaacg acttttgaa cacgttttg 
      taaagtgtg gttccacga tgaaatgtt ccacgacga 
      tttcatatt ttatgaagg ttacaaaat tgtgagatt 
      taaaaatgt gtcagaata cgtgagtca tattgagac 
      ttatgcaac aagtgatcc tccgcaagt ctacggact 
      tcatccaaa tgctgacat tacttatca aacaaacac 
      gattgcaag catgtttta tactatggt ctctattca 
      gcctaagga ggctggagc tggtggtgg tgaaacaag 
      ggaagatgc ggtaacaag acaggcaaa agaaatgtt 
      ggaaaagct tccatcgaa ttacgatcc gtacgaagt 
      gaaagaaag actgcgaat tatgggaat tttaaatcc 
      tttgaatat atttttgcg acaagagat tgatcgcat 
      gcagaaagt cattacaaa tgtacggac gacgttgaa 
      agacttgct acttgcgat tgaagggat tataatcat 
      gaatgagtc gttgcgaga cgctctcga caacatcta 
      cgacgctcg tgtaccatt tgtgtggag aagaggttc 
      atggactgc caacacact tggtttttg gtttacaga 
      gttgttaga aagaaatgc ccaatttag tacttggtg 
      ttttggtgg cagaccttt aactttttg gatggctgg 
      atttttcaa tcctcaagg atttttgac tgcaatgaa 
      acaagaagt tgctcgggc ccacaaagg ctgggcttt 
      ggatcaagt caagttaca aaatatggt gacaaagaa 
      cataaaaga ggaaatttt gcaaccacc tttggaggg 
      tgtttacgt tcatggact gtttcttga cggtgccgg 
      ttgggatcg cagaaacgc gaggcttaa tgagtcgat 
      taataaagt tttgtatac catgatccc ggttgtgca 
      tatttttgc aacatatgg aacggagtt gaaaacgac 
      gaatctata tgtctgtcc gatttacaa aaagatgcg 
      aaggactga tttaaatta tatcaccag tttgtattt 
      gcaaactgt gaaaccgcc agaacattg ggtccttcg 
      tggagtggc tctactgtg tgatacgca gtaataaat 
      gaattgttg atgcacttt tttaatata atttttctt 
      tcatt
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