Status
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Gene information
General information
TC006530 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007423.3: 11051063..11053239
Sequence information
Transcripts / Proteins (2) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC006530
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
    {{ blurIdResult }}
    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
    We will use your email address only for possible questions regarding this annotation. We will never show your address or give it away.
    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.

    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_01058

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 20.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 1 (9 dpi)
    Days post injection


    Analysis of larval stage 1 cuticle
    number of eggs/embryos/larvae on slide: < 50
    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 50.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 70.0% (includes death as larva, prepupa, pupa, adult)

    larva lethality late (L7) - Number of animals showing the phenotype: 4 (11 dpi)
    Days post injection


    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC006530 RA
      MSTQPKTNL LDYISSLDI TAKPKYLRL TGIVCTIGP 
      ACQKVEILE KMLEAGMNV ARLNFSHGT HEYHVDLIK 
      NIRTAVDNY SKRIGRYCP LAIAIDTKG SEIRTGVLE 
      GGISAEVVL EKGSKVTVT TDEKYAKKC TKSVIYVDY 
      KNITKVQKP GNQIFIDDG LITLNCEKI QGSEITCSV 
      ANGGKLGSS KGVNLPGVE KDLPTVSEK DKKDLKFAV 
      EQNVDCVFA SFTRNAEEV RQIRSILGD SNIRVIAKI 
      ENTQGVKNM DEIIEAADG ILIDRGDLG MEISFQKVF 
      LAQKAIIAR CNKVGKPII IATHLLESM VDKPRPTRA 
      ESSDVANAV LDGADCVML AGETAKGLY PVECVETMA 
      LICKEAEAA VWQKQLFND LKSQPKVPL DIVQTTAIS 
      TVEASMNSL ATAIIVVTK TGKSAQLLS KYKPKCPII 
      AVTRNAQVA RQLHLFRAI MPLYFDGLC DFKGEGDCY 
      VWVLQAKAQ PSG
    • >TC006530 RB
      MSTQPKTNL LDYISSLDI TAKPKYLRL TGIVCTIGP 
      ACQKVEILE KMLEAGMNV ARLNFSHGT HEYHVDLIK 
      NIRTAVDNY SKRIGRYCP LAIAIDTKG SEIRTGVLE 
      GGISAEVVL EKGSKVTVT TDEKYAKKC TKSVIYVDY 
      KNITKVQKP GNQIFIDDG LITLNCEKI QGSEITCSV 
      ANGGKLGSS KGVNLPGVE KDLPTVSEK DKKDLKFAV 
      EQNVDCVFA SFTRNAEEV RQIRSILGD SNIRVIAKI 
      ENTQGVKNM DEIIEAADG ILIDRGDLG MEISFQKVF 
      LAQKAIIAR CNKVGKPII IATHLLESM VDKPRPTRA 
      ESSDVANAV LDGADCVML AGETAKGLY PVECVETMA 
      LICKEAEAA VWQKQLFND LKSQPKVPL DIVQTTAIS 
      TVEASMNSL ATAIIVVTK TGKSAQLLS KYKPKCPII 
      AVTRNAQVA RQLHLFRAI MPLYFDGQS PTEWLKNVE 
      VRVKAGVSY GKSLGFVKS GDTVIIVTG LHQGPGSTN 
      TLTLMTVQ
    CDS sequence
    • >TC006530 RA
      atgagtacg cagccgaaa acaaacctc ctggactac 
      atcagtagt ttggacatt acagccaaa ccgaaatat 
      ctgcggcta acgggaatc gtgtgtacg atcggacca 
      gcatgccag aaggtagag attttggag aaaatgctc 
      gaagctgga atgaacgtg gcacgtttg aacttctct 
      cacggtact cacgagtac cacgtcgat ttgatcaaa 
      aacataagg accgctgtg gacaactac agcaagaga 
      ataggccgc tactgcccc cttgccatc gccatcgac 
      accaaaggc tccgaaatc cgaactgga gtactagaa 
      gggggcatc tctgccgaa gtggtcctg gagaaaggg 
      tcaaaagtg accgtgaca accgacgaa aagtatgcc 
      aaaaagtgc accaagagc gtcatctac gtcgattat 
      aaaaacatc accaaggtg cagaaaccc ggaaaccag 
      attttcatc gacgacggt ttgattacc ctcaactgt 
      gagaaaatc caaggctcg gagatcact tgctcggtt 
      gccaatggg ggaaaactg gggagtagt aaaggggtg 
      aacctgcca ggcgtcgag aaagacctg cccacggtt 
      tcggaaaag gacaagaag gatttgaaa ttcgcagtt 
      gagcagaac gtcgactgt gttttcgcc tcgttcaca 
      cgaaacgcc gaagaagtg cgccagatt cgctccatt 
      ttaggcgac agcaacatt cgggtgatt gccaagatc 
      gagaacacg caaggtgtg aagaacatg gacgagatt 
      attgaagct gccgatggg attctcatc gatcggggc 
      gacctgggg atggaaatc tccttccag aaggtgttc 
      ctcgcccag aaagccatc atcgcgagg tgtaacaag 
      gttggaaag cccattatt atcgccacc catttgctg 
      gaatcaatg gttgataaa ccaaggcct acgagagcc 
      gagagctcg gatgtggcc aatgctgtg ctggacggt 
      gccgactgt gtgatgcta gcaggggag acggccaag 
      ggcttgtac cctgtggag tgtgtggag accatggct 
      ttgatttgc aaagaggcc gaggcagcg gtgtggcaa 
      aaacagctc tttaacgac ctcaaaagc cagcctaaa 
      gtaccgctt gacatcgtc caaactacc gcaatatcc 
      acagttgaa gcctcgatg aactcgcta gccacggcc 
      atcatcgtg gtcacgaaa acgggaaaa tcggcacaa 
      ttgttgtca aaatacaag ccaaagtgc ccgattatt 
      gcagtgacg aggaatgcg caagttgcg cgccagtta 
      cacttgttc agggcgatt atgcccttg tattttgac 
      ggtttgtgt gattttaag ggtgagggt gattgttac 
      gtgtgggtt ttgcaggcc aaagcccaa ccgagtggt 
      tga
    • >TC006530 RB
      atgagtacg cagccgaaa acaaacctc ctggactac 
      atcagtagt ttggacatt acagccaaa ccgaaatat 
      ctgcggcta acgggaatc gtgtgtacg atcggacca 
      gcatgccag aaggtagag attttggag aaaatgctc 
      gaagctgga atgaacgtg gcacgtttg aacttctct 
      cacggtact cacgagtac cacgtcgat ttgatcaaa 
      aacataagg accgctgtg gacaactac agcaagaga 
      ataggccgc tactgcccc cttgccatc gccatcgac 
      accaaaggc tccgaaatc cgaactgga gtactagaa 
      gggggcatc tctgccgaa gtggtcctg gagaaaggg 
      tcaaaagtg accgtgaca accgacgaa aagtatgcc 
      aaaaagtgc accaagagc gtcatctac gtcgattat 
      aaaaacatc accaaggtg cagaaaccc ggaaaccag 
      attttcatc gacgacggt ttgattacc ctcaactgt 
      gagaaaatc caaggctcg gagatcact tgctcggtt 
      gccaatggg ggaaaactg gggagtagt aaaggggtg 
      aacctgcca ggcgtcgag aaagacctg cccacggtt 
      tcggaaaag gacaagaag gatttgaaa ttcgcagtt 
      gagcagaac gtcgactgt gttttcgcc tcgttcaca 
      cgaaacgcc gaagaagtg cgccagatt cgctccatt 
      ttaggcgac agcaacatt cgggtgatt gccaagatc 
      gagaacacg caaggtgtg aagaacatg gacgagatt 
      attgaagct gccgatggg attctcatc gatcggggc 
      gacctgggg atggaaatc tccttccag aaggtgttc 
      ctcgcccag aaagccatc atcgcgagg tgtaacaag 
      gttggaaag cccattatt atcgccacc catttgctg 
      gaatcaatg gttgataaa ccaaggcct acgagagcc 
      gagagctcg gatgtggcc aatgctgtg ctggacggt 
      gccgactgt gtgatgcta gcaggggag acggccaag 
      ggcttgtac cctgtggag tgtgtggag accatggct 
      ttgatttgc aaagaggcc gaggcagcg gtgtggcaa 
      aaacagctc tttaacgac ctcaaaagc cagcctaaa 
      gtaccgctt gacatcgtc caaactacc gcaatatcc 
      acagttgaa gcctcgatg aactcgcta gccacggcc 
      atcatcgtg gtcacgaaa acgggaaaa tcggcacaa 
      ttgttgtca aaatacaag ccaaagtgc ccgattatt 
      gcagtgacg aggaatgcg caagttgcg cgccagtta 
      cacttgttc agggcgatt atgcccttg tattttgac 
      ggccaaagc ccaaccgag tggttgaaa aatgtggaa 
      gtccgggtt aaagccgga gttagttat ggaaagtcg 
      ttggggttt gttaaatca ggggatact gtaattatt 
      gtgacgggt ttgcatcaa gggcctggc tctacaaac 
      actcttacg ttgatgact gtccaatga
    mRNA sequence
    • >TC006530 RA
      gataagaaa acacaaata ttaaaataa gcaaacgtg 
      aaacgactc cacagcgtt tgttattcc agtcgcaat 
      cacgccgag tgatttttg tacgaactg ataatcagt 
      aagcacact caatgatcc ccactatca gctcctctt 
      acataaaca tctctatca cgcatcgtt tcccaatat 
      catcccaac ttgtgtgaa agtcaaaac gaacaagac 
      ctcaaacca tttagttag tcaaaatga gtacgcagc 
      cgaaaacaa acctcctgg actacatca gtagtttgg 
      acattacag ccaaaccga aatatctgc ggctaacgg 
      gaatcgtgt gtacgatcg gaccagcat gccagaagg 
      tagagattt tggagaaaa tgctcgaag ctggaatga 
      acgtggcac gtttgaact tctctcacg gtactcacg 
      agtaccacg tcgatttga tcaaaaaca taaggaccg 
      ctgtggaca actacagca agagaatag gccgctact 
      gcccccttg ccatcgcca tcgacacca aaggctccg 
      aaatccgaa ctggagtac tagaagggg gcatctctg 
      ccgaagtgg tcctggaga aagggtcaa aagtgaccg 
      tgacaaccg acgaaaagt atgccaaaa agtgcacca 
      agagcgtca tctacgtcg attataaaa acatcacca 
      aggtgcaga aacccggaa accagattt tcatcgacg 
      acggtttga ttaccctca actgtgaga aaatccaag 
      gctcggaga tcacttgct cggttgcca atgggggaa 
      aactgggga gtagtaaag gggtgaacc tgccaggcg 
      tcgagaaag acctgccca cggtttcgg aaaaggaca 
      agaaggatt tgaaattcg cagttgagc agaacgtcg 
      actgtgttt tcgcctcgt tcacacgaa acgccgaag 
      aagtgcgcc agattcgct ccattttag gcgacagca 
      acattcggg tgattgcca agatcgaga acacgcaag 
      gtgtgaaga acatggacg agattattg aagctgccg 
      atgggattc tcatcgatc ggggcgacc tggggatgg 
      aaatctcct tccagaagg tgttcctcg cccagaaag 
      ccatcatcg cgaggtgta acaaggttg gaaagccca 
      ttattatcg ccacccatt tgctggaat caatggttg 
      ataaaccaa ggcctacga gagccgaga gctcggatg 
      tggccaatg ctgtgctgg acggtgccg actgtgtga 
      tgctagcag gggagacgg ccaagggct tgtaccctg 
      tggagtgtg tggagacca tggctttga tttgcaaag 
      aggccgagg cagcggtgt ggcaaaaac agctcttta 
      acgacctca aaagccagc ctaaagtac cgcttgaca 
      tcgtccaaa ctaccgcaa tatccacag ttgaagcct 
      cgatgaact cgctagcca cggccatca tcgtggtca 
      cgaaaacgg gaaaatcgg cacaattgt tgtcaaaat 
      acaagccaa agtgcccga ttattgcag tgacgagga 
      atgcgcaag ttgcgcgcc agttacact tgttcaggg 
      cgattatgc ccttgtatt ttgacggtt tgtgtgatt 
      ttaagggtg agggtgatt gttacgtgt gggttttgc 
      aggccaaag cccaaccga gtggttgaa aaatgtgga 
      agtccgggt taaagccgg agttagtta tggaaagtc 
      gttggggtt tgttaaatc aggggatac tgtaattat 
      tgtgacggg tttgcatca agggcctgg ctctacaaa 
      cactcttac gttgatgtg agttggcag aaatgtgtg 
      tttaattat taaatgttt gtttacagg actgtccaa 
      tgaggttga gtgttttgg gtttagtat tgtgttgct 
      aattaaaac tgtaataat gttgttaat ttaaaacgt 
      tgttttttt aataattct gcttattaa agctagtga 
      ttattgacg attgtccct aattgtaac ataacatgc 
      gtaataaag taattgtat cgat
    • >TC006530 RB
      gataagaaa acacaaata ttaaaataa gcaaacgtg 
      aaacgactc cacagcgtt tgttattcc agtcgcaat 
      cacgccgag tgatttttg tacgaactg ataatcagt 
      aagcacact caatgatcc ccactatca gctcctctt 
      acataaaca tctctatca cgcatcgtt tcccaatat 
      catcccaac ttgtgtgaa agtcaaaac gaacaagac 
      ctcaaacca tttagttag tcaaaatga gtacgcagc 
      cgaaaacaa acctcctgg actacatca gtagtttgg 
      acattacag ccaaaccga aatatctgc ggctaacgg 
      gaatcgtgt gtacgatcg gaccagcat gccagaagg 
      tagagattt tggagaaaa tgctcgaag ctggaatga 
      acgtggcac gtttgaact tctctcacg gtactcacg 
      agtaccacg tcgatttga tcaaaaaca taaggaccg 
      ctgtggaca actacagca agagaatag gccgctact 
      gcccccttg ccatcgcca tcgacacca aaggctccg 
      aaatccgaa ctggagtac tagaagggg gcatctctg 
      ccgaagtgg tcctggaga aagggtcaa aagtgaccg 
      tgacaaccg acgaaaagt atgccaaaa agtgcacca 
      agagcgtca tctacgtcg attataaaa acatcacca 
      aggtgcaga aacccggaa accagattt tcatcgacg 
      acggtttga ttaccctca actgtgaga aaatccaag 
      gctcggaga tcacttgct cggttgcca atgggggaa 
      aactgggga gtagtaaag gggtgaacc tgccaggcg 
      tcgagaaag acctgccca cggtttcgg aaaaggaca 
      agaaggatt tgaaattcg cagttgagc agaacgtcg 
      actgtgttt tcgcctcgt tcacacgaa acgccgaag 
      aagtgcgcc agattcgct ccattttag gcgacagca 
      acattcggg tgattgcca agatcgaga acacgcaag 
      gtgtgaaga acatggacg agattattg aagctgccg 
      atgggattc tcatcgatc ggggcgacc tggggatgg 
      aaatctcct tccagaagg tgttcctcg cccagaaag 
      ccatcatcg cgaggtgta acaaggttg gaaagccca 
      ttattatcg ccacccatt tgctggaat caatggttg 
      ataaaccaa ggcctacga gagccgaga gctcggatg 
      tggccaatg ctgtgctgg acggtgccg actgtgtga 
      tgctagcag gggagacgg ccaagggct tgtaccctg 
      tggagtgtg tggagacca tggctttga tttgcaaag 
      aggccgagg cagcggtgt ggcaaaaac agctcttta 
      acgacctca aaagccagc ctaaagtac cgcttgaca 
      tcgtccaaa ctaccgcaa tatccacag ttgaagcct 
      cgatgaact cgctagcca cggccatca tcgtggtca 
      cgaaaacgg gaaaatcgg cacaattgt tgtcaaaat 
      acaagccaa agtgcccga ttattgcag tgacgagga 
      atgcgcaag ttgcgcgcc agttacact tgttcaggg 
      cgattatgc ccttgtatt ttgacggcc aaagcccaa 
      ccgagtggt tgaaaaatg tggaagtcc gggttaaag 
      ccggagtta gttatggaa agtcgttgg ggtttgtta 
      aatcagggg atactgtaa ttattgtga cgggtttgc 
      atcaagggc ctggctcta caaacactc ttacgttga 
      tgactgtcc aatgaggtt gagtgtttt gggtttagt 
      attgtgttg ctaattaaa actgtaata atgttgtta 
      atttaaaac gttgttttt ttaataatt ctgcttatt 
      aaagctagt gattattga cgattgtcc ctaattgta 
      acataacat gcgtaataa agtaattgt atcgat
    The data is licensed under a Creative Commons Attribution 3.0 Unported License. (CC-BY) CC-BY