| General information | |||
| TC003976 | Gene
The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser. |
NC_007418.3: 29527233..29545207 | |
| Sequence information | |||
| Transcripts / Proteins (1) | Get mRNA sequence
Get CDS sequence Get protein sequence |
||
| Ortholog information (from OrthoDB)
The information about the homolog genes in Drosophila
is provided by OrthoDB http://www.orthodb.org/.
The homologs are sorted according to their similarity score. For an orthology statement additional
analysis are required. | |||
| Closest fly homologs |
|
TC003976 | |
GO terms for Tribolium
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There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.
GO terms for the homologous Drosophila genes
Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.
| Gene | {{ goGene }} |
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| GO ID | * {{ blurIdResult }} |
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| Evidence | {{ blurEvidenceResult }} |
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| Reference | * {{ blurReferenceResult }} |
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| Quotation | ||
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| Publish name | ||
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* : mandatory fields
For help on how to submit larger datasets or non experimental data please contact us.
Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.
| General information | ||||
| iB_00645 | iB fragment
The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser. |
Get FastA Get primers |
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Usually 10 injected animals
Pupal injection procedure
Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.
3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.
9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.
11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.
Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.
13 dpi: Egg productivity and Ovary analysis
The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi).
In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.
14 dpi: Analysis of embryonic musculature and early embryonic development
Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.
15 dpi: Analysis of larval instar 1 cuticle
Offspring of injected females were analysed and cuticle phenotypes were annotated.
22 dpi: Stink gland analysis
Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.
Terms used in the pupal injection procedure
- larval pantagmatic defects
- At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
- empty eggs
- Just empty shells are visible, no cuticle has been developed.
- strong defects
- L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
- strongly fragmented (cuticle crumbs)
- No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
- cuticle remnants (with unidentifiable segments)
- Segments or parts of appendages are recognizable, but identity is not clear.
- cuticle remnants (with some identifiable segments)
- At least one segment or appendage is clearly regonizable.
- number of eggs on slide
- affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
For the embryonic muscle analysis the hatched as well as the not hatched were analysed. - total number of affected eggs/embryos/larvae
- Summary of all different phenotypes/ phenotypic series which were annotated.
- inside-out
- The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
- starved
- Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
- eclosion not fulfilled
- The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
Metamorphosis and survival
Lethality 11 days after pupal injection: 10.0% (includes death as pupa, adult)
adult lethality - Number of animals showing the phenotype: 1 (9 dpi)Days post injection
Analysis of embryonic musculature and early development
number of eggs/embryos/larvae on slide: > 50
remarks: muscle pattern potentially obscured by segmentation defect,
Analysis of larval stage 1 cuticle
number of eggs/embryos/larvae on slide: > 50
cuticle remnants with some identifiable segments - Penetrance (percentage of animals/eggs on slide): less than 30%
larva appendages shortened - Penetrance (percentage of animals/eggs on slide): less than 30%
labrum not present - Penetrance (percentage of animals/eggs on slide): 30% - 50%
gena triplet seta number increased - Penetrance (percentage of animals/eggs on slide): less than 30%
affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): 50% - 80%
remarks: bad quality of preparation,
cuticle remnants with some identifiable segments - Penetrance (percentage of animals/eggs on slide): less than 30%
larva appendages shortened - Penetrance (percentage of animals/eggs on slide): less than 30%
labrum not present - Penetrance (percentage of animals/eggs on slide): 30% - 50%
gena triplet seta number increased - Penetrance (percentage of animals/eggs on slide): less than 30%
affected eggs/embryos/larvae total percentage of affected eggs/embryos/larvae on slide - Penetrance (percentage of animals/eggs on slide): 50% - 80%
remarks: bad quality of preparation,
Usually 10 injected animals
Larval injection procedure
Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.
11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.
16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.
19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.
22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.
41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).
Terms used in the larval injection procedure
- pupal/ adult pantagmatic defects
- At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
- pupal molt not fulfilled
- The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
- eclosion not fulfilled
- The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
- starved
- Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
Metamorphosis and survival
Lethalities 11 days after larval injection: 20.0% (includes death as larva, prepupa, pupa)
Lethalities 22 days after larval injection: 30.0% (includes death as larva, prepupa, pupa, adult)
Days post injection
remarks: animals lost, later than schedule,
Pupal morphology
remarks: animals lost, later than schedule,
Adult morphology
remarks: animals lost, later than schedule,
- >TC003976 RA
MLSLNLSQF FVFEFLTTL DKMLDKRVT IKVIKPGSV IRKRKILGF TSFDVGTIW FQKDHQLYH KWAILAAPS KDYAGGTRG YLKLDVSVL SKGEMPKIP PTVDTNEIE GNLFLPSGV TTERQRVIF IFDVYKGVD LVKKNPIQE LKRAENAPS TTIEICFSG VSVKTSTKK GSIAPNWNE RLVLPELFP PLCQRFRIQ LYHDGTIRS TCYLNLKSI SNDKEEGFL PTFGPAFLH FYSPNHLEG YLGKVLLAL QTSLLGEIA EYEVKHSTI YPEAPLLKE ETFLKYENF VLHATIFEA TMINKKFSD KAISFRISC GPLQSDASG DKIAAMVTP PMKPKVMNK NYCYLPITG KKACIFVTL SLPDVRKRM FNYNFLSKI LKDLKSRLD KIEYIVQNK DYDIASAQT EALLLETAD FISFVSGKY LDIVSSYSL TEETFLDQR RIKMCLKEM ESVNVVAKS VSGEQNKKK IFQKVEKIY TKIESLVDD LEDWPLIYL WMIYGAKRV AYLFLQPRD FLHSTVDEE KGTHCGKLR PFYFQAEDS QELPEIITS VCKMDAIIW IGLPRHLTT YQPQGFTFS HETIPRSLK TQEMYHFEA RVHIFQGRF TPGSDKSGL SDPFVHVII SSQFKETQV LQKTLNPVW DQTLVFRNV ELYGNRDFI TANPPSVFI EIFDKDECQ QIEVIGKCV LRPIIKTLK GEQGSGSLR LTWYRVHNV FDVSAEILA AAELLEVTA KTAETRRDQ IVKIPPEIK PHLISHRIE VVFWGVRDL KKVQMAQIT KPKVVVELG TNLVSSDTL ANAKKHLNF TNPIKSIEA SFAEEEEYA PTLSLKMYD SRNFGISVF AGTHIMPMQ MFFYQPQTT DERHLKLMT VRRNSLDFD ESIESLIQK LDAQSGTKI HFEKKLTSE SKWRKFFDC LTCRRRKKP PPPKPLELE QPELEDSSD FDWWTKFYA SLEETPLTG KIPLSHKYK LKVYSHELE QQPEFEGFC DTLRSFEMY KGKRTGDEA VDEANTTGV FKGALRIYQ WPLNGDDFV TPTGLPLQG GIFQDFPTN TPINFVLRV YCVRGLNLR PKDISGKSD PYLHLTLNQ SVINDKQNC IKRQINPIF GRCFEFNGI FPQDHTLVI AVKDWDAVS ADDLIGQTK IDLENRFYS KHRGHCGLA ADYLTVGYC QWRDQQKPS TILENLCKK YNIPDLEYK EKSIIVGPQ EFFLDNQNV DLRHQALAL LALKRWAEV PLVGCVLVP EHVETRSLF HPQRPGVEQ GKLQLWLDI LPVTDFPTP RQVTITPRK PVSYELRVI VWNAEGIIL EEKDILTGE KKADVYVKG WLTGPNTAQ YTDVHYRIL SGEAMFNWR FIFPFQYLS TENKIVQKH KTVFEESEE KIPCKLTIQ AWENDAFSP DDFLGVVTL ELSRLHRGA SLFRNCSPA LTKPNAPVL NLFKIRRTR GWWPLKNVD TRTRKEVFA GGVELEFEL LTKEEAERN PAGLGRREP QGLPKPNRP DTSFSWFWN PWRAIKYTL KFYKKKIIK FIIIVIVVA VTVYLLYRF GEFGWEKLM VQLKKSPVL LLAILCSIC VGELTDREL SVLCPKGIK CVTSKTFIF CENNNIFLA YGKKIFACE ENFVCDEQD PYNGCVHQK FYKDLTQDK TKIVVDINI VDKDKKKGE NCSSDDDFP IDGSLTKLS PPLDSNLVE KPTNNSNSS QESVTDSNL VNKSTTLKN DEDGKETTP VLSSDTIFR PKPFNSSST DVPFSDKNT KKNPDFPLE ASTLPSHID EKKASTVAY SPKEALQSV KLPAINKPT TSEDHTVST SKVSTPPTD ASDKKSTQG DVTNEPSDT SSSEESSAD FNSEEDDDD DDGTLDNVS SDTTFRPES YPRQPNGIF RPPSQAVQP TDTENQEIP SDDRNPFSN KGEKTPDFP LEASTLSSH IDKEKASTV AYSPEEALQ SVKLPAINK PTTSEDHTV STSKVSTPP TDASDKKIT QGDVTNESL DTSSSEESS ADSNSEEDD DDGTLDNVS SDTKLPPES HPRQPNGIF RPQSKSVQP TDIENQEIS LDDRNPFSN KGGKKPDFP LEASTLASN TDDQEASTE AHSLEEVPE DVLSPVTNK PLTYQHHIV VSNKVSTTV TDASDEKSS TGDATNESL ESSEESTTD LNSKEKDDN MLRPDSKPK QNGIFRPHP KPEKVQPSE NHNPFSNKP GKKPYSPLE TSTLSNNTD KDKASLVPQ LPENDLQFV TFSTLPSVD HDRTGLLST LPTAEETTS DITTPLQIK ENDGTIERP QNPTNSIFR PKPPESTTP CQNNIFRPK PHKPHNDSQ TNSDKLSSK SENDIDFPV EASTLPNEK TTVPLPTEE DDKFVRAST IPSDKASNN EPSLIEDDT SVFLESSTL PTNLEDKNQ QSSDVLFSH EVSTPPNSD SKITTSQTS NLVDSTLSS DKSEVEVPT EPPMNKEVP DGQPKISKP SFIFRPKIL SPKNFTKPD TKQEHPDVY FSSVFTTPP NEPTTLLTD KGEEEIPTE IPPPEFFKD TSTIPSLNE EATSLNFEI STRNPVSTD DQSSIFRPK IQVPKNFTE PDKYHDNPD IDIPSVFTT PPNHKSSET EPTTLQMAD DSDFFMEAS TLPNDKQGE EIFTELPPP QEDTTTYFK ASDKDNDKV PDLDEETTS LNDDDSTVP TNLINNEET PQKNLDSPP KLSPPSAIF RPKVHASKN LTDSDKDHQ NPDVYFPSV FTTPPNQKN SENEPTTLQ SADDSDFYV EASTLPNDR QEEGYFIEF SPPQEDNTF YEDSTRPSN KDSDKAPGL DEETTSLSV EISTVSTNL INNEENPEE NFDSTPKIR PPSSIFRPK VNAPKNSTN FDNKNQNPE VYFSSVFTT PPNQDSESE PTTLQTADD SDVFVETST LPNDKQEEE YFTELPPPQ EHTTIFKDS TKPSDKDTD WREETTSLN LENSTPSLE SRPVSIFRP KIHTPKNVA EPDKDKKIP DEFFSPQYS TPPSEVNSE KGNITPDFS AEASTPFSD TSEERTDSQ FVEASTLAN NMDETENQN TVLPTNLPD EESASNDLQ SQEDSPIYR PLQENKPQI SPPKPVSPD NPDIIFRPK IPILQNRTD DKLNQSTPG VSTPPAKNI ENEPSTPEK DFDFLVETS TLPYDLLKN NTTLKPFDE DLQFNEFNT VPNNIDDKE YLDKDVTLV PPNSTPSNN ENNEDSTES DNVTLSPST PQPVSQPNS IYRPKPKPK PKLLPGVNT VPSVTTEKI AQLPEEDPQ FVEYSTVPN LDKVSTFVP PEKSTPPTY TDKDNLLEP SAPPEMNPT EILLSDDSV TDSLTALPP KTESFTTQP SSKPEVIYR PKPKPNLSN STIFRPPLY LPQEEPDPE KLKEEERNI LFSPEVSTL ANIPCDNEA TTVLQLPEK NVQFSEYST IQSETELSS GQHETSTPL SSRDTEEEL TSTDVVSTS PPIENSTPQ LEVIYRPKP KPQPKPTKP TEISTVLQP SEEDLQFYE YSTIPNVDS KVPNPQKPV KPKPKPSEN IIFRPALSI PTKEKENEK LDQEEQGIL FPPEVSTLP NIPRDNEAT TVLQLLETD FQFSEFSTI PNNIQSETD LSSSQDEIS TPPTTRDTE EELTSSDVA STSPPIENS TPYPEVVYR PKPKPQPKP TKPTETSTV LQPSEEDLQ FYEYSTIPN VDSKVPNPQ KPVKPNPKP SENIIFRPA LLVPPKEKE IEKLDQEEQ GIMFPPEVS TLPPCDNKS STVPQRSED DFQDFEFST IPNFGTTDQ EETFATTER TTPPTFTED KTTEKISFS TLQPDATLR PKPKPNGTT IFRPKLRIP PKEKGSDST IITSDTFEI PDLPEKDHQ FSESSTMPN AIDNDNTSL EQEVDKGPE KPTGDNDIP SSPNETIFR PKLHKQINS TKAEQTDTL FPPEVSTLS SRTEGSTLP IDSDIQTTL RPFEINTVL NDKNEQITE IFPSQYTTV PTFDTITDM VQEVSTLPS KTTMLNDHK ESNKSLQEP PVKKKDDNF MDSQVTTLN SKKDYKKTP PKEDEVFFA HPSTLKPNK KDSYAHPTT LKPKKEESV TNLSTPPSG NKTKETIKI SNTQKSQNH TKLSHSKTK KPPLRHNTS SEESDESDE SGETSINIE NSQSLQANI NIGSGDNLT ADKERNNRP NPFEPKPSQ DNKKSYGTS VKIENSQNL NLNINTGKE TLNTKNSNL SNATGSATD KGRGGESNK ESSNTSVNV ENAQKLNVN VNSDGQTIS HSNNNSKPT AQNNSLSNA IGSGPNKNV SSGKFDHTS VNIENTQSL NVNINTGDR QNTKNNLPN ASGGDDMKA VLKTTLLSS IDSSNVKKK TPVKLAPFS GTKNKNRLP AGKPNEVNN DPTELSIKE VRGDYTKTI SSYEKNKSS PKRPQLLSV KTHIKKPTK SSIENNTVR PNRFTLPSN DPTEVYNDY PTELARNIY PNAVGSYDE SNLLNKLTV SSEDDDNDD TKVGPSKLN YDNPEKSPV DKVNSLDKN RGRTKRPKI SSDSLSQGD NPTKPASTE MKDHVQKSI ASYGKNKNT PKESKTKQK YSQTSDIIK NESIDNLKE PQTNSGINE SEENVANHI YLREKAKLP PTDVEDAKT TKLDSETVS QESENLSLS TEEEREIVF VEFHKRKDQ ESLVYSVKV DLQKHSLSD YIPRTRFEE IKITTGFVY QLLNKHIGP IHRMRPYKL TFRNQIYEL GENLLAGTS NMEEFQVSV GTLTEIEDG VFRGEKLKY LNLRDNKIS EIASHAFDD MTQLTKISL INNQLAEYN PNWFHNCPK LQTILLSYN KIRTLPPFA FKNLNLNLH FRIFLDYNE ITTISDSTF LKSPANSLN PQYFDNLRK KGFRIHLKG NRLKCVTED VSKTFVAKV ITMKRNPFT CECQRKILK WKKTHPRIQ IYLDYNTFI LSSFKHNMR FFWLFLATF CLAKASLFS QYVKLYEDK KPPNIFLKF IGKGGEALI EIKTPGFRP LFHRIVKKY EADTKRISF VSTFNSDNG IEKNFFR
- >TC003976 RA
atgctgtcc ctaaacctt tcccagttt tttgtattc gaatttctc acaactctc gacaagatg cttgataaa agagttacc atcaaagtt atcaaacct ggaagtgtg attcgcaaa cgcaaaatc ctcggtttt acgtctttc gatgttggt accatctgg ttccagaaa gaccaccag ttgtaccac aaatgggcg attctcgca gccccgagc aaagactat gctggtggt accagaggg tacctcaaa ctagacgtc agtgttttg tctaaaggt gaaatgccc aaaattccc ccaactgtg gataccaac gaaattgaa ggaaacctt ttcctacca agcggagtt accacagaa aggcaacga gtgattttc atttttgac gtttataaa ggtgttgat ttggtcaaa aagaaccca attcaggag ttaaaacgg gcggaaaac gcaccaagt actaccatc gaaatttgt ttttctggt gttagtgtt aaaactagt accaaaaag ggttcaatt gctccaaat tggaacgaa cgtttggta ctacctgaa ctgttccct cctctttgc caacggttt cgaatccag ttgtaccat gatggtacc atacgatcc acttgctac ctaaacctt aaaagcatc tcaaatgat aaggaagag ggttttttg cccactttt gggcccgct tttcttcat ttctactcc cccaatcac ttggagggt tacttgggc aaggtactt ctagctctc cagacctct ctattgggc gaaatagca gaatacgaa gtcaaacat agcacaatt taccccgaa gctcctctt ctaaaggaa gaaacgttc ctcaaatat gaaaatttc gtcttgcac gctacaatt tttgaggcc acgatgatt aataagaaa ttttcggat aaagcgatc tcgtttcgg atttcttgt ggtcctctt cagagcgac gctagtggt gataaaatc gctgcgatg gtcacacca ccaatgaaa ccaaaagta atgaacaaa aactactgc tacttgccc ataactggg aagaaagct tgcattttt gtgactttg tcgttgcct gatgttagg aaacgaatg tttaattat aattttttg agcaaaata ttgaaagat ttgaagtca aggttagac aaaatcgag tatattgtc caaaacaaa gactatgac attgcaagt gcacagact gaagctctc ctgttagag acagccgat ttcatttct tttgtctct ggaaaatat ctcgatata gtatcgagt tatagtctc actgaggag acttttctc gaccaaagg cggatcaaa atgtgcctg aaagagatg gaatcggtg aatgtggtg gcaaagtcg gtgtcaggc gagcaaaac aagaagaaa atcttccag aaggttgaa aaaatctat accaagatc gaaagtttg gtcgatgat ttggaagat tggcctttg atttattta tggatgatc tatggtgcc aaaagagtg gcatatttg ttcctccaa cctcgagac tttcttcac tccacagtt gacgaagag aaaggaact cattgtggg aaattacgc ccgttttat ttccaagca gaagactct caagaactt cccgaaatc ataacaagt gtttgcaaa atggacgcc atcatctgg atcggttta ccacgacat ttgaccact taccaacct caaggtttc acattttca cacgaaacc atccctcgt tcgttgaaa acccaagaa atgtaccat tttgaggcc cgggttcat atcttccaa gggaggttt accccaggg tcggacaaa agtggtctt tctgaccct tttgttcac gttattatc tcgtcccag tttaaggaa actcaagtt ttgcaaaaa accttaaac ccggtttgg gatcaaacc ctcgttttt agaaatgta gaattgtat ggaaatcgt gattttatc actgctaat ccaccaagt gtctttatc gaaattttt gacaaggat gagtgtcaa caaatcgaa gttattggc aaatgtgtt cttagacca attatcaaa acgcttaag ggggaacaa ggatcaggt tctcttaga ctcacttgg tatcgcgtc cataatgtg tttgatgtg agtgccgaa attttggca gccgctgaa ctccttgaa gttacggca aaaactgca gaaacacgt cgtgaccaa atcgttaaa ataccacca gaaatcaag ccacacttg atcagccat cgaatcgaa gtggttttt tggggagtc agggacttg aaaaaggtc caaatggcc caaatcacc aaacctaag gttgtggtc gaacttggc accaatttg gtgtcttcc gacactcta gcaaatgcc aaaaaacac ctaaacttt acaaacccg atcaagtca attgaagca agttttgca gaagaggaa gaatacgcc cccactttg tctttaaaa atgtacgat agtcgaaat tttggtatt agtgtgttt gctggcacg cacatcatg ccaatgcaa atgttcttc taccaaccc caaaccaca gacgaacgg catttaaag ttgatgact gtgcgaaga aattcgctt gattttgac gaatccatc gagtcactg atacaaaaa ttggatgca cagtccgga accaaaatc cattttgag aaaaaacta acgtcagaa agcaagtgg cggaagttt ttcgactgt ttgacttgc agaaggcgc aaaaaacca ccaccaccc aaaccacta gagttggaa caaccggag cttgaagat agtagcgat tttgactgg tggacaaaa ttttacgcc tccttggag gaaactcct cttacaggg aaaatacca ctgagtcac aagtacaag ttgaaagtc tactctcac gagcttgag caacagccg gaatttgag ggtttttgt gacacttta cgctccttt gaaatgtat aaagggaag agaactgga gacgaagcc gtcgatgaa gccaacacg actggggtt tttaagggc gctttgaga atctatcag tggccttta aacggcgac gattttgtc acaccgact ggtttacct ctacaaggt ggaattttc caagacttt cccacaaat accccaata aattttgtt ttgagggtt tattgcgtc cgagggttg aatttaaga ccaaaggac atctctggc aagtctgac ccttacctc cacctaacc ctcaaccaa agtgtgatc aacgacaag caaaactgc attaaacga caaattaac ccgattttt ggccgttgt tttgagttt aatgggatt tttccacaa gaccacact ttggtaatt gcagtcaaa gactgggac gctgttagt gccgacgat ctgatcggg caaacgaaa atcgacttg gaaaatcgc ttttatagc aaacatcgc ggtcattgt ggcttagct gcagactac ttgactgta ggttattgt caatggaga gaccagcaa aaaccaagc acgattttg gaaaatctg tgcaaaaaa tacaatatc cccgacttg gagtacaag gagaagtcc ataattgta ggaccacag gaatttttc ttggataat cagaatgtg gatttgagg caccaagcc ttggcattg ttggctttg aagcgctgg gctgaagta ccattggtt gggtgcgtc ctagtaccg gaacatgtt gagactagg tcgttgttt cacccccaa aggcctgga gttgaacag ggaaaatta caattgtgg cttgatatt ttaccagta accgatttt ccaactcct cggcaagtt accataact ccaagaaaa ccggtttcg tacgaattg agggtcatt gtgtggaac gccgaaggg attatttta gaagagaaa gatatttta acaggggag aagaaagcc gatgtttat gttaaaggg tggcttact ggtccaaac acagcccag tacacagat gtccactat agaatctta tcaggggaa gctatgttc aattggagg ttcattttt ccatttcag tatctttca actgagaac aaaatcgtt caaaaacat aaaactgtg tttgaagaa agtgaagaa aaaatcccc tgtaaacta acgatccag gcgtgggaa aacgacgct ttctcccct gatgatttc ctaggtgtt gtcactttg gaactatca aggcttcat cgaggcgca agtctattc cgaaattgc tcaccagct ctaaccaaa cctaacgct ccagtccta aacctgttc aaaattcgc agaactagg ggttggtgg ccgttgaaa aacgtcgat actcgcacc cggaaggaa gtatttgca ggtggtgtt gagctagag tttgaattg ttgacaaag gaggaagct gaaaggaat ccagctgga cttggaagg cgtgaacca caaggacta ccaaaacca aatcgtcct gatacttcg ttttcctgg ttttggaac ccatggagg gcgattaag tatacgctt aagttttac aagaagaaa attatcaag tttattatt atcgtgatt gtggttgct gttactgtg tacctgttg tatcgcttt ggcgagttt ggctgggaa aagctaatg gtgcagtta aaaaaatcc ccggtgttg ctattagca attctatgt tccatctgt gttggagag ctaacagat cgggaattg tcagttttg tgtccgaaa ggaattaaa tgtgtgact agtaaaacg tttattttt tgcgagaac aataatatt tttctcgct tatggcaaa aaaattttt gcctgtgaa gaaaatttt gtttgtgat gagcaagat ccatacaat ggttgtgtg catcaaaag ttttacaaa gatttaacc caagataag acgaagatt gttgttgat attaatatc gtcgataag gataaaaag aaaggcgag aattgttca tctgatgat gattttccg atagatgga agcctaact aagttatct ccaccgtta gattctaac ttggtggaa aaacctact aataattcc aactcgtct caagaatct gtcactgat tctaattta gtaaacaaa tctaccact ctaaagaat gatgaagat ggtaaagaa acaactcca gttttgtca tccgatacc atatttcgc cctaaacct tttaactca tcatctaca gatgttcca tttagtgac aaaaacaca aagaaaaat cctgatttt ccactagaa gccagtact ttacctagc cacatagat gaaaaaaaa gcatctact gttgcatat tcaccaaag gaggctctt cagtctgtc aaattacca gcaattaat aaaccaact acgagtgaa gatcacact gtttcaact tctaaagtt agtactcca cctactgat gctagcgat aaaaaatct actcaaggt gatgtaaca aatgaaccg tcagatacg agttcgtca gaggaatct tctgctgat ttcaattca gaagaggat gatgacgat gacgatggt actctagat aatgtatca tccgatact acattccga cctgaatcc tatcctaga caaccaaat ggtattttt agaccacca tcgcaagct gtgcaacca acagataca gaaaaccaa gaaatccca tcagatgac cgtaatcca tttagtaac aaaggagaa aaaacacct gattttcca ctagaagcc agtacttta tccagccac atagataaa gaaaaagca tctactgta gcatattca ccagaagaa gctcttcag tctgtcaaa ttaccagca attaataaa ccaactacg agtgaagat cacactgtt tcaacttct aaagttagt actccacct acagatgct agtgataaa aaaattact caaggtgat gttacaaat gaatcatta gatacaagt tcgtcggag gaatcttct gctgattcc aattcagaa gaggatgat gacgatggc actttagat aatgtttca tctgatact aaacttcca cctgaatcc catcctaga caaccaaat ggtattttt agaccacaa tctaaatct gtgcaacca acagatata gaaaaccaa gaaatctca ttagatgat cgtaatcca tttagtaac aaaggagga aaaaaacct gattttcca ctagaagct agtacttta gctagcaac acagatgac caagaagca tctacagaa gcacattca ctggaagaa gttcctgag gatgtctta tcaccagtt actaataaa ccacttacg taccaacat cacatcgtt gtatctaat aaagttagt actacagtt accgacgcc agcgatgaa aaatctagt acaggtgat gcaacaaat gaatcatta gagtcgtcg gaagaatcc acaactgat ctgaattca aaagagaaa gatgataat atgcttcga cccgactct aaaccaaaa caaaatggt atttttaga ccacatcct aaaccagaa aaagtgcaa ccatcagaa aaccataat ccatttagt aacaaaccg gggaaaaaa ccatattct ccactagaa accagtact ttgtctaac aacacagat aaagataaa gcttcccta gtaccacag ttaccagaa aacgatctc cagtttgtt acatttagt acactacca tctgtggac cacgatcgt actggttta ctatctact ctacccact gctgaagaa accacttct gatattaca acaccactt caaatcaaa gaaaacgat ggtactatt gaacgacca caaaaccca accaattct atttttcgg ccaaagccg cctgaaagt actactcct tgtcaaaat aatatattt cgacctaaa ccacacaaa ccacataac gatagtcaa acaaattct gacaagctt tcgtcaaaa tcagaaaat gatatagat tttcccgta gaagccagt actttacca aatgaaaaa acgacagta cctctacca acggaagaa gatgataaa tttgtaaga gctagtaca ataccaagt gataaagca agtaacaat gaaccaagt ttgattgaa gacgataca tctgtgttt cttgaaagt agtactcta ccaacgaat ctagaagat aaaaaccag caatcttca gatgttctt ttctcacat gaggttagt actccacca aattctgac agtaaaatc actacatct caaacgagt aatttggta gatagtact ttgtctagc gataaatca gaagtagaa gtaccaaca gaaccaccc atgaataag gaggttcca gatggtcaa cctaaaatt tcaaaacca agtttcata tttaggcct aaaattctt tcaccgaaa aattttact aaacctgat acgaaacag gaacatcca gatgtttat ttttcatct gtgtttaca actccacca aatgaaccc accactttg ctaactgat aaaggagaa gaagaaata cctactgaa attccacca ccagaattt ttcaaagat actagcaca atacctagt ttgaatgaa gaagctaca tctttaaat tttgaaatt agcactagg aatccagtc agtactgat gatcaaagt tctatattt cggccaaaa attcaagta ccaaagaat tttactgaa cctgataag tatcatgat aatccagat attgatatc ccttctgtg tttaccact ccaccaaat cataaaagt tctgaaact gaacctact acacttcaa atggcggat gattctgat tttttcatg gaagctagt actttacct aatgataaa caaggagaa gaaatattt actgaactt ccaccacca caagaagac accaccacg tatttcaaa gcgagtgat aaagataat gataaagta ccagatttg gatgaagaa actacgtct ctgaacgat gacgatagt actgtacct acgaatcta attaataat gaagaaact ccacaaaag aatcttgat agtccacct aaactctca ccaccaagt gcgatattt agacctaaa gttcatgca tctaaaaat ttgacagat tctgataag gatcatcaa aatcccgat gtttatttt ccatctgta tttactact ccaccaaat caaaaaaat tctgaaaat gaacccact acacttcaa tcagcagat gattctgat ttttatgtg gaagctagt actttgcct aatgacaga caagaagaa ggatatttt atagaattt tcaccacca caagaagac aacacattt tacgaagat agtacaaga ccgagtaat aaagatagt gataaagca ccaggtttg gatgaagaa actacgtca ttgagcgtt gaaattagt actgtatct acgaatcta attaataat gaagaaaat ccagaagag aattttgat agtacacct aaaatacga ccaccaagt tcgatattt aggccaaaa gttaatgca cctaaaaat tctacaaat tttgataac aaaaatcaa aatccagag gtttatttt tcatctgtt ttcacgact ccaccaaat caagattct gaaagtgaa cccactaca cttcaaacg gcagatgat tctgatgtt tttgtggaa acctctact ttgcctaat gataaacaa gaagaagaa tattttaca gaacttcca ccaccacaa gaacacacc actattttc aaagattct acaaaaccg agtgacaaa gatacagat tggcgtgaa gaaactacg tctttgaat cttgaaaac tcaacgcca agcttagaa tctcgacct gtttctata tttagaccg aaaatacat acaccaaaa aatgttgct gaacctgat aaggataaa aaaattcca gatgagttt ttctcacct cagtatagt actccacca agtgaagta aattcagaa aaaggaaac atcacacca gatttttct gcagaagct agtacgcca tttagtgac acatctgaa gaaagaaca gattcccaa tttgttgaa gctagtacc ttagccaat aatatggat gaaaccgaa aatcaaaac actgtatta cctacaaat ttaccagat gaagaaagt gcttccaat gatcttcaa agtcaagaa gattctccc atttatcga ccattgcaa gaaaataaa ccacaaatt agtccaccc aaacctgtt tctccagat aaccctgat atcatattt agacctaaa atcccaata ttacaaaat cgaactgac gataagttg aatcaaagt acaccagga gttagtaca ccaccagca aaaaatatt gaaaacgaa ccaagtaca ccagagaaa gattttgat tttttggtt gaaactagt actcttcct tatgattta ttgaaaaat aacacaact ttgaaaccg tttgacgaa gatcttcaa tttaacgaa tttaatacc gtgccaaat aatatagac gataaagag tatttggac aaggatgtt actttagta cctcctaac agtactcca tcgaataat gaaaataat gaagacagt acagaaagt gataatgta acgctttcg ccatctacc ccacaacct gtttctcaa cctaactca atatatcgg cctaaacct aaacccaag cctaaactt ctacctgga gttaatact gtacccagc gtaacaact gagaaaatt gctcaactc ccggaagaa gatcctcaa tttgtcgaa tacagtact gtccccaat ctggataaa gtaagtact tttgtgcca cctgaaaaa agtactcca cccacatat acagacaag gataactta cttgaacct agtgcacct ccagaaatg aatccaact gaaatacta cttagcgat gatagtgta actgatagt ttaacagcc ttgccaccc aaaactgaa agttttaca acacaacct agttctaaa ccagaagtg atatatcgg cctaaacct aaaccaaat ctaagtaac agtactatc ttccgacct ccgctgtat ttaccacaa gaggaacca gatcccgaa aagttaaaa gaggaagaa agaaacatt ttattttca cctgaagtt agtacttta gctaacatc ccatgtgat aatgaagca acgacagta cttcaacta ccagagaaa aatgtccaa ttttctgag tatagtacc attcaaagt gaaacagaa ctaagttca ggtcaacac gaaacaagt actccactc tcatctaga gatactgaa gaagaactg actagtact gatgtagtt tcaacgtcg ccacctatt gaaaattct acaccacaa cttgaagta atatatcga cctaaacct aaacctcag cctaagcca actaaacca actgaaata tcaactgtg cttcaacca tctgaagag gatcttcaa ttttacgaa tatagtact attcctaat gtggacagt aaagttcca aatccacaa aaaccagta aaacctaaa ccaaaacct agtgaaaac attattttc cgaccggca ctttccata ccaacaaaa gaaaaagaa aacgaaaag ttagatcag gaagaacaa ggcattcta tttccacct gaggttagt actctacct aatattcca cgtgacaat gaagcaacg acagttctt caactgcta gaaacagat ttccagttt tctgaattc agtaccata cctaacaat attcaaagt gaaacagat ctaagttca agtcaagac gaaataagt actccacct acaactaga gacactgaa gaagaacta actagctct gatgtagct tcaacgtct ccaccaatc gaaaattct acaccatat cctgaagta gtatatcgg cctaaacct aaacctcag cctaagcca actaaacca actgaaaca tcaactgtg cttcaacca tctgaagag gatcttcaa ttttacgaa tatagtact attcctaat gtggacagt aaagttcca aatccacaa aaaccagta aaacctaat ccaaaaccc agtgaaaac attattttc cgaccggca ctcctcgta ccaccaaaa gaaaaagaa atcgaaaag ttagatcaa gaagaacaa ggcattatg tttccacct gaagtcagt actttacct ccatgtgat aataaatca tctacagta cctcaacgt tcagaagat gactttcaa gatttcgag tttagtacc ataccaaat tttggcact acagaccaa gaggaaaca tttgcaaca actgaaaga actactcca cctactttt acagaagat aaaactaca gaaaaaata tcgttttcc acattgcaa cctgatgca acgcttaga cctaaacct aaaccaaat ggaactact atctttcgg cctaaactc cgtatacct ccgaaagaa aagggatct gattctacc attataaca agcgataca tttgaaata ccagattta ccagaaaaa gatcatcaa ttttctgaa tctagtacc atgccaaat gctatagat aatgataac actagtcta gaacaagaa gttgacaaa ggcccagaa aaaccaact ggtgacaat gatattcca agttcacct aatgaaacc atatttcgg ccgaaactt cataaacaa ataaattct acgaaagcc gaacaaaca gatactcta tttccacct gaagttagt actctttcc agcaggaca gagggtagt actctacct attgacagt gacatacaa acaactcta cggccattc gaaattaat acagtgctt aatgataaa aatgagcaa attacagaa atttttcct tctcaatat actacagta cctacattt gatacaata actgacatg gtacaagaa gttagtact ttacctagt aagactaca atgttgaat gaccataaa gaaagtaac aaatccctt caagagcct ccagtgaag aaaaaagat gataatttc atggattcg caagtaact actctaaac agtaaaaaa gactataaa aaaacacca ccaaaagaa gatgaagtc tttttcgct cacccaagt actctgaaa ccaaacaaa aaagacagt tacgcacac ccaactact ctaaaacca aaaaaagaa gagtctgtc actaatcta agtactcct ccaagtggc aataaaact aaagaaact ataaaaatt tctaataca caaaaatca cagaatcat acaaaacta tcacacagc aaaaccaaa aaacctcct cttcgccac aatacgtca agtgaagaa agtgacgaa agtgacgaa agtggtgaa acatcaatt aatatcgaa aactcacaa tcactacaa gccaatatt aacattggg agtggtgat aatttaact gctgataag gagagaaat aaccgtcca aatcctttt gaaccaaaa ccaagtcaa gacaataaa aaatcatac ggcacttct gttaaaatt gaaaactct caaaattta aatcttaat attaacact ggtaaggaa acacttaac acgaagaac agtaacctc tctaatgct actggtagt gctactgat aaaggtcga ggtggtgaa agtaataaa gaatcttct aacacttct gtaaatgta gaaaacgcc caaaaatta aatgtaaat gtcaatagt gatggacag acaatttcc cattcgaat aacaactca aaaccaaca gcacagaac aattcactt tcaaacgct atcggcagt ggtcctaat aaaaacgtc tcaagtgga aaatttgac cacacatct gtgaatatt gaaaacacg caatcacta aatgtaaat attaatacc ggtgatcga caaaacaca aaaaataat cttccaaat gcttctggt ggtgatgat atgaaagct gtactaaaa actactctt ctttcatct attgactca agtaatgtg aagaagaaa acgcctgta aaacttgcc cctttttct ggtacaaaa aacaaaaat cgtcttccg gctggtaaa ccaaatgaa gtaaacaat gatcctaca gaactatca ataaaagaa gtcagaggt gactacacc aagaccatt agtagctat gagaagaat aaaagtagt ccaaaacgt cctcagctt ttatcagtt aaaacacat atcaagaaa cctacaaaa tcatcaata gagaataat acagtgaga ccaaaccgt tttactctt ccatctaac gatccaact gaagtttac aacgattat cccacagaa ctagcaaga aatatatat ccaaatgct gttggtagt tatgatgaa agtaatctg ttaaataaa ctaactgta tcaagtgaa gatgacgac aacgatgac actaaagtt ggaccaagc aaactaaat tacgataat cctgaaaaa tcaccagtt gataaagtt aatagtctt gacaagaat agaggtaga acaaaacgt cctaaaatt tcatctgat tctctaagt caaggagat aatcctaca aaaccagca tcaactgaa atgaaggat cacgttcaa aagtccatt gcgagttat ggcaagaat aaaaataca ccaaaagaa agtaaaaca aagcaaaaa tattctcaa acttctgac ataataaaa aacgaaagt atcgacaat ttaaaggaa ccacaaaca aacagtgga attaatgag agtgaagaa aatgtagct aatcacatt tatttgcgt gaaaaagca aaactacct ccaactgac gtcgaagat gcaaaaacc acaaaactg gattcagaa actgtgagc caggaatca gaaaactta agtttgtcc acggaggaa gaacgtgag atagttttt gtcgagttc cacaagaga aaagatcaa gaatctctg gtatacagt gttaaagtc gatctgcaa aaacacagt ctttctgac tatatccca agaactcgc tttgaagaa atcaaaatt acaacaggg tttgtttat cagttgctc aacaaacac atcggacct attcaccgc atgagaccg tacaaactc actttccgt aaccagata tacgagttg ggtgaaaat cttctagct ggtacttca aatatggaa gagttccaa gtatcagtt ggtacttta actgaaatc gaagatggt gttttcaga ggcgaaaaa ctgaaatat ctcaacctg agagacaac aaaatttct gaaatcgcg tcacatgcc tttgacgat atgacacag cttacgaaa atttctctc atcaataac caattggcg gaatacaac ccgaattgg ttccacaac tgtccgaag cttcagaca atacttttg agttacaac aagatcaga actttgccg ccttttgct ttcaaaaac ttaaatctc aatctgcat ttccgaata tttttggat tacaatgag attaccact attagtgac tcaacattc ctcaaaagt cctgcaaac agcttaaac cctcaatat tttgacaac ttgcgtaaa aaagggttt aggattcac ttgaaaggc aaccgattg aaatgtgtg actgaagac gtgtcgaaa actttcgtc gccaaagtc attactatg aagagaaat cccttcacg tgcgaatgc cagaggaaa attcttaaa tggaagaaa acacacccc agaattcaa atttattta gactacaac acgttcatt ttatcctca tttaagcac aatatgagg tttttttgg ctgttcctt gcaactttt tgtttagca aaagcttcc cttttctcg caatatgtt aaactgtac gaagataaa aaaccgcca aatattttt ttaaagttt attggaaaa ggaggtgag gccctcatt gagatcaaa acgccagga tttagacca cttttccat agaattgtg aaaaagtat gaagccgac acaaaacga atcagcttc gtttcgacg ttcaactct gacaatggc attgaaaaa aactttttt cgttga
- >TC003976 RA
taagaccac caaaatgct gtccctaaa cctttccca gttttttgt attcgaatt tctcacaac tctcgacaa gatgcttga taaaagagt taccatcaa agttatcaa acctggaag tgtgattcg caaacgcaa aatcctcgg ttttacgtc tttcgatgt tggtaccat ctggttcca gaaagacca ccagttgta ccacaaatg ggcgattct cgcagcccc gagcaaaga ctatgctgg tggtaccag agggtacct caaactaga cgtcagtgt tttgtctaa aggtgaaat gcccaaaat tcccccaac tgtggatac caacgaaat tgaaggaaa ccttttcct accaagcgg agttaccac agaaaggca acgagtgat tttcatttt tgacgttta taaaggtgt tgatttggt caaaaagaa cccaattca ggagttaaa acgggcgga aaacgcacc aagtactac catcgaaat ttgtttttc tggtgttag tgttaaaac tagtaccaa aaagggttc aattgctcc aaattggaa cgaacgttt ggtactacc tgaactgtt ccctcctct ttgccaacg gtttcgaat ccagttgta ccatgatgg taccatacg atccacttg ctacctaaa ccttaaaag catctcaaa tgataagga agagggttt tttgcccac ttttgggcc cgcttttct tcatttcta ctcccccaa tcacttgga gggttactt gggcaaggt acttctagc tctccagac ctctctatt gggcgaaat agcagaata cgaagtcaa acatagcac aatttaccc cgaagctcc tcttctaaa ggaagaaac gttcctcaa atatgaaaa tttcgtctt gcacgctac aatttttga ggccacgat gattaataa gaaattttc ggataaagc gatctcgtt tcggatttc ttgtggtcc tcttcagag cgacgctag tggtgataa aatcgctgc gatggtcac accaccaat gaaaccaaa agtaatgaa caaaaacta ctgctactt gcccataac tgggaagaa agcttgcat ttttgtgac tttgtcgtt gcctgatgt taggaaacg aatgtttaa ttataattt tttgagcaa aatattgaa agatttgaa gtcaaggtt agacaaaat cgagtatat tgtccaaaa caaagacta tgacattgc aagtgcaca gactgaagc tctcctgtt agagacagc cgatttcat ttcttttgt ctctggaaa atatctcga tatagtatc gagttatag tctcactga ggagacttt tctcgacca aaggcggat caaaatgtg cctgaaaga gatggaatc ggtgaatgt ggtggcaaa gtcggtgtc aggcgagca aaacaagaa gaaaatctt ccagaaggt tgaaaaaat ctataccaa gatcgaaag tttggtcga tgatttgga agattggcc tttgattta tttatggat gatctatgg tgccaaaag agtggcata tttgttcct ccaacctcg agactttct tcactccac agttgacga agagaaagg aactcattg tgggaaatt acgcccgtt ttatttcca agcagaaga ctctcaaga acttcccga aatcataac aagtgtttg caaaatgga cgccatcat ctggatcgg tttaccacg acatttgac cacttacca acctcaagg tttcacatt ttcacacga aaccatccc tcgttcgtt gaaaaccca agaaatgta ccattttga ggcccgggt tcatatctt ccaagggag gtttacccc agggtcgga caaaagtgg tctttctga cccttttgt tcacgttat tatctcgtc ccagtttaa ggaaactca agttttgca aaaaacctt aaacccggt ttgggatca aaccctcgt ttttagaaa tgtagaatt gtatggaaa tcgtgattt tatcactgc taatccacc aagtgtctt tatcgaaat ttttgacaa ggatgagtg tcaacaaat cgaagttat tggcaaatg tgttcttag accaattat caaaacgct taaggggga acaaggatc aggttctct tagactcac ttggtatcg cgtccataa tgtgtttga tgtgagtgc cgaaatttt ggcagccgc tgaactcct tgaagttac ggcaaaaac tgcagaaac acgtcgtga ccaaatcgt taaaatacc accagaaat caagccaca cttgatcag ccatcgaat cgaagtggt tttttgggg agtcaggga cttgaaaaa ggtccaaat ggcccaaat caccaaacc taaggttgt ggtcgaact tggcaccaa tttggtgtc ttccgacac tctagcaaa tgccaaaaa acacctaaa ctttacaaa cccgatcaa gtcaattga agcaagttt tgcagaaga ggaagaata cgcccccac tttgtcttt aaaaatgta cgatagtcg aaattttgg tattagtgt gtttgctgg cacgcacat catgccaat gcaaatgtt cttctacca accccaaac cacagacga acggcattt aaagttgat gactgtgcg aagaaattc gcttgattt tgacgaatc catcgagtc actgataca aaaattgga tgcacagtc cggaaccaa aatccattt tgagaaaaa actaacgtc agaaagcaa gtggcggaa gtttttcga ctgtttgac ttgcagaag gcgcaaaaa accaccacc acccaaacc actagagtt ggaacaacc ggagcttga agatagtag cgattttga ctggtggac aaaatttta cgcctcctt ggaggaaac tcctcttac agggaaaat accactgag tcacaagta caagttgaa agtctactc tcacgagct tgagcaaca gccggaatt tgagggttt ttgtgacac tttacgctc ctttgaaat gtataaagg gaagagaac tggagacga agccgtcga tgaagccaa cacgactgg ggtttttaa gggcgcttt gagaatcta tcagtggcc tttaaacgg cgacgattt tgtcacacc gactggttt acctctaca aggtggaat tttccaaga ctttcccac aaatacccc aataaattt tgttttgag ggtttattg cgtccgagg gttgaattt aagaccaaa ggacatctc tggcaagtc tgaccctta cctccacct aaccctcaa ccaaagtgt gatcaacga caagcaaaa ctgcattaa acgacaaat taacccgat ttttggccg ttgttttga gtttaatgg gatttttcc acaagacca cactttggt aattgcagt caaagactg ggacgctgt tagtgccga cgatctgat cgggcaaac gaaaatcga cttggaaaa tcgctttta tagcaaaca tcgcggtca ttgtggctt agctgcaga ctacttgac tgtaggtta ttgtcaatg gagagacca gcaaaaacc aagcacgat tttggaaaa tctgtgcaa aaaatacaa tatccccga cttggagta caaggagaa gtccataat tgtaggacc acaggaatt tttcttgga taatcagaa tgtggattt gaggcacca agccttggc attgttggc tttgaagcg ctgggctga agtaccatt ggttgggtg cgtcctagt accggaaca tgttgagac taggtcgtt gtttcaccc ccaaaggcc tggagttga acagggaaa attacaatt gtggcttga tattttacc agtaaccga ttttccaac tcctcggca agttaccat aactccaag aaaaccggt ttcgtacga attgagggt cattgtgtg gaacgccga agggattat tttagaaga gaaagatat tttaacagg ggagaagaa agccgatgt ttatgttaa agggtggct tactggtcc aaacacagc ccagtacac agatgtcca ctatagaat cttatcagg ggaagctat gttcaattg gaggttcat ttttccatt tcagtatct ttcaactga gaacaaaat cgttcaaaa acataaaac tgtgtttga agaaagtga agaaaaaat cccctgtaa actaacgat ccaggcgtg ggaaaacga cgctttctc ccctgatga tttcctagg tgttgtcac tttggaact atcaaggct tcatcgagg cgcaagtct attccgaaa ttgctcacc agctctaac caaacctaa cgctccagt cctaaacct gttcaaaat tcgcagaac taggggttg gtggccgtt gaaaaacgt cgatactcg cacccggaa ggaagtatt tgcaggtgg tgttgagct agagtttga attgttgac aaaggagga agctgaaag gaatccagc tggacttgg aaggcgtga accacaagg actaccaaa accaaatcg tcctgatac ttcgttttc ctggttttg gaacccatg gagggcgat taagtatac gcttaagtt ttacaagaa gaaaattat caagtttat tattatcgt gattgtggt tgctgttac tgtgtacct gttgtatcg ctttggcga gtttggctg ggaaaagct aatggtgca gttaaaaaa atccccggt gttgctatt agcaattct atgttccat ctgtgttgg agagctaac agatcggga attgtcagt tttgtgtcc gaaaggaat taaatgtgt gactagtaa aacgtttat tttttgcga gaacaataa tatttttct cgcttatgg caaaaaaat ttttgcctg tgaagaaaa ttttgtttg tgatgagca agatccata caatggttg tgtgcatca aaagtttta caaagattt aacccaaga taagacgaa gattgttgt tgatattaa tatcgtcga taaggataa aaagaaagg cgagaattg ttcatctga tgatgattt tccgataga tggaagcct aactaagtt atctccacc gttagattc taacttggt ggaaaaacc tactaataa ttccaactc gtctcaaga atctgtcac tgattctaa tttagtaaa caaatctac cactctaaa gaatgatga agatggtaa agaaacaac tccagtttt gtcatccga taccatatt tcgccctaa accttttaa ctcatcatc tacagatgt tccatttag tgacaaaaa cacaaagaa aaatcctga ttttccact agaagccag tactttacc tagccacat agatgaaaa aaaagcatc tactgttgc atattcacc aaaggaggc tcttcagtc tgtcaaatt accagcaat taataaacc aactacgag tgaagatca cactgtttc aacttctaa agttagtac tccacctac tgatgctag cgataaaaa atctactca aggtgatgt aacaaatga accgtcaga tacgagttc gtcagagga atcttctgc tgatttcaa ttcagaaga ggatgatga cgatgacga tggtactct agataatgt atcatccga tactacatt ccgacctga atcctatcc tagacaacc aaatggtat ttttagacc accatcgca agctgtgca accaacaga tacagaaaa ccaagaaat cccatcaga tgaccgtaa tccatttag taacaaagg agaaaaaac acctgattt tccactaga agccagtac tttatccag ccacataga taaagaaaa agcatctac tgtagcata ttcaccaga agaagctct tcagtctgt caaattacc agcaattaa taaaccaac tacgagtga agatcacac tgtttcaac ttctaaagt tagtactcc acctacaga tgctagtga taaaaaaat tactcaagg tgatgttac aaatgaatc attagatac aagttcgtc ggaggaatc ttctgctga ttccaattc agaagagga tgatgacga tggcacttt agataatgt ttcatctga tactaaact tccacctga atcccatcc tagacaacc aaatggtat ttttagacc acaatctaa atctgtgca accaacaga tatagaaaa ccaagaaat ctcattaga tgatcgtaa tccatttag taacaaagg aggaaaaaa acctgattt tccactaga agctagtac tttagctag caacacaga tgaccaaga agcatctac agaagcaca ttcactgga agaagttcc tgaggatgt cttatcacc agttactaa taaaccact tacgtacca acatcacat cgttgtatc taataaagt tagtactac agttaccga cgccagcga tgaaaaatc tagtacagg tgatgcaac aaatgaatc attagagtc gtcggaaga atccacaac tgatctgaa ttcaaaaga gaaagatga taatatgct tcgacccga ctctaaacc aaaacaaaa tggtatttt tagaccaca tcctaaacc agaaaaagt gcaaccatc agaaaacca taatccatt tagtaacaa accggggaa aaaaccata ttctccact agaaaccag tactttgtc taacaacac agataaaga taaagcttc cctagtacc acagttacc agaaaacga tctccagtt tgttacatt tagtacact accatctgt ggaccacga tcgtactgg tttactatc tactctacc cactgctga agaaaccac ttctgatat tacaacacc acttcaaat caaagaaaa cgatggtac tattgaacg accacaaaa cccaaccaa ttctatttt tcggccaaa gccgcctga aagtactac tccttgtca aaataatat atttcgacc taaaccaca caaaccaca taacgatag tcaaacaaa ttctgacaa gctttcgtc aaaatcaga aaatgatat agattttcc cgtagaagc cagtacttt accaaatga aaaaacgac agtacctct accaacgga agaagatga taaatttgt aagagctag tacaatacc aagtgataa agcaagtaa caatgaacc aagtttgat tgaagacga tacatctgt gtttcttga aagtagtac tctaccaac gaatctaga agataaaaa ccagcaatc ttcagatgt tcttttctc acatgaggt tagtactcc accaaattc tgacagtaa aatcactac atctcaaac gagtaattt ggtagatag tactttgtc tagcgataa atcagaagt agaagtacc aacagaacc acccatgaa taaggaggt tccagatgg tcaacctaa aatttcaaa accaagttt catatttag gcctaaaat tctttcacc gaaaaattt tactaaacc tgatacgaa acaggaaca tccagatgt ttatttttc atctgtgtt tacaactcc accaaatga acccaccac tttgctaac tgataaagg agaagaaga aatacctac tgaaattcc accaccaga atttttcaa agatactag cacaatacc tagtttgaa tgaagaagc tacatcttt aaattttga aattagcac taggaatcc agtcagtac tgatgatca aagttctat atttcggcc aaaaattca agtaccaaa gaattttac tgaacctga taagtatca tgataatcc agatattga tatcccttc tgtgtttac cactccacc aaatcataa aagttctga aactgaacc tactacact tcaaatggc ggatgattc tgatttttt catggaagc tagtacttt acctaatga taaacaagg agaagaaat atttactga acttccacc accacaaga agacaccac cacgtattt caaagcgag tgataaaga taatgataa agtaccaga tttggatga agaaactac gtctctgaa cgatgacga tagtactgt acctacgaa tctaattaa taatgaaga aactccaca aaagaatct tgatagtcc acctaaact ctcaccacc aagtgcgat atttagacc taaagttca tgcatctaa aaatttgac agattctga taaggatca tcaaaatcc cgatgttta ttttccatc tgtatttac tactccacc aaatcaaaa aaattctga aaatgaacc cactacact tcaatcagc agatgattc tgattttta tgtggaagc tagtacttt gcctaatga cagacaaga agaaggata ttttataga attttcacc accacaaga agacaacac attttacga agatagtac aagaccgag taataaaga tagtgataa agcaccagg tttggatga agaaactac gtcattgag cgttgaaat tagtactgt atctacgaa tctaattaa taatgaaga aaatccaga agagaattt tgatagtac acctaaaat acgaccacc aagttcgat atttaggcc aaaagttaa tgcacctaa aaattctac aaattttga taacaaaaa tcaaaatcc agaggttta tttttcatc tgttttcac gactccacc aaatcaaga ttctgaaag tgaacccac tacacttca aacggcaga tgattctga tgtttttgt ggaaacctc tactttgcc taatgataa acaagaaga agaatattt tacagaact tccaccacc acaagaaca caccactat tttcaaaga ttctacaaa accgagtga caaagatac agattggcg tgaagaaac tacgtcttt gaatcttga aaactcaac gccaagctt agaatctcg acctgtttc tatatttag accgaaaat acatacacc aaaaaatgt tgctgaacc tgataagga taaaaaaat tccagatga gtttttctc acctcagta tagtactcc accaagtga agtaaattc agaaaaagg aaacatcac accagattt ttctgcaga agctagtac gccatttag tgacacatc tgaagaaag aacagattc ccaatttgt tgaagctag taccttagc caataatat ggatgaaac cgaaaatca aaacactgt attacctac aaatttacc agatgaaga aagtgcttc caatgatct tcaaagtca agaagattc tcccattta tcgaccatt gcaagaaaa taaaccaca aattagtcc acccaaacc tgtttctcc agataaccc tgatatcat atttagacc taaaatccc aatattaca aaatcgaac tgacgataa gttgaatca aagtacacc aggagttag tacaccacc agcaaaaaa tattgaaaa cgaaccaag tacaccaga gaaagattt tgatttttt ggttgaaac tagtactct tccttatga tttattgaa aaataacac aactttgaa accgtttga cgaagatct tcaatttaa cgaatttaa taccgtgcc aaataatat agacgataa agagtattt ggacaagga tgttacttt agtacctcc taacagtac tccatcgaa taatgaaaa taatgaaga cagtacaga aagtgataa tgtaacgct ttcgccatc taccccaca acctgtttc tcaacctaa ctcaatata tcggcctaa acctaaacc caagcctaa acttctacc tggagttaa tactgtacc cagcgtaac aactgagaa aattgctca actcccgga agaagatcc tcaatttgt cgaatacag tactgtccc caatctgga taaagtaag tacttttgt gccacctga aaaaagtac tccacccac atatacaga caaggataa cttacttga acctagtgc acctccaga aatgaatcc aactgaaat actacttag cgatgatag tgtaactga tagtttaac agccttgcc acccaaaac tgaaagttt tacaacaca acctagttc taaaccaga agtgatata tcggcctaa acctaaacc aaatctaag taacagtac tatcttccg acctccgct gtatttacc acaagagga accagatcc cgaaaagtt aaaagagga agaaagaaa cattttatt ttcacctga agttagtac tttagctaa catcccatg tgataatga agcaacgac agtacttca actaccaga gaaaaatgt ccaattttc tgagtatag taccattca aagtgaaac agaactaag ttcaggtca acacgaaac aagtactcc actctcatc tagagatac tgaagaaga actgactag tactgatgt agtttcaac gtcgccacc tattgaaaa ttctacacc acaacttga agtaatata tcgacctaa acctaaacc tcagcctaa gccaactaa accaactga aatatcaac tgtgcttca accatctga agaggatct tcaatttta cgaatatag tactattcc taatgtgga cagtaaagt tccaaatcc acaaaaacc agtaaaacc taaaccaaa acctagtga aaacattat tttccgacc ggcactttc cataccaac aaaagaaaa agaaaacga aaagttaga tcaggaaga acaaggcat tctatttcc acctgaggt tagtactct acctaatat tccacgtga caatgaagc aacgacagt tcttcaact gctagaaac agatttcca gttttctga attcagtac catacctaa caatattca aagtgaaac agatctaag ttcaagtca agacgaaat aagtactcc acctacaac tagagacac tgaagaaga actaactag ctctgatgt agcttcaac gtctccacc aatcgaaaa ttctacacc atatcctga agtagtata tcggcctaa acctaaacc tcagcctaa gccaactaa accaactga aacatcaac tgtgcttca accatctga agaggatct tcaatttta cgaatatag tactattcc taatgtgga cagtaaagt tccaaatcc acaaaaacc agtaaaacc taatccaaa acccagtga aaacattat tttccgacc ggcactcct cgtaccacc aaaagaaaa agaaatcga aaagttaga tcaagaaga acaaggcat tatgtttcc acctgaagt cagtacttt acctccatg tgataataa atcatctac agtacctca acgttcaga agatgactt tcaagattt cgagtttag taccatacc aaattttgg cactacaga ccaagagga aacatttgc aacaactga aagaactac tccacctac ttttacaga agataaaac tacagaaaa aatatcgtt ttccacatt gcaacctga tgcaacgct tagacctaa acctaaacc aaatggaac tactatctt tcggcctaa actccgtat acctccgaa agaaaaggg atctgattc taccattat aacaagcga tacatttga aataccaga tttaccaga aaaagatca tcaattttc tgaatctag taccatgcc aaatgctat agataatga taacactag tctagaaca agaagttga caaaggccc agaaaaacc aactggtga caatgatat tccaagttc acctaatga aaccatatt tcggccgaa acttcataa acaaataaa ttctacgaa agccgaaca aacagatac tctatttcc acctgaagt tagtactct ttccagcag gacagaggg tagtactct acctattga cagtgacat acaaacaac tctacggcc attcgaaat taatacagt gcttaatga taaaaatga gcaaattac agaaatttt tccttctca atatactac agtacctac atttgatac aataactga catggtaca agaagttag tactttacc tagtaagac tacaatgtt gaatgacca taaagaaag taacaaatc ccttcaaga gcctccagt gaagaaaaa agatgataa tttcatgga ttcgcaagt aactactct aaacagtaa aaaagacta taaaaaaac accaccaaa agaagatga agtcttttt cgctcaccc aagtactct gaaaccaaa caaaaaaga cagttacgc acacccaac tactctaaa accaaaaaa agaagagtc tgtcactaa tctaagtac tcctccaag tggcaataa aactaaaga aactataaa aatttctaa tacacaaaa atcacagaa tcatacaaa actatcaca cagcaaaac caaaaaacc tcctcttcg ccacaatac gtcaagtga agaaagtga cgaaagtga cgaaagtgg tgaaacatc aattaatat cgaaaactc acaatcact acaagccaa tattaacat tgggagtgg tgataattt aactgctga taaggagag aaataaccg tccaaatcc ttttgaacc aaaaccaag tcaagacaa taaaaaatc atacggcac ttctgttaa aattgaaaa ctctcaaaa tttaaatct taatattaa cactggtaa ggaaacact taacacgaa gaacagtaa cctctctaa tgctactgg tagtgctac tgataaagg tcgaggtgg tgaaagtaa taaagaatc ttctaacac ttctgtaaa tgtagaaaa cgcccaaaa attaaatgt aaatgtcaa tagtgatgg acagacaat ttcccattc gaataacaa ctcaaaacc aacagcaca gaacaattc actttcaaa cgctatcgg cagtggtcc taataaaaa cgtctcaag tggaaaatt tgaccacac atctgtgaa tattgaaaa cacgcaatc actaaatgt aaatattaa taccggtga tcgacaaaa cacaaaaaa taatcttcc aaatgcttc tggtggtga tgatatgaa agctgtact aaaaactac tcttctttc atctattga ctcaagtaa tgtgaagaa gaaaacgcc tgtaaaact tgccccttt ttctggtac aaaaaacaa aaatcgtct tccggctgg taaaccaaa tgaagtaaa caatgatcc tacagaact atcaataaa agaagtcag aggtgacta caccaagac cattagtag ctatgagaa gaataaaag tagtccaaa acgtcctca gcttttatc agttaaaac acatatcaa gaaacctac aaaatcatc aatagagaa taatacagt gagaccaaa ccgttttac tcttccatc taacgatcc aactgaagt ttacaacga ttatcccac agaactagc aagaaatat atatccaaa tgctgttgg tagttatga tgaaagtaa tctgttaaa taaactaac tgtatcaag tgaagatga cgacaacga tgacactaa agttggacc aagcaaact aaattacga taatcctga aaaatcacc agttgataa agttaatag tcttgacaa gaatagagg tagaacaaa acgtcctaa aatttcatc tgattctct aagtcaagg agataatcc tacaaaacc agcatcaac tgaaatgaa ggatcacgt tcaaaagtc cattgcgag ttatggcaa gaataaaaa tacaccaaa agaaagtaa aacaaagca aaaatattc tcaaacttc tgacataat aaaaaacga aagtatcga caatttaaa ggaaccaca aacaaacag tggaattaa tgagagtga agaaaatgt agctaatca catttattt gcgtgaaaa agcaaaact acctccaac tgacgtcga agatgcaaa aaccacaaa actggattc agaaactgt gagccagga atcagaaaa cttaagttt gtccacgga ggaagaacg tgagatagt ttttgtcga gttccacaa gagaaaaga tcaagaatc tctggtata cagtgttaa agtcgatct gcaaaaaca cagtctttc tgactatat cccaagaac tcgctttga agaaatcaa aattacaac agggtttgt ttatcagtt gctcaacaa acacatcgg acctattca ccgcatgag accgtacaa actcacttt ccgtaacca gatatacga gttgggtga aaatcttct agctggtac ttcaaatat ggaagagtt ccaagtatc agttggtac tttaactga aatcgaaga tggtgtttt cagaggcga aaaactgaa atatctcaa cctgagaga caacaaaat ttctgaaat cgcgtcaca tgcctttga cgatatgac acagcttac gaaaatttc tctcatcaa taaccaatt ggcggaata caacccgaa ttggttcca caactgtcc gaagcttca gacaatact tttgagtta caacaagat cagaacttt gccgccttt tgctttcaa aaacttaaa tctcaatct gcatttccg aatattttt ggattacaa tgagattac cactattag tgactcaac attcctcaa aagtcctgc aaacagctt aaaccctca atattttga caacttgcg taaaaaagg gtttaggat tcacttgaa aggcaaccg attgaaatg tgtgactga agacgtgtc gaaaacttt cgtcgccaa agtcattac tatgaagag aaatccctt cacgtgcga atgccagag gaaaattct taaatggaa gaaaacaca ccccagaat tcaaattta tttagacta caacacgtt cattttatc ctcatttaa gcacaatat gaggttttt ttggctgtt ccttgcaac tttttgttt agcaaaagc ttccctttt ctcgcaata tgttaaact gtacgaaga taaaaaacc gccaaatat ttttttaaa gtttattgg aaaaggagg tgaggccct cattgagat caaaacgcc aggatttag accactttt ccatagaat tgtgaaaaa gtatgaagc cgacacaaa acgaatcag cttcgtttc gacgttcaa ctctgacaa tggcattga aaaaaactt ttttcgttg aataatttt ttggtgttc agtcaaggc tatcctttg atataatta ataattatt taataaact aacttgtta atg
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