Status
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Gene information
General information
TC002881 Gene

The sequence from the iB fragment is matched against the genes from the official gene set. The matche(s) is/are visualizied in a genome browser.

NC_007418.3: 7521922..7535717
Sequence information
Transcripts / Proteins (1) Get mRNA sequence
Get CDS sequence
Get protein sequence
Ortholog information (from OrthoDB)

The information about the homolog genes in Drosophila is provided by OrthoDB http://www.orthodb.org/. The homologs are sorted according to their similarity score. For an orthology statement additional analysis are required.
The data basis for the orthologs is OrthoDB v9 containing OGS3 for Tribolium castaneum and 2015_04 (r6.07) for Drosophila melanogaster.

Closest fly homologs
    TC002881
    Gene ontology

    GO terms for Tribolium

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    There are no GO terms for Tribolium at the moment. You can help the community by providing some GO terms for this gene.


    GO terms for the homologous Drosophila genes


    Assign a GO term to this Tribolium gene by filling in the fields. Repeat to add several GO terms. Search AmiGO for the correct GO ID. Use only the most specific term - use "graph views" to browse related terms ("child terms" are more specific; the more general "parent" terms will be automatically linked). Only information based on Tribolium data should be entered - do not define terms just based on Drosophila knowledge. We will review this information and submit the annotation to the Gene Ontology consortium.


    Gene
    {{ goGene }}
    The Tribolium gene the GO term is assigned to.
    GO ID *
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    The ID of the GO term you assign to the gene. Please enter only the ID of the GO term with proceeding 'GO:'. This information is mandatory.
    Evidence
    {{ blurEvidenceResult }}
    The evidence code describes with which method the function or location, expressed by the GO term, was show for this gene. Please refer to this page for a definition of the evidence code and a decision tree.
    Reference *
    {{ blurReferenceResult }}
    The reference where the function or location is described for the gene. Please enter a PubMed ID. This information is mandatory.
    Quotation
    If you paste here the relevant section of the reference it is for us a great help to review your annotation. The quotation may be also be displayed to the users of iBeetle-Base.
    Name
    You may enter your name. The contact information can help us to clarify any questions. If you agree, we may show your name on this page to honor your contribution.
    Email
    We will use your email address only for possible questions regarding this annotation. We will never show your address or give it away.
    Publish name
    If you have entered your name and agree by marking the checkbox. we might show your name on this page to honor your contribution.
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    * : mandatory fields
    For help on how to submit larger datasets or non experimental data please contact us.
    iBeetle screen iB_00462

    Attention! iBeetle is a first pass screen. Hence, the documented phenotypes need to be confirmed by independent experiments using non-overlapping dsRNA fragments! Phenotypes with a penetrance > 50% are frequently reproduced. See Schmitt-Engel et al. 2015 for details on reproducibility.

    iB sequence
    Phenotype after pupal injection
    Usually 10 injected animals

    Pupal injection procedure

    Day 0: 10 female pupae of the pBA19 strain (muscle enhancer trap line) were injected with dsRNA.

    3 days post injection (dpi): Hatch control: Pupal and adult lethality as well as metamorphosis defects (molting, eclosion) were documented. For mating, 4 males of the black strain were added.

    9 dpi: First egg-lay was collected and incubated for cuticle analysis. Adult lethality and egg production (reduced/ no egg-lay) was documented.

    11 dpi: Second egg-lay was collected and incubated for embryonic muscle analysis. Adult lethality and egg production (reduced/ no egg-lay) were documented.

    Note: The adult morphology was not analyzed systematically at 3/9/11 dpi. Only obvious phenotypes, visible without magnification, have been annotated.

    13 dpi: Egg productivity and Ovary analysis
    The percentage of hatched larvae was documented and not hatched larvae/ eggs were embedded for cuticle analysis (15 dpi). In case of a reduction of egg production, 4 injected females were dissected to analyze the gross morphology of the ovaries.

    14 dpi: Analysis of embryonic musculature and early embryonic development
    Offspring of the injected females (hatched and not hatched larvae/ eggs) were analysed for embryonic lethality and muscle defects.

    15 dpi: Analysis of larval instar 1 cuticle
    Offspring of injected females were analysed and cuticle phenotypes were annotated.

    22 dpi: Stink gland analysis
    Documentation of defects in abdominal and thoracic stink glands (colour, size, content) of the injected femals.

    Terms used in the pupal injection procedure

    larval pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    empty eggs
    Just empty shells are visible, no cuticle has been developed.
    strong defects
    L1 cuticle larvae which show severe defects. These strong defects are subdivided into three categories
    strongly fragmented (cuticle crumbs)
    No segments or appendages are identifiable, only residues of cuticle and bristles can be identified.
    cuticle remnants (with unidentifiable segments)
    Segments or parts of appendages are recognizable, but identity is not clear.
    cuticle remnants (with some identifiable segments)
    At least one segment or appendage is clearly regonizable.
    number of eggs on slide
    affected embryos usually (not always) do not hatch. Only the not hatched were used for cuticle analysis.
    For the embryonic muscle analysis the hatched as well as the not hatched were analysed.
    total number of affected eggs/embryos/larvae
    Summary of all different phenotypes/ phenotypic series which were annotated.
    inside-out
    The L1 larva shows a partial or complete inversion., e.g. bristles, appendages or parts of the abdominal segments are inverted into the interior of the cuticle.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    Please see the help page for more information
    Metamorphosis and survival

    Lethality 11 days after pupal injection: 100.0% (includes death as pupa, adult)

    eclosion not fulfilled (with pupal and adult features) - Number of animals showing the phenotype: 1 (3 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 2 (9 dpi)
    Days post injection


    adult lethality - Number of animals showing the phenotype: 7 (11 dpi)
    Days post injection


    Phenotype after larval injection
    Usually 10 injected animals

    Larval injection procedure

    Day 0: 10 female L5-6 larvae of the D17Xhom strain (females express RFP in the eyes and in the CNS; pupae express GFP in the thorax) were injected with dsRNA.

    11 days post injection (dpi): Pupal morphology Documentation of larval/ pupal death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of pupal head and appendages, pupal thorax, pupal thoracic musculature, pupal legs, pupal wings, pupal abdomen and pupal genital lobes.

    16 dpi: Adult morphology Documentation of larval/ pupal and adult death and defects of metamorphosis (eclosion, delayed development). Screening for alterations of adult head and appendages, adult thorax, adult elytra and hindwings, adult legs and cuticle properties. For mating 4 males of the black strain were added.

    19 dpi: Sieving and egg-lay Documentation of adult lethality and enduring metamorphosis defects.

    22 dpi: Ovary analysis (Fertility) In case of a reduction of egg production 4 females were dissected and the gross morphology of the ovaries were analysed.

    41 dpi: Fertility and stink gland analysis Documentation of defects in abdominal and thoracic stink glands development (colour, size, content) of the injected females. Check for fertility of injected larvae (no or decreased offspring).

    Terms used in the larval injection procedure

    pupal/ adult pantagmatic defects
    At least two tagmata (head, thorax, abdomen or terminus) show similar/ comparable defects.
    pupal molt not fulfilled
    The hatching from the larva to the pupa is interrupted. Either it dies as prepupa or the phenotype shows larval as well as pupal features.
    eclosion not fulfilled
    The emergence of the adult from the pupa stage is interrupted. This phenotype shows pupal as well as adult features.
    starved
    Dissected females show a strong resorption of fatbody predominately in the abdomen and the oogenesis is blocked. These are considered as eventually lethal phenotypes and the blocked oogenesis probably a secondary defect due to starvation.
    Metamorphosis and survival

    Lethalities 11 days after larval injection: 100.0% (includes death as larva, prepupa, pupa)
    Lethalities 22 days after larval injection: 100.0% (includes death as larva, prepupa, pupa, adult)

    larva lethality early (L5/6) - Number of animals showing the phenotype: 6 (11 dpi)
    Days post injection


    pupation not fulfilled (died as prepupa) - Number of animals showing the phenotype: 4 (11 dpi)
    Days post injection


    remarks: later than schedule, hours 24
    Pupal morphology
    remarks: later than schedule, hours 24
    Adult morphology
    remarks: later than schedule, hours 24
    Fertility
    remarks: later than schedule, hours 24
    RNAi sequence
    Primers
    Left: Right:
    Protein sequence
    • >TC002881 RA
      MFPTRKADV DKHVEECLK KINNETERN LRCLSFAKQ 
      YFKIERFED ARRYVSTYL SARPNSAEA HCLLGKCLE 
      ALGRKEAAL QAYTTSLRL DSKQNNLVL KVCELLASD 
      DVEMDHSGA RYFCEMAQS FDPHNPAIF NLKQRILTS 
      ENDDPRDVS NLILKELET RPTDVKLRV RLLKHLLQH 
      HLVKEAYKH AADIEAKDL AIFCNVTWY EAVAEVLVK 
      YQRTVSLPN SLGWEFWFL SVSVLDKLA ALTLSETSE 
      NIKTTTEYI NAIFNFDQT LTKAALNIG DCPDKHLIQ 
      EFLNHHSAQ LCFHFVTLV FKQAQKDLI KYKEAANIT 
      LPLLFAAYH SQPPDLQSM WFNHAPENR RNLVRRWRK 
      EAAFRCSQA GHVLQAAAK DRKSILIEK ANQYSVGMW 
      REQLFKKLF VTRDQQLKM KTSYFLSDQ KLLEITIRL 
      PESGELLKY DEEAQLIFP DSLHHHIWI ALNNKLSDL 
      KCTVFEGLQ YSIKNLKNC GAETLNVLD VQAFIYCAT 
      LCSKYNQEN LRHISYYNL DKPNVLPAA VTQELGTHN 
      QNIFFKAAY KMYKNEYDS GLDQLRLTL VDGIKILRC 
      VDNSLDVKL LVTLAQTFA ERSKNTTKQ SEIEFNEAR 
      AELYYKAAL PILEKMKNN QAVSYPPNK LFNYKSKDM 
      PLTEICAHI EAAKLFSGC QLMKKKENE KALRIFETL 
      RDPYASFYQ AQIYKHMAD QQTSQNRES VTSEMRSQN 
      IILLSRARD CLYLTLDRL REPSVDQKH PLNEQLGTE 
      IEKIERLLS RIDPDCTNR NECDGMSDE NVSSPDSTG 
      DHYVTGYTG NTSSYFNGV FTPRAENHN HSTPYRSDL 
      FKREAKPSP ERLDAQLRQ LTASKDAAI NHILEHNKM 
      MMESHKTLV DELRSFKDA VNNLTVTVD ELKTVKHSY 
      EELKDVKKS VNELKASVD ELDSFKNIT DMVYEMKKE 
      LTELRKEVN KTGQLSDED IYGLANEYG AEYNLNSNL 
      AAYNSNFYQ NYQARMPGT SLYGPPPLY PGMYPPMAY 
      AYGGLGLPQ GGALPFPQE QIPGISGQD FRAISAALS 
      QVQQPAVTY GQTTPQTGL NLLTAQAQG ISTPNPLFK 
      TTPATSQSV FPTIGGVTV TTTPTTKAP PVNVVITAS 
      DPLPTPKVT TTQPILSVT IPPQHLKGN VPKSQPHNY 
      QIPLPTTTA PNTSPSVLS KPPPAISTQ SILSNVAPP 
      VYSAVSDKT PVNVSLGLQ IEKTLEQSY NASKNESLN 
      KSNVSTSSL EEHDPCPDF KPIIPLPDE VPVVTGEEN 
      DVVLFCERA RLFRYVTET KEWKERGVG TLKILKNPE 
      TKKVRILMR RDQVHKICA NHFITKEMA LTPNAKCDR 
      AYIWAAHDY ADEEVVLEK LCVRFKTSE EAKKFYDVF 
      EAAKKGLDT EESKEAAPK PASLGGFVF TSTPTFKPK 
      EEKVVIPVM KEEPVKASP FSNFVFGST KNTSFPTFQ 
      TNFSPVQKQ SESPGGKAK EPVDDETEE FVPTAEFKP 
      VVPLPELVE VKTGEENCE VLFESRAKI LRFDTSEET 
      KVWKEKGVG VFKLLKDAT TIRLVMRRD QVLKVCCNH 
      QLLKNMEFK FMTNNPKAL TWCAKDFSE GVLKPETLA 
      IRFKTEELA NSFLKAIQT AQESLDENN CVSGKTPKI 
      ESPVKPTGF GDKFKPAKG SWECKNCFV VNDGKANYC 
      VACETPKND TVPKKSESD ASGAAFSFG VGVSNSWGN 
      AFKPKEGSW ECKTCYIRN DADKTHCMS CESPKDDTI 
      PKKEPEKGV NLDTGGLKF TFGVPKTAD KPTTGWGDL 
      FKPKEGSWE CKNCLIQNN SDVVYCVAC ESPKDDTVP 
      KKEGPKGVN LDTPGQKYT FGIPSTQAG AKATFTFGQ 
      SSISTEKPF VFKPNVSVE KKDTSATEK FVFGSPQKH 
      DFEFTPRSP RRISSGGKD EESDASYVE EEADNIYFK 
      PVIPLPDKV EVKTGEEEE DVLYCHRAK LYRFVDKEW 
      KERGIGDLK ILRRKDTGK LRVLMRREQ VFKICLNHI 
      LTTDIKYLP KDDKTWLFH ASDYSEGEI TEEQFCLRF 
      KNAEIAQEF MKAVNDALS GASCDTGKK IDETSEGED 
      VEFISETKV TPEEEKEAL RLMLPPKFM SYRQLPDCQ 
      CAQCKKDDE YLKDLFKTS DQKSTATPP ISQIFKNSN 
      TPSISTSSS TSSIFTTPK EEVFSFKAA TETVSSPAD 
      SSLTLKSLL SKPSLLVTP VTTSSGIFS SANNSSNIF 
      SSPATSSNL FGSKSPSIF QTASETKNE SFTFGAKTP 
      DTTSSSIFA PPTTAAKST GSIFGSGSV FGSGGGSIF 
      GSKSTPVFG SGPGIFAAT TPTTTAQSS GIFGGATTT 
      SSFKTTGSL FGTPATTTT GSIFGGSPA VFGKGTNKP 
      IFGGGDSLA KATESPVRP VFGAAVAPT DVKTTNLKD 
      EDAPVLNAE SGITFASLA AKSTEKPAF AKEKNDSET 
      PFAFLGAGA PVFGSATPD KSKSVASEE AEGGGDEEY 
      DPHYDPIVP LPDAIVVST GEEDEEVLF NERARLYRF 
      DADNKEWKE RGVGQMKIL HHPINNTYR FLLRREQVH 
      KVVLNQLVI PDLELQPMT TSDKAWVWG GYNYTDDGS 
      ALEKLAVRF KNCDLAQSF YKVVQDVLD KVKKIQLEK 
      SKTETAGQV DLTKLIPSS IQNFGVEEV SGDEQAGKE 
      VSYEEEDDE EEEDDEDED DDRTVMFMK RCTLSEEVN 
      GEWKEVALG DLQVYYDPD LYAARICVS NDNGEIVSN 
      TVIEKNTVM ELDKNNCVW SAYDEWGDE YRNRTLRAT 
      FSSAAAAQE FHCNYVEGL NYAHEFDVV NEMPVATEE 
      ETESLGH
    CDS sequence
    • >TC002881 RA
      atgtttccc acaaggaaa gccgatgtc gataaacac 
      gttgaagaa tgcttgaag aagataaat aacgagaca 
      gagcgcaat cttcgttgc ctgtctttc gctaagcag 
      tatttcaaa atcgagcgt ttcgaggac gctcgtcgt 
      tacgtctcg acgtatctc agtgcaaga ccaaattct 
      gcagaagct cattgcttg ctgggcaaa tgcctggaa 
      gcactgggc cgtaaagaa gccgctctt caagcctac 
      acgaccagc cttcggctt gactccaaa caaaataat 
      ctcgtcctg aaagtttgc gaactctta gcctccgac 
      gacgtggaa atggaccat tccggtgct cggtacttt 
      tgcgaaatg gcccagtct ttcgaccct cacaatcct 
      gccatcttc aacctgaaa cagcgcatc ctcacgtcg 
      gaaaatgac gatcctcgt gatgtctcc aatctgatt 
      ttgaaggag ttagaaacg cggccgact gacgtcaag 
      ttgcgggtg cgtctgtta aaacatctc ctgcaacat 
      catttggtg aaagaggcg tacaagcat gctgcggat 
      attgaagcc aaagacttg gcgattttt tgcaatgtc 
      acttggtac gaagccgta gccgaggtc ttggtcaag 
      taccaaaga acggtttcg ttgcctaac tcgctcggt 
      tgggagttt tggtttttg tcggtctcc gttctggac 
      aaattggcc gcattgact ttgtccgaa accagcgaa 
      aatatcaaa actacaacc gaatacatc aatgcaata 
      tttaacttt gaccaaact ttgacaaaa gctgctctc 
      aacatcggc gattgtccc gacaaacac ctcattcaa 
      gaatttctg aatcaccac agcgcgcag ttgtgcttc 
      catttcgtc actttggtg tttaaacaa gcacaaaaa 
      gatcttatt aagtacaag gaagccgca aatatcact 
      ctaccgcta cttttcgcg gcttatcac tcacagcca 
      cccgatcta caaagcatg tggttcaac cacgcgcct 
      gaaaatcgc agaaatttg gtacggagg tggcgaaag 
      gaagccgcg ttcaggtgt tcacaagcc gggcatgtt 
      ttacaagcg gctgccaaa gaccggaag tcgatactc 
      atcgagaaa gccaaccag tattcagtg ggcatgtgg 
      cgagagcaa ttgtttaaa aaattgttc gtcacacgt 
      gaccaacaa ctgaaaatg aaaacaagt tactttttg 
      agcgaccaa aaactacta gaaatcaca ataaggttg 
      ccggaaagt ggcgaattg cttaaatac gacgaagag 
      gcacagttg atattcccc gactcttta caccaccac 
      atttggatc gcactgaat aacaaacta tccgatttg 
      aaatgcaca gtgttcgaa ggtttgcaa tactcgatc 
      aagaacctg aaaaattgc ggcgccgaa actctgaac 
      gtgttggac gtccaggcg tttatttac tgcgccacc 
      ttgtgttcc aaatacaat caggaaaat ctgcgccac 
      atttcgtac tacaatctc gacaaacct aacgtactt 
      ccggccgcc gtgacgcaa gagttgggc actcacaac 
      caaaatatt ttcttcaag gcggcctac aaaatgtac 
      aagaatgaa tacgactcc ggtttggat caactgaga 
      ctgactttg gtggacgga ataaaaatt ctccggtgt 
      gtggataac agtttagac gtcaagctt ctagtgaca 
      ctggcacag acattcgcc gaacggtcc aaaaacacg 
      acaaaacag tccgagatt gagtttaac gaggcgcga 
      gccgagctg tactacaaa gcggcgtta ccgattttg 
      gaaaaaatg aagaacaat caagcggtt tcgtacccc 
      cctaataaa ctgttcaat tacaagtcg aaagacatg 
      cctttgact gagatttgt gcccatatc gaggccgcg 
      aaattattc agcggttgc caactcatg aagaagaag 
      gagaacgaa aaagcgttg cgcattttc gaaactttg 
      agagacccg tatgcgagt ttttaccag gctcagatc 
      tacaaacac atggctgat caacaaacg agtcagaat 
      cgggagagt gtgacttcg gagatgcgc agtcagaat 
      ataatcctg ctctcgcgt gctagggat tgtctctac 
      ttgacgctg gatcggctt agggaaccg tcagtcgat 
      cagaagcac cccttaaac gaacagttg gggactgag 
      attgagaaa atcgagcgc ttgttgtct agaattgac 
      ccggactgt accaacagg aatgagtgt gatgggatg 
      tcggacgaa aacgtctca tcgcctgat agcaccggt 
      gatcactac gtaacggga tacactggc aatacttca 
      agttacttt aacggggtt tttacacca agggcggaa 
      aatcacaat cattccact ccttaccgg tccgatctt 
      ttcaaacgt gaggccaaa ccgagccct gaacgactc 
      gatgcccaa ttgagacag ctaacagcg tcgaaagac 
      gctgccatt aaccatatt ctagaacac aataaaatg 
      atgatggag tcgcacaaa accctagta gatgagttg 
      agaagtttc aaagacgct gttaataac ctcacggtg 
      actgtcgat gaacttaag acggtgaaa cacagttac 
      gaggagttg aaagacgtg aaaaagtcg gtgaacgaa 
      ttgaaggcg tctgtggac gaattggac agttttaag 
      aacatcacc gacatggtc tacgaaatg aagaaggaa 
      ctgacggag ttgaggaaa gaagttaac aagactgga 
      cagttaagt gatgaggat atctatggc ttggcgaac 
      gaatacggt gctgagtac aacttaaat tcgaacttg 
      gcggcttac aattcgaat ttctaccag aactatcag 
      gcgagaatg cccggaacg tcgctctat ggccctccg 
      cccttatac ccgggcatg tacccgccc atggcgtac 
      gcctacggc ggtctaggc ttgccccag ggcggtgcg 
      ttgccgttc cctcaggaa caaattccg ggaatttcc 
      gggcaggac ttccgcgcg atttccgcc gccttgtca 
      caagtgcaa caacctgca gtaacctac ggccaaact 
      acaccccaa actggcctt aacctactc acggctcag 
      gcgcaaggg atttccacc cctaaccca ttatttaag 
      accacgcca gccaccagt cagagtgtt ttcccgacg 
      attggaggt gttaccgtc acaacgaca cccacaacg 
      aaagcccct cctgtgaat gttgttatt acagcctct 
      gatcccttg cccacaccc aaggttacg accacccaa 
      cccatcctt tcagtcacc attccgccc caacatttg 
      aaaggcaac gtccccaaa agccaacct cacaattac 
      caaattccc ctcccgacc accacagcc cccaacacc 
      tcgccgtca gttttgagt aaaccaccg ccggccatt 
      tcaactcag agtattttg tcgaatgtc gcaccgccg 
      gtttactcc gccgtgtcg gataaaacc ccggtcaat 
      gtcagtctg ggcttgcaa atcgaaaaa accctcgaa 
      cagagttac aatgcgagc aagaacgag tcgttgaat 
      aagagcaac gtttcgacg agttcgctt gaagaacac 
      gacccgtgt cccgatttt aagccgatt attccgctt 
      ccggacgaa gttccggtt gtgaccggc gaggaaaac 
      gatgtggtg ttgttctgc gaacgcgct aggttgttc 
      cggtacgtc accgagact aaggagtgg aaggaacgc 
      ggtgtgggc actttgaag attttgaag aacccggaa 
      acgaagaaa gttcgcatt ttgatgcgc agagatcaa 
      gtgcataag atatgtgcc aatcatttt attacgaaa 
      gaaatggcg ctgactccg aatgccaag tgtgacagg 
      gcgtacatt tgggcggcg cacgattac gccgatgaa 
      gaagtcgtg ttggagaag ttgtgtgtg aggtttaag 
      acgtccgaa gaagcgaag aagttttac gatgtgttt 
      gaagcggcc aaaaagggg ttagacacc gaggaaagt 
      aaagaggcg gcgccaaaa cccgcctct cttggtggt 
      tttgttttc acgagcacg ccgactttt aagcccaag 
      gaggagaaa gttgtcata cctgttatg aaagaggag 
      ccggttaaa gctagtcct ttctcgaac tttgtgttc 
      ggttctacg aaaaacacg agttttccc acgttccaa 
      actaacttt tcaccagtt cagaaacaa agtgaaagc 
      ccaggtggc aaagctaag gaaccggtc gatgatgag 
      actgaagag tttgttcca acggctgag ttcaaacca 
      gtcgtgcct ttgcccgaa ttagtcgaa gtcaaaact 
      ggcgaagaa aattgcgaa gtcttgttt gagagccga 
      gcgaaaatc ctccgtttt gacacgagt gaagaaacg 
      aaagtatgg aaggagaaa ggagttggt gttttcaaa 
      ctgcttaag gacgcaaca accatcaga ctagtcatg 
      aggcgagac caagtcttg aaagtgtgt tgtaaccac 
      caactactc aaaaacatg gaatttaaa ttcatgaca 
      aataatccc aaagcactg acttggtgc gcgaaagac 
      ttctctgaa ggcgtcctt aaaccggaa acgctggct 
      ataagattc aaaacagaa gagctggct aattcgttc 
      ttgaaagcc atccaaacc gctcaagag tcactcgat 
      gaaaataac tgcgtgtcg ggtaaaacc ccgaaaatc 
      gaatctccg gttaaaccg accggtttc ggcgataag 
      ttcaaaccg gcgaaggga agttgggag tgtaaaaat 
      tgcttcgtt gtgaacgac ggcaaagcc aactactgt 
      gtggcttgc gagacacct aaaaacgac acagttccg 
      aaaaaaagc gagagtgac gcttctgga gctgcgttt 
      tctttcgga gttggcgtg tccaactcc tggggcaac 
      gccttcaag cctaaggaa ggttcatgg gagtgcaag 
      acttgctac atcagaaat gacgccgat aagacacac 
      tgtatgtcg tgtgaatcg cccaaagac gacacaatt 
      ccgaaaaaa gagcccgaa aagggggtg aatttggac 
      actggtggt ttgaaattc acgttcggg gttccgaaa 
      actgccgac aagccaacc accggctgg ggcgattta 
      ttcaagccc aaggaaggg tcttgggag tgtaagaat 
      tgtctaatc cagaacaat tccgatgtc gtttattgt 
      gtggcatgt gagagtccg aaagatgat acagttccg 
      aaaaaggaa ggtccgaaa ggtgtcaat ttggacact 
      ccgggtcag aaatacact ttcgggatt ccttcgact 
      caagccgga gctaaagcc acgtttact tttggccag 
      agtagcata tcaaccgag aaaccgttc gttttcaaa 
      cccaatgtc agtgtggag aaaaaagac acttcagcg 
      actgaaaaa ttcgtgttt ggctcgcca caaaagcac 
      gattttgaa ttcactccg cggtcaccc agacgtatc 
      agcagcggc ggtaaagac gaggagtct gatgccagt 
      tacgtggag gaagaggct gataatatt tacttcaaa 
      ccggtgatt ccgctcccg gataaggtt gaagtgaag 
      acgggtgag gaggaagag gacgtcttg tattgtcat 
      cgagcgaag ctttaccgt ttcgtggat aaggaatgg 
      aaggagaga ggaatcggt gatttgaag attttgagg 
      cggaaagat accggcaaa ttaagggtt ttgatgcgg 
      cgggagcaa gtgtttaag atttgtttg aaccatatt 
      ctcactact gacattaag tatttgccc aaggatgat 
      aagacatgg ctgttccat gcgtcggat tattccgaa 
      ggcgaaata accgaagaa caattttgt cttaggttt 
      aagaacgct gaaattgct caggaattt atgaaggct 
      gtgaacgat gctttgagt ggagcgtcc tgtgataca 
      ggcaagaaa attgatgaa acatccgaa ggggaagac 
      gtggaattc atttccgag acaaaagta acaccagaa 
      gaagaaaaa gaagctctc agattaatg ttgcctcca 
      aagtttatg tcttatcgt caattaccc gactgtcaa 
      tgcgcgcag tgcaaaaaa gacgacgaa tatttgaaa 
      gatctcttc aaaacgagc gaccaaaag tctaccgca 
      acccctcca atcagtcaa attttcaaa aattcgaat 
      acgccatct atcagtacg tcttctagc acaagttcg 
      attttcacg acaccgaaa gaagaagtg ttcagtttt 
      aaagcagct actgagaca gtatcatcg cctgccgat 
      agctcgctc actcttaaa agtcttcta agcaaaccg 
      tcacttctg gtcactcct gtaacaact tccagtgga 
      atattcagt tctgccaac aattcatcg aatatcttc 
      tcttctcct gccacctca agcaattta ttcggctca 
      aaatcgccc tcgattttt caaacggcc agtgaaacc 
      aagaacgaa tcgttcaca ttcggggct aaaacaccc 
      gacactacc tcttccagc attttcgcg ccgccaaca 
      acagctgcg aaatcaacc ggaagtatt ttcgggtcc 
      ggtagtgtg ttcggaagc ggtggcgga agcattttc 
      ggctcgaaa tcgacccca gttttcggt tcgggaccg 
      ggaattttc gctgctacg accccaacg accacagct 
      cagtctagt ggaattttt gggggtgca accactacg 
      agcagtttt aaaaccacg ggtagtctt tttggtact 
      ccggccaca accacaacg gggagtatt ttcgggggt 
      tcacctgca gtttttggt aaaggtaca aataagccg 
      atatttgga ggaggcgac agtctggcg aaagcgacc 
      gaatcgccc gtcagacct gtttttggt gctgcggtt 
      gcgccaacc gacgtcaaa acaacgaat ttgaaggat 
      gaggatgct ccggttttg aatgctgag tctggaatc 
      acgtttgca agcttggcg gccaaaagt acggaaaaa 
      ccggcgttc gccaaagag aaaaatgac tctgaaacc 
      ccatttgcg tttttgggt gccggggcc ccagttttt 
      ggctctgcc acccccgac aagagcaaa tcagtggct 
      tcagaagag gcagaaggt ggaggtgat gaggagtac 
      gatcctcat tacgacccc atagtgcct ctaccagac 
      gccattgtt gtttcaaca ggcgaggaa gacgaagaa 
      gtgcttttc aacgaacgg gcaagactg tacagattc 
      gacgctgat aataaagaa tggaaggaa agaggagtt 
      ggccaaatg aagattttg catcatcca atcaacaat 
      acttaccgg tttttgtta aggcgtgag caggtccac 
      aaagtggta cttaatcag ttagttatc ccagatttg 
      gagctccaa ccaatgacg acgtctgat aaagcctgg 
      gtctggggg ggctataat tacaccgac gatggttca 
      gctttagaa aagttggct gtgagattc aaaaactgc 
      gacttggcc caaagtttt tacaaagtt gtgcaagac 
      gtgcttgat aaagttaag aaaattcag ttggagaaa 
      tccaaaact gaaacagcg gggcaagtc gacttaacg 
      aaacttatt ccgtcttcg attcaaaat ttcggggtt 
      gaggaggtg agtggggac gagcaagcc ggtaaggaa 
      gtttcctac gaggaggag gacgatgag gaagaggag 
      gatgatgag gatgaggac gatgatcgt acagtgatg 
      ttcatgaaa cggtgtact ctcagtgaa gaggttaat 
      ggcgaatgg aaagaggta gctcttggt gacttgcaa 
      gtttattac gacccggat ctctatgcg gcaagaatt 
      tgcgttagc aacgataat ggtgaaatt gtgagcaat 
      acggttatt gaaaagaat accgtcatg gagttggat 
      aagaacaac tgcgtttgg agtgcgtac gatgagtgg 
      ggagatgaa taccggaac aggacactc agggctaca 
      ttcagcagc gcagcagct gcacaagaa tttcactgt 
      aactacgtg gaaggcttg aactacgcc catgagttc 
      gacgtggtg aatgaaatg ccggtagcg actgaggaa 
      gagactgaa tcgttaggt cattaa
    mRNA sequence
    • >TC002881 RA
      actgacgtc agttgtaag atggtggac gtccgttcg 
      tgcgttgtg aaatctcat gttgtaacg gttttataa 
      acgttttct aaaatttgt gaaattgct cgtttaaat 
      gtacgtttg agtggacgc ttttcaaaa tgtttccca 
      caaggaaag ccgatgtcg ataaacacg ttgaagaat 
      gcttgaaga agataaata acgagacag agcgcaatc 
      ttcgttgcc tgtctttcg ctaagcagt atttcaaaa 
      tcgagcgtt tcgaggacg ctcgtcgtt acgtctcga 
      cgtatctca gtgcaagac caaattctg cagaagctc 
      attgcttgc tgggcaaat gcctggaag cactgggcc 
      gtaaagaag ccgctcttc aagcctaca cgaccagcc 
      ttcggcttg actccaaac aaaataatc tcgtcctga 
      aagtttgcg aactcttag cctccgacg acgtggaaa 
      tggaccatt ccggtgctc ggtactttt gcgaaatgg 
      cccagtctt tcgaccctc acaatcctg ccatcttca 
      acctgaaac agcgcatcc tcacgtcgg aaaatgacg 
      atcctcgtg atgtctcca atctgattt tgaaggagt 
      tagaaacgc ggccgactg acgtcaagt tgcgggtgc 
      gtctgttaa aacatctcc tgcaacatc atttggtga 
      aagaggcgt acaagcatg ctgcggata ttgaagcca 
      aagacttgg cgatttttt gcaatgtca cttggtacg 
      aagccgtag ccgaggtct tggtcaagt accaaagaa 
      cggtttcgt tgcctaact cgctcggtt gggagtttt 
      ggtttttgt cggtctccg ttctggaca aattggccg 
      cattgactt tgtccgaaa ccagcgaaa atatcaaaa 
      ctacaaccg aatacatca atgcaatat ttaactttg 
      accaaactt tgacaaaag ctgctctca acatcggcg 
      attgtcccg acaaacacc tcattcaag aatttctga 
      atcaccaca gcgcgcagt tgtgcttcc atttcgtca 
      ctttggtgt ttaaacaag cacaaaaag atcttatta 
      agtacaagg aagccgcaa atatcactc taccgctac 
      ttttcgcgg cttatcact cacagccac ccgatctac 
      aaagcatgt ggttcaacc acgcgcctg aaaatcgca 
      gaaatttgg tacggaggt ggcgaaagg aagccgcgt 
      tcaggtgtt cacaagccg ggcatgttt tacaagcgg 
      ctgccaaag accggaagt cgatactca tcgagaaag 
      ccaaccagt attcagtgg gcatgtggc gagagcaat 
      tgtttaaaa aattgttcg tcacacgtg accaacaac 
      tgaaaatga aaacaagtt actttttga gcgaccaaa 
      aactactag aaatcacaa taaggttgc cggaaagtg 
      gcgaattgc ttaaatacg acgaagagg cacagttga 
      tattccccg actctttac accaccaca tttggatcg 
      cactgaata acaaactat ccgatttga aatgcacag 
      tgttcgaag gtttgcaat actcgatca agaacctga 
      aaaattgcg gcgccgaaa ctctgaacg tgttggacg 
      tccaggcgt ttatttact gcgccacct tgtgttcca 
      aatacaatc aggaaaatc tgcgccaca tttcgtact 
      acaatctcg acaaaccta acgtacttc cggccgccg 
      tgacgcaag agttgggca ctcacaacc aaaatattt 
      tcttcaagg cggcctaca aaatgtaca agaatgaat 
      acgactccg gtttggatc aactgagac tgactttgg 
      tggacggaa taaaaattc tccggtgtg tggataaca 
      gtttagacg tcaagcttc tagtgacac tggcacaga 
      cattcgccg aacggtcca aaaacacga caaaacagt 
      ccgagattg agtttaacg aggcgcgag ccgagctgt 
      actacaaag cggcgttac cgattttgg aaaaaatga 
      agaacaatc aagcggttt cgtaccccc ctaataaac 
      tgttcaatt acaagtcga aagacatgc ctttgactg 
      agatttgtg cccatatcg aggccgcga aattattca 
      gcggttgcc aactcatga agaagaagg agaacgaaa 
      aagcgttgc gcattttcg aaactttga gagacccgt 
      atgcgagtt tttaccagg ctcagatct acaaacaca 
      tggctgatc aacaaacga gtcagaatc gggagagtg 
      tgacttcgg agatgcgca gtcagaata taatcctgc 
      tctcgcgtg ctagggatt gtctctact tgacgctgg 
      atcggctta gggaaccgt cagtcgatc agaagcacc 
      ccttaaacg aacagttgg ggactgaga ttgagaaaa 
      tcgagcgct tgttgtcta gaattgacc cggactgta 
      ccaacagga atgagtgtg atgggatgt cggacgaaa 
      acgtctcat cgcctgata gcaccggtg atcactacg 
      taacgggat acactggca atacttcaa gttacttta 
      acggggttt ttacaccaa gggcggaaa atcacaatc 
      attccactc cttaccggt ccgatcttt tcaaacgtg 
      aggccaaac cgagccctg aacgactcg atgcccaat 
      tgagacagc taacagcgt cgaaagacg ctgccatta 
      accatattc tagaacaca ataaaatga tgatggagt 
      cgcacaaaa ccctagtag atgagttga gaagtttca 
      aagacgctg ttaataacc tcacggtga ctgtcgatg 
      aacttaaga cggtgaaac acagttacg aggagttga 
      aagacgtga aaaagtcgg tgaacgaat tgaaggcgt 
      ctgtggacg aattggaca gttttaaga acatcaccg 
      acatggtct acgaaatga agaaggaac tgacggagt 
      tgaggaaag aagttaaca agactggac agttaagtg 
      atgaggata tctatggct tggcgaacg aatacggtg 
      ctgagtaca acttaaatt cgaacttgg cggcttaca 
      attcgaatt tctaccaga actatcagg cgagaatgc 
      ccggaacgt cgctctatg gccctccgc ccttatacc 
      cgggcatgt acccgccca tggcgtacg cctacggcg 
      gtctaggct tgccccagg gcggtgcgt tgccgttcc 
      ctcaggaac aaattccgg gaatttccg ggcaggact 
      tccgcgcga tttccgccg ccttgtcac aagtgcaac 
      aacctgcag taacctacg gccaaacta caccccaaa 
      ctggcctta acctactca cggctcagg cgcaaggga 
      tttccaccc ctaacccat tatttaaga ccacgccag 
      ccaccagtc agagtgttt tcccgacga ttggaggtg 
      ttaccgtca caacgacac ccacaacga aagcccctc 
      ctgtgaatg ttgttatta cagcctctg atcccttgc 
      ccacaccca aggttacga ccacccaac ccatccttt 
      cagtcacca ttccgcccc aacatttga aaggcaacg 
      tccccaaaa gccaacctc acaattacc aaattcccc 
      tcccgacca ccacagccc ccaacacct cgccgtcag 
      ttttgagta aaccaccgc cggccattt caactcaga 
      gtattttgt cgaatgtcg caccgccgg tttactccg 
      ccgtgtcgg ataaaaccc cggtcaatg tcagtctgg 
      gcttgcaaa tcgaaaaaa ccctcgaac agagttaca 
      atgcgagca agaacgagt cgttgaata agagcaacg 
      tttcgacga gttcgcttg aagaacacg acccgtgtc 
      ccgatttta agccgatta ttccgcttc cggacgaag 
      ttccggttg tgaccggcg aggaaaacg atgtggtgt 
      tgttctgcg aacgcgcta ggttgttcc ggtacgtca 
      ccgagacta aggagtgga aggaacgcg gtgtgggca 
      ctttgaaga ttttgaaga acccggaaa cgaagaaag 
      ttcgcattt tgatgcgca gagatcaag tgcataaga 
      tatgtgcca atcatttta ttacgaaag aaatggcgc 
      tgactccga atgccaagt gtgacaggg cgtacattt 
      gggcggcgc acgattacg ccgatgaag aagtcgtgt 
      tggagaagt tgtgtgtga ggtttaaga cgtccgaag 
      aagcgaaga agttttacg atgtgtttg aagcggcca 
      aaaaggggt tagacaccg aggaaagta aagaggcgg 
      cgccaaaac ccgcctctc ttggtggtt ttgttttca 
      cgagcacgc cgactttta agcccaagg aggagaaag 
      ttgtcatac ctgttatga aagaggagc cggttaaag 
      ctagtcctt tctcgaact ttgtgttcg gttctacga 
      aaaacacga gttttccca cgttccaaa ctaactttt 
      caccagttc agaaacaaa gtgaaagcc caggtggca 
      aagctaagg aaccggtcg atgatgaga ctgaagagt 
      ttgttccaa cggctgagt tcaaaccag tcgtgcctt 
      tgcccgaat tagtcgaag tcaaaactg gcgaagaaa 
      attgcgaag tcttgtttg agagccgag cgaaaatcc 
      tccgttttg acacgagtg aagaaacga aagtatgga 
      aggagaaag gagttggtg ttttcaaac tgcttaagg 
      acgcaacaa ccatcagac tagtcatga ggcgagacc 
      aagtcttga aagtgtgtt gtaaccacc aactactca 
      aaaacatgg aatttaaat tcatgacaa ataatccca 
      aagcactga cttggtgcg cgaaagact tctctgaag 
      gcgtcctta aaccggaaa cgctggcta taagattca 
      aaacagaag agctggcta attcgttct tgaaagcca 
      tccaaaccg ctcaagagt cactcgatg aaaataact 
      gcgtgtcgg gtaaaaccc cgaaaatcg aatctccgg 
      ttaaaccga ccggtttcg gcgataagt tcaaaccgg 
      cgaagggaa gttgggagt gtaaaaatt gcttcgttg 
      tgaacgacg gcaaagcca actactgtg tggcttgcg 
      agacaccta aaaacgaca cagttccga aaaaaagcg 
      agagtgacg cttctggag ctgcgtttt ctttcggag 
      ttggcgtgt ccaactcct ggggcaacg ccttcaagc 
      ctaaggaag gttcatggg agtgcaaga cttgctaca 
      tcagaaatg acgccgata agacacact gtatgtcgt 
      gtgaatcgc ccaaagacg acacaattc cgaaaaaag 
      agcccgaaa agggggtga atttggaca ctggtggtt 
      tgaaattca cgttcgggg ttccgaaaa ctgccgaca 
      agccaacca ccggctggg gcgatttat tcaagccca 
      aggaagggt cttgggagt gtaagaatt gtctaatcc 
      agaacaatt ccgatgtcg tttattgtg tggcatgtg 
      agagtccga aagatgata cagttccga aaaaggaag 
      gtccgaaag gtgtcaatt tggacactc cgggtcaga 
      aatacactt tcgggattc cttcgactc aagccggag 
      ctaaagcca cgtttactt ttggccaga gtagcatat 
      caaccgaga aaccgttcg ttttcaaac ccaatgtca 
      gtgtggaga aaaaagaca cttcagcga ctgaaaaat 
      tcgtgtttg gctcgccac aaaagcacg attttgaat 
      tcactccgc ggtcaccca gacgtatca gcagcggcg 
      gtaaagacg aggagtctg atgccagtt acgtggagg 
      aagaggctg ataatattt acttcaaac cggtgattc 
      cgctcccgg ataaggttg aagtgaaga cgggtgagg 
      aggaagagg acgtcttgt attgtcatc gagcgaagc 
      tttaccgtt tcgtggata aggaatgga aggagagag 
      gaatcggtg atttgaaga ttttgaggc ggaaagata 
      ccggcaaat taagggttt tgatgcggc gggagcaag 
      tgtttaaga tttgtttga accatattc tcactactg 
      acattaagt atttgccca aggatgata agacatggc 
      tgttccatg cgtcggatt attccgaag gcgaaataa 
      ccgaagaac aattttgtc ttaggttta agaacgctg 
      aaattgctc aggaattta tgaaggctg tgaacgatg 
      ctttgagtg gagcgtcct gtgatacag gcaagaaaa 
      ttgatgaaa catccgaag gggaagacg tggaattca 
      tttccgaga caaaagtaa caccagaag aagaaaaag 
      aagctctca gattaatgt tgcctccaa agtttatgt 
      cttatcgtc aattacccg actgtcaat gcgcgcagt 
      gcaaaaaag acgacgaat atttgaaag atctcttca 
      aaacgagcg accaaaagt ctaccgcaa cccctccaa 
      tcagtcaaa ttttcaaaa attcgaata cgccatcta 
      tcagtacgt cttctagca caagttcga ttttcacga 
      caccgaaag aagaagtgt tcagtttta aagcagcta 
      ctgagacag tatcatcgc ctgccgata gctcgctca 
      ctcttaaaa gtcttctaa gcaaaccgt cacttctgg 
      tcactcctg taacaactt ccagtggaa tattcagtt 
      ctgccaaca attcatcga atatcttct cttctcctg 
      ccacctcaa gcaatttat tcggctcaa aatcgccct 
      cgatttttc aaacggcca gtgaaacca agaacgaat 
      cgttcacat tcggggcta aaacacccg acactacct 
      cttccagca ttttcgcgc cgccaacaa cagctgcga 
      aatcaaccg gaagtattt tcgggtccg gtagtgtgt 
      tcggaagcg gtggcggaa gcattttcg gctcgaaat 
      cgaccccag ttttcggtt cgggaccgg gaattttcg 
      ctgctacga ccccaacga ccacagctc agtctagtg 
      gaatttttg ggggtgcaa ccactacga gcagtttta 
      aaaccacgg gtagtcttt ttggtactc cggccacaa 
      ccacaacgg ggagtattt tcgggggtt cacctgcag 
      tttttggta aaggtacaa ataagccga tatttggag 
      gaggcgaca gtctggcga aagcgaccg aatcgcccg 
      tcagacctg tttttggtg ctgcggttg cgccaaccg 
      acgtcaaaa caacgaatt tgaaggatg aggatgctc 
      cggttttga atgctgagt ctggaatca cgtttgcaa 
      gcttggcgg ccaaaagta cggaaaaac cggcgttcg 
      ccaaagaga aaaatgact ctgaaaccc catttgcgt 
      ttttgggtg ccggggccc cagtttttg gctctgcca 
      cccccgaca agagcaaat cagtggctt cagaagagg 
      cagaaggtg gaggtgatg aggagtacg atcctcatt 
      acgacccca tagtgcctc taccagacg ccattgttg 
      tttcaacag gcgaggaag acgaagaag tgcttttca 
      acgaacggg caagactgt acagattcg acgctgata 
      ataaagaat ggaaggaaa gaggagttg gccaaatga 
      agattttgc atcatccaa tcaacaata cttaccggt 
      ttttgttaa ggcgtgagc aggtccaca aagtggtac 
      ttaatcagt tagttatcc cagatttgg agctccaac 
      caatgacga cgtctgata aagcctggg tctgggggg 
      gctataatt acaccgacg atggttcag ctttagaaa 
      agttggctg tgagattca aaaactgcg acttggccc 
      aaagttttt acaaagttg tgcaagacg tgcttgata 
      aagttaaga aaattcagt tggagaaat ccaaaactg 
      aaacagcgg ggcaagtcg acttaacga aacttattc 
      cgtcttcga ttcaaaatt tcggggttg aggaggtga 
      gtggggacg agcaagccg gtaaggaag tttcctacg 
      aggaggagg acgatgagg aagaggagg atgatgagg 
      atgaggacg atgatcgta cagtgatgt tcatgaaac 
      ggtgtactc tcagtgaag aggttaatg gcgaatgga 
      aagaggtag ctcttggtg acttgcaag tttattacg 
      acccggatc tctatgcgg caagaattt gcgttagca 
      acgataatg gtgaaattg tgagcaata cggttattg 
      aaaagaata ccgtcatgg agttggata agaacaact 
      gcgtttgga gtgcgtacg atgagtggg gagatgaat 
      accggaaca ggacactca gggctacat tcagcagcg 
      cagcagctg cacaagaat ttcactgta actacgtgg 
      aaggcttga actacgccc atgagttcg acgtggtga 
      atgaaatgc cggtagcga ctgaggaag agactgaat 
      cgttaggtc attaatctg tgtttttat atatttcca 
      ctgttcctt ttacaaagt tttagttta ggaatttta 
      taggaaagt aggttttac gcaaataaa aactttaac 
      gaatt
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